hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_08700.1
Complex Portal: CPX-21948
Confidence: High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| APOA2 | Apolipoprotein A-II (Apo-AII) (ApoA-II) (Apolipoprotein A2) [Cleaved into: Proapolipoprotein A-II (ProapoA-II); Truncated apolipoprotein A-II (Apolipoprotein A-II(1-76))] | 5 | UniProt NCBI |
| CP | Ceruloplasmin (Cuproxidase ceruloplasmin) (EC 1.16.3.4) (Ferroxidase ceruloplasmin) (EC 1.16.3.1) | 5 | UniProt NCBI |
| AHSG | Alpha-2-HS-glycoprotein (Alpha-2-Z-globulin) (Ba-alpha-2-glycoprotein) (Fetuin-A) [Cleaved into: Alpha-2-HS-glycoprotein chain A; Alpha-2-HS-glycoprotein chain B] | 5 | UniProt NCBI |
| A1BG | Alpha-1B-glycoprotein (Alpha-1-B glycoprotein) | 5 | UniProt NCBI |
| C4A | Complement C4-A (Acidic complement C4) (C3 and PZP-like alpha-2-macroglobulin domain-containing protein 2) [Cleaved into: Complement C4 beta chain; Complement C4-A alpha chain; C4a anaphylatoxin; C4b-A; C4d-A; Complement C4 gamma chain] | 5 | UniProt NCBI |
| ORM1 | Alpha-1-acid glycoprotein 1 (AGP 1) (Orosomucoid-1) (OMD 1) | 5 | UniProt NCBI |
| ALB | Albumin | 5 | UniProt NCBI |
| HPX | Hemopexin (Beta-1B-glycoprotein) | 5 | UniProt NCBI |
| APOA4 | Apolipoprotein A-IV (Apo-AIV) (ApoA-IV) (Apolipoprotein A4) | 5 | UniProt NCBI |
| MAPK6 | Mitogen-activated protein kinase 6 (MAP kinase 6) (MAPK 6) (EC 2.7.11.24) (Extracellular signal-regulated kinase 3) (ERK-3) (MAP kinase isoform p97) (p97-MAPK) | 5 | UniProt NCBI |
| SERPINA1 | Alpha-1-antitrypsin (Alpha-1 protease inhibitor) (Alpha-1-antiproteinase) (Serpin A1) [Cleaved into: Short peptide from AAT (SPAAT)] | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0072562 | 6.18522661273e-14 | 0.818181818182 | ALB ORM1 CP C4A APOA4 AHSG HPX A1BG APOA2 | blood microparticle |
| REAC:R-HSA-8957275 | 4.36487498631e-09 | 0.545454545455 | ALB C4A SERPINA1 AHSG CP APOA2 | Post-translational protein phosphorylation |
| REAC:R-HSA-381426 | 1.02642565575e-08 | 0.545454545455 | ALB C4A SERPINA1 AHSG CP APOA2 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| REAC:R-HSA-114608 | 2.01111843172e-06 | 0.454545454545 | ORM1 SERPINA1 ALB AHSG A1BG | Platelet degranulation |
| REAC:R-HSA-76005 | 2.54473068313e-06 | 0.454545454545 | ORM1 SERPINA1 ALB AHSG A1BG | Response to elevated platelet cytosolic Ca2+ |
| GO:0005788 | 5.63631328439e-06 | 0.636363636364 | ALB SERPINA1 CP C4A AHSG APOA4 APOA2 | endoplasmic reticulum lumen |
| GO:0031093 | 1.56152195436e-05 | 0.454545454545 | ORM1 SERPINA1 ALB AHSG A1BG | platelet alpha granule lumen |
| GO:0031091 | 7.00968258654e-05 | 0.454545454545 | ORM1 SERPINA1 ALB AHSG A1BG | platelet alpha granule |
| REAC:R-HSA-76002 | 7.67052263618e-05 | 0.454545454545 | ORM1 SERPINA1 ALB AHSG A1BG | Platelet activation, signaling and aggregation |
| REAC:R-HSA-8963899 | 0.000211646090565 | 0.272727272727 | APOA4 APOA2 ALB | Plasma lipoprotein remodeling |
| GO:0070062 | 0.000454628173938 | 0.909090909091 | ALB SERPINA1 ORM1 CP C4A APOA4 AHSG HPX A1BG APOA2 | extracellular exosome |
| GO:1903561 | 0.000498164164505 | 0.909090909091 | ALB SERPINA1 ORM1 CP C4A APOA4 AHSG HPX A1BG APOA2 | extracellular vesicle |
| GO:0043230 | 0.000500837846091 | 0.909090909091 | ALB SERPINA1 ORM1 CP C4A APOA4 AHSG HPX A1BG APOA2 | extracellular organelle |
| GO:0065010 | 0.000500837846091 | 0.909090909091 | ALB SERPINA1 ORM1 CP C4A APOA4 AHSG HPX A1BG APOA2 | extracellular membrane-bounded organelle |
| GO:0062023 | 0.0015381483597 | 0.545454545455 | ORM1 A1BG SERPINA1 AHSG HPX APOA4 | collagen-containing extracellular matrix |
| REAC:R-HSA-174824 | 0.00274691920236 | 0.272727272727 | APOA4 APOA2 ALB | Plasma lipoprotein assembly, remodeling, and clearance |
| WP:WP5110 | 0.00294589150453 | 0.181818181818 | APOA2 APOA4 | Familial hyperlipidemia type 3 |
| WP:WP5112 | 0.00353361833038 | 0.181818181818 | APOA2 APOA4 | Familial hyperlipidemia type 5 |
| WP:WP5109 | 0.0041743797154 | 0.181818181818 | APOA2 APOA4 | Familial hyperlipidemia type 2 |
| REAC:R-HSA-8963901 | 0.00478951429206 | 0.181818181818 | APOA2 APOA4 | Chylomicron remodeling |
| GO:0030312 | 0.00516380874703 | 0.545454545455 | ORM1 A1BG SERPINA1 AHSG HPX APOA4 | external encapsulating structure |
| GO:0031012 | 0.00516380874703 | 0.545454545455 | ORM1 A1BG SERPINA1 AHSG HPX APOA4 | extracellular matrix |
| WP:WP5108 | 0.00561474372017 | 0.181818181818 | APOA2 APOA4 | Familial hyperlipidemia type 1 |
| REAC:R-HSA-109582 | 0.0058690188131 | 0.454545454545 | ORM1 SERPINA1 ALB AHSG A1BG | Hemostasis |
| REAC:R-HSA-8963888 | 0.005984434688 | 0.181818181818 | APOA2 APOA4 | Chylomicron assembly |
| WP:WP5111 | 0.0072664591732 | 0.181818181818 | APOA2 APOA4 | Familial hyperlipidemia type 4 |
| REAC:R-HSA-2168880 | 0.00876996466453 | 0.181818181818 | HPX ALB | Scavenging of heme from plasma |
| GO:0005615 | 0.0117489175163 | 0.909090909091 | ALB SERPINA1 ORM1 CP C4A APOA4 AHSG HPX A1BG APOA2 | extracellular space |
| WP:WP430 | 0.0123169771573 | 0.181818181818 | APOA2 APOA4 | Statin inhibition of cholesterol production |
| REAC:R-HSA-8963898 | 0.0159192181681 | 0.181818181818 | APOA2 APOA4 | Plasma lipoprotein assembly |
| REAC:R-HSA-392499 | 0.0164010508062 | 0.636363636364 | ALB SERPINA1 CP C4A AHSG APOA4 APOA2 | Metabolism of proteins |
| KEGG:04979 | 0.021182820588 | 0.181818181818 | APOA2 APOA4 | Cholesterol metabolism |
| REAC:R-HSA-597592 | 0.0292756297165 | 0.545454545455 | ALB C4A SERPINA1 AHSG CP APOA2 | Post-translational protein modification |
| GO:0005576 | 0.0305194206532 | 0.909090909091 | ALB SERPINA1 ORM1 CP C4A APOA4 AHSG HPX A1BG APOA2 | extracellular region |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| AHSG | ALB | 0.987 | 0.52 |
mutually_exclusive (O43240)
|
bioplex_WMM bioplex3_WMM bioplex3_HCT116 boldt_WMM WMM_only |
| APOA2 | CP | 0.985 | 0.554 | bioplex_WMM bioplex3_WMM WMM_only | |
| APOA2 | HPX | 0.985 | 0.468 | bioplex_WMM bioplex3_WMM WMM_only | |
| AHSG | HPX | 0.984 | 0.306 | bioplex_WMM bioplex3_WMM WMM_only | |
| AHSG | ORM1 | 0.984 | 0.282 |
mutually_exclusive (O43240)
|
bioplex_WMM bioplex3_WMM WMM_only |
| AHSG | CP | 0.984 | 0.086 | bioplex_WMM bioplex3_WMM WMM_only | |
| AHSG | SERPINA1 | 0.983 | 0.352 |
structurally_consistent (dimer)
|
bioplex_WMM bioplex3_WMM WMM_only |
| CP | HPX | 0.983 | 0.36 | bioplex_WMM bioplex3_WMM WMM_only | |
| ORM1 | HPX | 0.982 | 0.376 | bioplex_WMM bioplex3_WMM WMM_only | |
| ORM1 | CP | 0.982 | 0.672 | bioplex_WMM bioplex3_WMM WMM_only | |
| APOA4 | CP | 0.981 | 0.494 | bioplex_WMM bioplex3_WMM WMM_only | |
| CP | A1BG | 0.981 | 0.532 | bioplex_WMM bioplex3_WMM WMM_only | |
| AHSG | APOA2 | 0.981 | 0.416 | bioplex_WMM bioplex3_WMM WMM_only boldt_WMM | |
| APOA4 | HPX | 0.979 | 0.404 | bioplex_WMM bioplex3_WMM WMM_only | |
| A1BG | HPX | 0.978 | 0.606 | bioplex_WMM bioplex3_WMM WMM_only | |
| ORM1 | SERPINA1 | 0.978 | 0.648 |
mutually_exclusive (O43240)
|
bioplex_WMM bioplex3_WMM WMM_only |
| AHSG | APOA4 | 0.977 | 0.138 |
structurally_consistent (dimer)
|
bioplex_WMM bioplex3_WMM WMM_only |
| ORM1 | APOA4 | 0.977 | 0.406 | bioplex_WMM bioplex3_WMM WMM_only | |
| MAPK6 | ALB | 0.976 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| ORM1 | APOA2 | 0.974 | 0.65 | bioplex_WMM bioplex3_WMM WMM_only | |
| APOA4 | APOA2 | 0.974 | 0.454 | bioplex_WMM bioplex3_WMM WMM_only | |
| APOA2 | A1BG | 0.972 | 0.41 | bioplex_WMM bioplex3_WMM WMM_only | |
| SERPINA1 | APOA2 | 0.968 | 0.478 | bioplex_WMM bioplex3_WMM WMM_only | |
| C4A | ORM1 | 0.966 | 0.492 | bioplex_WMM bioplex3_WMM WMM_only | |
| SERPINA1 | CP | 0.965 | 0.292 | bioplex_WMM bioplex3_WMM WMM_only | |
| SERPINA1 | ALB | 0.962 | 0.466 | bioplex_WMM bioplex3_WMM WMM_only boldt_WMM | |
| SERPINA1 | A1BG | 0.962 | 0.6 | bioplex_WMM bioplex3_WMM WMM_only | |
| MAPK6 | SERPINA1 | 0.959 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| AHSG | A1BG | 0.956 | 0.33 | bioplex_WMM bioplex3_WMM WMM_only | |
| ORM1 | A1BG | 0.956 | 0.774 |
mutually_exclusive (P19652)
|
bioplex_WMM bioplex3_WMM WMM_only |
| APOA4 | ALB | 0.955 | 0.454909090909 | bioplex_WMM bioplex3_WMM WMM_only | |
| SERPINA1 | HPX | 0.953 | 0.576 | bioplex_WMM bioplex3_WMM WMM_only | |
| APOA4 | A1BG | 0.953 | 0.486 | bioplex_WMM bioplex3_WMM WMM_only | |
| APOA4 | SERPINA1 | 0.952 | 0.3 |
structurally_consistent (P02765)
|
bioplex_WMM bioplex3_WMM WMM_only |
| ORM1 | ALB | 0.951 | 0.652 |
mixed_interface
|
bioplex_WMM bioplex3_WMM WMM_only |
| AHSG | C4A | 0.946 | 0.31 | bioplex_WMM bioplex3_WMM WMM_only | |
| C4A | APOA2 | 0.945 | 0.496 | bioplex_WMM bioplex3_WMM WMM_only | |
| C4A | CP | 0.94 | 0.146 | bioplex_WMM bioplex3_WMM WMM_only | |
| APOA2 | ALB | 0.937 | 0.71 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt_WMM WMM_only | |
| A1BG | ALB | 0.936 | 0.62 | bioplex_WMM bioplex3_WMM WMM_only | |
| C4A | HPX | 0.935 | 0.402 | bioplex_WMM bioplex3_WMM WMM_only | |
| CP | ALB | 0.934 | 0.356 | bioplex_WMM bioplex3_WMM WMM_only | |
| HPX | ALB | 0.93 | 0.614 | bioplex_WMM bioplex3_WMM WMM_only | |
| C4A | SERPINA1 | 0.923 | 0.392 | bioplex_WMM bioplex3_WMM WMM_only | |
| AHSG | MAPK6 | 0.79 |
mutually_exclusive (P01009)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| C4A | APOA4 | 0.617 | 0.46 | bioplex_WMM bioplex3_WMM WMM_only | |
| ORM1 | MAPK6 | 0.606 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| C4A | ALB | 0.541 | 0.386 | bioplex_WMM bioplex3_WMM WMM_only boldt_WMM | |
| C4A | A1BG | 0.393 | 0.486 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes