hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_08698.1
Complex Portal: CPX-17194
Confidence: High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| ERN1 | Serine/threonine-protein kinase/endoribonuclease IRE1 (Endoplasmic reticulum-to-nucleus signaling 1) (Inositol-requiring protein 1) (hIRE1p) (Ire1-alpha) (IRE1a) [Includes: Serine/threonine-protein kinase (EC 2.7.11.1); Endoribonuclease (EC 3.1.26.-)] | 5 | UniProt NCBI |
| SHB | SH2 domain-containing adapter protein B | 5 | UniProt NCBI |
| RAD54L | DNA repair and recombination protein RAD54-like (EC 3.6.4.12) (RAD54 homolog) (hHR54) (hRAD54) | 5 | UniProt NCBI |
| NET1 | Neuroepithelial cell-transforming gene 1 protein (Proto-oncogene p65 Net1) (Rho guanine nucleotide exchange factor 8) | 5 | UniProt NCBI |
| NTAQ1 | Protein N-terminal glutamine amidohydrolase (EC 3.5.1.122) (Protein NH2-terminal glutamine deamidase) (N-terminal Gln amidase) (Nt(Q)-amidase) (WDYHV motif-containing protein 1) | 5 | UniProt NCBI |
| SBNO1 | Protein strawberry notch homolog 1 (Monocyte protein 3) (MOP-3) | 4 | UniProt NCBI |
| ZHX3 | Zinc fingers and homeoboxes protein 3 (Triple homeobox protein 1) (Zinc finger and homeodomain protein 3) | 5 | UniProt NCBI |
| TAFA1 | Chemokine-like protein TAFA-1 | 3 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP2864 | 0.0223720274659 | 0.25 | ERN1 NET1 | Apoptosis related network due to altered Notch3 in ovarian cancer |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| RAD54L | NTAQ1 | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| ERN1 | NTAQ1 | 0.997 | 0.116 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| NTAQ1 | TAFA1 | 0.996 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| NTAQ1 | ZHX3 | 0.984 | 0.136 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| SHB | NTAQ1 | 0.978 | 0.236 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| NTAQ1 | NET1 | 0.958 | 0.086 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| NTAQ1 | SBNO1 | 0.95 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM fraction | ||
| ERN1 | RAD54L | 0.611 | bioplex_WMM bioplex3_WMM WMM_only | ||
| SHB | NET1 | 0.4 | 0.12 | bioplex_WMM bioplex3_WMM boldt boldt_WMM WMM_only | |
| RAD54L | SBNO1 | 0.323 | bioplex_WMM bioplex3_WMM WMM_only | ||
| SBNO1 | NET1 | 0.223 | bioplex_WMM bioplex3_WMM WMM_only | ||
| SHB | ERN1 | 0.213 | 0.112 | bioplex_WMM bioplex3_WMM WMM_only | |
| ERN1 | SBNO1 | 0.205 | bioplex_WMM bioplex3_WMM WMM_only | ||
| ERN1 | ZHX3 | 0.187 | 0.256 | bioplex_WMM bioplex3_WMM WMM_only | |
| RAD54L | ZHX3 | 0.172 | bioplex_WMM bioplex3_WMM WMM_only | ||
| SHB | RAD54L | 0.172 | bioplex_WMM bioplex3_WMM WMM_only | ||
| RAD54L | NET1 | 0.172 | bioplex_WMM bioplex3_WMM WMM_only | ||
| SHB | ZHX3 | 0.164 | 0.118 | bioplex_WMM bioplex3_WMM WMM_only | |
| SHB | SBNO1 | 0.164 | bioplex_WMM bioplex3_WMM WMM_only | ||
| ERN1 | NET1 | 0.162 | 0.134 | bioplex_WMM bioplex3_WMM WMM_only | |
| ZHX3 | NET1 | 0.143 | 0.13 | bioplex_WMM bioplex3_WMM WMM_only | |
| SBNO1 | ZHX3 | 0.074 | bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only |
Related Complexes