hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_08708.1

Complex Portal: CPX-20115

Confidence: High

Genename	Protein Name	Uniprot Annotation Score	Links
DOHH	Deoxyhypusine hydroxylase (hDOHH) (EC 1.14.99.29) (Deoxyhypusine dioxygenase) (Deoxyhypusine monooxygenase) (HEAT-like repeat-containing protein 1)	5	UniProt NCBI
EIF5A	Eukaryotic translation initiation factor 5A-1 (eIF-5A-1) (eIF-5A1) (Eukaryotic initiation factor 5A isoform 1) (eIF-5A) (Rev-binding factor) (eIF-4D)	5	UniProt NCBI

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
REAC:R-HSA-204626	1.02525705128e-05	1.0	DOHH EIF5A	Hypusine synthesis from eIF5A-lysine
REAC:R-HSA-163841	0.00113803532692	1.0	DOHH EIF5A	Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation
WP:WP3302	0.0248784837172	0.5	EIF5A	eIF5A regulation in response to inhibition of the nuclear export system
HP:0007697	0.0499436884913	0.5	EIF5A	Hypoplasia of the lower eyelids

Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap	Evidence
DOHH	EIF5A	0.997		structurally_consistent (dimer)	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116

Related Complexes

Genename	Complexes
DOHH	huMAP3_00908.1 huMAP3_02506.1 huMAP3_06567.1 huMAP3_07334.1 huMAP3_07438.1 huMAP3_08491.1 huMAP3_08708.1 huMAP3_11233.1 huMAP3_11319.1 huMAP3_12543.1 huMAP3_14182.1
EIF5A	huMAP3_04913.1 huMAP3_07334.1 huMAP3_07438.1 huMAP3_08491.1 huMAP3_08708.1 huMAP3_10705.1 huMAP3_11233.1 huMAP3_12543.1 huMAP3_13998.1 huMAP3_14182.1 huMAP3_14625.1