hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_08755.1
Complex Portal: CPX-18050
Confidence: High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| RAB11B | Ras-related protein Rab-11B (EC 3.6.5.2) (GTP-binding protein YPT3) | 5 | UniProt NCBI |
| WDR44 | WD repeat-containing protein 44 (Rab11-binding protein) (Rab11BP) (Rabphilin-11) | 5 | UniProt NCBI |
| SH3BP5 | SH3 domain-binding protein 5 (SH3BP-5) (SH3 domain-binding protein that preferentially associates with BTK) | 5 | UniProt NCBI |
| RAB11FIP1 | Rab11 family-interacting protein 1 (Rab11-FIP1) (Rab-coupling protein) | 5 | UniProt NCBI |
| RAB11A | Ras-related protein Rab-11A (Rab-11) (EC 3.6.5.2) (YL8) | 5 | UniProt NCBI |
| RAB25 | Ras-related protein Rab-25 (CATX-8) | 5 | UniProt NCBI |
| RAB11FIP2 | Rab11 family-interacting protein 2 (Rab11-FIP2) (NRip11) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP4856 | 1.22823081635e-05 | 0.428571428571 | RAB11B RAB11A RAB25 | Intracellular trafficking proteins involved in CMT neuropathy |
| CORUM:3941 | 2.05265451394e-05 | 0.285714285714 | RAB11FIP1 RAB11A | RAB11FIP1-RAB11A complex |
| CORUM:6253 | 6.1565588648e-05 | 0.285714285714 | RAB11FIP2 RAB11A | myosin-Vb-Rab11-FIP2-Rab11a complex |
| KEGG:04144 | 0.000107023311575 | 0.571428571429 | RAB11FIP2 RAB11B RAB11FIP1 RAB11A | Endocytosis |
| REAC:R-HSA-8873719 | 0.000487210059522 | 0.428571428571 | RAB11B RAB11A RAB25 | RAB geranylgeranylation |
| GO:0006887 | 0.000847239663712 | 0.714285714286 | RAB11FIP2 RAB11B RAB11FIP1 RAB25 RAB11A | exocytosis |
| GO:0031489 | 0.00122180600483 | 0.428571428571 | RAB11B RAB11A RAB25 | myosin V binding |
| KEGG:04962 | 0.00793622460548 | 0.285714285714 | RAB11B RAB11A | Vasopressin-regulated water reabsorption |
| WP:WP5085 | 0.0137733753117 | 0.285714285714 | RAB11B RAB11A | Vasopressin regulated water reabsorption |
| REAC:R-HSA-432040 | 0.0212237900738 | 0.285714285714 | RAB11FIP2 RAB11A | Vasopressin regulates renal water homeostasis via Aquaporins |
| REAC:R-HSA-445717 | 0.0238233224402 | 0.285714285714 | RAB11FIP2 RAB11A | Aquaporin-mediated transport |
| REAC:R-HSA-8854214 | 0.028001578843 | 0.285714285714 | RAB11B RAB11A | TBC/RABGAPs |
| GO:0032940 | 0.031117355086 | 0.714285714286 | RAB11FIP2 RAB11B RAB11FIP1 RAB25 RAB11A | secretion by cell |
| GO:0046903 | 0.0493130580912 | 0.714285714286 | RAB11FIP2 RAB11B RAB11FIP1 RAB25 RAB11A | secretion |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| RAB11B | RAB11FIP1 | 1.0 | 0.276 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116 gupta_WMM | |
| RAB11A | RAB11FIP2 | 0.999 | 0.258814814815 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116 | |
| RAB11B | RAB11FIP2 | 0.998 | 0.284 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM | |
| RAB11B | SH3BP5 | 0.998 | 0.172166666667 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| RAB11B | RAB25 | 0.997 | 0.8 |
mutually_exclusive (Q7L8J4)
structurally_consistent (dimer) |
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| RAB11A | RAB11FIP1 | 0.996 | 0.274 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM hein () bioplex3_HCT116 | |
| RAB11FIP2 | RAB11FIP1 | 0.995 | 0.076 | hein_WMM bioplex_WMM bioplex3_WMM boldt gupta_WMM boldt_WMM WMM_only | |
| RAB11A | RAB25 | 0.995 | 0.26 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM treiber_WMM |
| RAB11B | WDR44 | 0.992 | 0.268 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM | |
| RAB11B | RAB11A | 0.961 | 0.427041666667 | hein_WMM bioplex3_WMM hein () bioplex3_HCT116 | |
| SH3BP5 | RAB11A | 0.947 | 0.31 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| WDR44 | RAB11A | 0.934 | 0.232 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM hein () | |
| SH3BP5 | RAB11FIP2 | 0.905 | 0.11 | bioplex_WMM bioplex3_WMM WMM_only | |
| SH3BP5 | RAB11FIP1 | 0.905 | 0.064 | bioplex_WMM bioplex3_WMM WMM_only | |
| WDR44 | SH3BP5 | 0.837 | 0.06 | bioplex_WMM bioplex3_WMM WMM_only | |
| WDR44 | RAB25 | 0.834 | 0.124 | bioplex_WMM bioplex3_WMM WMM_only | |
| WDR44 | RAB11FIP2 | 0.386 | 0.054 | hein_WMM bioplex_WMM bioplex3_WMM gupta_WMM WMM_only | |
| WDR44 | RAB11FIP1 | 0.345 | 0.04 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only | |
| SH3BP5 | RAB25 | 0.28 | 0.07 | bioplex_WMM bioplex3_WMM WMM_only | |
| RAB25 | RAB11FIP2 | 0.167 | 0.112 | bioplex_WMM bioplex3_WMM WMM_only | |
| RAB25 | RAB11FIP1 | 0.166 | 0.192 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes