hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_08691.1

Confidence: High

Genename	Protein Name	Uniprot Annotation Score	Links
EIF4G1	Eukaryotic translation initiation factor 4 gamma 1 (eIF-4-gamma 1) (eIF-4G 1) (eIF-4G1) (p220)	5	UniProt NCBI
EIF4G3	Eukaryotic translation initiation factor 4 gamma 3 (eIF-4-gamma 3) (eIF-4G 3) (eIF4G 3) (eIF-4-gamma II) (eIF4GII)	5	UniProt NCBI
EIF4EBP1	Eukaryotic translation initiation factor 4E-binding protein 1 (4E-BP1) (eIF4E-binding protein 1) (Phosphorylated heat- and acid-stable protein regulated by insulin 1) (PHAS-I)	5	UniProt NCBI
EIF4E	Eukaryotic translation initiation factor 4E (eIF-4E) (eIF4E) (eIF-4F 25 kDa subunit) (mRNA cap-binding protein)	5	UniProt NCBI
EIF4EBP2	Eukaryotic translation initiation factor 4E-binding protein 2 (4E-BP2) (eIF4E-binding protein 2)	5	UniProt NCBI
EIF4E1B	Eukaryotic translation initiation factor 4E type 1B	2	UniProt NCBI
ANGEL1	Protein angel homolog 1	4	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
WP:WP107	6.49944406578e-10	0.714285714286	EIF4E EIF4G1 EIF4EBP2 EIF4G3 EIF4EBP1	Translation factors
GO:0031369	1.52271260241e-08	0.714285714286	EIF4G1 ANGEL1 EIF4EBP2 EIF4EBP1 EIF4E	translation initiation factor binding
GO:0045182	5.51041937092e-08	0.857142857143	EIF4G3 EIF4G1 EIF4E1B EIF4E EIF4EBP2 EIF4EBP1	translation regulator activity
GO:0008190	6.44235965654e-08	0.571428571429	EIF4G1 ANGEL1 EIF4EBP1 EIF4EBP2	eukaryotic initiation factor 4E binding
WP:WP4566	1.67931425357e-07	0.571428571429	EIF4E EIF4G1 EIF4G3 EIF4EBP1	Translation inhibitors in chronically activated PDGFRA cells
GO:0016281	6.57500588447e-07	0.571428571429	EIF4G1 EIF4E1B EIF4G3 EIF4E	eukaryotic translation initiation factor 4F complex
GO:0034518	1.67281284871e-06	0.571428571429	EIF4G1 EIF4E1B EIF4G3 EIF4E	RNA cap binding complex
GO:0006413	1.80511788521e-05	0.714285714286	EIF4E EIF4G1 EIF4EBP2 EIF4G3 EIF4EBP1	translational initiation
REAC:R-HSA-166208	2.62784267685e-05	0.428571428571	EIF4G1 EIF4EBP1 EIF4E	mTORC1-mediated signalling
CORUM:5253	0.000123103089524	0.285714285714	EIF4G1 EIF4E	MNK1-eIF4F complex
GO:0003743	0.00012419921232	0.571428571429	EIF4G1 EIF4E1B EIF4G3 EIF4E	translation initiation factor activity
REAC:R-HSA-165159	0.000137920329377	0.428571428571	EIF4G1 EIF4EBP1 EIF4E	MTOR signalling
KEGG:01521	0.000224342633213	0.428571428571	EIF4E EIF4EBP1 EIF4E1B	EGFR tyrosine kinase inhibitor resistance
KEGG:04211	0.000294849715299	0.428571428571	EIF4E EIF4EBP1 EIF4E1B	Longevity regulating pathway
REAC:R-HSA-72662	0.000441015138927	0.428571428571	EIF4G1 EIF4EBP1 EIF4E	Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
KEGG:04066	0.000540033582053	0.428571428571	EIF4E EIF4EBP1 EIF4E1B	HIF-1 signaling pathway
REAC:R-HSA-1169408	0.000589010657253	0.428571428571	EIF4G1 EIF4G3 EIF4E	ISG15 antiviral mechanism
REAC:R-HSA-1169410	0.000766722633593	0.428571428571	EIF4G1 EIF4G3 EIF4E	Antiviral mechanism by IFN-stimulated genes
GO:0008135	0.000835286748042	0.571428571429	EIF4G1 EIF4E1B EIF4G3 EIF4E	translation factor activity, RNA binding
GO:0006446	0.000885008735247	0.571428571429	EIF4G1 EIF4EBP2 EIF4G3 EIF4EBP1	regulation of translational initiation
KEGG:04910	0.00111447798076	0.428571428571	EIF4E EIF4EBP1 EIF4E1B	Insulin signaling pathway
WP:WP4549	0.00128668469801	0.428571428571	EIF4G1 EIF4EBP2 EIF4E	Fragile X syndrome
KEGG:04150	0.00180438218152	0.428571428571	EIF4E EIF4EBP1 EIF4E1B	mTOR signaling pathway
GO:0090079	0.0018400127105	0.571428571429	EIF4G1 EIF4E1B EIF4G3 EIF4E	translation regulator activity, nucleic acid binding
GO:0006417	0.00199809004794	0.714285714286	EIF4E EIF4G1 EIF4EBP2 EIF4G3 EIF4EBP1	regulation of translation
WP:WP516	0.00271530250843	0.285714285714	EIF4E EIF4EBP1	Hypertrophy model
GO:0000339	0.00273674384085	0.428571428571	EIF4E EIF4G3 EIF4E1B	RNA cap binding
REAC:R-HSA-72737	0.00339905182906	0.428571428571	EIF4G1 EIF4EBP1 EIF4E	Cap-dependent Translation Initiation
REAC:R-HSA-72613	0.00339905182906	0.428571428571	EIF4G1 EIF4EBP1 EIF4E	Eukaryotic Translation Initiation
WP:WP3879	0.00372433499977	0.285714285714	EIF4E EIF4EBP1	4 hydroxytamoxifen dexamethasone and retinoic acids regulation of p27 expression
GO:0034248	0.00456772258253	0.714285714286	EIF4E EIF4G1 EIF4EBP2 EIF4G3 EIF4EBP1	regulation of amide metabolic process
REAC:R-HSA-429947	0.0104655132242	0.285714285714	EIF4G1 EIF4E	Deadenylation of mRNA
REAC:R-HSA-913531	0.0110497496792	0.428571428571	EIF4G1 EIF4G3 EIF4E	Interferon Signaling
KEGG:04151	0.0127794263112	0.428571428571	EIF4E EIF4EBP1 EIF4E1B	PI3K-Akt signaling pathway
GO:0010608	0.0141223504114	0.714285714286	EIF4E EIF4G1 EIF4EBP2 EIF4G3 EIF4EBP1	post-transcriptional regulation of gene expression
KEGG:05416	0.0145134445639	0.285714285714	EIF4G1 EIF4G3	Viral myocarditis
WP:WP3932	0.0145518366115	0.428571428571	EIF4E EIF4EBP1 EIF4E1B	Focal adhesion PI3K Akt mTOR signaling pathway
WP:WP4172	0.0189167579285	0.428571428571	EIF4E EIF4EBP1 EIF4E1B	PI3K Akt signaling pathway
WP:WP585	0.0224576883083	0.285714285714	EIF4E EIF4EBP1	Interferon type I signaling pathways
WP:WP2034	0.039968890476	0.285714285714	EIF4E EIF4EBP1	Leptin signaling pathway
WP:WP4674	0.0423532804888	0.285714285714	EIF4E EIF4EBP1	Head and neck squamous cell carcinoma
REAC:R-HSA-72766	0.0484381900975	0.428571428571	EIF4G1 EIF4EBP1 EIF4E	Translation

Edges

Protein 1	Protein 2	Score	ProteomeHD	Evidence
EIF4E	EIF4G3	0.999	0.21	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 fraction
EIF4E	EIF4EBP2	0.998	0.124	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 fraction
EIF4E	ANGEL1	0.998	0.126	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
EIF4EBP1	EIF4E	0.998	0.1384	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 fraction
EIF4E	EIF4G1	0.997		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 fraction
EIF4E1B	EIF4E	0.982		bioplex3_WMM bioplex3_HCT116 WMM_only
EIF4EBP1	EIF4EBP2	0.982	0.042	bioplex_WMM bioplex3_WMM fraction
EIF4E1B	EIF4EBP1	0.977		bioplex3_WMM bioplex3_HCT116 WMM_only
EIF4EBP1	EIF4G3	0.908	0.148	bioplex_WMM bioplex3_WMM WMM_only
EIF4E1B	EIF4EBP2	0.904		bioplex3_WMM WMM_only
EIF4G3	EIF4EBP2	0.902	0.03	bioplex_WMM bioplex3_WMM WMM_only
EIF4EBP2	ANGEL1	0.845	0.066	bioplex_WMM bioplex3_WMM WMM_only
EIF4G1	EIF4G3	0.786		bioplex_WMM bioplex3_WMM WMM_only treiber_WMM
EIF4G1	EIF4EBP2	0.756		bioplex_WMM bioplex3_WMM gupta_WMM WMM_only
EIF4E1B	EIF4G3	0.675		bioplex3_WMM WMM_only
EIF4G3	ANGEL1	0.663	0.066	bioplex_WMM bioplex3_WMM WMM_only
EIF4E1B	ANGEL1	0.367		bioplex3_WMM WMM_only
EIF4EBP1	ANGEL1	0.325	0.06	bioplex_WMM bioplex3_WMM WMM_only
EIF4E1B	EIF4G1	0.245		bioplex3_WMM WMM_only
EIF4EBP1	EIF4G1	0.188		bioplex_WMM bioplex3_WMM gupta_WMM WMM_only
EIF4G1	ANGEL1	0.109		bioplex_WMM bioplex3_WMM WMM_only

Related Complexes

Genename	Complexes
EIF4G1	huMAP3_00972.1 huMAP3_00975.1 huMAP3_03615.1 huMAP3_04825.1 huMAP3_06085.1 huMAP3_08691.1 huMAP3_09957.1 huMAP3_11246.1 huMAP3_13175.1
EIF4G3	huMAP3_01678.1 huMAP3_01924.1 huMAP3_04825.1 huMAP3_06085.1 huMAP3_08691.1 huMAP3_09863.1 huMAP3_09957.1 huMAP3_10733.1 huMAP3_12323.1 huMAP3_12383.1 huMAP3_13122.1 huMAP3_13436.1
EIF4EBP1	huMAP3_00082.1 huMAP3_01678.1 huMAP3_01924.1 huMAP3_04702.1 huMAP3_04825.1 huMAP3_07077.1 huMAP3_08691.1 huMAP3_09957.1 huMAP3_10733.1 huMAP3_12323.1 huMAP3_12383.1 huMAP3_13122.1 huMAP3_13436.1
EIF4E	huMAP3_00082.1 huMAP3_01678.1 huMAP3_01924.1 huMAP3_04702.1 huMAP3_04825.1 huMAP3_07077.1 huMAP3_08691.1 huMAP3_09957.1 huMAP3_10733.1 huMAP3_12323.1 huMAP3_12383.1 huMAP3_13122.1 huMAP3_13436.1
EIF4EBP2	huMAP3_01924.1 huMAP3_04702.1 huMAP3_04825.1 huMAP3_07077.1 huMAP3_08691.1 huMAP3_09957.1 huMAP3_10733.1 huMAP3_12323.1 huMAP3_12383.1 huMAP3_13122.1 huMAP3_13436.1
EIF4E1B	huMAP3_00082.1 huMAP3_01678.1 huMAP3_01924.1 huMAP3_04825.1 huMAP3_07077.1 huMAP3_08691.1 huMAP3_09957.1 huMAP3_10733.1 huMAP3_12323.1 huMAP3_12383.1 huMAP3_13122.1 huMAP3_13436.1
ANGEL1	huMAP3_02824.1 huMAP3_02876.1 huMAP3_08691.1 huMAP3_12323.1 huMAP3_12383.1 huMAP3_13122.1 huMAP3_13436.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_08691.1