hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_08769.1
Complex Portal: CPX-13001
Confidence: High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| SAP18 | Histone deacetylase complex subunit SAP18 (18 kDa Sin3-associated polypeptide) (2HOR0202) (Cell growth-inhibiting gene 38 protein) (Sin3-associated polypeptide p18) | 5 | UniProt NCBI |
| SETD2 | Histone-lysine N-methyltransferase SETD2 (EC 2.1.1.359) (HIF-1) (Huntingtin yeast partner B) (Huntingtin-interacting protein 1) (HIP-1) (Huntingtin-interacting protein B) (Lysine N-methyltransferase 3A) (Protein-lysine N-methyltransferase SETD2) (EC 2.1.1.-) (SET domain-containing protein 2) (hSET2) (p231HBP) | 5 | UniProt NCBI |
| RSBN1L | Lysine-specific demethylase RSBN1L (EC 1.14.11.-) (Round spermatid basic protein 1-like protein) | 3 | UniProt NCBI |
| NKTR | NK-tumor recognition protein (NK-TR protein) (Natural-killer cells cyclophilin-related protein) (Peptidyl-prolyl cis-trans isomerase NKTR) (PPIase) (EC 5.2.1.8) (Rotamase) | 5 | UniProt NCBI |
| ACIN1 | Apoptotic chromatin condensation inducer in the nucleus (Acinus) | 5 | UniProt NCBI |
| GPATCH8 | G patch domain-containing protein 8 | 4 | UniProt NCBI |
| RNPS1 | RNA-binding protein with serine-rich domain 1 (SR-related protein LDC2) | 5 | UniProt NCBI |
| NFKBIL1 | NF-kappa-B inhibitor-like protein 1 (Inhibitor of kappa B-like protein) (I-kappa-B-like protein) (IkappaBL) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:760 | 9.82248594942e-09 | 0.375 | SAP18 RNPS1 ACIN1 | Apoptosis- and splicing-associated protein complex (ASAP-L), SAP18, RNPS1, Acinus-L |
| GO:0061574 | 2.15253635486e-05 | 0.375 | SAP18 RNPS1 ACIN1 | ASAP complex |
| KEGG:03015 | 0.000632962160982 | 0.375 | SAP18 RNPS1 ACIN1 | mRNA surveillance pathway |
| KEGG:03013 | 0.000866047705047 | 0.375 | SAP18 RNPS1 ACIN1 | Nucleocytoplasmic transport |
| GO:0048025 | 0.00300428100757 | 0.375 | SAP18 RNPS1 ACIN1 | negative regulation of mRNA splicing, via spliceosome |
| GO:0050686 | 0.0043754188034 | 0.375 | SAP18 RNPS1 ACIN1 | negative regulation of mRNA processing |
| GO:0035145 | 0.00610957850275 | 0.375 | SAP18 RNPS1 ACIN1 | exon-exon junction complex |
| GO:0033119 | 0.00712601113833 | 0.375 | SAP18 RNPS1 ACIN1 | negative regulation of RNA splicing |
| REAC:R-HSA-72163 | 0.029020763802 | 0.375 | SAP18 RNPS1 ACIN1 | mRNA Splicing - Major Pathway |
| REAC:R-HSA-72172 | 0.0321176973542 | 0.375 | SAP18 RNPS1 ACIN1 | mRNA Splicing |
| HPA:0090933 | 0.0376528572033 | 0.25 | SAP18 ACIN1 | cerebellum; GLUC cells - nucleus[High] |
| HPA:0090913 | 0.0454164811755 | 0.25 | SAP18 ACIN1 | cerebellum; Bergmann glia - nucleus[High] |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| ACIN1 | SAP18 | 1.0 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM fraction | ||
| RNPS1 | GPATCH8 | 0.999 | 0.376 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM hein () bioplex3_HCT116 gupta_WMM fraction | |
| ACIN1 | NFKBIL1 | 0.999 | 0.082 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | |
| RNPS1 | SAP18 | 0.999 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex_WMM Guru bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM fraction | |
| ACIN1 | RNPS1 | 0.998 | 0.92 |
mutually_exclusive (P61326)
|
bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM fraction |
| SETD2 | SAP18 | 0.998 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 WMM_only | ||
| ACIN1 | NKTR | 0.996 | 0.362 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | |
| RNPS1 | SETD2 | 0.994 | 0.126 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM WMM_only | |
| RNPS1 | NKTR | 0.994 | 0.316 | bioplex_WMM bioplex3_WMM bioplex3_HCT116 boldt_WMM WMM_only | |
| RNPS1 | NFKBIL1 | 0.993 | 0.108 |
mutually_exclusive (O00422)
|
bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| NFKBIL1 | SAP18 | 0.99 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | |
| RNPS1 | RSBN1L | 0.988 | 0.092 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 | |
| NKTR | SAP18 | 0.985 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only | ||
| GPATCH8 | SAP18 | 0.963 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only | ||
| NFKBIL1 | RSBN1L | 0.954 | 0.1 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only | |
| SETD2 | GPATCH8 | 0.929 | 0.084 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only boldt_WMM | |
| NKTR | GPATCH8 | 0.928 | 0.178 | bioplex_WMM bioplex3_WMM WMM_only | |
| ACIN1 | GPATCH8 | 0.886 | 0.35 | bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM fraction | |
| NFKBIL1 | GPATCH8 | 0.878 | 0.062 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only | |
| NFKBIL1 | SETD2 | 0.833 | 0.144 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only | |
| NKTR | SETD2 | 0.641 | 0.204 | bioplex_WMM bioplex3_WMM WMM_only | |
| NKTR | RSBN1L | 0.594 | 0.106 | bioplex_WMM bioplex3_WMM WMM_only | |
| ACIN1 | SETD2 | 0.468 | 0.166 | bioplex_WMM bioplex3_WMM youn_WMM fraction | |
| RSBN1L | GPATCH8 | 0.33 | 0.056 | bioplex3_WMM youn_WMM WMM_only | |
| NKTR | NFKBIL1 | 0.308 | 0.128 | bioplex_WMM bioplex3_WMM WMM_only | |
| ACIN1 | RSBN1L | 0.201 | 0.226 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| RSBN1L | SETD2 | 0.172 | 0.158 | bioplex3_WMM youn_WMM WMM_only | |
| RSBN1L | SAP18 | 0.076 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 |
Related Complexes