hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_08680.1
Confidence: High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| EIF2B2 | Translation initiation factor eIF2B subunit beta (S20I15) (S20III15) (eIF2B GDP-GTP exchange factor subunit beta) | 5 | UniProt NCBI |
| EIF2B1 | Translation initiation factor eIF2B subunit alpha (eIF2B GDP-GTP exchange factor subunit alpha) | 5 | UniProt NCBI |
| EXOG | Nuclease EXOG, mitochondrial (EC 3.1.30.-) (Endonuclease G-like 1) (Endo G-like 1) | 5 | UniProt NCBI |
| GMPPA | Mannose-1-phosphate guanyltransferase alpha (GDP-mannose pyrophosphorylase A) (GMPP-alpha) (GTP-mannose-1-phosphate guanylyltransferase alpha) | 5 | UniProt NCBI |
| PTAFR | Platelet-activating factor receptor (PAF-R) (PAFr) | 5 | UniProt NCBI |
| EIF2B5 | Translation initiation factor eIF2B subunit epsilon (eIF2B GDP-GTP exchange factor subunit epsilon) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:7292 | 2.80175822576e-08 | 0.6 | EIF2B2 EIF2B1 EIF2B5 | EIF2B1-EIF2B2-EIF2B3-EIF2B4-EIF2B5 complex |
| REAC:R-HSA-72731 | 1.7467401872e-07 | 0.6 | EIF2B2 EIF2B1 EIF2B5 | Recycling of eIF2:GDP |
| GO:0005851 | 9.61003071434e-06 | 0.6 | EIF2B2 EIF2B1 EIF2B5 | eukaryotic translation initiation factor 2B complex |
| WP:WP107 | 2.21427564884e-05 | 0.6 | EIF2B2 EIF2B1 EIF2B5 | Translation factors |
| CORUM:7291 | 8.18785830799e-05 | 0.4 | EIF2B2 EIF2B5 | EIF2B2-EIF2B3-EIF2B4-EIF2B5 complex |
| GO:0014003 | 0.000652677252708 | 0.6 | EIF2B2 EIF2B1 EIF2B5 | oligodendrocyte development |
| REAC:R-HSA-72737 | 0.000823183245594 | 0.6 | EIF2B2 EIF2B1 EIF2B5 | Cap-dependent Translation Initiation |
| REAC:R-HSA-72613 | 0.000823183245594 | 0.6 | EIF2B2 EIF2B1 EIF2B5 | Eukaryotic Translation Initiation |
| GO:0048709 | 0.00627040828674 | 0.6 | EIF2B2 EIF2B1 EIF2B5 | oligodendrocyte differentiation |
| KEGG:05168 | 0.00734334502917 | 0.6 | EIF2B2 EIF2B1 EIF2B5 | Herpes simplex virus 1 infection |
| REAC:R-HSA-72766 | 0.0119387407373 | 0.6 | EIF2B2 EIF2B1 EIF2B5 | Translation |
| GO:0003743 | 0.0126766174236 | 0.6 | EIF2B2 EIF2B1 EIF2B5 | translation initiation factor activity |
| GO:0021782 | 0.018748745536 | 0.6 | EIF2B2 EIF2B1 EIF2B5 | glial cell development |
| GO:0009408 | 0.0327001087246 | 0.6 | EIF2B2 EIF2B1 EIF2B5 | response to heat |
| WP:WP5316 | 0.0477224874935 | 0.4 | EIF2B2 EIF2B5 | Primary ovarian insufficiency |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| EIF2B2 | EIF2B5 | 1.0 | 0.882 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt Malo bioplex3_HCT116 fraction boldt_WMM |
| EIF2B2 | EIF2B1 | 1.0 | 0.538 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM Malo bioplex3_HCT116 fraction boldt_WMM |
| EIF2B5 | EIF2B1 | 1.0 | 0.57 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM Malo bioplex3_HCT116 fraction boldt_WMM |
| EXOG | EIF2B2 | 0.998 | 0.028 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| GMPPA | EIF2B5 | 0.981 | 0.078 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| EIF2B2 | PTAFR | 0.977 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| EXOG | EIF2B1 | 0.97 | 0.048 | bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| EXOG | EIF2B5 | 0.969 | 0.044 | bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| PTAFR | EIF2B5 | 0.959 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| GMPPA | EIF2B2 | 0.238 | 0.076 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| GMPPA | EXOG | 0.164 | 0.02 | bioplex_WMM bioplex3_WMM WMM_only |
| GMPPA | EIF2B1 | 0.044 | 0.062 | bioplex_WMM bioplex3_WMM fraction |
| PTAFR | EIF2B1 | 0.021 | bioplex3_WMM bioplex3_HCT116 WMM_only |
Related Complexes