hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_08734.1
Confidence: High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| NPRL2 | GATOR1 complex protein NPRL2 (Gene 21 protein) (G21 protein) (Nitrogen permease regulator 2-like protein) (NPR2-like protein) (Tumor suppressor candidate 4) | 5 | UniProt NCBI |
| ITFG2 | KICSTOR complex protein ITFG2 (Integrin-alpha FG-GAP repeat-containing protein 2) | 5 | UniProt NCBI |
| NPRL3 | GATOR1 complex protein NPRL3 (-14 gene protein) (Alpha-globin regulatory element-containing gene protein) (Nitrogen permease regulator 3-like protein) (Protein CGTHBA) | 5 | UniProt NCBI |
| OGA | Protein O-GlcNAcase (OGA) (EC 3.2.1.169) (Beta-N-acetylglucosaminidase) (Beta-N-acetylhexosaminidase) (Beta-hexosaminidase) (Meningioma-expressed antigen 5) (N-acetyl-beta-D-glucosaminidase) (N-acetyl-beta-glucosaminidase) (Nuclear cytoplasmic O-GlcNAcase and acetyltransferase) (NCOAT) | 5 | UniProt NCBI |
| KICS2 | KICSTOR subunit 2 (KICSTOR complex protein C12orf66) | 5 | UniProt NCBI |
| BMT2 | S-adenosylmethionine sensor upstream of mTORC1 (Probable methyltransferase BMT2 homolog) (EC 2.1.1.-) | 5 | UniProt NCBI |
| SZT2 | KICSTOR complex protein SZT2 (Seizure threshold 2 protein homolog) | 5 | UniProt NCBI |
| DEPDC5 | GATOR1 complex protein DEPDC5 (DEP domain-containing protein 5) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-9639288 | 9.2721575282e-15 | 0.875 | ITFG2 NPRL2 DEPDC5 NPRL3 BMT2 KICS2 SZT2 | Amino acids regulate mTORC1 |
| GO:1904262 | 3.81615940916e-13 | 0.875 | ITFG2 NPRL2 DEPDC5 NPRL3 BMT2 KICS2 SZT2 | negative regulation of TORC1 signaling |
| GO:0034198 | 4.55791680217e-13 | 0.875 | ITFG2 NPRL2 DEPDC5 NPRL3 BMT2 KICS2 SZT2 | cellular response to amino acid starvation |
| GO:1990928 | 6.4179173539e-13 | 0.875 | ITFG2 NPRL2 DEPDC5 NPRL3 BMT2 KICS2 SZT2 | response to amino acid starvation |
| GO:0032007 | 4.82072946562e-12 | 0.875 | ITFG2 NPRL2 DEPDC5 NPRL3 BMT2 KICS2 SZT2 | negative regulation of TOR signaling |
| REAC:R-HSA-9711097 | 2.02571505707e-11 | 0.875 | ITFG2 NPRL2 DEPDC5 NPRL3 BMT2 KICS2 SZT2 | Cellular response to starvation |
| GO:1903432 | 6.96387244609e-11 | 0.875 | ITFG2 NPRL2 DEPDC5 NPRL3 BMT2 KICS2 SZT2 | regulation of TORC1 signaling |
| GO:0038202 | 9.71897992726e-11 | 0.875 | ITFG2 NPRL2 DEPDC5 NPRL3 BMT2 KICS2 SZT2 | TORC1 signaling |
| GO:0009267 | 7.88720233391e-10 | 0.875 | ITFG2 NPRL2 DEPDC5 NPRL3 BMT2 KICS2 SZT2 | cellular response to starvation |
| GO:0032006 | 1.05954711439e-09 | 0.875 | ITFG2 NPRL2 DEPDC5 NPRL3 BMT2 KICS2 SZT2 | regulation of TOR signaling |
| GO:0042594 | 2.05277464614e-09 | 0.875 | ITFG2 NPRL2 DEPDC5 NPRL3 BMT2 KICS2 SZT2 | response to starvation |
| GO:0031929 | 2.27863017901e-09 | 0.875 | ITFG2 NPRL2 DEPDC5 NPRL3 BMT2 KICS2 SZT2 | TOR signaling |
| GO:0031669 | 6.84579196878e-09 | 0.875 | ITFG2 NPRL2 DEPDC5 NPRL3 BMT2 KICS2 SZT2 | cellular response to nutrient levels |
| GO:1990130 | 9.20740386965e-09 | 0.5 | DEPDC5 NPRL2 SZT2 NPRL3 | GATOR1 complex |
| CORUM:6215 | 9.82248594942e-09 | 0.375 | DEPDC5 NPRL2 NPRL3 | GATOR1 complex |
| GO:0031668 | 1.00839009417e-08 | 0.875 | ITFG2 NPRL2 DEPDC5 NPRL3 BMT2 KICS2 SZT2 | cellular response to extracellular stimulus |
| GO:0071496 | 3.68263860098e-08 | 0.875 | ITFG2 NPRL2 DEPDC5 NPRL3 BMT2 KICS2 SZT2 | cellular response to external stimulus |
| CORUM:6754 | 3.92798604902e-08 | 0.375 | KICS2 ITFG2 SZT2 | KICSTOR complex |
| GO:0031667 | 6.08959054939e-08 | 0.875 | ITFG2 NPRL2 DEPDC5 NPRL3 BMT2 KICS2 SZT2 | response to nutrient levels |
| GO:0009991 | 8.61618932216e-08 | 0.875 | ITFG2 NPRL2 DEPDC5 NPRL3 BMT2 KICS2 SZT2 | response to extracellular stimulus |
| CORUM:6217 | 5.49353690762e-07 | 0.375 | DEPDC5 NPRL2 NPRL3 | GATOR complex |
| CORUM:6753 | 5.49353690762e-07 | 0.375 | NPRL2 SZT2 NPRL3 | SOG complex |
| REAC:R-HSA-2262752 | 1.14895565205e-06 | 0.875 | ITFG2 NPRL2 DEPDC5 NPRL3 BMT2 KICS2 SZT2 | Cellular responses to stress |
| REAC:R-HSA-8953897 | 1.22892843975e-06 | 0.875 | ITFG2 NPRL2 DEPDC5 NPRL3 BMT2 KICS2 SZT2 | Cellular responses to stimuli |
| GO:0035859 | 1.31435310045e-06 | 0.5 | DEPDC5 NPRL2 SZT2 NPRL3 | Seh1-associated complex |
| HP:0012004 | 1.85468240293e-06 | 0.375 | DEPDC5 NPRL2 NPRL3 | Focal cognitive seizure with deja vu/jamais vu |
| HP:0012005 | 1.85468240293e-06 | 0.375 | DEPDC5 NPRL2 NPRL3 | Deja vu aura |
| HP:0032680 | 1.85468240293e-06 | 0.375 | DEPDC5 NPRL2 NPRL3 | Focal cognitive seizure |
| HP:0008765 | 3.24486114137e-06 | 0.375 | DEPDC5 NPRL2 NPRL3 | Auditory hallucination |
| GO:1902532 | 3.63720803992e-06 | 0.875 | ITFG2 NPRL2 DEPDC5 NPRL3 BMT2 KICS2 SZT2 | negative regulation of intracellular signal transduction |
| HP:0033346 | 7.78366934707e-06 | 0.375 | DEPDC5 NPRL2 NPRL3 | Psychic epileptic aura |
| HP:0012002 | 7.78366934707e-06 | 0.375 | DEPDC5 NPRL2 NPRL3 | Experiential epileptic aura |
| HP:0002427 | 1.52815019226e-05 | 0.375 | DEPDC5 NPRL2 NPRL3 | Expressive aphasia |
| GO:0140007 | 2.15253635486e-05 | 0.375 | KICS2 ITFG2 SZT2 | KICSTOR complex |
| HP:0031951 | 3.36859619488e-05 | 0.375 | DEPDC5 NPRL2 NPRL3 | Nocturnal seizures |
| HP:0032046 | 3.36859619488e-05 | 0.375 | DEPDC5 NPRL2 NPRL3 | Focal cortical dysplasia |
| HP:0007206 | 3.36859619488e-05 | 0.375 | DEPDC5 NPRL2 NPRL3 | Hemimegalencephaly |
| HP:0002367 | 4.20966415736e-05 | 0.375 | DEPDC5 NPRL2 NPRL3 | Visual hallucination |
| HP:0033348 | 8.95599246893e-05 | 0.375 | DEPDC5 NPRL2 NPRL3 | Epileptic aura |
| HP:0002349 | 0.000122862261006 | 0.375 | DEPDC5 NPRL2 NPRL3 | Focal aware seizure |
| HP:0011171 | 0.000122862261006 | 0.375 | DEPDC5 NPRL2 NPRL3 | Simple febrile seizure |
| GO:0005765 | 0.000158682935794 | 0.75 | ITFG2 NPRL2 DEPDC5 NPRL3 KICS2 SZT2 | lysosomal membrane |
| GO:0098852 | 0.000158682935794 | 0.75 | ITFG2 NPRL2 DEPDC5 NPRL3 KICS2 SZT2 | lytic vacuole membrane |
| HP:0032052 | 0.000226027933833 | 0.25 | NPRL3 DEPDC5 | Focal cortical dysplasia type IIa |
| GO:0005774 | 0.000251548604579 | 0.75 | ITFG2 NPRL2 DEPDC5 NPRL3 KICS2 SZT2 | vacuolar membrane |
| HP:0032679 | 0.000550944707746 | 0.375 | DEPDC5 NPRL2 NPRL3 | Focal non-motor seizure |
| HP:0001355 | 0.000714829774892 | 0.375 | DEPDC5 NPRL2 NPRL3 | Megalencephaly |
| HP:0002521 | 0.000729087723825 | 0.5 | DEPDC5 NPRL2 SZT2 NPRL3 | Hypsarrhythmia |
| HP:0033259 | 0.00105272399502 | 0.5 | DEPDC5 NPRL2 SZT2 NPRL3 | Non-motor seizure |
| GO:0009968 | 0.00108906957513 | 0.875 | ITFG2 NPRL2 DEPDC5 NPRL3 BMT2 KICS2 SZT2 | negative regulation of signal transduction |
| HP:0031284 | 0.00121624033932 | 0.375 | DEPDC5 NPRL2 NPRL3 | Flushing |
| GO:0010648 | 0.00136404184275 | 0.875 | ITFG2 NPRL2 DEPDC5 NPRL3 BMT2 KICS2 SZT2 | negative regulation of cell communication |
| GO:0023057 | 0.00142778628397 | 0.875 | ITFG2 NPRL2 DEPDC5 NPRL3 BMT2 KICS2 SZT2 | negative regulation of signaling |
| WP:WP4657 | 0.00154917047236 | 0.375 | DEPDC5 NPRL2 NPRL3 | 22q11 2 copy number variation syndrome |
| HP:0002539 | 0.00190898999554 | 0.375 | DEPDC5 NPRL2 NPRL3 | Cortical dysplasia |
| HP:0032051 | 0.00225842370351 | 0.25 | NPRL3 DEPDC5 | Focal cortical dysplasia type II |
| HP:0011146 | 0.00243526133051 | 0.5 | DEPDC5 NPRL2 SZT2 NPRL3 | Dialeptic seizure |
| KEGG:04150 | 0.00271802931306 | 0.375 | DEPDC5 NPRL2 NPRL3 | mTOR signaling pathway |
| HP:0010841 | 0.00329066427231 | 0.375 | DEPDC5 NPRL2 NPRL3 | Multifocal epileptiform discharges |
| HP:0011198 | 0.00361329276868 | 0.5 | DEPDC5 NPRL2 SZT2 NPRL3 | EEG with generalized epileptiform discharges |
| GO:0000323 | 0.00463367841136 | 0.75 | ITFG2 NPRL2 DEPDC5 NPRL3 KICS2 SZT2 | lytic vacuole |
| GO:0005764 | 0.00463367841136 | 0.75 | ITFG2 NPRL2 DEPDC5 NPRL3 KICS2 SZT2 | lysosome |
| GO:0048585 | 0.00518576601331 | 0.875 | ITFG2 NPRL2 DEPDC5 NPRL3 BMT2 KICS2 SZT2 | negative regulation of response to stimulus |
| HP:0011182 | 0.006874223998 | 0.5 | DEPDC5 NPRL2 SZT2 NPRL3 | Interictal epileptiform activity |
| HP:0025373 | 0.00717720349197 | 0.5 | DEPDC5 NPRL2 SZT2 NPRL3 | Interictal EEG abnormality |
| HP:0007359 | 0.00803360911744 | 0.5 | DEPDC5 NPRL2 SZT2 NPRL3 | Focal-onset seizure |
| GO:0005773 | 0.00822555362628 | 0.75 | ITFG2 NPRL2 DEPDC5 NPRL3 KICS2 SZT2 | vacuole |
| HP:0002381 | 0.00866066452106 | 0.375 | DEPDC5 NPRL2 NPRL3 | Aphasia |
| GO:1902531 | 0.010312469237 | 0.875 | ITFG2 NPRL2 DEPDC5 NPRL3 BMT2 KICS2 SZT2 | regulation of intracellular signal transduction |
| HP:0002069 | 0.0141677251894 | 0.5 | DEPDC5 NPRL2 SZT2 NPRL3 | Bilateral tonic-clonic seizure |
| HP:0002384 | 0.0142015381179 | 0.375 | DEPDC5 NPRL2 NPRL3 | Focal impaired awareness seizure |
| GO:0033554 | 0.0151848602789 | 0.875 | ITFG2 NPRL2 DEPDC5 NPRL3 BMT2 KICS2 SZT2 | cellular response to stress |
| HP:0011185 | 0.0169469260837 | 0.375 | DEPDC5 NPRL2 NPRL3 | EEG with focal epileptiform discharges |
| HP:0003401 | 0.0205674938424 | 0.375 | DEPDC5 NPRL2 NPRL3 | Paresthesia |
| HP:0002373 | 0.0222634787801 | 0.375 | DEPDC5 NPRL2 NPRL3 | Febrile seizure (within the age range of 3 months to 6 years) |
| HP:0032892 | 0.0222634787801 | 0.375 | DEPDC5 NPRL2 NPRL3 | Infection-related seizure |
| HP:0032894 | 0.0222634787801 | 0.375 | DEPDC5 NPRL2 NPRL3 | Seizure precipitated by febrile infection |
| HP:0020219 | 0.0244780673068 | 0.5 | DEPDC5 NPRL2 SZT2 NPRL3 | Motor seizure |
| HP:0003829 | 0.0272311859386 | 0.375 | DEPDC5 NPRL2 NPRL3 | Typified by incomplete penetrance |
| HP:0000738 | 0.0321347823735 | 0.375 | DEPDC5 NPRL2 NPRL3 | Hallucinations |
| HP:0012469 | 0.033635423268 | 0.375 | DEPDC5 NPRL2 NPRL3 | Infantile spasms |
| HP:0000980 | 0.0359718252675 | 0.375 | DEPDC5 NPRL2 NPRL3 | Pallor |
| GO:0009605 | 0.0411970326794 | 0.875 | ITFG2 NPRL2 DEPDC5 NPRL3 BMT2 KICS2 SZT2 | response to external stimulus |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| NPRL2 | DEPDC5 | 1.0 | 0.138 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| SZT2 | ITFG2 | 1.0 | 0.156 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| KICS2 | ITFG2 | 0.999 | 0.134 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| NPRL2 | NPRL3 | 0.999 | 0.138 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| BMT2 | DEPDC5 | 0.997 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| BMT2 | SZT2 | 0.997 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| BMT2 | KICS2 | 0.996 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| DEPDC5 | NPRL3 | 0.996 | 0.118 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only |
| NPRL2 | BMT2 | 0.995 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| KICS2 | SZT2 | 0.989 | 0.066 | bioplex_WMM bioplex3_WMM WMM_only |
| BMT2 | ITFG2 | 0.987 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| OGA | BMT2 | 0.982 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| BMT2 | NPRL3 | 0.98 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| NPRL2 | ITFG2 | 0.978 | 0.15 | bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| DEPDC5 | ITFG2 | 0.959 | 0.108 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| ITFG2 | NPRL3 | 0.92 | 0.178 | bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| NPRL2 | SZT2 | 0.65 | 0.104 | bioplex_WMM bioplex3_WMM WMM_only |
| NPRL2 | KICS2 | 0.648 | 0.104 | bioplex_WMM bioplex3_WMM WMM_only |
| KICS2 | NPRL3 | 0.636 | 0.114 | bioplex_WMM bioplex3_WMM WMM_only |
| SZT2 | NPRL3 | 0.6 | 0.156 | bioplex_WMM bioplex3_WMM WMM_only |
| DEPDC5 | KICS2 | 0.576 | 0.112 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| OGA | DEPDC5 | 0.345 | 0.074 | bioplex_WMM bioplex3_WMM WMM_only |
| NPRL2 | OGA | 0.254 | 0.05 | bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| DEPDC5 | SZT2 | 0.247 | 0.202 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| OGA | KICS2 | 0.124 | 0.1 | bioplex_WMM bioplex3_WMM WMM_only |
| OGA | SZT2 | 0.099 | 0.064 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| OGA | NPRL3 | 0.063 | 0.064 | bioplex_WMM bioplex3_WMM WMM_only |
| OGA | ITFG2 | 0.026 | 0.084 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes