hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_08799.1
Confidence: High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| RTN2 | Reticulon-2 (Neuroendocrine-specific protein-like 1) (NSP-like protein 1) (Neuroendocrine-specific protein-like I) (NSP-like protein I) (NSPLI) | 5 | UniProt NCBI |
| RTN4 | Reticulon-4 (Foocen) (Neurite outgrowth inhibitor) (Nogo protein) (Neuroendocrine-specific protein) (NSP) (Neuroendocrine-specific protein C homolog) (RTN-x) (Reticulon-5) | 5 | UniProt NCBI |
| ARL6IP5 | PRA1 family protein 3 (ADP-ribosylation factor-like protein 6-interacting protein 5) (ARL-6-interacting protein 5) (Aip-5) (Cytoskeleton-related vitamin A-responsive protein) (Dermal papilla-derived protein 11) (GTRAP3-18) (Glutamate transporter EAAC1-interacting protein) (JM5) (Prenylated Rab acceptor protein 2) (Protein JWa) (Putative MAPK-activating protein PM27) | 5 | UniProt NCBI |
| RTN1 | Reticulon-1 (Neuroendocrine-specific protein) | 5 | UniProt NCBI |
| REEP6 | Receptor expression-enhancing protein 6 (Polyposis locus protein 1-like 1) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:1902430 | 0.000274621184043 | 0.6 | RTN2 RTN1 RTN4 | negative regulation of amyloid-beta formation |
| GO:1902992 | 0.000436807598019 | 0.6 | RTN2 RTN1 RTN4 | negative regulation of amyloid precursor protein catabolic process |
| GO:1902003 | 0.00280458876292 | 0.6 | RTN2 RTN1 RTN4 | regulation of amyloid-beta formation |
| GO:1902991 | 0.00430818612204 | 0.6 | RTN2 RTN1 RTN4 | regulation of amyloid precursor protein catabolic process |
| GO:0034205 | 0.00522817157061 | 0.6 | RTN2 RTN1 RTN4 | amyloid-beta formation |
| GO:0050435 | 0.00807957978043 | 0.6 | RTN2 RTN1 RTN4 | amyloid-beta metabolic process |
| GO:0042987 | 0.0109904490822 | 0.6 | RTN2 RTN1 RTN4 | amyloid precursor protein catabolic process |
| GO:0042982 | 0.0264997162634 | 0.6 | RTN2 RTN1 RTN4 | amyloid precursor protein metabolic process |
| GO:0071787 | 0.0468008499735 | 0.4 | RTN4 RTN1 | endoplasmic reticulum tubular network formation |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| RTN4 | RTN2 | 0.999 | 0.114 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| RTN1 | RTN2 | 0.998 | 0.102 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| RTN1 | RTN4 | 0.998 | 0.226 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM |
| ARL6IP5 | RTN4 | 0.997 | 0.154 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM fraction |
| REEP6 | RTN2 | 0.958 | bioplex_WMM bioplex3_WMM WMM_only | |
| RTN1 | ARL6IP5 | 0.84 | 0.112 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM |
| REEP6 | RTN4 | 0.821 | bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 WMM_only | |
| ARL6IP5 | RTN2 | 0.808 | 0.07 | bioplex_WMM bioplex3_WMM WMM_only |
| ARL6IP5 | REEP6 | 0.762 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| RTN1 | REEP6 | 0.506 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
Related Complexes