hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_08809.1
Complex Portal: CPX-19409
Confidence: High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| DYNC1I2 | Cytoplasmic dynein 1 intermediate chain 2 (Cytoplasmic dynein intermediate chain 2) (Dynein intermediate chain 2, cytosolic) (DH IC-2) | 5 | UniProt NCBI |
| DYNLT1 | Dynein light chain Tctex-type 1 (Protein CW-1) (T-complex testis-specific protein 1 homolog) | 5 | UniProt NCBI |
| PCBP4 | Poly(rC)-binding protein 4 (Alpha-CP4) | 4 | UniProt NCBI |
| DYNC1H1 | Cytoplasmic dynein 1 heavy chain 1 (Cytoplasmic dynein heavy chain 1) (Dynein heavy chain, cytosolic) | 5 | UniProt NCBI |
| DYNC1LI1 | Cytoplasmic dynein 1 light intermediate chain 1 (LIC1) (Dynein light chain A) (DLC-A) (Dynein light intermediate chain 1, cytosolic) (DLIC-1) | 5 | UniProt NCBI |
| DYNLRB1 | Dynein light chain roadblock-type 1 (Bithoraxoid-like protein) (BLP) (Dynein light chain 2A, cytoplasmic) (Dynein-associated protein Km23) (Roadblock domain-containing protein 1) | 5 | UniProt NCBI |
| DYNLT3 | Dynein light chain Tctex-type 3 (Protein 91/23) (T-complex-associated testis-expressed 1-like) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP4532 | 1.38638958491e-14 | 0.857142857143 | DYNLT1 DYNC1H1 DYNC1I2 DYNC1LI1 DYNLRB1 DYNLT3 | Intraflagellar transport proteins binding to dynein |
| GO:0005868 | 1.40340440006e-12 | 0.857142857143 | DYNLT1 DYNC1H1 DYNC1I2 DYNC1LI1 DYNLRB1 DYNLT3 | cytoplasmic dynein complex |
| GO:0030286 | 2.862432668e-11 | 0.857142857143 | DYNLT1 DYNC1H1 DYNC1I2 DYNC1LI1 DYNLRB1 DYNLT3 | dynein complex |
| KEGG:04814 | 6.12035763775e-10 | 0.857142857143 | DYNLT1 DYNC1H1 DYNC1I2 DYNC1LI1 DYNLRB1 DYNLT3 | Motor proteins |
| KEGG:05132 | 4.37451225231e-09 | 0.857142857143 | DYNLT1 DYNC1H1 DYNC1I2 DYNC1LI1 DYNLRB1 DYNLT3 | Salmonella infection |
| WP:WP4352 | 4.98895232645e-09 | 0.857142857143 | DYNLT1 DYNC1H1 DYNC1I2 DYNC1LI1 DYNLRB1 DYNLT3 | Ciliary landscape |
| GO:0005875 | 1.09242060629e-07 | 0.857142857143 | DYNLT1 DYNC1H1 DYNC1I2 DYNC1LI1 DYNLRB1 DYNLT3 | microtubule associated complex |
| CORUM:6236 | 1.54229147311e-06 | 0.428571428571 | DYNLT3 DYNLT1 DYNLRB1 | Dynein-2 complex, cytoplasmic |
| GO:0007018 | 1.32595390184e-05 | 0.857142857143 | DYNLT1 DYNC1H1 DYNC1I2 DYNC1LI1 DYNLRB1 DYNLT3 | microtubule-based movement |
| KEGG:04962 | 3.44327359757e-05 | 0.428571428571 | DYNC1I2 DYNC1H1 DYNC1LI1 | Vasopressin-regulated water reabsorption |
| WP:WP5085 | 5.97582627984e-05 | 0.428571428571 | DYNC1I2 DYNC1H1 DYNC1LI1 | Vasopressin regulated water reabsorption |
| CORUM:6038 | 0.000123103089524 | 0.285714285714 | DYNC1LI1 DYNC1H1 | Dynein complex |
| REAC:R-HSA-9646399 | 0.000137920329377 | 0.428571428571 | DYNC1I2 DYNC1H1 DYNC1LI1 | Aggrephagy |
| WP:WP4906 | 0.00017635857097 | 0.428571428571 | DYNLT3 DYNLT1 DYNLRB1 | 3q29 copy number variation syndrome |
| CORUM:6039 | 0.000205125012531 | 0.285714285714 | DYNC1LI1 DYNC1H1 | Dynein-dynactin complex |
| REAC:R-HSA-6811436 | 0.000253118097004 | 0.428571428571 | DYNC1I2 DYNC1H1 DYNC1LI1 | COPI-independent Golgi-to-ER retrograde traffic |
| REAC:R-HSA-3371497 | 0.000285286159018 | 0.428571428571 | DYNC1I2 DYNC1H1 DYNC1LI1 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand |
| REAC:R-HSA-69620 | 0.000842721142757 | 0.571428571429 | DYNC1I2 DYNC1LI1 PCBP4 DYNC1H1 | Cell Cycle Checkpoints |
| REAC:R-HSA-9663891 | 0.000867554862533 | 0.428571428571 | DYNC1I2 DYNC1H1 DYNC1LI1 | Selective autophagy |
| GO:0045505 | 0.00122180600483 | 0.428571428571 | DYNLT3 DYNLT1 DYNLRB1 | dynein intermediate chain binding |
| KEGG:04145 | 0.00128120910497 | 0.428571428571 | DYNC1I2 DYNC1H1 DYNC1LI1 | Phagosome |
| REAC:R-HSA-141424 | 0.00160779946306 | 0.428571428571 | DYNC1I2 DYNC1H1 DYNC1LI1 | Amplification of signal from the kinetochores |
| REAC:R-HSA-141444 | 0.00160779946306 | 0.428571428571 | DYNC1I2 DYNC1H1 DYNC1LI1 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal |
| REAC:R-HSA-6807878 | 0.00182778376728 | 0.428571428571 | DYNC1I2 DYNC1H1 DYNC1LI1 | COPI-mediated anterograde transport |
| REAC:R-HSA-69618 | 0.0026052001297 | 0.428571428571 | DYNC1I2 DYNC1H1 DYNC1LI1 | Mitotic Spindle Checkpoint |
| REAC:R-HSA-9648025 | 0.00298469048813 | 0.428571428571 | DYNC1I2 DYNC1H1 DYNC1LI1 | EML4 and NUDC in mitotic spindle formation |
| REAC:R-HSA-2132295 | 0.00331331870922 | 0.428571428571 | DYNC1I2 DYNC1H1 DYNC1LI1 | MHC class II antigen presentation |
| REAC:R-HSA-9609690 | 0.00357489216687 | 0.428571428571 | DYNC1I2 DYNC1H1 DYNC1LI1 | HCMV Early Events |
| REAC:R-HSA-2500257 | 0.00366502300707 | 0.428571428571 | DYNC1I2 DYNC1H1 DYNC1LI1 | Resolution of Sister Chromatid Cohesion |
| GO:0007017 | 0.00377199817885 | 0.857142857143 | DYNLT1 DYNC1H1 DYNC1I2 DYNC1LI1 DYNLRB1 DYNLT3 | microtubule-based process |
| REAC:R-HSA-8856688 | 0.00413825544794 | 0.428571428571 | DYNC1I2 DYNC1H1 DYNC1LI1 | Golgi-to-ER retrograde transport |
| REAC:R-HSA-1632852 | 0.00413825544794 | 0.428571428571 | DYNC1I2 DYNC1H1 DYNC1LI1 | Macroautophagy |
| REAC:R-HSA-5663220 | 0.00475735783939 | 0.428571428571 | DYNC1I2 DYNC1H1 DYNC1LI1 | RHO GTPases Activate Formins |
| REAC:R-HSA-9612973 | 0.00579605132299 | 0.428571428571 | DYNC1I2 DYNC1H1 DYNC1LI1 | Autophagy |
| REAC:R-HSA-9609646 | 0.00591992337161 | 0.428571428571 | DYNC1I2 DYNC1H1 DYNC1LI1 | HCMV Infection |
| REAC:R-HSA-199977 | 0.00604553029649 | 0.428571428571 | DYNC1I2 DYNC1H1 DYNC1LI1 | ER to Golgi Anterograde Transport |
| REAC:R-HSA-948021 | 0.0104945039722 | 0.428571428571 | DYNC1I2 DYNC1H1 DYNC1LI1 | Transport to the Golgi and subsequent modification |
| REAC:R-HSA-2467813 | 0.012830717613 | 0.428571428571 | DYNC1I2 DYNC1H1 DYNC1LI1 | Separation of Sister Chromatids |
| REAC:R-HSA-5617833 | 0.01389705158 | 0.428571428571 | DYNC1I2 DYNC1H1 DYNLRB1 | Cilium Assembly |
| REAC:R-HSA-6811442 | 0.0147908747224 | 0.428571428571 | DYNC1I2 DYNC1H1 DYNC1LI1 | Intra-Golgi and retrograde Golgi-to-ER traffic |
| REAC:R-HSA-68877 | 0.015251615709 | 0.428571428571 | DYNC1I2 DYNC1H1 DYNC1LI1 | Mitotic Prometaphase |
| REAC:R-HSA-68882 | 0.022722403222 | 0.428571428571 | DYNC1I2 DYNC1H1 DYNC1LI1 | Mitotic Anaphase |
| REAC:R-HSA-2555396 | 0.0230260807304 | 0.428571428571 | DYNC1I2 DYNC1H1 DYNC1LI1 | Mitotic Metaphase and Anaphase |
| REAC:R-HSA-1640170 | 0.0231929958906 | 0.571428571429 | DYNC1I2 DYNC1LI1 PCBP4 DYNC1H1 | Cell Cycle |
| GO:0015630 | 0.0362273678325 | 0.857142857143 | DYNLT1 DYNC1H1 DYNC1I2 DYNC1LI1 DYNLRB1 DYNLT3 | microtubule cytoskeleton |
| WP:WP5094 | 0.0388021990103 | 0.285714285714 | DYNLT1 DYNLT3 | Orexin receptor pathway |
| REAC:R-HSA-1852241 | 0.0422635503964 | 0.428571428571 | DYNC1I2 DYNC1H1 DYNLRB1 | Organelle biogenesis and maintenance |
| REAC:R-HSA-446203 | 0.0459981559702 | 0.428571428571 | DYNC1I2 DYNC1H1 DYNC1LI1 | Asparagine N-linked glycosylation |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| DYNC1I2 | DYNC1LI1 | 1.0 | 0.63 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM hein () Malo bioplex3_HCT116 gupta_WMM fraction boldt_WMM | |
| DYNC1LI1 | DYNLT1 | 1.0 | 0.256 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM gupta () boldt youn_WMM hein () Malo bioplex3_HCT116 gupta_WMM fraction boldt_WMM | |
| DYNC1I2 | DYNLT1 | 1.0 | 0.71 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM gupta () boldt youn_WMM bioplex3_HCT116 gupta_WMM boldt_WMM | |
| DYNC1H1 | DYNLT1 | 0.999 | 0.502 | hein_WMM bioplex_WMM bioplex3_WMM gupta () boldt Malo gupta_WMM fraction boldt_WMM | |
| DYNC1H1 | DYNC1LI1 | 0.999 | 0.618 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt hein () Malo bioplex3_HCT116 gupta_WMM fraction boldt_WMM | |
| DYNC1I2 | DYNC1H1 | 0.999 | 0.922 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt hein () Malo bioplex3_HCT116 gupta_WMM fraction boldt_WMM treiber_WMM | |
| DYNC1LI1 | DYNLT3 | 0.998 | 0.084 | hein_WMM bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 boldt_WMM WMM_only | |
| DYNC1LI1 | DYNLRB1 | 0.998 | 0.528 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt hein () bioplex3_HCT116 gupta_WMM fraction boldt_WMM | |
| DYNC1I2 | DYNLT3 | 0.997 | 0.434 | hein_WMM bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 boldt_WMM WMM_only | |
| DYNC1I2 | DYNLRB1 | 0.991 | 0.856 |
structurally_consistent (dimer)
|
hein_WMM bioplex_WMM bioplex3_WMM boldt youn_WMM hein () bioplex3_HCT116 gupta_WMM fraction boldt_WMM |
| DYNLT3 | DYNLRB1 | 0.989 | 0.156 | hein_WMM bioplex_WMM bioplex3_WMM boldt hein () boldt_WMM | |
| PCBP4 | DYNC1LI1 | 0.978 | 0.172 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| DYNC1H1 | DYNLT3 | 0.972 | 0.336 | hein_WMM bioplex_WMM bioplex3_WMM boldt hein () boldt_WMM | |
| DYNLT1 | DYNLRB1 | 0.972 | 0.386 | hein_WMM bioplex_WMM bioplex3_WMM gupta () boldt gupta_WMM boldt_WMM | |
| PCBP4 | DYNC1I2 | 0.969 | 0.05 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| PCBP4 | DYNLT1 | 0.952 | 0.068 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| PCBP4 | DYNC1H1 | 0.918 | 0.19 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| PCBP4 | DYNLRB1 | 0.889 | 0.098 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| DYNLT3 | DYNLT1 | 0.853 | 0.046 |
mutually_exclusive (Q8WW35)
structurally_consistent (dimer) |
bioplex3_WMM boldt boldt_WMM WMM_only |
| DYNC1H1 | DYNLRB1 | 0.732 | 0.48 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt hein () gupta_WMM fraction boldt_WMM |
Related Complexes