hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_08762.1
Complex Portal: CPX-11526
Confidence: High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| AKR1C1 | Aldo-keto reductase family 1 member C1 (EC 1.1.1.-) (EC 1.1.1.112) (EC 1.1.1.209) (EC 1.1.1.210) (EC 1.1.1.357) (EC 1.1.1.51) (EC 1.1.1.53) (EC 1.1.1.62) (EC 1.3.1.20) (20-alpha-hydroxysteroid dehydrogenase) (20-alpha-HSD) (EC 1.1.1.149) (Chlordecone reductase homolog HAKRC) (Dihydrodiol dehydrogenase 1) (DD1) (High-affinity hepatic bile acid-binding protein) (HBAB) | 5 | UniProt NCBI |
| AKR1D1 | Aldo-keto reductase family 1 member D1 (EC 1.3.1.3) (3-oxo-5-beta-steroid 4-dehydrogenase) (Delta(4)-3-ketosteroid 5-beta-reductase) (Delta(4)-3-oxosteroid 5-beta-reductase) | 5 | UniProt NCBI |
| AKR1C3 | Aldo-keto reductase family 1 member C3 (EC 1.1.1.-) (EC 1.1.1.210) (EC 1.1.1.53) (EC 1.1.1.62) (17-beta-hydroxysteroid dehydrogenase type 5) (17-beta-HSD 5) (3-alpha-HSD type II, brain) (3-alpha-hydroxysteroid dehydrogenase type 2) (3-alpha-HSD type 2) (EC 1.1.1.357) (Chlordecone reductase homolog HAKRb) (Dihydrodiol dehydrogenase 3) (DD-3) (DD3) (Dihydrodiol dehydrogenase type I) (HA1753) (Prostaglandin F synthase) (PGFS) (EC 1.1.1.188) (Testosterone 17-beta-dehydrogenase 5) (EC 1.1.1.239, EC 1.1.1.64) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP5279 | 6.51135762131e-09 | 1.0 | AKR1D1 AKR1C1 AKR1C3 | Mineralocorticoid biosynthesis |
| WP:WP5280 | 9.30193945901e-09 | 1.0 | AKR1D1 AKR1C1 AKR1C3 | Glucocorticoid biosynthesis |
| REAC:R-HSA-193775 | 2.61297199043e-08 | 1.0 | AKR1D1 AKR1C1 AKR1C3 | Synthesis of bile acids and bile salts via 24-hydroxycholesterol |
| REAC:R-HSA-193807 | 5.59922569377e-08 | 1.0 | AKR1D1 AKR1C1 AKR1C3 | Synthesis of bile acids and bile salts via 27-hydroxycholesterol |
| REAC:R-HSA-193368 | 1.69843179378e-07 | 1.0 | AKR1D1 AKR1C1 AKR1C3 | Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol |
| KEGG:00140 | 5.16122829258e-07 | 1.0 | AKR1D1 AKR1C1 AKR1C3 | Steroid hormone biosynthesis |
| REAC:R-HSA-192105 | 6.20580847727e-07 | 1.0 | AKR1D1 AKR1C1 AKR1C3 | Synthesis of bile acids and bile salts |
| GO:0047086 | 9.61200410764e-07 | 1.0 | AKR1D1 AKR1C1 AKR1C3 | ketosteroid monooxygenase activity |
| REAC:R-HSA-194068 | 1.70496422375e-06 | 1.0 | AKR1D1 AKR1C1 AKR1C3 | Bile acid and bile salt metabolism |
| WP:WP5277 | 1.1325886453e-05 | 0.666666666667 | AKR1D1 AKR1C1 | Steroid hormone precursor biosynthesis |
| GO:0004032 | 1.15344049292e-05 | 1.0 | AKR1D1 AKR1C1 AKR1C3 | alditol:NADP+ 1-oxidoreductase activity |
| WP:WP702 | 3.10835934447e-05 | 1.0 | AKR1D1 AKR1C1 AKR1C3 | Metapathway biotransformation Phase I and II |
| WP:WP696 | 3.17081411632e-05 | 0.666666666667 | AKR1C3 AKR1C1 | Benzo a pyrene metabolism |
| GO:0008106 | 7.84339535184e-05 | 1.0 | AKR1D1 AKR1C1 AKR1C3 | alcohol dehydrogenase (NADP+) activity |
| GO:0008207 | 0.000127839654632 | 1.0 | AKR1D1 AKR1C1 AKR1C3 | C21-steroid hormone metabolic process |
| REAC:R-HSA-8957322 | 0.000137759616152 | 1.0 | AKR1D1 AKR1C1 AKR1C3 | Metabolism of steroids |
| GO:0016709 | 0.000170228592746 | 1.0 | AKR1D1 AKR1C1 AKR1C3 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen |
| GO:0004033 | 0.000194546963139 | 1.0 | AKR1D1 AKR1C1 AKR1C3 | aldo-keto reductase (NADP) activity |
| GO:0016229 | 0.000221076094476 | 1.0 | AKR1D1 AKR1C1 AKR1C3 | steroid dehydrogenase activity |
| WP:WP98 | 0.000634541489717 | 0.666666666667 | AKR1C3 AKR1C1 | Prostaglandin synthesis and regulation |
| WP:WP4313 | 0.00186764162171 | 0.666666666667 | AKR1C3 AKR1C1 | Ferroptosis |
| GO:0004497 | 0.00345936027834 | 1.0 | AKR1D1 AKR1C1 AKR1C3 | monooxygenase activity |
| GO:0018636 | 0.00421361424067 | 0.666666666667 | AKR1C3 AKR1C1 | phenanthrene 9,10-monooxygenase activity |
| REAC:R-HSA-975634 | 0.00530917647079 | 0.666666666667 | AKR1C3 AKR1C1 | Retinoid metabolism and transport |
| REAC:R-HSA-6806667 | 0.00614555007695 | 0.666666666667 | AKR1C3 AKR1C1 | Metabolism of fat-soluble vitamins |
| GO:0071395 | 0.00842684400117 | 0.666666666667 | AKR1C3 AKR1C1 | cellular response to jasmonic acid stimulus |
| GO:0009753 | 0.00842684400117 | 0.666666666667 | AKR1C3 AKR1C1 | response to jasmonic acid |
| KEGG:05208 | 0.0153557884392 | 0.666666666667 | AKR1C3 AKR1C1 | Chemical carcinogenesis - reactive oxygen species |
| GO:0016616 | 0.0165038110528 | 1.0 | AKR1D1 AKR1C1 AKR1C3 | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| REAC:R-HSA-556833 | 0.0177385429708 | 1.0 | AKR1D1 AKR1C1 AKR1C3 | Metabolism of lipids |
| KEGG:01100 | 0.0189521995452 | 1.0 | AKR1D1 AKR1C1 AKR1C3 | Metabolic pathways |
| REAC:R-HSA-2187338 | 0.0204048321881 | 0.666666666667 | AKR1C3 AKR1C1 | Visual phototransduction |
| GO:0016614 | 0.0207446272651 | 1.0 | AKR1D1 AKR1C1 AKR1C3 | oxidoreductase activity, acting on CH-OH group of donors |
| GO:0047023 | 0.0210651876021 | 0.666666666667 | AKR1C3 AKR1C1 | androsterone dehydrogenase activity |
| GO:0016705 | 0.0250037062852 | 1.0 | AKR1D1 AKR1C1 AKR1C3 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen |
| KEGG:00120 | 0.0334562504346 | 0.333333333333 | AKR1D1 | Primary bile acid biosynthesis |
| GO:0042445 | 0.0360123345897 | 1.0 | AKR1D1 AKR1C1 AKR1C3 | hormone metabolic process |
| WP:WP5420 | 0.0379798583444 | 0.666666666667 | AKR1C3 AKR1C1 | ADHD and autism ASD linked metabolic pathways and SNP |
| GO:0042448 | 0.0393180950424 | 0.666666666667 | AKR1C3 AKR1C1 | progesterone metabolic process |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| AKR1C1 | AKR1D1 | 0.997 | 0.238 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| AKR1D1 | AKR1C3 | 0.997 | 0.54 |
structurally_consistent (Q04828)
structurally_consistent (dimer) |
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| AKR1C1 | AKR1C3 | 0.997 | 0.348 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM treiber_WMM |
Related Complexes
| Genename | Complexes |
|---|---|
| AKR1C1 | huMAP3_01225.1 huMAP3_08762.1 huMAP3_10318.1 |
| AKR1D1 | huMAP3_01225.1 huMAP3_08762.1 huMAP3_10318.1 |
| AKR1C3 | huMAP3_01225.1 huMAP3_08762.1 huMAP3_10318.1 |