hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_08747.1
Complex Portal: CPX-22775
Confidence: High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| WIPF1 | WAS/WASL-interacting protein family member 1 (Protein PRPL-2) (Wiskott-Aldrich syndrome protein-interacting protein) (WASP-interacting protein) | 5 | UniProt NCBI |
| PIK3AP1 | Phosphoinositide 3-kinase adapter protein 1 (B-cell adapter for phosphoinositide 3-kinase) (B-cell phosphoinositide 3-kinase adapter protein 1) | 5 | UniProt NCBI |
| WIPF2 | WAS/WASL-interacting protein family member 2 (WASP-interacting protein-related protein) (WIP- and CR16-homologous protein) (WIP-related protein) | 5 | UniProt NCBI |
| WIPF3 | WAS/WASL-interacting protein family member 3 (Corticosteroids and regional expression protein 16 homolog) | 4 | UniProt NCBI |
| CBLB | E3 ubiquitin-protein ligase CBL-B (EC 2.3.2.27) (Casitas B-lineage lymphoma proto-oncogene b) (RING finger protein 56) (RING-type E3 ubiquitin transferase CBL-B) (SH3-binding protein CBL-B) (Signal transduction protein CBL-B) | 5 | UniProt NCBI |
| NHS | Actin remodeling regulator NHS (Congenital cataracts and dental anomalies protein) (Nance-Horan syndrome protein) | 5 | UniProt NCBI |
| TNK2 | Activated CDC42 kinase 1 (ACK-1) (EC 2.7.10.2) (EC 2.7.11.1) (Tyrosine kinase non-receptor protein 2) | 5 | UniProt NCBI |
| DOK1 | Docking protein 1 (Downstream of tyrosine kinase 1) (p62(dok)) (pp62) | 5 | UniProt NCBI |
| SEMA6A | Semaphorin-6A (Semaphorin VIA) (Sema VIA) (Semaphorin-6A-1) (SEMA6A-1) | 5 | UniProt NCBI |
| ARAP1 | Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 (Centaurin-delta-2) (Cnt-d2) | 5 | UniProt NCBI |
| TNIK | TRAF2 and NCK-interacting protein kinase (EC 2.7.11.1) | 5 | UniProt NCBI |
| ASAP2 | Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 (Development and differentiation-enhancing factor 2) (Paxillin-associated protein with ARF GAP activity 3) (PAG3) (Pyk2 C-terminus-associated protein) (PAP) | 5 | UniProt NCBI |
| NCK1 | SH2/SH3 adapter protein NCK1 (Cytoplasmic protein NCK1) (NCK adapter protein 1) (Nck-1) (SH2/SH3 adapter protein NCK-alpha) | 5 | UniProt NCBI |
| NCK2 | Cytoplasmic protein NCK2 (Growth factor receptor-bound protein 4) (NCK adaptor protein 2) (Nck-2) (SH2/SH3 adaptor protein NCK-beta) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:04144 | 1.30767601098e-06 | 0.461538461538 | WIPF3 WIPF1 ARAP1 ASAP2 WIPF2 CBLB | Endocytosis |
| REAC:R-HSA-9013149 | 4.54466258455e-05 | 0.384615384615 | NHS WIPF2 ARAP1 WIPF1 WIPF3 | RAC1 GTPase cycle |
| REAC:R-HSA-9012999 | 0.000147618134817 | 0.461538461538 | NHS WIPF3 NCK2 WIPF1 WIPF2 ARAP1 | RHO GTPase cycle |
| KEGG:05130 | 0.000591852287469 | 0.307692307692 | WIPF2 NCK2 WIPF1 WIPF3 | Pathogenic Escherichia coli infection |
| REAC:R-HSA-5663213 | 0.000884720867689 | 0.230769230769 | WIPF2 WIPF1 WIPF3 | RHO GTPases Activate WASPs and WAVEs |
| REAC:R-HSA-9013148 | 0.000968817441565 | 0.307692307692 | ARAP1 WIPF2 WIPF1 WIPF3 | CDC42 GTPase cycle |
| REAC:R-HSA-194315 | 0.00226583970621 | 0.461538461538 | NHS WIPF3 NCK2 WIPF1 WIPF2 ARAP1 | Signaling by Rho GTPases |
| REAC:R-HSA-9716542 | 0.00257126439658 | 0.461538461538 | NHS WIPF3 NCK2 WIPF1 WIPF2 ARAP1 | Signaling by Rho GTPases, Miro GTPases and RHOBTB3 |
| REAC:R-HSA-9664407 | 0.00342983267549 | 0.230769230769 | WIPF2 WIPF1 WIPF3 | Parasite infection |
| REAC:R-HSA-9664417 | 0.00342983267549 | 0.230769230769 | WIPF2 WIPF1 WIPF3 | Leishmania phagocytosis |
| REAC:R-HSA-9664422 | 0.00342983267549 | 0.230769230769 | WIPF2 WIPF1 WIPF3 | FCGR3A-mediated phagocytosis |
| REAC:R-HSA-2029482 | 0.00405227038126 | 0.230769230769 | WIPF2 WIPF1 WIPF3 | Regulation of actin dynamics for phagocytic cup formation |
| REAC:R-HSA-8849469 | 0.00715899645867 | 0.153846153846 | DOK1 ARAP1 | PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 |
| KEGG:05135 | 0.00733158154625 | 0.230769230769 | WIPF2 WIPF1 WIPF3 | Yersinia infection |
| REAC:R-HSA-2029480 | 0.0109961634966 | 0.230769230769 | WIPF2 WIPF1 WIPF3 | Fcgamma receptor (FCGR) dependent phagocytosis |
| REAC:R-HSA-162582 | 0.0244930985656 | 0.615384615385 | WIPF3 PIK3AP1 NHS NCK2 ARAP1 DOK1 WIPF2 WIPF1 | Signal Transduction |
| WP:WP437 | 0.0291131087055 | 0.230769230769 | TNK2 CBLB NCK2 | EGF EGFR signaling pathway |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap |
|---|---|---|---|---|
| NCK2 | WIPF2 | 1.0 | 0.044 | |
| NCK1 | NCK2 | 1.0 | 0.084 | |
| NCK1 | WIPF2 | 0.999 | 0.1 | |
| ARAP1 | NCK2 | 0.999 | 0.082 | |
| PIK3AP1 | NCK2 | 0.998 | 0.06 | |
| NCK2 | TNK2 | 0.998 | 0.07 | |
| NCK1 | WIPF1 | 0.997 | 0.052 | |
| NCK1 | PIK3AP1 | 0.994 | 0.056 | |
| NCK2 | WIPF1 | 0.994 | 0.04 | |
| WIPF1 | WIPF2 | 0.993 | 0.16 | |
| NCK2 | WIPF3 | 0.992 | ||
| NHS | NCK2 | 0.988 | 0.096 | |
| NCK2 | ASAP2 | 0.986 | 0.054 | |
| NCK1 | TNK2 | 0.984 | 0.204 | |
| DOK1 | NCK2 | 0.979 | 0.062 | |
| NCK1 | NHS | 0.976 | 0.15 | |
| NCK2 | CBLB | 0.973 | 0.03 | |
| PIK3AP1 | TNK2 | 0.972 | 0.106 | |
| PIK3AP1 | WIPF2 | 0.972 | 0.112 | |
| ARAP1 | TNK2 | 0.966 | 0.074 | |
| SEMA6A | NCK2 | 0.965 | ||
| NCK2 | TNIK | 0.964 | 0.128 | |
| NCK1 | ARAP1 | 0.959 | 0.044 | |
| ARAP1 | WIPF2 | 0.958 | 0.242 | |
| NCK1 | ASAP2 | 0.953 | 0.06 | |
| ARAP1 | PIK3AP1 | 0.939 | 0.042 | |
| NCK1 | WIPF3 | 0.933 | ||
| WIPF1 | TNK2 | 0.928 | 0.056 | |
| WIPF2 | TNK2 | 0.914 | 0.148 | |
| WIPF2 | WIPF3 | 0.785 | ||
| WIPF1 | WIPF3 | 0.785 | ||
| ARAP1 | ASAP2 | 0.763 | 0.102 | |
| ARAP1 | CBLB | 0.626 | 0.128 | |
| PIK3AP1 | WIPF3 | 0.622 | ||
| WIPF3 | TNK2 | 0.622 | ||
| PIK3AP1 | WIPF1 | 0.622 | 0.092 | |
| WIPF1 | ASAP2 | 0.614 | 0.092 | |
| ARAP1 | WIPF3 | 0.614 | ||
| WIPF3 | ASAP2 | 0.614 | ||
| ARAP1 | WIPF1 | 0.614 | 0.128 | |
| PIK3AP1 | ASAP2 | 0.614 | 0.068 | |
| TNK2 | ASAP2 | 0.614 | 0.104 | |
| WIPF2 | ASAP2 | 0.614 | 0.258 | |
| NCK1 | TNIK | 0.519 | 0.052 | |
| DOK1 | TNK2 | 0.513 | 0.156 | |
| DOK1 | CBLB | 0.513 | 0.078 | |
| DOK1 | WIPF1 | 0.513 | 0.182 | |
| DOK1 | WIPF3 | 0.513 | ||
| DOK1 | WIPF2 | 0.513 | 0.104 | |
| DOK1 | PIK3AP1 | 0.513 | 0.108 | |
| NHS | TNK2 | 0.499 | 0.144 | |
| NHS | WIPF2 | 0.49 | 0.168 | |
| NHS | PIK3AP1 | 0.49 | 0.072 | |
| NCK1 | SEMA6A | 0.45 | ||
| NHS | ARAP1 | 0.433 | 0.196 | |
| DOK1 | TNIK | 0.377 | 0.05 | |
| DOK1 | ARAP1 | 0.377 | 0.106 | |
| DOK1 | ASAP2 | 0.377 | 0.072 | |
| WIPF2 | TNIK | 0.363 | 0.17 | |
| DOK1 | NCK1 | 0.339 | 0.096 | |
| SEMA6A | TNK2 | 0.324 | ||
| SEMA6A | WIPF3 | 0.324 | ||
| SEMA6A | PIK3AP1 | 0.324 | ||
| SEMA6A | WIPF2 | 0.324 | ||
| SEMA6A | WIPF1 | 0.324 | ||
| WIPF1 | TNIK | 0.3 | 0.182 | |
| TNIK | ASAP2 | 0.3 | 0.044 | |
| WIPF3 | TNIK | 0.3 | ||
| ARAP1 | TNIK | 0.3 | 0.074 | |
| PIK3AP1 | CBLB | 0.291 | 0.116 | |
| CBLB | WIPF2 | 0.291 | 0.064 | |
| CBLB | ASAP2 | 0.291 | 0.102 | |
| CBLB | WIPF1 | 0.291 | 0.076 | |
| CBLB | WIPF3 | 0.291 | ||
| CBLB | TNK2 | 0.291 | 0.142 | |
| SEMA6A | ASAP2 | 0.233 | ||
| SEMA6A | ARAP1 | 0.233 | ||
| TNIK | TNK2 | 0.223 | 0.054 | |
| CBLB | TNIK | 0.215 | 0.048 | |
| SEMA6A | CBLB | 0.212 | ||
| PIK3AP1 | TNIK | 0.202 | 0.036 | |
| DOK1 | SEMA6A | 0.188 | ||
| NCK1 | CBLB | 0.188 | 0.07 | |
| NHS | ASAP2 | 0.175 | 0.084 | |
| DOK1 | NHS | 0.131 | 0.108 | |
| NHS | TNIK | 0.106 | 0.062 | |
| NHS | WIPF1 | 0.106 | 0.11 | |
| NHS | WIPF3 | 0.106 | ||
| NHS | SEMA6A | 0.098 | ||
| SEMA6A | TNIK | 0.066 | ||
| NHS | CBLB | 0.046 | 0.104 |
Related Complexes