hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_08727.1
Confidence: High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| WTAP | Pre-mRNA-splicing regulator WTAP (Female-lethal(2)D homolog) (hFL(2)D) (WT1-associated protein) (Wilms tumor 1-associating protein) | 5 | UniProt NCBI |
| METTL14 | N6-adenosine-methyltransferase non-catalytic subunit (Methyltransferase-like protein 14) (hMETTL14) | 5 | UniProt NCBI |
| METTL3 | N6-adenosine-methyltransferase catalytic subunit (EC 2.1.1.348) (Methyltransferase-like protein 3) (hMETTL3) (N6-adenosine-methyltransferase 70 kDa subunit) (MT-A70) | 5 | UniProt NCBI |
| ZC3H13 | Zinc finger CCCH domain-containing protein 13 | 5 | UniProt NCBI |
| CBLL2 | E3 ubiquitin-protein ligase CBLL2 (EC 2.3.2.27) (Cbl proto-oncogene-like protein 2) (RING-type E3 ubiquitin transferase ZNF645) (Zinc finger protein 645) (c-Cbl-like protein 2) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0036396 | 9.20740386965e-09 | 0.8 | METTL14 ZC3H13 WTAP METTL3 | RNA N6-methyladenosine methyltransferase complex |
| GO:0045293 | 9.40213012535e-08 | 0.8 | METTL14 ZC3H13 WTAP METTL3 | mRNA editing complex |
| GO:0080009 | 3.12897432326e-07 | 0.8 | METTL14 ZC3H13 WTAP METTL3 | mRNA methylation |
| GO:0016556 | 2.69021579342e-06 | 0.8 | METTL14 ZC3H13 WTAP METTL3 | mRNA modification |
| GO:0001510 | 0.000186904603412 | 0.8 | METTL14 ZC3H13 WTAP METTL3 | RNA methylation |
| GO:0034708 | 0.000349949920328 | 0.8 | METTL14 ZC3H13 WTAP METTL3 | methyltransferase complex |
| GO:0043414 | 0.00139398670092 | 0.8 | METTL14 ZC3H13 WTAP METTL3 | macromolecule methylation |
| GO:0032259 | 0.00162736464815 | 0.8 | METTL14 ZC3H13 WTAP METTL3 | methylation |
| GO:0009451 | 0.00294018150071 | 0.8 | METTL14 ZC3H13 WTAP METTL3 | RNA modification |
| CORUM:929 | 0.00762425856341 | 0.4 | ZC3H13 WTAP | CEN complex |
| REAC:R-HSA-72203 | 0.0102904130445 | 0.6 | METTL14 WTAP METTL3 | Processing of Capped Intron-Containing Pre-mRNA |
| GO:0021861 | 0.0140440992017 | 0.4 | METTL14 METTL3 | forebrain radial glial cell differentiation |
| GO:0001734 | 0.0280843539964 | 0.4 | METTL14 METTL3 | mRNA (N6-adenosine)-methyltransferase activity |
| GO:0060019 | 0.0468008499735 | 0.4 | METTL14 METTL3 | radial glial cell differentiation |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| METTL14 | METTL3 | 1.0 | 0.214 | hein_WMM bioplex3_HEK293 bioplex3_WMM youn_WMM hein () Malo fraction |
| WTAP | CBLL2 | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| WTAP | METTL3 | 0.999 | 0.196 | hein_WMM bioplex_WMM youn_WMM hein () |
| CBLL2 | ZC3H13 | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| WTAP | ZC3H13 | 0.995 | 0.242 | bioplex_WMM Guru bioplex3_WMM youn_WMM Malo fraction |
| WTAP | METTL14 | 0.986 | 0.238 | hein_WMM youn_WMM WMM_only |
| METTL3 | ZC3H13 | 0.011 | 0.186 | youn_WMM WMM_only |
Related Complexes