hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_08722.1
Complex Portal: CPX-18619
Confidence: High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| RAC2 | Ras-related C3 botulinum toxin substrate 2 (GX) (Small G protein) (p21-Rac2) | 5 | UniProt NCBI |
| DOCK3 | Dedicator of cytokinesis protein 3 (Modifier of cell adhesion) (Presenilin-binding protein) (PBP) | 5 | UniProt NCBI |
| ELMO1 | Engulfment and cell motility protein 1 (Protein ced-12 homolog) | 5 | UniProt NCBI |
| DOCK2 | Dedicator of cytokinesis protein 2 | 5 | UniProt NCBI |
| ELMO3 | Engulfment and cell motility protein 3 | 3 | UniProt NCBI |
| DOCK4 | Dedicator of cytokinesis protein 4 | 5 | UniProt NCBI |
| ELMO2 | Engulfment and cell motility protein 2 (Protein ced-12 homolog A) (hCed-12A) | 5 | UniProt NCBI |
| DOCK1 | Dedicator of cytokinesis protein 1 (180 kDa protein downstream of CRK) (DOCK180) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-9013408 | 7.02826700511e-09 | 0.714285714286 | DOCK2 DOCK1 ELMO2 DOCK3 DOCK4 | RHOG GTPase cycle |
| KEGG:05100 | 1.21881878023e-06 | 0.571428571429 | ELMO1 DOCK1 ELMO3 ELMO2 | Bacterial invasion of epithelial cells |
| REAC:R-HSA-8849471 | 3.72165755864e-06 | 0.428571428571 | ELMO1 ELMO2 DOCK1 | PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases |
| REAC:R-HSA-9013404 | 6.47472263115e-06 | 0.571428571429 | DOCK2 DOCK1 DOCK3 DOCK4 | RAC2 GTPase cycle |
| CORUM:5341 | 2.05265451394e-05 | 0.285714285714 | ELMO1 DOCK2 | ELMO1-DOCK2 complex |
| CORUM:5337 | 2.05265451394e-05 | 0.285714285714 | ELMO1 DOCK1 | ELMO1-DOCK1 complex |
| REAC:R-HSA-9012999 | 5.40512105848e-05 | 0.714285714286 | DOCK2 DOCK1 ELMO2 DOCK3 DOCK4 | RHO GTPase cycle |
| CORUM:5343 | 6.1565588648e-05 | 0.285714285714 | ELMO1 DOCK1 | ELMO1-DOCK1-CRKII complex |
| CORUM:5342 | 6.1565588648e-05 | 0.285714285714 | ELMO1 DOCK1 | ELMO1-DOCK1-RAC1 complex |
| REAC:R-HSA-983231 | 8.47853345493e-05 | 0.571428571429 | DOCK2 DOCK1 DOCK3 DOCK4 | Factors involved in megakaryocyte development and platelet production |
| REAC:R-HSA-9013149 | 8.69731520059e-05 | 0.571428571429 | DOCK2 DOCK1 DOCK3 DOCK4 | RAC1 GTPase cycle |
| GO:0005085 | 0.000177986150733 | 0.714285714286 | ELMO1 DOCK1 DOCK4 DOCK3 DOCK2 | guanyl-nucleotide exchange factor activity |
| REAC:R-HSA-9006927 | 0.000196198755006 | 0.428571428571 | ELMO1 ELMO2 DOCK1 | Signaling by Non-Receptor Tyrosine Kinases |
| REAC:R-HSA-8848021 | 0.000196198755006 | 0.428571428571 | ELMO1 ELMO2 DOCK1 | Signaling by PTK6 |
| REAC:R-HSA-9664417 | 0.00030234111687 | 0.428571428571 | ELMO1 ELMO2 DOCK1 | Leishmania phagocytosis |
| REAC:R-HSA-9664407 | 0.00030234111687 | 0.428571428571 | ELMO1 ELMO2 DOCK1 | Parasite infection |
| REAC:R-HSA-9664422 | 0.00030234111687 | 0.428571428571 | ELMO1 ELMO2 DOCK1 | FCGR3A-mediated phagocytosis |
| REAC:R-HSA-2029482 | 0.000357539654198 | 0.428571428571 | ELMO1 ELMO2 DOCK1 | Regulation of actin dynamics for phagocytic cup formation |
| REAC:R-HSA-194315 | 0.000554819347598 | 0.714285714286 | DOCK2 DOCK1 ELMO2 DOCK3 DOCK4 | Signaling by Rho GTPases |
| REAC:R-HSA-9716542 | 0.000618457686161 | 0.714285714286 | DOCK2 DOCK1 ELMO2 DOCK3 DOCK4 | Signaling by Rho GTPases, Miro GTPases and RHOBTB3 |
| REAC:R-HSA-164944 | 0.000799384186586 | 0.285714285714 | ELMO1 DOCK2 | Nef and signal transduction |
| KEGG:05135 | 0.000847297701863 | 0.428571428571 | ELMO1 ELMO2 DOCK1 | Yersinia infection |
| REAC:R-HSA-2029480 | 0.000976813602208 | 0.428571428571 | ELMO1 ELMO2 DOCK1 | Fcgamma receptor (FCGR) dependent phagocytosis |
| REAC:R-HSA-4420097 | 0.00135845178782 | 0.428571428571 | ELMO1 ELMO2 DOCK1 | VEGFA-VEGFR2 Pathway |
| REAC:R-HSA-194138 | 0.00177103051244 | 0.428571428571 | ELMO1 ELMO2 DOCK1 | Signaling by VEGF |
| REAC:R-HSA-9006934 | 0.00475797272612 | 0.571428571429 | ELMO1 DOCK1 DOCK3 ELMO2 | Signaling by Receptor Tyrosine Kinases |
| REAC:R-HSA-9658195 | 0.00520230847661 | 0.428571428571 | ELMO1 ELMO2 DOCK1 | Leishmania infection |
| REAC:R-HSA-9824443 | 0.00520230847661 | 0.428571428571 | ELMO1 ELMO2 DOCK1 | Parasitic Infection Pathways |
| KEGG:05131 | 0.00645082416518 | 0.428571428571 | ELMO1 ELMO2 DOCK1 | Shigellosis |
| GO:0060589 | 0.00806492853678 | 0.714285714286 | ELMO1 DOCK1 DOCK4 DOCK3 DOCK2 | nucleoside-triphosphatase regulator activity |
| GO:0030695 | 0.00806492853678 | 0.714285714286 | ELMO1 DOCK1 DOCK4 DOCK3 DOCK2 | GTPase regulator activity |
| REAC:R-HSA-162582 | 0.00838328139233 | 0.857142857143 | DOCK1 DOCK4 ELMO2 ELMO1 DOCK2 DOCK3 | Signal Transduction |
| REAC:R-HSA-109582 | 0.0102424024409 | 0.571428571429 | DOCK2 DOCK1 DOCK3 DOCK4 | Hemostasis |
| REAC:R-HSA-164952 | 0.0133002920771 | 0.285714285714 | ELMO1 DOCK2 | The role of Nef in HIV-1 replication and disease pathogenesis |
| GO:0031267 | 0.0370032799768 | 0.571428571429 | DOCK2 DOCK1 DOCK3 DOCK4 | small GTPase binding |
| GO:0048870 | 0.0445851080752 | 0.857142857143 | DOCK1 DOCK4 ELMO2 ELMO1 ELMO3 DOCK2 | cell motility |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| ELMO1 | ELMO2 | 1.0 | 0.126 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| ELMO1 | DOCK4 | 1.0 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| ELMO1 | DOCK1 | 0.999 | 0.138 |
structurally_consistent (Q96JJ3)
structurally_consistent (dimer) |
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| ELMO3 | DOCK1 | 0.999 | 0.17 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| ELMO3 | DOCK4 | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| ELMO1 | DOCK3 | 0.999 | 0.166 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| ELMO3 | DOCK3 | 0.999 | 0.08 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| DOCK4 | ELMO2 | 0.998 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM WMM_only | ||
| ELMO2 | DOCK1 | 0.997 | 0.23 |
structurally_consistent (dimer)
|
hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
| ELMO2 | DOCK3 | 0.997 | 0.156 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only | |
| DOCK2 | ELMO3 | 0.993 | 0.112 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| ELMO3 | ELMO2 | 0.991 | 0.052 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| DOCK4 | DOCK3 | 0.99 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only | ||
| ELMO1 | ELMO3 | 0.982 | 0.082 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| RAC2 | DOCK1 | 0.978 | 0.3 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| DOCK4 | DOCK1 | 0.976 |
mutually_exclusive (Q92556)
|
bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| RAC2 | ELMO3 | 0.966 | 0.180711111111 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| RAC2 | ELMO2 | 0.952 | 0.208 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| RAC2 | DOCK4 | 0.952 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| RAC2 | ELMO1 | 0.916 | 0.24 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| DOCK2 | DOCK3 | 0.902 | 0.1 | bioplex3_WMM WMM_only | |
| DOCK1 | DOCK3 | 0.9 | 0.136 | bioplex_WMM bioplex3_WMM WMM_only | |
| DOCK2 | DOCK4 | 0.869 |
mutually_exclusive (Q92556)
|
bioplex3_WMM WMM_only | |
| DOCK2 | DOCK1 | 0.869 | 0.188 | bioplex3_WMM WMM_only | |
| DOCK2 | ELMO2 | 0.768 | 0.062 | bioplex3_WMM WMM_only | |
| RAC2 | DOCK3 | 0.587 | 0.256 | bioplex3_WMM WMM_only | |
| RAC2 | DOCK2 | 0.133 | 0.262 |
structurally_consistent (dimer)
|
bioplex3_WMM WMM_only |
| ELMO1 | DOCK2 | 0.055 | 0.328 |
structurally_consistent (dimer)
|
bioplex3_WMM WMM_only |
Related Complexes