hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_08674.1
Complex Portal: CPX-17090
Confidence: High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| HLA-DQA1 | HLA class II histocompatibility antigen, DQ alpha 1 chain (DC-1 alpha chain) (DC-alpha) (HLA-DCA) (MHC class II DQA1) | 5 | UniProt NCBI |
| TMEM219 | Insulin-like growth factor-binding protein 3 receptor (IGFBP-3R) (Transmembrane protein 219) | 4 | UniProt NCBI |
| HLA-DQA2 | HLA class II histocompatibility antigen, DQ alpha 2 chain (DX alpha chain) (HLA class II histocompatibility antigen, DQ(6) alpha chain) (HLA-DQA1) (MHC class II DQA2) | 5 | UniProt NCBI |
| DOP1B | Protein dopey-2 | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-202430 | 0.000798898068561 | 0.5 | HLA-DQA1 HLA-DQA2 | Translocation of ZAP-70 to Immunological synapse |
| REAC:R-HSA-202427 | 0.0013924419067 | 0.5 | HLA-DQA1 HLA-DQA2 | Phosphorylation of CD3 and TCR zeta chains |
| REAC:R-HSA-389948 | 0.00156635412759 | 0.5 | HLA-DQA1 HLA-DQA2 | PD-1 signaling |
| REAC:R-HSA-202433 | 0.00282403231951 | 0.5 | HLA-DQA1 HLA-DQA2 | Generation of second messenger molecules |
| REAC:R-HSA-388841 | 0.0162811003561 | 0.5 | HLA-DQA1 HLA-DQA2 | Costimulation by the CD28 family |
| REAC:R-HSA-877300 | 0.0290229039331 | 0.5 | HLA-DQA1 HLA-DQA2 | Interferon gamma signaling |
| REAC:R-HSA-202424 | 0.0398310607487 | 0.5 | HLA-DQA1 HLA-DQA2 | Downstream TCR signaling |
| GO:0032395 | 0.042122686785 | 0.5 | HLA-DQA1 HLA-DQA2 | MHC class II receptor activity |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| HLA-DQA2 | HLA-DQA1 | 0.998 | 0.352 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| DOP1B | HLA-DQA1 | 0.984 | 0.078 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| HLA-DQA1 | TMEM219 | 0.963 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| DOP1B | HLA-DQA2 | 0.703 | 0.054 | bioplex3_WMM WMM_only | |
| HLA-DQA2 | TMEM219 | 0.055 | bioplex3_WMM WMM_only | ||
| DOP1B | TMEM219 | 0.026 | bioplex3_WMM WMM_only |
Related Complexes