hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_08772.1
Confidence: High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| RARG | Retinoic acid receptor gamma (RAR-gamma) (Nuclear receptor subfamily 1 group B member 3) | 5 | UniProt NCBI |
| NR1H4 | Bile acid receptor (Farnesoid X-activated receptor) (Farnesol receptor HRR-1) (Nuclear receptor subfamily 1 group H member 4) (Retinoid X receptor-interacting protein 14) (RXR-interacting protein 14) | 5 | UniProt NCBI |
| NR1H3 | Oxysterols receptor LXR-alpha (Liver X receptor alpha) (Nuclear receptor subfamily 1 group H member 3) | 5 | UniProt NCBI |
| RXRB | Retinoic acid receptor RXR-beta (Nuclear receptor subfamily 2 group B member 2) (Retinoid X receptor beta) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-9031528 | 4.09070097144e-05 | 0.666666666667 | NR1H3 RXRB | NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose |
| REAC:R-HSA-9632974 | 6.81752388431e-05 | 0.666666666667 | NR1H3 RXRB | NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis |
| REAC:R-HSA-9031525 | 6.81752388431e-05 | 0.666666666667 | NR1H3 RXRB | NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake |
| REAC:R-HSA-1989781 | 7.31860792369e-05 | 1.0 | NR1H4 NR1H3 RXRB | PPARA activates gene expression |
| REAC:R-HSA-400206 | 7.54495662236e-05 | 1.0 | NR1H4 NR1H3 RXRB | Regulation of lipid metabolism by PPARalpha |
| REAC:R-HSA-9029558 | 0.000190864539041 | 0.666666666667 | NR1H3 RXRB | NR1H2 & NR1H3 regulate gene expression linked to lipogenesis |
| REAC:R-HSA-9623433 | 0.00024538606603 | 0.666666666667 | NR1H3 RXRB | NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis |
| WP:WP299 | 0.000286309588192 | 0.666666666667 | NR1H4 NR1H3 | Nuclear receptors in lipid metabolism and toxicity |
| WP:WP170 | 0.000427669224246 | 0.666666666667 | NR1H3 RXRB | Nuclear receptors |
| GO:0004879 | 0.000878441055398 | 1.0 | NR1H4 NR1H3 RXRB | nuclear receptor activity |
| GO:0098531 | 0.000949666005835 | 1.0 | NR1H4 NR1H3 RXRB | ligand-activated transcription factor activity |
| KEGG:03320 | 0.00130273084965 | 0.666666666667 | NR1H3 RXRB | PPAR signaling pathway |
| WP:WP3942 | 0.00155728900053 | 0.666666666667 | NR1H3 RXRB | PPAR signaling pathway |
| REAC:R-HSA-9029569 | 0.00316638779295 | 0.666666666667 | NR1H3 RXRB | NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux |
| REAC:R-HSA-9024446 | 0.00504394814871 | 0.666666666667 | NR1H3 RXRB | NR1H2 and NR1H3-mediated signaling |
| WP:WP4396 | 0.0104876474497 | 0.666666666667 | NR1H4 NR1H3 | Nonalcoholic fatty liver disease |
| REAC:R-HSA-556833 | 0.0177385429708 | 1.0 | NR1H4 NR1H3 RXRB | Metabolism of lipids |
| CORUM:5367 | 0.0249718442456 | 0.333333333333 | RXRB | THRB-RXRB complex |
| WP:WP2882 | 0.0351361093338 | 0.666666666667 | NR1H4 NR1H3 | Nuclear receptors meta pathway |
| WP:WP1531 | 0.0496447587094 | 0.333333333333 | RXRB | Vitamin D metabolism |
| WP:WP5397 | 0.0496447587094 | 0.333333333333 | RXRB | Vitamin A1 and A5 X pathways |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| RXRB | NR1H4 | 0.996 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| RXRB | RARG | 0.995 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| RXRB | NR1H3 | 0.984 | bioplex3_HEK293 bioplex3_WMM WMM_only |
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