hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_08787.1
Confidence: High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| CRIPTO | Protein Cripto (Cripto, EGF-CFC family member) (Cripto-1 growth factor) (CRGF) (Epidermal growth factor-like cripto protein CR1) (Teratocarcinoma-derived growth factor 1) | 5 | UniProt NCBI |
| SKI | Ski oncogene (Proto-oncogene c-Ski) | 5 | UniProt NCBI |
| WDR26 | WD repeat-containing protein 26 (CUL4- and DDB1-associated WDR protein 2) (Myocardial ischemic preconditioning up-regulated protein 2) | 5 | UniProt NCBI |
| HTRA2 | Serine protease HTRA2, mitochondrial (EC 3.4.21.108) (High temperature requirement protein A2) (HtrA2) (Omi stress-regulated endoprotease) (Serine protease 25) (Serine proteinase OMI) | 5 | UniProt NCBI |
| SPON1 | Spondin-1 (F-spondin) (Vascular smooth muscle cell growth-promoting factor) | 5 | UniProt NCBI |
| GID8 | Glucose-induced degradation protein 8 homolog (Two hybrid-associated protein 1 with RanBPM) (Twa1) | 5 | UniProt NCBI |
| HBP1 | HMG box-containing protein 1 (HMG box transcription factor 1) (High mobility group box transcription factor 1) | 5 | UniProt NCBI |
| RANBP9 | Ran-binding protein 9 (RanBP9) (BPM-L) (BPM90) (Ran-binding protein M) (RanBPM) (RanBP7) | 5 | UniProt NCBI |
| YPEL5 | Protein yippee-like 5 | 5 | UniProt NCBI |
| ARMC8 | Armadillo repeat-containing protein 8 | 5 | UniProt NCBI |
| RANBP10 | Ran-binding protein 10 (RanBP10) | 5 | UniProt NCBI |
| GID4 | Glucose-induced degradation protein 4 homolog (Vacuolar import and degradation protein 24 homolog) | 5 | UniProt NCBI |
| GDF15 | Growth/differentiation factor 15 (GDF-15) (Macrophage inhibitory cytokine 1) (MIC-1) (NSAID-activated gene 1 protein) (NAG-1) (NSAID-regulated gene 1 protein) (NRG-1) (Placental TGF-beta) (Placental bone morphogenetic protein) (Prostate differentiation factor) | 5 | UniProt NCBI |
| PRG3 | Proteoglycan 3 (Eosinophil major basic protein homolog) (Prepro-major basic protein homolog) (Prepro-MBPH) | 5 | UniProt NCBI |
| MAEA | E3 ubiquitin-protein transferase MAEA (EC 2.3.2.27) (Cell proliferation-inducing gene 5 protein) (Erythroblast macrophage protein) (Human lung cancer oncogene 10 protein) (HLC-10) (Macrophage erythroblast attacher) (P44EMLP) | 5 | UniProt NCBI |
| RMND5A | E3 ubiquitin-protein transferase RMND5A (EC 2.3.2.27) (P44CTLH) (Protein RMD5 homolog A) | 5 | UniProt NCBI |
| MKLN1 | Muskelin | 5 | UniProt NCBI |
| INSL6 | Insulin-like peptide INSL6 (Insulin-like peptide 6) (Relaxin/insulin-like factor 1) [Cleaved into: Insulin-like peptide INSL6 B chain; Insulin-like peptide INSL6 A chain] | 3 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP4352 | 1.79496823215e-15 | 0.6875 | GID4 RANBP9 RANBP10 MKLN1 ARMC8 GID8 WDR26 HTRA2 RMND5A YPEL5 MAEA | Ciliary landscape |
| CORUM:3071 | 3.57556175758e-14 | 0.3125 | RMND5A MAEA MKLN1 RANBP9 ARMC8 | CTLH complex |
| WP:WP5381 | 7.78571136952e-11 | 0.5 | GID4 MAEA ARMC8 RANBP9 WDR26 RMND5A MKLN1 HBP1 | Smith Magenis and Potocki Lupski syndrome copy number variation |
| GO:0000151 | 1.91139574907e-09 | 0.625 | GID4 RANBP9 RANBP10 MKLN1 ARMC8 GID8 WDR26 RMND5A YPEL5 MAEA | ubiquitin ligase complex |
| CORUM:639 | 1.95604750042e-07 | 0.1875 | MKLN1 GID8 RANBP9 | RANBPM-Muskelin-TWA1-HSMpp8 complex |
| GO:0034657 | 2.39287617466e-07 | 0.25 | WDR26 RMND5A ARMC8 MAEA | GID complex |
| GO:1990234 | 5.09850948962e-05 | 0.625 | GID4 RANBP9 RANBP10 MKLN1 ARMC8 GID8 WDR26 RMND5A YPEL5 MAEA | transferase complex |
| GO:0140535 | 8.92931882432e-05 | 0.625 | GID4 RANBP9 RANBP10 MKLN1 ARMC8 GID8 WDR26 RMND5A YPEL5 MAEA | intracellular protein-containing complex |
| GO:1902494 | 0.0020932348776 | 0.6875 | GID4 RANBP9 RANBP10 MKLN1 ARMC8 GID8 WDR26 HTRA2 RMND5A YPEL5 MAEA | catalytic complex |
| REAC:R-HSA-8851805 | 0.00916453694962 | 0.125 | RANBP10 RANBP9 | MET activates RAS signaling |
| GO:0043161 | 0.0441715737941 | 0.375 | GID4 MAEA ARMC8 WDR26 RMND5A GID8 | proteasome-mediated ubiquitin-dependent protein catabolic process |
| CORUM:641 | 0.0497620750785 | 0.0625 | RANBP9 | RANBPM-SMP1 complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD |
|---|---|---|---|
| GID8 | RANBP10 | 1.0 | 0.126 |
| RMND5A | MAEA | 1.0 | 0.478 |
| YPEL5 | ARMC8 | 1.0 | 0.048 |
| RANBP10 | ARMC8 | 1.0 | 0.152 |
| GID8 | MKLN1 | 1.0 | 0.064 |
| RMND5A | RANBP10 | 1.0 | 0.196 |
| RANBP9 | RMND5A | 1.0 | 0.272 |
| GID8 | RANBP9 | 1.0 | 0.264 |
| MKLN1 | ARMC8 | 1.0 | 0.024 |
| RMND5A | WDR26 | 1.0 | 0.288 |
| GID8 | ARMC8 | 1.0 | 0.13 |
| MAEA | ARMC8 | 1.0 | 0.072 |
| GID8 | YPEL5 | 1.0 | 0.076 |
| RMND5A | ARMC8 | 1.0 | 0.14 |
| RANBP9 | ARMC8 | 1.0 | 0.1 |
| GID8 | WDR26 | 1.0 | 0.18 |
| RMND5A | MKLN1 | 1.0 | 0.096 |
| GID8 | MAEA | 1.0 | 0.144 |
| GID4 | RMND5A | 0.999 | 0.102 |
| HTRA2 | ARMC8 | 0.999 | 0.04 |
| HTRA2 | RMND5A | 0.999 | 0.034 |
| GID4 | GID8 | 0.999 | 0.17 |
| RMND5A | YPEL5 | 0.999 | 0.068 |
| GID4 | ARMC8 | 0.999 | 0.056 |
| RANBP9 | MAEA | 0.999 | 0.152 |
| GID8 | RMND5A | 0.999 | 0.482 |
| YPEL5 | RANBP10 | 0.999 | 0.06 |
| YPEL5 | MAEA | 0.999 | 0.066 |
| WDR26 | ARMC8 | 0.999 | 0.112 |
| RANBP9 | YPEL5 | 0.999 | 0.044 |
| RANBP10 | MKLN1 | 0.999 | 0.1312 |
| RANBP9 | MKLN1 | 0.998 | 0.036 |
| MAEA | RANBP10 | 0.998 | 0.154 |
| YPEL5 | MKLN1 | 0.998 | 0.026 |
| RANBP9 | RANBP10 | 0.998 | 0.048 |
| MAEA | MKLN1 | 0.998 | 0.06 |
| RANBP10 | WDR26 | 0.997 | 0.114 |
| RMND5A | INSL6 | 0.996 | |
| INSL6 | WDR26 | 0.996 | |
| PRG3 | RANBP10 | 0.996 | |
| SKI | RMND5A | 0.996 | 0.078 |
| PRG3 | WDR26 | 0.996 | |
| PRG3 | RMND5A | 0.996 | |
| PRG3 | ARMC8 | 0.995 | 0.168 |
| INSL6 | RANBP10 | 0.995 | |
| PRG3 | MAEA | 0.995 | |
| GID8 | HBP1 | 0.995 | |
| INSL6 | MAEA | 0.995 | |
| INSL6 | MKLN1 | 0.994 | |
| INSL6 | ARMC8 | 0.994 | |
| RANBP9 | PRG3 | 0.993 | |
| HTRA2 | GID8 | 0.993 | 0.066 |
| GID8 | PRG3 | 0.993 | |
| PRG3 | MKLN1 | 0.993 | |
| HBP1 | RMND5A | 0.993 | |
| CRIPTO | GID4 | 0.993 | |
| CRIPTO | WDR26 | 0.993 | |
| HBP1 | ARMC8 | 0.992 | |
| GID4 | RANBP10 | 0.99 | 0.108 |
| GID4 | RANBP9 | 0.99 | 0.088 |
| CRIPTO | RMND5A | 0.99 | |
| CRIPTO | ARMC8 | 0.989 | |
| INSL6 | YPEL5 | 0.989 | |
| GID4 | YPEL5 | 0.989 | 0.084 |
| GID4 | MKLN1 | 0.989 | 0.086 |
| GID4 | WDR26 | 0.989 | 0.192 |
| GID4 | MAEA | 0.989 | 0.084 |
| RANBP9 | INSL6 | 0.989 | |
| YPEL5 | WDR26 | 0.989 | 0.192 |
| CRIPTO | RANBP10 | 0.989 | |
| SKI | ARMC8 | 0.988 | 0.102 |
| SKI | GID8 | 0.988 | 0.106 |
| SPON1 | YPEL5 | 0.988 | 0.022 |
| HTRA2 | GID4 | 0.987 | 0.076 |
| CRIPTO | MKLN1 | 0.987 | |
| CRIPTO | GID8 | 0.986 | |
| HTRA2 | RANBP10 | 0.985 | 0.05 |
| CRIPTO | RANBP9 | 0.985 | |
| GID4 | INSL6 | 0.985 | |
| CRIPTO | MAEA | 0.985 | |
| CRIPTO | YPEL5 | 0.984 | |
| GDF15 | MAEA | 0.984 | 0.01 |
| MAEA | WDR26 | 0.983 | 0.31 |
| GDF15 | MKLN1 | 0.982 | 0.026 |
| RANBP9 | GDF15 | 0.979 | 0.044 |
| RANBP9 | WDR26 | 0.979 | 0.264 |
| SPON1 | RANBP9 | 0.979 | 0.054 |
| HTRA2 | MAEA | 0.979 | 0.024 |
| HTRA2 | YPEL5 | 0.978 | 0.046 |
| SPON1 | MKLN1 | 0.977 | 0.082 |
| MKLN1 | WDR26 | 0.977 | 0.024 |
| HTRA2 | SKI | 0.976 | 0.116 |
| GID8 | INSL6 | 0.975 | |
| GDF15 | WDR26 | 0.975 | 0.02 |
| GDF15 | ARMC8 | 0.972 | 0.092 |
| SPON1 | GID8 | 0.972 | 0.05 |
| GID4 | GDF15 | 0.97 | 0.096 |
| GDF15 | YPEL5 | 0.969 | 0.062 |
| GID8 | GDF15 | 0.969 | 0.036 |
| HTRA2 | MKLN1 | 0.967 | 0.028 |
| GID4 | PRG3 | 0.967 | |
| HTRA2 | RANBP9 | 0.967 | 0.05 |
| GDF15 | RMND5A | 0.967 | 0.052 |
| SPON1 | RMND5A | 0.964 | 0.064 |
| GDF15 | RANBP10 | 0.96 | 0.016 |
| SPON1 | WDR26 | 0.952 | 0.052 |
| PRG3 | YPEL5 | 0.949 | |
| HTRA2 | HBP1 | 0.948 | |
| HTRA2 | GDF15 | 0.947 | 0.056 |
| SKI | YPEL5 | 0.945 | 0.104 |
| HTRA2 | WDR26 | 0.939 | 0.06 |
| SPON1 | MAEA | 0.934 | 0.044 |
| HBP1 | WDR26 | 0.911 | |
| HBP1 | MAEA | 0.905 | |
| SKI | MKLN1 | 0.905 | 0.052 |
| SPON1 | ARMC8 | 0.904 | 0.06 |
| HBP1 | RANBP10 | 0.902 | |
| GID4 | SKI | 0.902 | 0.084 |
| HBP1 | MKLN1 | 0.887 | |
| GID4 | HBP1 | 0.887 | |
| SKI | WDR26 | 0.885 | 0.132 |
| SKI | MAEA | 0.882 | 0.108 |
| RANBP9 | HBP1 | 0.87 | |
| HTRA2 | INSL6 | 0.863 | |
| HBP1 | YPEL5 | 0.859 | |
| GDF15 | PRG3 | 0.856 | |
| SKI | RANBP10 | 0.849 | 0.18 |
| SKI | RANBP9 | 0.832 | 0.096 |
| SKI | HBP1 | 0.777 | |
| SPON1 | RANBP10 | 0.758 | 0.054 |
| SPON1 | GID4 | 0.749 | 0.06 |
| HBP1 | GDF15 | 0.663 | |
| CRIPTO | HTRA2 | 0.354 | |
| SKI | GDF15 | 0.305 | 0.086 |
| HTRA2 | PRG3 | 0.294 | 0.052 |
| SPON1 | GDF15 | 0.038 | 0.056 |
| CRIPTO | GDF15 | 0.027 |
Related Complexes