hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_08830.1
Confidence: High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| PPP2R5C | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform (PP2A B subunit isoform B'-gamma) (PP2A B subunit isoform B56-gamma) (PP2A B subunit isoform PR61-gamma) (PP2A B subunit isoform R5-gamma) (Renal carcinoma antigen NY-REN-29) | 5 | UniProt NCBI |
| CCNG1 | Cyclin-G1 (Cyclin-G) | 5 | UniProt NCBI |
| PPP2R5E | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform (PP2A B subunit isoform B'-epsilon) (PP2A B subunit isoform B56-epsilon) (PP2A B subunit isoform PR61-epsilon) (PP2A B subunit isoform R5-epsilon) | 5 | UniProt NCBI |
| PPP2R5A | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform (PP2A B subunit isoform B'-alpha) (PP2A B subunit isoform B56-alpha) (PP2A B subunit isoform PR61-alpha) (PR61alpha) (PP2A B subunit isoform R5-alpha) | 5 | UniProt NCBI |
| C1orf21 | Uncharacterized protein C1orf21 (Cell proliferation-inducing gene 13 protein) | 2 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-4839748 | 1.13468173222e-06 | 0.6 | PPP2R5A PPP2R5C PPP2R5E | Signaling by AMER1 mutants |
| REAC:R-HSA-4839744 | 1.13468173222e-06 | 0.6 | PPP2R5A PPP2R5C PPP2R5E | Signaling by APC mutants |
| REAC:R-HSA-4839735 | 1.13468173222e-06 | 0.6 | PPP2R5A PPP2R5C PPP2R5E | Signaling by AXIN mutants |
| REAC:R-HSA-5467340 | 1.13468173222e-06 | 0.6 | PPP2R5A PPP2R5C PPP2R5E | AXIN missense mutants destabilize the destruction complex |
| REAC:R-HSA-5467337 | 1.13468173222e-06 | 0.6 | PPP2R5A PPP2R5C PPP2R5E | APC truncation mutants have impaired AXIN binding |
| REAC:R-HSA-5467348 | 1.13468173222e-06 | 0.6 | PPP2R5A PPP2R5C PPP2R5E | Truncations of AMER1 destabilize the destruction complex |
| REAC:R-HSA-5358747 | 1.41820648707e-06 | 0.6 | PPP2R5A PPP2R5C PPP2R5E | CTNNB1 S33 mutants aren't phosphorylated |
| REAC:R-HSA-4839743 | 1.41820648707e-06 | 0.6 | PPP2R5A PPP2R5C PPP2R5E | Signaling by CTNNB1 phospho-site mutants |
| REAC:R-HSA-5358749 | 1.41820648707e-06 | 0.6 | PPP2R5A PPP2R5C PPP2R5E | CTNNB1 S37 mutants aren't phosphorylated |
| REAC:R-HSA-5339716 | 1.41820648707e-06 | 0.6 | PPP2R5A PPP2R5C PPP2R5E | Signaling by GSK3beta mutants |
| REAC:R-HSA-5358751 | 1.41820648707e-06 | 0.6 | PPP2R5A PPP2R5C PPP2R5E | CTNNB1 S45 mutants aren't phosphorylated |
| REAC:R-HSA-5358752 | 1.41820648707e-06 | 0.6 | PPP2R5A PPP2R5C PPP2R5E | CTNNB1 T41 mutants aren't phosphorylated |
| REAC:R-HSA-432142 | 1.74530562074e-06 | 0.6 | PPP2R5A PPP2R5C PPP2R5E | Platelet sensitization by LDL |
| REAC:R-HSA-196299 | 2.11908198931e-06 | 0.6 | PPP2R5A PPP2R5C PPP2R5E | Beta-catenin phosphorylation cascade |
| REAC:R-HSA-389513 | 2.54263716986e-06 | 0.6 | PPP2R5A PPP2R5C PPP2R5E | CTLA4 inhibitory signaling |
| WP:WP5117 | 5.41229412316e-06 | 0.6 | PPP2R5A PPP2R5C PPP2R5E | Cohesin complex Cornelia de Lange syndrome |
| WP:WP500 | 9.34985361286e-06 | 0.6 | PPP2R5A PPP2R5C PPP2R5E | Glycogen synthesis and degradation |
| REAC:R-HSA-5673000 | 1.26352756558e-05 | 0.6 | PPP2R5A PPP2R5C PPP2R5E | RAF activation |
| REAC:R-HSA-4641262 | 1.39876172793e-05 | 0.6 | PPP2R5A PPP2R5C PPP2R5E | Disassembly of the destruction complex and recruitment of AXIN to the membrane |
| REAC:R-HSA-4791275 | 1.69745830215e-05 | 0.6 | PPP2R5A PPP2R5C PPP2R5E | Signaling by WNT in cancer |
| REAC:R-HSA-5675221 | 2.62324018845e-05 | 0.6 | PPP2R5A PPP2R5C PPP2R5E | Negative regulation of MAPK pathway |
| REAC:R-HSA-388841 | 9.08085842447e-05 | 0.6 | PPP2R5A PPP2R5C PPP2R5E | Costimulation by the CD28 family |
| KEGG:03015 | 0.000112348611335 | 0.6 | PPP2R5A PPP2R5C PPP2R5E | mRNA surveillance pathway |
| KEGG:04660 | 0.000163348497779 | 0.6 | PPP2R5A PPP2R5C PPP2R5E | T cell receptor signaling pathway |
| KEGG:04071 | 0.000163348497779 | 0.6 | PPP2R5A PPP2R5C PPP2R5E | Sphingolipid signaling pathway |
| KEGG:04114 | 0.000168183083601 | 0.6 | PPP2R5A PPP2R5C PPP2R5E | Oocyte meiosis |
| REAC:R-HSA-418346 | 0.00018480745401 | 0.6 | PPP2R5A PPP2R5C PPP2R5E | Platelet homeostasis |
| KEGG:04728 | 0.000193785633278 | 0.6 | PPP2R5A PPP2R5C PPP2R5E | Dopaminergic synapse |
| REAC:R-HSA-6811558 | 0.000200829823911 | 0.6 | PPP2R5A PPP2R5C PPP2R5E | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling |
| KEGG:04152 | 0.00021603679603 | 0.6 | PPP2R5A PPP2R5C PPP2R5E | AMPK signaling pathway |
| KEGG:04261 | 0.0002524957978 | 0.6 | PPP2R5A PPP2R5C PPP2R5E | Adrenergic signaling in cardiomyocytes |
| REAC:R-HSA-195253 | 0.000264137476094 | 0.6 | PPP2R5A PPP2R5C PPP2R5E | Degradation of beta-catenin by the destruction complex |
| REAC:R-HSA-199418 | 0.000264137476094 | 0.6 | PPP2R5A PPP2R5C PPP2R5E | Negative regulation of the PI3K/AKT network |
| GO:0072542 | 0.000274621184043 | 0.6 | PPP2R5A PPP2R5C PPP2R5E | protein phosphatase activator activity |
| GO:0019211 | 0.000349481973524 | 0.6 | PPP2R5A PPP2R5C PPP2R5E | phosphatase activator activity |
| REAC:R-HSA-141424 | 0.000388335652279 | 0.6 | PPP2R5A PPP2R5C PPP2R5E | Amplification of signal from the kinetochores |
| REAC:R-HSA-141444 | 0.000388335652279 | 0.6 | PPP2R5A PPP2R5C PPP2R5E | Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal |
| KEGG:04110 | 0.000516961308947 | 0.6 | PPP2R5A PPP2R5C PPP2R5E | Cell cycle |
| REAC:R-HSA-69618 | 0.000630278165562 | 0.6 | PPP2R5A PPP2R5C PPP2R5E | Mitotic Spindle Checkpoint |
| REAC:R-HSA-9648025 | 0.000722460713996 | 0.6 | PPP2R5A PPP2R5C PPP2R5E | EML4 and NUDC in mitotic spindle formation |
| GO:0000159 | 0.000783132248318 | 0.6 | PPP2R5A PPP2R5C PPP2R5E | protein phosphatase type 2A complex |
| REAC:R-HSA-2500257 | 0.000887870732144 | 0.6 | PPP2R5A PPP2R5C PPP2R5E | Resolution of Sister Chromatid Cohesion |
| REAC:R-HSA-5663220 | 0.00115380230305 | 0.6 | PPP2R5A PPP2R5C PPP2R5E | RHO GTPases Activate Formins |
| WP:WP3932 | 0.00295696208302 | 0.6 | PPP2R5A PPP2R5C PPP2R5E | Focal adhesion PI3K Akt mTOR signaling pathway |
| REAC:R-HSA-2467813 | 0.0031285811726 | 0.6 | PPP2R5A PPP2R5C PPP2R5E | Separation of Sister Chromatids |
| KEGG:04151 | 0.00349664244214 | 0.6 | PPP2R5A PPP2R5C PPP2R5E | PI3K-Akt signaling pathway |
| REAC:R-HSA-68877 | 0.00372311058954 | 0.6 | PPP2R5A PPP2R5C PPP2R5E | Mitotic Prometaphase |
| KEGG:05165 | 0.00379627929445 | 0.6 | PPP2R5A PPP2R5C PPP2R5E | Human papillomavirus infection |
| WP:WP4172 | 0.00385309020299 | 0.6 | PPP2R5A PPP2R5C PPP2R5E | PI3K Akt signaling pathway |
| REAC:R-HSA-201681 | 0.0044520864339 | 0.6 | PPP2R5A PPP2R5C PPP2R5E | TCF dependent signaling in response to WNT |
| REAC:R-HSA-5673001 | 0.00484953278503 | 0.6 | PPP2R5A PPP2R5C PPP2R5E | RAF/MAP kinase cascade |
| REAC:R-HSA-5684996 | 0.00512712329405 | 0.6 | PPP2R5A PPP2R5C PPP2R5E | MAPK1/MAPK3 signaling |
| REAC:R-HSA-68882 | 0.00556290465695 | 0.6 | PPP2R5A PPP2R5C PPP2R5E | Mitotic Anaphase |
| REAC:R-HSA-2555396 | 0.00563783422619 | 0.6 | PPP2R5A PPP2R5C PPP2R5E | Mitotic Metaphase and Anaphase |
| REAC:R-HSA-1257604 | 0.00610146618873 | 0.6 | PPP2R5A PPP2R5C PPP2R5E | PIP3 activates AKT signaling |
| REAC:R-HSA-5683057 | 0.00773441075999 | 0.6 | PPP2R5A PPP2R5C PPP2R5E | MAPK family signaling cascades |
| REAC:R-HSA-6804757 | 0.00900400267976 | 0.4 | PPP2R5C CCNG1 | Regulation of TP53 Degradation |
| REAC:R-HSA-9006925 | 0.00931456721467 | 0.6 | PPP2R5A PPP2R5C PPP2R5E | Intracellular signaling by second messengers |
| REAC:R-HSA-6806003 | 0.00953234360475 | 0.4 | PPP2R5C CCNG1 | Regulation of TP53 Expression and Degradation |
| REAC:R-HSA-69620 | 0.0108605941756 | 0.6 | PPP2R5A PPP2R5C PPP2R5E | Cell Cycle Checkpoints |
| REAC:R-HSA-195258 | 0.0129544055333 | 0.6 | PPP2R5A PPP2R5C PPP2R5E | RHO GTPase Effectors |
| REAC:R-HSA-195721 | 0.0130852308339 | 0.6 | PPP2R5A PPP2R5C PPP2R5E | Signaling by WNT |
| GO:1903293 | 0.018748745536 | 0.6 | PPP2R5A PPP2R5C PPP2R5E | phosphatase complex |
| GO:0008287 | 0.018748745536 | 0.6 | PPP2R5A PPP2R5C PPP2R5E | protein serine/threonine phosphatase complex |
| HPA:0570813 | 0.0224403274321 | 0.8 | PPP2R5A PPP2R5E PPP2R5C CCNG1 | testis; spermatogonia cells[High] |
| REAC:R-HSA-5663202 | 0.0253606811944 | 0.6 | PPP2R5A PPP2R5C PPP2R5E | Diseases of signal transduction by growth factor receptors and second messengers |
| WP:WP399 | 0.0253876492563 | 0.4 | PPP2R5C PPP2R5E | Wnt signaling pathway and pluripotency |
| REAC:R-HSA-68886 | 0.0287469323532 | 0.6 | PPP2R5A PPP2R5C PPP2R5E | M Phase |
| WP:WP710 | 0.0293032373139 | 0.4 | PPP2R5C PPP2R5E | DNA damage response only ATM dependent |
| GO:0019888 | 0.036132773595 | 0.6 | PPP2R5A PPP2R5C PPP2R5E | protein phosphatase regulator activity |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| PPP2R5E | PPP2R5A | 1.0 | 0.102 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only |
| PPP2R5E | PPP2R5C | 0.999 | 0.274 | hein_WMM bioplex_WMM Guru bioplex3_WMM boldt fraction boldt_WMM |
| PPP2R5E | C1orf21 | 0.997 | 0.062 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| PPP2R5A | PPP2R5C | 0.996 | 0.094 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
| PPP2R5A | C1orf21 | 0.993 | 0.056375 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only |
| CCNG1 | PPP2R5C | 0.973 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| CCNG1 | PPP2R5E | 0.972 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| CCNG1 | PPP2R5A | 0.356 | bioplex3_WMM WMM_only |
Related Complexes