hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_08840.1
Confidence: High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| GNAT2 | Guanine nucleotide-binding protein G(t) subunit alpha-2 (Transducin alpha-2 chain) | 5 | UniProt NCBI |
| LZTS1 | Leucine zipper putative tumor suppressor 1 (F37/esophageal cancer-related gene-coding leucine-zipper motif) (Fez1) | 5 | UniProt NCBI |
| PDE9A | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (EC 3.1.4.35) | 5 | UniProt NCBI |
| PALD1 | Paladin | 4 | UniProt NCBI |
| UNC119 | Protein unc-119 homolog A (Retinal protein 4) (hRG4) | 5 | UniProt NCBI |
| UNC119B | Protein unc-119 homolog B | 5 | UniProt NCBI |
| NPHP3 | Nephrocystin-3 | 5 | UniProt NCBI |
| PRKG2 | cGMP-dependent protein kinase 2 (cGK 2) (cGK2) (EC 2.7.11.12) (cGMP-dependent protein kinase II) (cGKII) | 5 | UniProt NCBI |
| RSPRY1 | RING finger and SPRY domain-containing protein 1 | 4 | UniProt NCBI |
| CYS1 | Cystin-1 (Cilia-associated protein) | 4 | UniProt NCBI |
| FAM13A | Protein FAM13A | 4 | UniProt NCBI |
| PSKH2 | Serine/threonine-protein kinase H2 (EC 2.7.11.1) (Protein serine kinase H2) (PSK-H2) | 5 | UniProt NCBI |
| RFTN1 | Raftlin (Cell migration-inducing gene 2 protein) (Raft-linking protein) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-5624138 | 1.50066220788e-06 | 0.230769230769 | NPHP3 UNC119B CYS1 | Trafficking of myristoylated proteins to the cilium |
| REAC:R-HSA-5620920 | 0.00223053386269 | 0.230769230769 | NPHP3 UNC119B CYS1 | Cargo trafficking to the periciliary membrane |
| HP:0004592 | 0.0113895015741 | 0.153846153846 | PRKG2 RSPRY1 | Thoracic platyspondyly |
| REAC:R-HSA-418457 | 0.0131050790297 | 0.153846153846 | PDE9A PRKG2 | cGMP effects |
| REAC:R-HSA-392154 | 0.0269367236592 | 0.153846153846 | PDE9A PRKG2 | Nitric oxide stimulates guanylate cyclase |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD |
|---|---|---|---|
| UNC119 | NPHP3 | 1.0 | 0.112 |
| UNC119 | UNC119B | 1.0 | 0.32 |
| UNC119B | NPHP3 | 1.0 | 0.07 |
| PALD1 | UNC119 | 0.999 | 0.066 |
| PDE9A | UNC119 | 0.999 | |
| UNC119 | LZTS1 | 0.998 | 0.036 |
| UNC119 | PSKH2 | 0.998 | |
| PALD1 | UNC119B | 0.997 | 0.014 |
| PSKH2 | UNC119B | 0.997 | |
| UNC119B | FAM13A | 0.996 | |
| UNC119 | FAM13A | 0.995 | |
| CYS1 | UNC119B | 0.994 | |
| UNC119 | GNAT2 | 0.987 | |
| UNC119 | CYS1 | 0.985 | |
| UNC119 | RFTN1 | 0.983 | 0.036 |
| UNC119 | RSPRY1 | 0.977 | 0.122 |
| RSPRY1 | UNC119B | 0.977 | 0.068 |
| UNC119B | GNAT2 | 0.973 | |
| UNC119 | PRKG2 | 0.966 | |
| UNC119B | LZTS1 | 0.955 | 0.04 |
| UNC119B | RFTN1 | 0.948 | 0.014 |
| PDE9A | PALD1 | 0.918 | |
| PDE9A | LZTS1 | 0.916 | |
| PDE9A | RFTN1 | 0.896 | |
| PDE9A | NPHP3 | 0.889 | |
| LZTS1 | RFTN1 | 0.868 | 0.046 |
| PALD1 | NPHP3 | 0.74 | 0.082 |
| RFTN1 | NPHP3 | 0.732 | 0.022 |
| PALD1 | RFTN1 | 0.73 | 0.042 |
| RSPRY1 | RFTN1 | 0.705 | 0.018 |
| PDE9A | RSPRY1 | 0.693 | |
| PDE9A | PRKG2 | 0.65 | |
| PDE9A | UNC119B | 0.605 | |
| PALD1 | LZTS1 | 0.582 | 0.072 |
| LZTS1 | NPHP3 | 0.572 | 0.12 |
| PRKG2 | LZTS1 | 0.572 | |
| PRKG2 | RFTN1 | 0.502 | |
| PALD1 | PRKG2 | 0.495 | |
| PALD1 | RSPRY1 | 0.468 | 0.036 |
| RSPRY1 | LZTS1 | 0.408 | 0.118 |
| PRKG2 | FAM13A | 0.35 | |
| PDE9A | FAM13A | 0.35 | |
| PRKG2 | NPHP3 | 0.334 | |
| RSPRY1 | NPHP3 | 0.292 | 0.086 |
| PALD1 | FAM13A | 0.223 | |
| PRKG2 | RSPRY1 | 0.201 | |
| FAM13A | NPHP3 | 0.187 | |
| LZTS1 | FAM13A | 0.172 | |
| PRKG2 | UNC119B | 0.165 | |
| RFTN1 | FAM13A | 0.164 | |
| RSPRY1 | FAM13A | 0.059 |
Related Complexes