hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_08676.1
Confidence: High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| PRIM1 | DNA primase small subunit (EC 2.7.7.102) (DNA primase 49 kDa subunit) (p49) | 5 | UniProt NCBI |
| POLA1 | DNA polymerase alpha catalytic subunit (EC 2.7.7.7) (DNA polymerase alpha catalytic subunit p180) | 5 | UniProt NCBI |
| NLGN4Y | Neuroligin-4, Y-linked (Neuroligin Y) | 5 | UniProt NCBI |
| PRIM2 | DNA primase large subunit (DNA primase 58 kDa subunit) (p58) | 5 | UniProt NCBI |
| POLA2 | DNA polymerase alpha subunit B (DNA polymerase alpha 70 kDa subunit) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:1100 | 3.83566049696e-13 | 0.8 | PRIM1 POLA2 PRIM2 POLA1 | DNA polymerase alpha-primase complex |
| REAC:R-HSA-68952 | 2.98941684079e-11 | 0.8 | PRIM1 POLA2 PRIM2 POLA1 | DNA replication initiation |
| CORUM:1107 | 4.831609132e-11 | 0.8 | PRIM1 POLA2 PRIM2 POLA1 | DNA synthesome core complex |
| CORUM:1098 | 8.05224085528e-11 | 0.8 | PRIM1 POLA2 PRIM2 POLA1 | DNA synthesome complex (13 subunits) |
| CORUM:1108 | 2.74114580914e-10 | 0.8 | PRIM1 POLA2 PRIM2 POLA1 | DNA synthesome complex (15 subunits) |
| REAC:R-HSA-113501 | 3.05263965109e-10 | 0.8 | PRIM1 POLA2 PRIM2 POLA1 | Inhibition of replication initiation of damaged DNA by RB1/E2F1 |
| REAC:R-HSA-174430 | 3.05263965109e-10 | 0.8 | PRIM1 POLA2 PRIM2 POLA1 | Telomere C-strand synthesis initiation |
| CORUM:1111 | 3.83739390783e-10 | 0.8 | PRIM1 POLA2 PRIM2 POLA1 | DNA synthesome complex (17 subunits) |
| CORUM:1099 | 3.83739390783e-10 | 0.8 | PRIM1 POLA2 PRIM2 POLA1 | DNA synthesome complex (17 subunits) |
| REAC:R-HSA-69166 | 4.27346139736e-10 | 0.8 | PRIM1 POLA2 PRIM2 POLA1 | Removal of the Flap Intermediate |
| REAC:R-HSA-69109 | 4.27346139736e-10 | 0.8 | PRIM1 POLA2 PRIM2 POLA1 | Leading Strand Synthesis |
| REAC:R-HSA-69091 | 4.27346139736e-10 | 0.8 | PRIM1 POLA2 PRIM2 POLA1 | Polymerase switching |
| REAC:R-HSA-69183 | 5.82712811345e-10 | 0.8 | PRIM1 POLA2 PRIM2 POLA1 | Processive synthesis on the lagging strand |
| GO:0006269 | 6.57779757665e-10 | 0.8 | PRIM1 POLA2 PRIM2 POLA1 | DNA replication, synthesis of RNA primer |
| GO:0005658 | 6.57779757665e-10 | 0.8 | PRIM1 POLA2 PRIM2 POLA1 | alpha DNA polymerase:primase complex |
| REAC:R-HSA-69186 | 2.06774373342e-09 | 0.8 | PRIM1 POLA2 PRIM2 POLA1 | Lagging Strand Synthesis |
| REAC:R-HSA-113510 | 3.12154543066e-09 | 0.8 | PRIM1 POLA2 PRIM2 POLA1 | E2F mediated regulation of DNA replication |
| REAC:R-HSA-174411 | 6.37824653444e-09 | 0.8 | PRIM1 POLA2 PRIM2 POLA1 | Polymerase switching on the C-strand of the telomere |
| KEGG:03030 | 7.51082457735e-09 | 0.8 | PRIM1 POLA2 PRIM2 POLA1 | DNA replication |
| REAC:R-HSA-69190 | 1.53368765668e-08 | 0.8 | PRIM1 POLA2 PRIM2 POLA1 | DNA strand elongation |
| REAC:R-HSA-68962 | 1.74513507793e-08 | 0.8 | PRIM1 POLA2 PRIM2 POLA1 | Activation of the pre-replicative complex |
| WP:WP466 | 1.84613378839e-08 | 0.8 | PRIM1 POLA2 PRIM2 POLA1 | DNA replication |
| REAC:R-HSA-174417 | 1.97771129067e-08 | 0.8 | PRIM1 POLA2 PRIM2 POLA1 | Telomere C-strand (Lagging Strand) Synthesis |
| REAC:R-HSA-180786 | 1.06470860481e-07 | 0.8 | PRIM1 POLA2 PRIM2 POLA1 | Extension of Telomeres |
| REAC:R-HSA-9710421 | 2.22216287327e-07 | 0.8 | PRIM1 POLA2 PRIM2 POLA1 | Defective pyroptosis |
| GO:0042575 | 6.36865069892e-07 | 0.8 | PRIM1 POLA2 PRIM2 POLA1 | DNA polymerase complex |
| GO:0043601 | 9.61435992643e-07 | 0.8 | PRIM1 POLA2 PRIM2 POLA1 | nuclear replisome |
| REAC:R-HSA-9645723 | 1.13620104002e-06 | 0.8 | PRIM1 POLA2 PRIM2 POLA1 | Diseases of programmed cell death |
| GO:0030894 | 1.396459195e-06 | 0.8 | PRIM1 POLA2 PRIM2 POLA1 | replisome |
| REAC:R-HSA-157579 | 1.66615928446e-06 | 0.8 | PRIM1 POLA2 PRIM2 POLA1 | Telomere Maintenance |
| REAC:R-HSA-69239 | 3.37055878382e-06 | 0.8 | PRIM1 POLA2 PRIM2 POLA1 | Synthesis of DNA |
| REAC:R-HSA-73886 | 4.38473721467e-06 | 0.8 | PRIM1 POLA2 PRIM2 POLA1 | Chromosome Maintenance |
| GO:0006270 | 4.72375798258e-06 | 0.8 | PRIM1 POLA2 PRIM2 POLA1 | DNA replication initiation |
| REAC:R-HSA-69206 | 4.81850742601e-06 | 0.8 | PRIM1 POLA2 PRIM2 POLA1 | G1/S Transition |
| REAC:R-HSA-69002 | 7.91332898893e-06 | 0.8 | PRIM1 POLA2 PRIM2 POLA1 | DNA Replication Pre-Initiation |
| REAC:R-HSA-453279 | 7.91332898893e-06 | 0.8 | PRIM1 POLA2 PRIM2 POLA1 | Mitotic G1 phase and G1/S transition |
| GO:0043596 | 1.08004637014e-05 | 0.8 | PRIM1 POLA2 PRIM2 POLA1 | nuclear replication fork |
| REAC:R-HSA-69242 | 1.08579866423e-05 | 0.8 | PRIM1 POLA2 PRIM2 POLA1 | S Phase |
| REAC:R-HSA-69306 | 1.56110049701e-05 | 0.8 | PRIM1 POLA2 PRIM2 POLA1 | DNA Replication |
| WP:WP45 | 4.999634375e-05 | 0.6 | PRIM1 POLA2 PRIM2 | G1 to S cell cycle control |
| GO:0005657 | 8.87760174517e-05 | 0.8 | PRIM1 POLA2 PRIM2 POLA1 | replication fork |
| GO:0055029 | 0.000365836607157 | 0.8 | PRIM1 POLA2 PRIM2 POLA1 | nuclear DNA-directed RNA polymerase complex |
| CORUM:1003 | 0.00038189088864 | 0.4 | POLA1 POLA2 | RC complex (Replication competent complex) |
| GO:0000428 | 0.000382257669512 | 0.8 | PRIM1 POLA2 PRIM2 POLA1 | DNA-directed RNA polymerase complex |
| GO:0030880 | 0.00043484599868 | 0.8 | PRIM1 POLA2 PRIM2 POLA1 | RNA polymerase complex |
| REAC:R-HSA-69278 | 0.00130844914147 | 0.8 | PRIM1 POLA2 PRIM2 POLA1 | Cell Cycle, Mitotic |
| GO:0006261 | 0.00206012733421 | 0.8 | PRIM1 POLA2 PRIM2 POLA1 | DNA-templated DNA replication |
| REAC:R-HSA-1640170 | 0.00298118644627 | 0.8 | PRIM1 POLA2 PRIM2 POLA1 | Cell Cycle |
| GO:0000228 | 0.00469791606681 | 0.8 | PRIM1 POLA2 PRIM2 POLA1 | nuclear chromosome |
| GO:0006260 | 0.01125755688 | 0.8 | PRIM1 POLA2 PRIM2 POLA1 | DNA replication |
| WP:WP2446 | 0.0212523049113 | 0.4 | PRIM1 POLA1 | Retinoblastoma gene in cancer |
| GO:0061695 | 0.0306592465565 | 0.8 | PRIM1 POLA2 PRIM2 POLA1 | transferase complex, transferring phosphorus-containing groups |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| PRIM1 | POLA2 | 0.999 | 0.81 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM fraction |
| PRIM1 | PRIM2 | 0.999 | 0.922 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM |
| PRIM1 | NLGN4Y | 0.997 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| NLGN4Y | PRIM2 | 0.996 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| PRIM1 | POLA1 | 0.994 | 0.818 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM fraction |
| POLA1 | POLA2 | 0.979 | 0.84 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM fraction |
| POLA1 | PRIM2 | 0.969 | 0.838 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only |
| PRIM2 | POLA2 | 0.966 | 0.872 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only |
Related Complexes