hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_08805.1
Complex Portal: CPX-12739
Confidence: High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| UFL1 | E3 UFM1-protein ligase 1 (EC 2.3.2.-) (E3 UFM1-protein transferase 1) (Multiple alpha-helix protein located at ER) (Novel LZAP-binding protein) (Regulator of C53/LZAP and DDRGK1) | 5 | UniProt NCBI |
| UFM1 | Ubiquitin-fold modifier 1 | 5 | UniProt NCBI |
| DDRGK1 | DDRGK domain-containing protein 1 (Dashurin) (UFM1-binding and PCI domain-containing protein 1) | 5 | UniProt NCBI |
| UFC1 | Ubiquitin-fold modifier-conjugating enzyme 1 (Ufm1-conjugating enzyme 1) | 5 | UniProt NCBI |
| UBA5 | Ubiquitin-like modifier-activating enzyme 5 (Ubiquitin-activating enzyme 5) (ThiFP1) (UFM1-activating enzyme) (Ubiquitin-activating enzyme E1 domain-containing protein 1) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:1990592 | 9.00439087303e-15 | 1.0 | UFM1 UBA5 UFC1 UFL1 DDRGK1 | protein K69-linked ufmylation |
| GO:1990564 | 9.00439087303e-15 | 1.0 | UFM1 UBA5 UFC1 UFL1 DDRGK1 | protein polyufmylation |
| GO:0071569 | 5.40263452382e-14 | 1.0 | UFM1 UBA5 UFC1 UFL1 DDRGK1 | protein ufmylation |
| GO:0061709 | 5.57191707223e-11 | 1.0 | UFM1 UBA5 UFC1 UFL1 DDRGK1 | reticulophagy |
| GO:0033146 | 1.16377978294e-06 | 0.8 | UFM1 UBA5 UFL1 DDRGK1 | regulation of intracellular estrogen receptor signaling pathway |
| GO:1903008 | 4.33118879937e-06 | 1.0 | UFM1 UBA5 UFC1 UFL1 DDRGK1 | organelle disassembly |
| GO:0034976 | 7.62382318531e-06 | 1.0 | UFM1 UBA5 UFC1 UFL1 DDRGK1 | response to endoplasmic reticulum stress |
| GO:0030520 | 1.08004637014e-05 | 0.8 | UFM1 UBA5 UFL1 DDRGK1 | intracellular estrogen receptor signaling pathway |
| GO:0033143 | 3.84216218146e-05 | 0.8 | UFM1 UBA5 UFL1 DDRGK1 | regulation of intracellular steroid hormone receptor signaling pathway |
| GO:0016236 | 0.000109670539315 | 1.0 | UFM1 UBA5 UFC1 UFL1 DDRGK1 | macroautophagy |
| GO:0030518 | 0.000382257669512 | 0.8 | UFM1 UBA5 UFL1 DDRGK1 | intracellular steroid hormone receptor signaling pathway |
| GO:0043401 | 0.000416750348108 | 0.8 | UFM1 UBA5 UFL1 DDRGK1 | steroid hormone mediated signaling pathway |
| GO:0022411 | 0.000807544779987 | 1.0 | UFM1 UBA5 UFC1 UFL1 DDRGK1 | cellular component disassembly |
| GO:0071383 | 0.00100329218716 | 0.8 | UFM1 UBA5 UFL1 DDRGK1 | cellular response to steroid hormone stimulus |
| GO:0009755 | 0.00130803575944 | 0.8 | UFM1 UBA5 UFL1 DDRGK1 | hormone-mediated signaling pathway |
| GO:0061919 | 0.00130936938487 | 1.0 | UFM1 UBA5 UFC1 UFL1 DDRGK1 | process utilizing autophagic mechanism |
| GO:0006914 | 0.00130936938487 | 1.0 | UFM1 UBA5 UFC1 UFL1 DDRGK1 | autophagy |
| GO:0048545 | 0.00172846622356 | 0.8 | UFM1 UBA5 UFL1 DDRGK1 | response to steroid hormone |
| GO:0071568 | 0.00468200720083 | 0.4 | UFC1 UFL1 | UFM1 transferase activity |
| GO:0032446 | 0.00518507269481 | 1.0 | UFM1 UBA5 UFC1 UFL1 DDRGK1 | protein modification by small protein conjugation |
| GO:0070647 | 0.00850725222417 | 1.0 | UFM1 UBA5 UFC1 UFL1 DDRGK1 | protein modification by small protein conjugation or removal |
| GO:0043687 | 0.0118211242494 | 1.0 | UFM1 UBA5 UFC1 UFL1 DDRGK1 | post-translational protein modification |
| GO:0030522 | 0.0180995584082 | 0.8 | UFM1 UBA5 UFL1 DDRGK1 | intracellular receptor signaling pathway |
| GO:1903895 | 0.0280843539964 | 0.4 | UFL1 DDRGK1 | negative regulation of IRE1-mediated unfolded protein response |
| GO:0071407 | 0.029345634756 | 0.8 | UFM1 UBA5 UFL1 DDRGK1 | cellular response to organic cyclic compound |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| UFL1 | DDRGK1 | 1.0 | 0.94 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM hein () bioplex3_HCT116 gupta_WMM | |
| UFM1 | UBA5 | 0.999 | 0.154 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116 |
| UFL1 | UFM1 | 0.998 | 0.214 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM hein () | |
| DDRGK1 | UFM1 | 0.994 | 0.128 |
structurally_consistent (Q96JB5)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| DDRGK1 | UFC1 | 0.994 | 0.28 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM | |
| UFC1 | UBA5 | 0.993 | 0.142 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| UFL1 | UFC1 | 0.989 | 0.104 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM hein () |
| UFM1 | UFC1 | 0.97 | 0.168 |
mutually_exclusive (Q9GZZ9)
|
hein_WMM bioplex_WMM bioplex3_WMM fraction |
| UFL1 | UBA5 | 0.053 | 0.112 |
mutually_exclusive (Q9Y3C8)
|
bioplex3_WMM WMM_only |
| DDRGK1 | UBA5 | 0.007 | 0.166 | fraction |
Related Complexes