hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_08783.1
Confidence: High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| PITPNM1 | Membrane-associated phosphatidylinositol transfer protein 1 (Drosophila retinal degeneration B homolog) (Phosphatidylinositol transfer protein, membrane-associated 1) (PITPnm 1) (Pyk2 N-terminal domain-interacting receptor 2) (NIR-2) | 5 | UniProt NCBI |
| OSBP | Oxysterol-binding protein 1 | 5 | UniProt NCBI |
| OSBP2 | Oxysterol-binding protein 2 (Oxysterol-binding protein-related protein 4) (ORP-4) (OSBP-related protein 4) | 5 | UniProt NCBI |
| SLC22A15 | Solute carrier family 22 member 15 (Fly-like putative transporter 1) (Flipt 1) | 5 | UniProt NCBI |
| PITPNM3 | Membrane-associated phosphatidylinositol transfer protein 3 (Phosphatidylinositol transfer protein, membrane-associated 3) (PITPnm 3) (Pyk2 N-terminal domain-interacting receptor 1) (NIR-1) | 5 | UniProt NCBI |
| VAPA | Vesicle-associated membrane protein-associated protein A (VAMP-A) (VAMP-associated protein A) (VAP-A) (33 kDa VAMP-associated protein) (VAP-33) | 5 | UniProt NCBI |
| OSBPL6 | Oxysterol-binding protein-related protein 6 (ORP-6) (OSBP-related protein 6) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0005319 | 2.86581369172e-05 | 0.714285714286 | OSBPL6 PITPNM1 PITPNM3 OSBP OSBP2 | lipid transporter activity |
| REAC:R-HSA-1483226 | 0.000380832872101 | 0.285714285714 | PITPNM1 PITPNM3 | Synthesis of PI |
| REAC:R-HSA-556833 | 0.00048075687601 | 0.714285714286 | OSBPL6 PITPNM1 VAPA OSBP PITPNM3 | Metabolism of lipids |
| GO:0097038 | 0.00228108846854 | 0.428571428571 | OSBP2 OSBP OSBPL6 | perinuclear endoplasmic reticulum |
| GO:0005215 | 0.00729549474285 | 0.857142857143 | PITPNM3 PITPNM1 SLC22A15 OSBP2 OSBPL6 OSBP | transporter activity |
| REAC:R-HSA-192105 | 0.00796834465067 | 0.285714285714 | OSBPL6 OSBP | Synthesis of bile acids and bile salts |
| GO:0015248 | 0.00870569405676 | 0.428571428571 | OSBP2 OSBP OSBPL6 | sterol transporter activity |
| REAC:R-HSA-194068 | 0.0153773615715 | 0.285714285714 | OSBPL6 OSBP | Bile acid and bile salt metabolism |
| REAC:R-HSA-1660661 | 0.0212237900738 | 0.285714285714 | OSBP VAPA | Sphingolipid de novo biosynthesis |
| GO:0120013 | 0.0305188440994 | 0.428571428571 | PITPNM1 OSBP PITPNM3 | lipid transfer activity |
| GO:0008654 | 0.0469790462071 | 0.571428571429 | PITPNM1 VAPA OSBP PITPNM3 | phospholipid biosynthetic process |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| VAPA | OSBPL6 | 0.999 | 0.140194444444 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 |
| VAPA | OSBP2 | 0.997 | 0.142 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM |
| VAPA | OSBP | 0.992 | 0.126 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM |
| VAPA | PITPNM3 | 0.992 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | |
| VAPA | PITPNM1 | 0.983 | 0.11 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| SLC22A15 | VAPA | 0.957 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| OSBP | OSBP2 | 0.94 | 0.122 | bioplex_WMM bioplex3_WMM WMM_only |
| SLC22A15 | PITPNM1 | 0.902 | bioplex3_WMM WMM_only | |
| PITPNM1 | OSBP2 | 0.897 | 0.108 | bioplex_WMM bioplex3_WMM WMM_only |
| PITPNM1 | PITPNM3 | 0.843 | bioplex_WMM bioplex3_WMM WMM_only | |
| PITPNM3 | OSBP2 | 0.778 | bioplex_WMM bioplex3_WMM WMM_only | |
| OSBP2 | OSBPL6 | 0.737 | 0.138 | bioplex_WMM bioplex3_WMM WMM_only |
| PITPNM1 | OSBPL6 | 0.737 | 0.054 | bioplex_WMM bioplex3_WMM WMM_only |
| PITPNM1 | OSBP | 0.731 | 0.102 | bioplex_WMM bioplex3_WMM WMM_only |
| SLC22A15 | OSBP2 | 0.722 | bioplex3_WMM WMM_only | |
| SLC22A15 | PITPNM3 | 0.717 | bioplex3_WMM WMM_only | |
| OSBP | PITPNM3 | 0.677 | bioplex_WMM bioplex3_WMM WMM_only | |
| OSBP | OSBPL6 | 0.653 | 0.148 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| PITPNM3 | OSBPL6 | 0.644 | bioplex_WMM bioplex3_WMM WMM_only | |
| SLC22A15 | OSBPL6 | 0.343 | bioplex3_WMM WMM_only | |
| SLC22A15 | OSBP | 0.323 | bioplex3_WMM WMM_only |
Related Complexes