hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_08743.1

Complex Portal: CPX-24980

Confidence: High

Genename	Protein Name	Uniprot Annotation Score	Links
OSBP	Oxysterol-binding protein 1	5	UniProt NCBI
OSBP2	Oxysterol-binding protein 2 (Oxysterol-binding protein-related protein 4) (ORP-4) (OSBP-related protein 4)	5	UniProt NCBI
SLC22A15	Solute carrier family 22 member 15 (Fly-like putative transporter 1) (Flipt 1)	5	UniProt NCBI
VAPA	Vesicle-associated membrane protein-associated protein A (VAMP-A) (VAMP-associated protein A) (VAP-A) (33 kDa VAMP-associated protein) (VAP-33)	5	UniProt NCBI
ACBD4	Acyl-CoA-binding domain-containing protein 4	5	UniProt NCBI
RASSF3	Ras association domain-containing protein 3	5	UniProt NCBI
PITPNM3	Membrane-associated phosphatidylinositol transfer protein 3 (Phosphatidylinositol transfer protein, membrane-associated 3) (PITPnm 3) (Pyk2 N-terminal domain-interacting receptor 1) (NIR-1)	5	UniProt NCBI
OSBPL6	Oxysterol-binding protein-related protein 6 (ORP-6) (OSBP-related protein 6)	5	UniProt NCBI
ZFPL1	Zinc finger protein-like 1 (Zinc finger protein MCG4)	5	UniProt NCBI
TTC39B	Tetratricopeptide repeat protein 39B (TPR repeat protein 39B)	4	UniProt NCBI
PITPNM2	Membrane-associated phosphatidylinositol transfer protein 2 (Phosphatidylinositol transfer protein, membrane-associated 2) (PITPnm 2) (Pyk2 N-terminal domain-interacting receptor 3) (NIR-3)	5	UniProt NCBI
OSBPL10	Oxysterol-binding protein-related protein 10 (ORP-10) (OSBP-related protein 10)	5	UniProt NCBI
ARHGEF12	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF)	5	UniProt NCBI
DOP1A	Protein dopey-1	3	UniProt NCBI
VAPB	Vesicle-associated membrane protein-associated protein B/C (VAMP-B/VAMP-C) (VAMP-associated protein B/C) (VAP-B/VAP-C)	5	UniProt NCBI
OSBPL3	Oxysterol-binding protein-related protein 3 (ORP-3) (OSBP-related protein 3)	5	UniProt NCBI
PITPNM1	Membrane-associated phosphatidylinositol transfer protein 1 (Drosophila retinal degeneration B homolog) (Phosphatidylinositol transfer protein, membrane-associated 1) (PITPnm 1) (Pyk2 N-terminal domain-interacting receptor 2) (NIR-2)	5	UniProt NCBI
USP33	Ubiquitin carboxyl-terminal hydrolase 33 (EC 3.4.19.12) (Deubiquitinating enzyme 33) (Ubiquitin thioesterase 33) (Ubiquitin-specific-processing protease 33) (VHL-interacting deubiquitinating enzyme 1) (hVDU1)	5	UniProt NCBI
TMEM38B	Trimeric intracellular cation channel type B (TRIC-B) (TRICB) (Transmembrane protein 38B)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
GO:0005319	4.03729410114e-08	0.421052631579	OSBPL3 OSBP2 OSBPL6 OSBP OSBPL10 PITPNM2 PITPNM1 PITPNM3	lipid transporter activity
REAC:R-HSA-556833	3.03018880167e-07	0.526315789474	OSBPL3 VAPA OSBPL10 OSBP VAPB OSBPL6 ACBD4 PITPNM2 PITPNM1 PITPNM3	Metabolism of lipids
REAC:R-HSA-1483226	5.56810784361e-06	0.157894736842	PITPNM1 PITPNM3 PITPNM2	Synthesis of PI
GO:0015248	6.77274746013e-06	0.263157894737	OSBP OSBPL3 OSBP2 OSBPL10 OSBPL6	sterol transporter activity
GO:0032934	0.00015530494364	0.263157894737	OSBP OSBPL3 OSBP2 OSBPL10 OSBPL6	sterol binding
GO:0097038	0.000240151635834	0.210526315789	OSBP OSBPL3 OSBP2 OSBPL6	perinuclear endoplasmic reticulum
GO:0005215	0.000495642940118	0.526315789474	OSBPL3 OSBP2 OSBPL10 OSBP SLC22A15 OSBPL6 PITPNM2 PITPNM1 TMEM38B PITPNM3	transporter activity
REAC:R-HSA-192105	0.000730887212416	0.157894736842	OSBP OSBPL3 OSBPL6	Synthesis of bile acids and bile salts
GO:0005496	0.000761518959677	0.263157894737	OSBP OSBPL3 OSBP2 OSBPL10 OSBPL6	steroid binding
GO:0006629	0.00186188944793	0.526315789474	OSBPL3 VAPA PITPNM2 OSBPL10 OSBP OSBPL6 PITPNM3 PITPNM1 TTC39B ACBD4	lipid metabolic process
REAC:R-HSA-194068	0.00199486182283	0.157894736842	OSBP OSBPL3 OSBPL6	Bile acid and bile salt metabolism
GO:0030301	0.00208502276371	0.263157894737	VAPB OSBP TTC39B VAPA OSBPL6	cholesterol transport
GO:0015918	0.00252442662788	0.263157894737	VAPB OSBP TTC39B VAPA OSBPL6	sterol transport
REAC:R-HSA-1483206	0.00268658025835	0.210526315789	OSBPL10 PITPNM1 PITPNM3 PITPNM2	Glycerophospholipid biosynthesis
REAC:R-HSA-1660661	0.00325350769026	0.157894736842	OSBP VAPA VAPB	Sphingolipid de novo biosynthesis
GO:0008526	0.00519447563198	0.157894736842	PITPNM1 PITPNM3 PITPNM2	phosphatidylinositol transfer activity
GO:0008289	0.0058626511846	0.421052631579	OSBPL3 OSBP2 OSBPL6 OSBP OSBPL10 PITPNM2 PITPNM1 ACBD4	lipid binding
REAC:R-HSA-1430728	0.00655588290973	0.526315789474	OSBPL3 VAPA OSBPL10 OSBP VAPB OSBPL6 ACBD4 PITPNM2 PITPNM1 PITPNM3	Metabolism
GO:0015485	0.00732075431576	0.210526315789	OSBPL6 OSBPL3 OSBP2 OSBPL10	cholesterol binding
GO:0120013	0.00815070712436	0.210526315789	OSBP PITPNM1 PITPNM3 PITPNM2	lipid transfer activity
GO:0005548	0.0110644348717	0.210526315789	OSBPL10 PITPNM1 PITPNM3 PITPNM2	phospholipid transporter activity
GO:0006869	0.0118611800979	0.315789473684	VAPA OSBPL6 OSBP VAPB PITPNM1 TTC39B	lipid transport
REAC:R-HSA-1483257	0.0204773874959	0.210526315789	OSBPL10 PITPNM1 PITPNM3 PITPNM2	Phospholipid metabolism
GO:0010876	0.0278296783769	0.315789473684	VAPA OSBPL6 OSBP VAPB PITPNM1 TTC39B	lipid localization
REAC:R-HSA-428157	0.0327497194068	0.157894736842	OSBP VAPA VAPB	Sphingolipid metabolism
GO:0043178	0.0385685136688	0.210526315789	OSBPL6 OSBPL3 OSBP2 OSBPL10	alcohol binding

Edges

Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap
VAPA	VAPB	1.0	0.746	structurally_consistent (dimer)
VAPA	OSBPL3	0.999	0.08
OSBPL6	VAPB	0.999	0.136810810811
VAPA	ZFPL1	0.999	0.17
VAPA	OSBPL6	0.999	0.140194444444
VAPB	ARHGEF12	0.999	0.118
PITPNM2	VAPB	0.999	0.099	mutually_exclusive (Q9P0L0)
VAPB	OSBPL3	0.999	0.066
OSBP	VAPB	0.998	0.206	structurally_consistent (dimer)
PITPNM3	VAPB	0.998
OSBP2	VAPB	0.998	0.144810810811
SLC22A15	VAPB	0.997
VAPB	OSBPL10	0.997	0.036
VAPA	OSBP2	0.997	0.142
ZFPL1	OSBPL3	0.996	0.086
VAPA	ARHGEF12	0.996	0.048	structurally_consistent (dimer)
VAPB	USP33	0.995	0.288
VAPA	OSBPL10	0.994	0.032
PITPNM1	VAPB	0.992	0.096
VAPA	OSBP	0.992	0.126
VAPA	PITPNM3	0.992
VAPB	TTC39B	0.99	0.234
OSBPL6	OSBPL3	0.985	0.082
VAPA	PITPNM1	0.983	0.11	structurally_consistent (dimer)
VAPB	RASSF3	0.981	0.096
ACBD4	VAPB	0.98	0.2
ZFPL1	PITPNM3	0.979
ZFPL1	OSBPL6	0.96	0.108
DOP1A	VAPB	0.958	0.14
SLC22A15	VAPA	0.957
VAPA	TMEM38B	0.952	0.194
VAPA	PITPNM2	0.944	0.104363095238	structurally_consistent (dimer)
OSBP	OSBP2	0.94	0.122
OSBP	USP33	0.938	0.182
PITPNM3	OSBPL3	0.909
SLC22A15	RASSF3	0.904
SLC22A15	PITPNM1	0.902
SLC22A15	PITPNM2	0.902
PITPNM2	RASSF3	0.902	0.072
PITPNM1	RASSF3	0.902	0.088
OSBP2	PITPNM2	0.897	0.082
PITPNM1	OSBP2	0.897	0.108
VAPA	USP33	0.89	0.158
SLC22A15	ZFPL1	0.889
PITPNM1	PITPNM2	0.881	0.086	mutually_exclusive (Q9P0L0)
PITPNM1	OSBPL10	0.88	0.064
PITPNM2	OSBPL10	0.88	0.036
OSBP2	OSBPL10	0.849	0.09
PITPNM3	PITPNM2	0.843
PITPNM1	PITPNM3	0.843
PITPNM3	USP33	0.818
PITPNM2	TTC39B	0.793	0.076
PITPNM1	TTC39B	0.793	0.126
PITPNM3	OSBP2	0.778
PITPNM1	ARHGEF12	0.769	0.0645751633987	mutually_exclusive (Q9P0L0)
PITPNM2	ARHGEF12	0.769	0.144575163399
OSBP	OSBPL10	0.751	0.076
VAPA	ACBD4	0.75	0.0812
OSBPL3	USP33	0.747	0.068
OSBP2	ARHGEF12	0.737	0.106
PITPNM1	OSBPL6	0.737	0.054
OSBP2	OSBPL6	0.737	0.138
OSBPL6	PITPNM2	0.737	0.048
USP33	TTC39B	0.732	0.088
OSBP	PITPNM2	0.731	0.088
PITPNM1	OSBP	0.731	0.102
PITPNM3	RASSF3	0.722
SLC22A15	OSBP2	0.722
PITPNM2	OSBPL3	0.72	0.03
PITPNM1	OSBPL3	0.72	0.028
OSBPL6	OSBPL10	0.72	0.062
SLC22A15	PITPNM3	0.717
OSBP2	OSBPL3	0.714	0.07
PITPNM2	USP33	0.699	0.064
PITPNM1	USP33	0.699	0.054
OSBP	PITPNM3	0.677
OSBPL6	TTC39B	0.665	0.08
SLC22A15	USP33	0.663
OSBPL6	USP33	0.657	0.142
OSBP	OSBPL6	0.653	0.148
OSBP2	RASSF3	0.647	0.066
PITPNM3	OSBPL6	0.644
SLC22A15	OSBPL10	0.633
OSBP	ARHGEF12	0.633	0.072
OSBPL6	ARHGEF12	0.633	0.187575163399
PITPNM3	OSBPL10	0.617
OSBP2	USP33	0.614	0.088
TTC39B	ARHGEF12	0.605	0.118
PITPNM3	TTC39B	0.604
OSBP2	TTC39B	0.604	0.134
PITPNM3	ARHGEF12	0.603
TTC39B	OSBPL10	0.603	0.09
OSBP	TTC39B	0.602	0.126
OSBPL3	OSBPL10	0.601	0.062
PITPNM1	ACBD4	0.571	0.052
ACBD4	PITPNM2	0.571	0.136
ZFPL1	VAPB	0.567	0.096
ZFPL1	PITPNM2	0.563	0.11
PITPNM1	ZFPL1	0.563	0.034
USP33	RASSF3	0.552	0.09
ARHGEF12	OSBPL10	0.545	0.044
OSBP	OSBPL3	0.509	0.082
PITPNM3	ACBD4	0.502
PITPNM1	DOP1A	0.502	0.056
DOP1A	PITPNM2	0.502	0.11
OSBPL3	ARHGEF12	0.492	0.052
SLC22A15	TTC39B	0.478
USP33	OSBPL10	0.475	0.122
ZFPL1	OSBP2	0.475	0.158
USP33	ARHGEF12	0.459	0.126
ACBD4	OSBPL10	0.428	0.054
TTC39B	RASSF3	0.427	0.106
SLC22A15	ARHGEF12	0.401
RASSF3	OSBPL10	0.401	0.032
ARHGEF12	RASSF3	0.356	0.128
OSBPL6	RASSF3	0.343	0.076
SLC22A15	OSBPL6	0.343
OSBP2	ACBD4	0.335	0.072
OSBP	RASSF3	0.335	0.048
DOP1A	ACBD4	0.333	0.046
SLC22A15	OSBP	0.323
DOP1A	PITPNM3	0.32
DOP1A	OSBP2	0.303	0.086
ZFPL1	ARHGEF12	0.282	0.062
VAPA	TTC39B	0.281	0.124
OSBP	DOP1A	0.259	0.204
SLC22A15	OSBPL3	0.245
OSBPL6	TMEM38B	0.243	0.124
ACBD4	OSBPL3	0.234	0.066
OSBP	ACBD4	0.234	0.092
OSBP	ZFPL1	0.227	0.11
ZFPL1	OSBPL10	0.223	0.058
TMEM38B	OSBPL10	0.223	0.072
DOP1A	OSBPL3	0.22	0.062
SLC22A15	ACBD4	0.214
DOP1A	OSBPL6	0.213	0.066
OSBPL3	RASSF3	0.203	0.064
ACBD4	ARHGEF12	0.202	0.088
ACBD4	OSBPL6	0.202	0.06
OSBPL3	TTC39B	0.176	0.046
ACBD4	TTC39B	0.172	0.082
DOP1A	TTC39B	0.172	0.094
ARHGEF12	TMEM38B	0.166	0.082
DOP1A	USP33	0.165	0.07
DOP1A	ARHGEF12	0.164	0.114575163399
DOP1A	OSBPL10	0.164	0.098
PITPNM2	TMEM38B	0.164	0.068
PITPNM1	TMEM38B	0.164	0.066
ZFPL1	ACBD4	0.157	0.068
VAPA	DOP1A	0.155	0.0701944444444
ACBD4	RASSF3	0.146	0.062
SLC22A15	DOP1A	0.146
ACBD4	USP33	0.144	0.096
ACBD4	TMEM38B	0.143	0.054
OSBP2	TMEM38B	0.143	0.114
OSBPL3	TMEM38B	0.112	0.042
DOP1A	RASSF3	0.108	0.046
VAPA	RASSF3	0.099	0.082
OSBP	TMEM38B	0.083	0.132
USP33	TMEM38B	0.08	0.05
ZFPL1	USP33	0.07	0.210255813953
ZFPL1	TMEM38B	0.05	0.114
VAPB	TMEM38B	0.044	0.156

Related Complexes

Genename	Complexes
OSBP	huMAP3_00112.1 huMAP3_00802.1 huMAP3_00862.1 huMAP3_01422.1 huMAP3_02032.1 huMAP3_05953.1 huMAP3_08362.1 huMAP3_08743.1 huMAP3_08783.1 huMAP3_08942.1 huMAP3_10293.1 huMAP3_10464.1 huMAP3_11340.1 huMAP3_11485.1 huMAP3_12065.1 huMAP3_12460.1 huMAP3_12585.1 huMAP3_12614.1 huMAP3_12946.1 huMAP3_13964.1 huMAP3_14131.1 huMAP3_14473.1 huMAP3_14791.1 huMAP3_14847.1 huMAP3_15032.1
OSBP2	huMAP3_00802.1 huMAP3_00862.1 huMAP3_01422.1 huMAP3_03016.1 huMAP3_08362.1 huMAP3_08743.1 huMAP3_08783.1 huMAP3_08942.1 huMAP3_11340.1 huMAP3_11485.1 huMAP3_11506.1 huMAP3_12460.1 huMAP3_12585.1 huMAP3_12614.1 huMAP3_12946.1 huMAP3_13169.1 huMAP3_14473.1 huMAP3_14729.1 huMAP3_14847.1
SLC22A15	huMAP3_00112.1 huMAP3_00802.1 huMAP3_01422.1 huMAP3_08362.1 huMAP3_08743.1 huMAP3_08783.1 huMAP3_10293.1 huMAP3_11485.1 huMAP3_11506.1 huMAP3_11633.1 huMAP3_11729.1 huMAP3_13169.1 huMAP3_14473.1 huMAP3_14729.1
VAPA	huMAP3_00112.1 huMAP3_00802.1 huMAP3_01422.1 huMAP3_02032.1 huMAP3_05790.1 huMAP3_07443.1 huMAP3_08362.1 huMAP3_08743.1 huMAP3_08783.1 huMAP3_10293.1 huMAP3_10464.1 huMAP3_11485.1 huMAP3_11506.1 huMAP3_14473.1
ACBD4	huMAP3_00802.1 huMAP3_01422.1 huMAP3_02416.1 huMAP3_02444.1 huMAP3_06849.1 huMAP3_08743.1 huMAP3_11485.1
RASSF3	huMAP3_01602.1 huMAP3_04903.1 huMAP3_07687.1 huMAP3_07691.1 huMAP3_08743.1 huMAP3_11485.1 huMAP3_11506.1 huMAP3_12772.1 huMAP3_13169.1 huMAP3_14473.1 huMAP3_14729.1 huMAP3_15155.1
PITPNM3	huMAP3_00750.1 huMAP3_00802.1 huMAP3_02032.1 huMAP3_07443.1 huMAP3_08362.1 huMAP3_08743.1 huMAP3_08783.1 huMAP3_10464.1 huMAP3_11485.1 huMAP3_11506.1 huMAP3_11833.1 huMAP3_12915.1 huMAP3_13169.1 huMAP3_14473.1 huMAP3_14729.1
OSBPL6	huMAP3_00802.1 huMAP3_02032.1 huMAP3_03632.1 huMAP3_05790.1 huMAP3_07443.1 huMAP3_08017.1 huMAP3_08362.1 huMAP3_08743.1 huMAP3_08783.1 huMAP3_10464.1 huMAP3_11944.1 huMAP3_12915.1
ZFPL1	huMAP3_00750.1 huMAP3_00802.1 huMAP3_02032.1 huMAP3_05790.1 huMAP3_07443.1 huMAP3_08362.1 huMAP3_08743.1 huMAP3_10464.1 huMAP3_11833.1 huMAP3_12915.1
TTC39B	huMAP3_01422.1 huMAP3_06849.1 huMAP3_08743.1 huMAP3_11660.1
PITPNM2	huMAP3_00802.1 huMAP3_01422.1 huMAP3_06849.1 huMAP3_07722.1 huMAP3_08743.1 huMAP3_09375.1 huMAP3_11485.1 huMAP3_11506.1 huMAP3_13169.1 huMAP3_14473.1 huMAP3_14729.1
OSBPL10	huMAP3_07560.1 huMAP3_08743.1 huMAP3_11485.1 huMAP3_11506.1 huMAP3_13169.1 huMAP3_14473.1 huMAP3_14729.1
ARHGEF12	huMAP3_01601.1 huMAP3_07436.1 huMAP3_08743.1 huMAP3_11485.1 huMAP3_14415.1
DOP1A	huMAP3_00162.1 huMAP3_00802.1 huMAP3_01422.1 huMAP3_06849.1 huMAP3_07612.1 huMAP3_08201.1 huMAP3_08743.1 huMAP3_11485.1 huMAP3_12705.1 huMAP3_13513.1
VAPB	huMAP3_00802.1 huMAP3_01422.1 huMAP3_06849.1 huMAP3_07388.1 huMAP3_07722.1 huMAP3_08743.1 huMAP3_09375.1 huMAP3_10725.1 huMAP3_11485.1
OSBPL3	huMAP3_00802.1 huMAP3_02032.1 huMAP3_03632.1 huMAP3_05790.1 huMAP3_07443.1 huMAP3_08362.1 huMAP3_08743.1 huMAP3_10464.1
PITPNM1	huMAP3_00112.1 huMAP3_00443.1 huMAP3_00802.1 huMAP3_01422.1 huMAP3_02032.1 huMAP3_08362.1 huMAP3_08743.1 huMAP3_08783.1 huMAP3_10293.1 huMAP3_10464.1 huMAP3_11485.1 huMAP3_11506.1 huMAP3_13169.1 huMAP3_14473.1 huMAP3_14729.1
USP33	huMAP3_00802.1 huMAP3_01370.1 huMAP3_01422.1 huMAP3_04282.1 huMAP3_06849.1 huMAP3_07360.1 huMAP3_08743.1 huMAP3_10759.1 huMAP3_11340.1 huMAP3_11485.1 huMAP3_11506.1 huMAP3_13964.1 huMAP3_14131.1 huMAP3_14473.1 huMAP3_14623.1 huMAP3_14791.1 huMAP3_15032.1
TMEM38B	huMAP3_04484.1 huMAP3_04572.1 huMAP3_07443.1 huMAP3_08743.1 huMAP3_12951.1 huMAP3_15312.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_08743.1

Complex Portal: CPX-24980