hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_08690.1

Confidence: High

Genename	Protein Name	Uniprot Annotation Score	Links
SP100	Nuclear autoantigen Sp-100 (Nuclear dot-associated Sp100 protein) (Speckled 100 kDa)	5	UniProt NCBI
HMGB1	High mobility group protein B1 (High mobility group protein 1) (HMG-1)	5	UniProt NCBI
HMGB2	High mobility group protein B2 (High mobility group protein 2) (HMG-2)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
CORUM:280	1.02521027753e-05	0.666666666667	HMGB1 HMGB2	HMGB1-HMGB2-HSC70-ERP60-GAPDH complex
REAC:R-HSA-140342	0.000531572756485	0.666666666667	HMGB1 HMGB2	Apoptosis induced DNA fragmentation
HPA:0460203	0.000583942356818	1.0	SP100 HMGB1 HMGB2	skin 1; endothelial cells[High]
HPA:0470203	0.000595778758735	1.0	SP100 HMGB1 HMGB2	skin 2; endothelial cells[High]
HPA:0461473	0.00109967999788	1.0	SP100 HMGB1 HMGB2	skin 1; lymphocytes[High]
HPA:0471473	0.00176667046737	1.0	SP100 HMGB1 HMGB2	skin 2; lymphocytes[High]
HPA:0460182	0.00312059671208	1.0	SP100 HMGB1 HMGB2	skin 1; cells in granular layer[>=Medium]
HPA:0400653	0.00341538204963	0.666666666667	HMGB1 HMGB2	rectum; fibroblasts[High]
HPA:0461472	0.00355239547512	1.0	SP100 HMGB1 HMGB2	skin 1; lymphocytes[>=Medium]
HPA:0461462	0.00373164266974	1.0	SP100 HMGB1 HMGB2	skin 1; langerhans cells[>=Medium]
HPA:0460202	0.00387515227421	1.0	SP100 HMGB1 HMGB2	skin 1; endothelial cells[>=Medium]
HPA:0091083	0.00388935050176	0.666666666667	SP100 HMGB1	cerebellum; white matter cells - nucleus[High]
HPA:0461412	0.00389594915582	1.0	SP100 HMGB1 HMGB2	skin 1; cells in spinous layer[>=Medium]
WP:WP2446	0.00412431213363	0.666666666667	HMGB1 HMGB2	Retinoblastoma gene in cancer
HPA:0470202	0.00474247809279	1.0	SP100 HMGB1 HMGB2	skin 2; endothelial cells[>=Medium]
HPA:0461392	0.00491069279856	1.0	SP100 HMGB1 HMGB2	skin 1; cells in basal layer[>=Medium]
HPA:0471472	0.00500857768833	1.0	SP100 HMGB1 HMGB2	skin 2; lymphocytes[>=Medium]
HPA:0470672	0.00503325048482	1.0	SP100 HMGB1 HMGB2	skin 2; melanocytes[>=Medium]
GO:0051101	0.00526161104852	1.0	SP100 HMGB1 HMGB2	regulation of DNA binding
HPA:0471462	0.0053614064234	1.0	SP100 HMGB1 HMGB2	skin 2; langerhans cells[>=Medium]
HPA:0471412	0.00581164540589	1.0	SP100 HMGB1 HMGB2	skin 2; cells in spinous layer[>=Medium]
HPA:0460181	0.00654790850334	1.0	SP100 HMGB1 HMGB2	skin 1; cells in granular layer[>=Low]
HPA:0461471	0.0066664200125	1.0	SP100 HMGB1 HMGB2	skin 1; lymphocytes[>=Low]
HPA:0461423	0.00704427967728	0.666666666667	HMGB1 HMGB2	skin 1; eccrine glands[High]
HPA:0461461	0.00706144293007	1.0	SP100 HMGB1 HMGB2	skin 1; langerhans cells[>=Low]
HPA:0470671	0.00731212240844	1.0	SP100 HMGB1 HMGB2	skin 2; melanocytes[>=Low]
HPA:0400203	0.00754626791577	0.666666666667	HMGB1 HMGB2	rectum; endothelial cells[High]
HPA:0030443	0.00754626791577	0.666666666667	HMGB1 HMGB2	appendix; non-germinal center cells[High]
HPA:0471392	0.00799822858561	1.0	SP100 HMGB1 HMGB2	skin 2; cells in basal layer[>=Medium]
REAC:R-HSA-75153	0.00800131218049	0.666666666667	HMGB1 HMGB2	Apoptotic execution phase
HPA:0461411	0.0084089015935	1.0	SP100 HMGB1 HMGB2	skin 1; cells in spinous layer[>=Low]
HPA:0400243	0.00896898592343	0.666666666667	HMGB1 HMGB2	rectum; peripheral nerve/ganglion[High]
HPA:0471461	0.00905089926356	1.0	SP100 HMGB1 HMGB2	skin 2; langerhans cells[>=Low]
HPA:0091082	0.00915542027567	0.666666666667	SP100 HMGB1	cerebellum; white matter cells - nucleus[>=Medium]
HPA:0091013	0.00934376365665	0.666666666667	SP100 HMGB1	cerebellum; molecular layer cells - nucleus[High]
HPA:0471471	0.00957222629825	1.0	SP100 HMGB1 HMGB2	skin 2; lymphocytes[>=Low]
HPA:0400652	0.00992024532416	0.666666666667	HMGB1 HMGB2	rectum; fibroblasts[>=Medium]
HPA:0091081	0.010314106725	0.666666666667	SP100 HMGB1	cerebellum; white matter cells - nucleus[>=Low]
HPA:0471442	0.0105118333285	1.0	SP100 HMGB1 HMGB2	skin 2; fibrohistiocytic cells[>=Medium]
HPA:0460201	0.0109208095397	1.0	SP100 HMGB1 HMGB2	skin 1; endothelial cells[>=Low]
HPA:0400651	0.0121808707248	0.666666666667	HMGB1 HMGB2	rectum; fibroblasts[>=Low]
HPA:0471411	0.012211103258	1.0	SP100 HMGB1 HMGB2	skin 2; cells in spinous layer[>=Low]
HPA:0470201	0.0128004018578	1.0	SP100 HMGB1 HMGB2	skin 2; endothelial cells[>=Low]
HPA:0461391	0.0128927121824	1.0	SP100 HMGB1 HMGB2	skin 1; cells in basal layer[>=Low]
GO:0097100	0.0140440992017	0.666666666667	HMGB1 HMGB2	supercoiled DNA binding
HPA:0471493	0.0144360249621	0.666666666667	HMGB1 HMGB2	skin 2; vascular mural cells[High]
HPA:0461493	0.0163771345036	0.666666666667	HMGB1 HMGB2	skin 1; vascular mural cells[High]
HPA:0471391	0.0165736132678	1.0	SP100 HMGB1 HMGB2	skin 2; cells in basal layer[>=Low]
HPA:0481353	0.0176520960163	0.666666666667	HMGB1 HMGB2	small intestine; paneth cells[High]
HPA:0131333	0.018175375241	0.666666666667	HMGB1 HMGB2	colon; mucosal lymphoid cells[High]
HPA:0471441	0.0193402202577	1.0	SP100 HMGB1 HMGB2	skin 2; fibrohistiocytic cells[>=Low]
HPA:0151353	0.0197907669302	0.666666666667	HMGB1 HMGB2	duodenum; paneth cells[High]
HPA:0091012	0.0203444084371	0.666666666667	SP100 HMGB1	cerebellum; molecular layer cells - nucleus[>=Medium]
HPA:0030893	0.0209056352186	0.666666666667	HMGB1 HMGB2	appendix; goblet cells[High]
HPA:0401333	0.0235249667108	0.666666666667	HMGB1 HMGB2	rectum; mucosal lymphoid cells[High]
HPA:0400202	0.0244321680476	0.666666666667	HMGB1 HMGB2	rectum; endothelial cells[>=Medium]
HPA:0091011	0.0247383540693	0.666666666667	SP100 HMGB1	cerebellum; molecular layer cells - nucleus[>=Low]
HPA:0031303	0.025668265156	0.666666666667	HMGB1 HMGB2	appendix; enterocytes[High]
HPA:0400242	0.0272559444841	0.666666666667	HMGB1 HMGB2	rectum; peripheral nerve/ganglion[>=Medium]
HPA:0130893	0.0279042496677	0.666666666667	HMGB1 HMGB2	colon; goblet cells[High]
HPA:0150893	0.0288908795224	0.666666666667	HMGB1 HMGB2	duodenum; goblet cells[High]
HPA:0461422	0.0302328294218	0.666666666667	HMGB1 HMGB2	skin 1; eccrine glands[>=Medium]
HPA:0480893	0.0302328294218	0.666666666667	HMGB1 HMGB2	small intestine; goblet cells[High]
HPA:0400893	0.0302328294218	0.666666666667	HMGB1 HMGB2	rectum; goblet cells[High]
HPA:0461492	0.0316049848456	0.666666666667	HMGB1 HMGB2	skin 1; vascular mural cells[>=Medium]
HPA:0461393	0.0323023843332	0.666666666667	HMGB1 HMGB2	skin 1; cells in basal layer[High]
HPA:0471492	0.0323023843332	0.666666666667	HMGB1 HMGB2	skin 2; vascular mural cells[>=Medium]
HPA:0131303	0.0344398444789	0.666666666667	HMGB1 HMGB2	colon; enterocytes[High]
HPA:0481352	0.0359025147948	0.666666666667	HMGB1 HMGB2	small intestine; paneth cells[>=Medium]
HPA:0031293	0.0370192963486	0.666666666667	HMGB1 HMGB2	appendix; endocrine cells[High]
HPA:0401303	0.0370192963486	0.666666666667	HMGB1 HMGB2	rectum; enterocytes[High]
HPA:0461413	0.037395322848	0.666666666667	HMGB1 HMGB2	skin 1; cells in spinous layer[High]
GO:0033151	0.0393180950424	0.666666666667	HMGB1 HMGB2	V(D)J recombination
GO:0050786	0.0393180950424	0.666666666667	HMGB1 HMGB2	RAGE receptor binding
HPA:0151303	0.0396910061138	0.666666666667	HMGB1 HMGB2	duodenum; enterocytes[High]
HPA:0461463	0.0412590843677	0.666666666667	HMGB1 HMGB2	skin 1; langerhans cells[High]
HPA:0481303	0.0416558043469	0.666666666667	HMGB1 HMGB2	small intestine; enterocytes[High]
HPA:0151352	0.0440755873239	0.666666666667	HMGB1 HMGB2	duodenum; paneth cells[>=Medium]
HPA:0131293	0.0448972088574	0.666666666667	HMGB1 HMGB2	colon; endocrine cells[High]
HPA:0400201	0.0461437218829	0.666666666667	HMGB1 HMGB2	rectum; endothelial cells[>=Low]
HPA:0481351	0.047407125424	0.666666666667	HMGB1 HMGB2	small intestine; paneth cells[>=Low]
HPA:0400241	0.0482587745405	0.666666666667	HMGB1 HMGB2	rectum; peripheral nerve/ganglion[>=Low]

Edges

Protein 1	Protein 2	Score	ProteomeHD	Evidence
HMGB1	SP100	0.984		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM
HMGB1	HMGB2	0.972	0.722	bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM fraction
HMGB2	SP100	0.211		bioplex3_HEK293 bioplex3_WMM WMM_only

Related Complexes

Genename	Complexes
SP100	huMAP3_06127.1 huMAP3_06912.1 huMAP3_08690.1 huMAP3_10049.1 huMAP3_12437.1 huMAP3_15034.1 huMAP3_15259.1
HMGB1	huMAP3_00806.1 huMAP3_06127.1 huMAP3_08690.1 huMAP3_10049.1 huMAP3_11653.1 huMAP3_12437.1 huMAP3_12523.1 huMAP3_14618.1
HMGB2	huMAP3_00806.1 huMAP3_08690.1 huMAP3_10093.1 huMAP3_11653.1 huMAP3_12523.1 huMAP3_14618.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_08690.1