hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_08741.1

Complex Portal: CPX-13324

Confidence: High

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Genename	Protein Name	Uniprot Annotation Score	Links
IDS	Iduronate 2-sulfatase (EC 3.1.6.13) (Alpha-L-iduronate sulfate sulfatase) (Idursulfase) [Cleaved into: Iduronate 2-sulfatase 42 kDa chain; Iduronate 2-sulfatase 14 kDa chain]	5	UniProt NCBI
MESD	LRP chaperone MESD (LDLR chaperone MESD) (Mesoderm development LRP chaperone MESD) (Mesoderm development candidate 2) (Mesoderm development protein) (Renal carcinoma antigen NY-REN-61)	5	UniProt NCBI
PCSK9	Proprotein convertase subtilisin/kexin type 9 (EC 3.4.21.-) (Neural apoptosis-regulated convertase 1) (NARC-1) (Proprotein convertase 9) (PC9) (Subtilisin/kexin-like protease PC9)	5	UniProt NCBI
PPIB	Peptidyl-prolyl cis-trans isomerase B (PPIase B) (EC 5.2.1.8) (CYP-S1) (Cyclophilin B) (Rotamase B) (S-cyclophilin) (SCYLP)	5	UniProt NCBI
RTCA	RNA 3'-terminal phosphate cyclase (RNA cyclase) (RNA-3'-phosphate cyclase) (EC 6.5.1.4) (RNA terminal phosphate cyclase domain-containing protein 1) (RTC domain-containing protein 1)	5	UniProt NCBI

Showing 1 to 5 of 5 entries

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Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
WP:WP2846	0.0165527833611	0.333333333333	PCSK9	PCSK9 mediated LDL receptor degradation
WP:WP3408	0.0165527833611	0.333333333333	PCSK9	Evolocumab mechanism to reduce LDL cholesterol

Showing 1 to 2 of 2 entries

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Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap	Evidence
MESD	IDS	0.987	0.062		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
PPIB	IDS	0.975	0.196		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
RTCA	IDS	0.959	0.04		bioplex3_WMM bioplex3_HCT116 WMM_only
IDS	PCSK9	0.952	0.134	structurally_consistent (dimer)	bioplex3_WMM bioplex3_HCT116 WMM_only
PPIB	MESD	0.939	0.22		bioplex_WMM bioplex3_WMM gupta_WMM WMM_only treiber_WMM
RTCA	PCSK9	0.263	0.114		bioplex3_WMM WMM_only
PPIB	PCSK9	0.06	0.102		bioplex3_HEK293 bioplex3_WMM WMM_only
PPIB	RTCA	0.046	0.122		bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 treiber_WMM WMM_only
MESD	PCSK9	0.014	0.078		bioplex3_WMM WMM_only
RTCA	MESD	0.003	0.028		bioplex3_WMM fraction

Showing 1 to 10 of 10 entries

Related Complexes

Genename	Complexes
MESD	huMAP3_01173.1 huMAP3_07395.1 huMAP3_07503.1 huMAP3_08741.1 huMAP3_10199.1 huMAP3_10766.1 huMAP3_13998.1 huMAP3_14982.1
PCSK9	huMAP3_02241.1 huMAP3_04426.1 huMAP3_04698.1 huMAP3_07112.1 huMAP3_07528.1 huMAP3_08571.1 huMAP3_08741.1 huMAP3_08802.1 huMAP3_09327.1 huMAP3_09675.1 huMAP3_09956.1
PPIB	huMAP3_00018.1 huMAP3_02241.1 huMAP3_04471.1 huMAP3_04483.1 huMAP3_04766.1 huMAP3_05492.1 huMAP3_07528.1 huMAP3_08741.1 huMAP3_09054.1 huMAP3_10032.1 huMAP3_10056.1 huMAP3_10782.1 huMAP3_12287.1 huMAP3_12688.1 huMAP3_13862.1 huMAP3_14866.1
RTCA	huMAP3_00098.1 huMAP3_06714.1 huMAP3_08741.1 huMAP3_10826.1
IDS	huMAP3_02241.1 huMAP3_07528.1 huMAP3_08741.1 huMAP3_09327.1 huMAP3_10485.1