hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_08741.1
Complex Portal: CPX-13324
Confidence: High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| MESD | LRP chaperone MESD (LDLR chaperone MESD) (Mesoderm development LRP chaperone MESD) (Mesoderm development candidate 2) (Mesoderm development protein) (Renal carcinoma antigen NY-REN-61) | 5 | UniProt NCBI |
| PCSK9 | Proprotein convertase subtilisin/kexin type 9 (EC 3.4.21.-) (Neural apoptosis-regulated convertase 1) (NARC-1) (Proprotein convertase 9) (PC9) (Subtilisin/kexin-like protease PC9) | 5 | UniProt NCBI |
| PPIB | Peptidyl-prolyl cis-trans isomerase B (PPIase B) (EC 5.2.1.8) (CYP-S1) (Cyclophilin B) (Rotamase B) (S-cyclophilin) (SCYLP) | 5 | UniProt NCBI |
| RTCA | RNA 3'-terminal phosphate cyclase (RNA cyclase) (RNA-3'-phosphate cyclase) (EC 6.5.1.4) (RNA terminal phosphate cyclase domain-containing protein 1) (RTC domain-containing protein 1) | 5 | UniProt NCBI |
| IDS | Iduronate 2-sulfatase (EC 3.1.6.13) (Alpha-L-iduronate sulfate sulfatase) (Idursulfase) [Cleaved into: Iduronate 2-sulfatase 42 kDa chain; Iduronate 2-sulfatase 14 kDa chain] | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP2846 | 0.0165527833611 | 0.333333333333 | PCSK9 | PCSK9 mediated LDL receptor degradation |
| WP:WP3408 | 0.0165527833611 | 0.333333333333 | PCSK9 | Evolocumab mechanism to reduce LDL cholesterol |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| MESD | IDS | 0.987 | 0.062 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| PPIB | IDS | 0.975 | 0.196 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| RTCA | IDS | 0.959 | 0.04 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| IDS | PCSK9 | 0.952 | 0.134 |
structurally_consistent (dimer)
|
bioplex3_WMM bioplex3_HCT116 WMM_only |
| PPIB | MESD | 0.939 | 0.22 | bioplex_WMM bioplex3_WMM gupta_WMM WMM_only treiber_WMM | |
| RTCA | PCSK9 | 0.263 | 0.114 | bioplex3_WMM WMM_only | |
| PPIB | PCSK9 | 0.06 | 0.102 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| PPIB | RTCA | 0.046 | 0.122 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 treiber_WMM WMM_only | |
| MESD | PCSK9 | 0.014 | 0.078 | bioplex3_WMM WMM_only | |
| RTCA | MESD | 0.003 | 0.028 | bioplex3_WMM fraction |
Related Complexes