hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_08733.1
Confidence: High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| PNRC1 | Proline-rich nuclear receptor coactivator 1 (Proline-rich protein 2) (Protein B4-2) | 4 | UniProt NCBI |
| MCRIP2 | MAPK regulated corepressor interacting protein 2 (Protein FAM195A) | 4 | UniProt NCBI |
| DCP1A | mRNA-decapping enzyme 1A (EC 3.6.1.62) (Smad4-interacting transcriptional co-activator) (Transcription factor SMIF) | 5 | UniProt NCBI |
| DCP1B | mRNA-decapping enzyme 1B (EC 3.6.1.62) | 5 | UniProt NCBI |
| PIM1 | Serine/threonine-protein kinase pim-1 (EC 2.7.11.1) | 5 | UniProt NCBI |
| DDX6 | Probable ATP-dependent RNA helicase DDX6 (EC 3.6.4.13) (ATP-dependent RNA helicase p54) (DEAD box protein 6) (Oncogene RCK) | 5 | UniProt NCBI |
| ATXN2L | Ataxin-2-like protein (Ataxin-2 domain protein) (Ataxin-2-related protein) | 5 | UniProt NCBI |
| EDC3 | Enhancer of mRNA-decapping protein 3 (LSM16 homolog) (YjeF N-terminal domain-containing protein 2) (YjeF_N2) (hYjeF_N2) (YjeF domain-containing protein 1) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-430039 | 4.86362738832e-09 | 0.571428571429 | DCP1B EDC3 DCP1A DDX6 | mRNA decay by 5' to 3' exoribonuclease |
| GO:0036464 | 5.16734486616e-09 | 1.0 | PNRC1 DCP1B DDX6 ATXN2L DCP1A MCRIP2 EDC3 | cytoplasmic ribonucleoprotein granule |
| GO:0035770 | 9.04948379795e-09 | 1.0 | PNRC1 DCP1B DDX6 ATXN2L DCP1A MCRIP2 EDC3 | ribonucleoprotein granule |
| CORUM:559 | 7.02050133195e-08 | 0.428571428571 | EDC3 DCP1A DDX6 | Decapping complex |
| KEGG:03018 | 1.03451366218e-06 | 0.571428571429 | DCP1B EDC3 DCP1A DDX6 | RNA degradation |
| REAC:R-HSA-429914 | 1.20724098212e-06 | 0.571428571429 | DCP1B EDC3 DCP1A DDX6 | Deadenylation-dependent mRNA decay |
| GO:0000932 | 3.23760764817e-06 | 0.714285714286 | DCP1B EDC3 PNRC1 DDX6 DCP1A | P-body |
| GO:0031087 | 3.362820138e-05 | 0.428571428571 | DCP1B DCP1A EDC3 | deadenylation-independent decapping of nuclear-transcribed mRNA |
| GO:0031086 | 6.72425931667e-05 | 0.428571428571 | DCP1B DCP1A EDC3 | nuclear-transcribed mRNA catabolic process, deadenylation-independent decay |
| GO:0099080 | 0.000131562698178 | 1.0 | PNRC1 DCP1B DDX6 ATXN2L DCP1A MCRIP2 EDC3 | supramolecular complex |
| GO:0110156 | 0.000960187650128 | 0.428571428571 | DCP1B DCP1A EDC3 | methylguanosine-cap decapping |
| GO:0110154 | 0.00187892941497 | 0.428571428571 | DCP1B DCP1A EDC3 | RNA decapping |
| GO:0003729 | 0.00231631929763 | 0.714285714286 | DCP1B EDC3 DCP1A ATXN2L DDX6 | mRNA binding |
| GO:0000956 | 0.00561895383414 | 0.571428571429 | DCP1B EDC3 PNRC1 DCP1A | nuclear-transcribed mRNA catabolic process |
| REAC:R-HSA-8953854 | 0.0288040045312 | 0.571428571429 | DCP1B EDC3 DCP1A DDX6 | Metabolism of RNA |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| DDX6 | DCP1B | 1.0 | 0.138 | youn () bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM bioplex3_HCT116 gupta_WMM boldt_WMM |
| DCP1B | EDC3 | 1.0 | 0.058 | youn () bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM bioplex3_HCT116 gupta_WMM boldt_WMM treiber_WMM |
| DDX6 | DCP1A | 1.0 | 0.208 | hein_WMM youn () bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM hein () bioplex3_HCT116 gupta_WMM boldt_WMM |
| DCP1A | EDC3 | 1.0 | 0.502 | hein_WMM youn () bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM hein () bioplex3_HCT116 gupta_WMM boldt_WMM treiber_WMM |
| MCRIP2 | ATXN2L | 0.999 | 0.09 | youn () bioplex3_HEK293 bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM WMM_only |
| DDX6 | EDC3 | 0.999 | 0.284 | hein_WMM youn () bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM bioplex3_HCT116 gupta_WMM fraction boldt_WMM |
| ATXN2L | DDX6 | 0.998 | 0.334 | youn () bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM bioplex3_HCT116 gupta_WMM boldt_WMM treiber_WMM |
| MCRIP2 | DDX6 | 0.998 | 0.122 | youn () bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM WMM_only |
| EDC3 | PIM1 | 0.997 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| PNRC1 | DCP1A | 0.997 | hein_WMM youn () bioplex_WMM bioplex3_WMM hein () | |
| DCP1A | PIM1 | 0.994 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| DDX6 | PNRC1 | 0.991 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM | |
| DCP1A | DCP1B | 0.991 | 0.04 | youn () bioplex_WMM bioplex3_WMM boldt youn_WMM gupta_WMM boldt_WMM treiber_WMM WMM_only |
| PNRC1 | EDC3 | 0.975 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| DDX6 | PIM1 | 0.973 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| DCP1B | PIM1 | 0.958 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| PNRC1 | DCP1B | 0.375 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| ATXN2L | PNRC1 | 0.366 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| ATXN2L | DCP1A | 0.106 | 0.066 | youn () bioplex_WMM bioplex3_WMM boldt youn_WMM gupta_WMM boldt_WMM WMM_only |
| ATXN2L | DCP1B | 0.048 | 0.21 | bioplex_WMM bioplex3_WMM boldt youn_WMM gupta_WMM boldt_WMM WMM_only |
| ATXN2L | EDC3 | 0.024 | 0.13 | youn () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM WMM_only |
| MCRIP2 | DCP1B | 0.012 | 0.052 | youn () youn_WMM gupta_WMM WMM_only |
| MCRIP2 | EDC3 | 0.009 | 0.038 | youn () youn_WMM gupta_WMM WMM_only |
| ATXN2L | PIM1 | 0.008 | bioplex3_HCT116 WMM_only | |
| MCRIP2 | DCP1A | 0.007 | 0.054 | youn () youn_WMM gupta_WMM WMM_only |
| MCRIP2 | PNRC1 | 0.005 | youn_WMM WMM_only |
Related Complexes