hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_08843.1

Complex Portal: CPX-22988

Confidence: High

Genename	Protein Name	Uniprot Annotation Score	Links
HDAC3	Histone deacetylase 3 (HD3) (EC 3.5.1.98) (Protein deacetylase HDAC3) (EC 3.5.1.-) (Protein deacylase HDAC3) (EC 3.5.1.-) (RPD3-2) (SMAP45)	5	UniProt NCBI
NCOR1	Nuclear receptor corepressor 1 (N-CoR) (N-CoR1)	5	UniProt NCBI
TBL1Y	F-box-like/WD repeat-containing protein TBL1Y (Transducin beta-like protein 1Y) (Transducin-beta-like protein 1, Y-linked)	5	UniProt NCBI
NCOR2	Nuclear receptor corepressor 2 (N-CoR2) (CTG repeat protein 26) (SMAP270) (Silencing mediator of retinoic acid and thyroid hormone receptor) (SMRT) (T3 receptor-associating factor) (TRAC) (Thyroid-, retinoic-acid-receptor-associated corepressor)	5	UniProt NCBI
ANKRD11	Ankyrin repeat domain-containing protein 11 (Ankyrin repeat-containing cofactor 1)	5	UniProt NCBI
GPS2	G protein pathway suppressor 2 (GPS-2)	5	UniProt NCBI
TBL1X	F-box-like/WD repeat-containing protein TBL1X (SMAP55) (Transducin beta-like protein 1X) (Transducin-beta-like protein 1, X-linked)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
REAC:R-HSA-9022537	4.39699156371e-15	0.714285714286	HDAC3 TBL1X NCOR2 GPS2 NCOR1	Loss of MECP2 binding ability to the NCoR/SMRT complex
REAC:R-HSA-9697154	1.84589380276e-13	0.714285714286	HDAC3 TBL1X NCOR2 GPS2 NCOR1	Disorders of Nervous System Development
REAC:R-HSA-9005891	1.84589380276e-13	0.714285714286	HDAC3 TBL1X NCOR2 GPS2 NCOR1	Loss of function of MECP2 in Rett syndrome
REAC:R-HSA-9005895	1.84589380276e-13	0.714285714286	HDAC3 TBL1X NCOR2 GPS2 NCOR1	Pervasive developmental disorders
REAC:R-HSA-9675151	1.84589380276e-13	0.714285714286	HDAC3 TBL1X NCOR2 GPS2 NCOR1	Disorders of Developmental Biology
CORUM:58	9.61159511016e-12	0.571428571429	HDAC3 TBL1X GPS2 NCOR2	SMRT complex
CORUM:741	9.61159511016e-12	0.571428571429	HDAC3 TBL1X GPS2 NCOR1	NCOR-HDAC3 complex
CORUM:15	2.88300486966e-11	0.571428571429	HDAC3 TBL1X GPS2 NCOR1	NCOR complex
REAC:R-HSA-9022692	8.67992499122e-11	0.714285714286	HDAC3 TBL1X NCOR2 GPS2 NCOR1	Regulation of MECP2 expression and activity
REAC:R-HSA-9029569	1.24161324729e-10	0.714285714286	HDAC3 TBL1X NCOR2 GPS2 NCOR1	NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux
CORUM:2183	4.033555059e-10	0.571428571429	HDAC3 TBL1X GPS2 NCOR1	Kaiso-NCOR complex
REAC:R-HSA-9024446	4.20346129105e-10	0.714285714286	HDAC3 TBL1X NCOR2 GPS2 NCOR1	NR1H2 and NR1H3-mediated signaling
REAC:R-HSA-8986944	2.09173590301e-09	0.714285714286	HDAC3 TBL1X NCOR2 GPS2 NCOR1	Transcriptional Regulation by MECP2
CORUM:752	7.02338504734e-09	0.428571428571	HDAC3 TBL1X NCOR2	SMRT core complex
CORUM:7480	7.02338504734e-09	0.428571428571	HDAC3 NCOR2 NCOR1	HDAC3-H1.3-SMRT-N-Cor complex
CORUM:1188	7.02338504734e-09	0.428571428571	HDAC3 TBL1X NCOR2	SMRT core complex
REAC:R-HSA-3214815	1.74688815385e-08	0.714285714286	HDAC3 TBL1X NCOR2 GPS2 NCOR1	HDACs deacetylate histones
REAC:R-HSA-350054	2.60340792443e-08	0.571428571429	HDAC3 NCOR2 TBL1X NCOR1	Notch-HLH transcription pathway
REAC:R-HSA-1989781	5.18598397867e-08	0.714285714286	HDAC3 TBL1X NCOR2 GPS2 NCOR1	PPARA activates gene expression
REAC:R-HSA-400206	5.45830450491e-08	0.714285714286	HDAC3 TBL1X NCOR2 GPS2 NCOR1	Regulation of lipid metabolism by PPARalpha
REAC:R-HSA-9609690	1.37851310836e-07	0.714285714286	HDAC3 TBL1X NCOR2 GPS2 NCOR1	HCMV Early Events
WP:WP4312	1.85577872789e-07	0.571428571429	NCOR1 TBL1X GPS2 NCOR2	Rett syndrome causing genes
CORUM:1505	2.45616649736e-07	0.428571428571	HDAC3 NCOR2 NCOR1	NCOR2 complex
REAC:R-HSA-9609646	3.23287246817e-07	0.714285714286	HDAC3 TBL1X NCOR2 GPS2 NCOR1	HCMV Infection
REAC:R-HSA-2122947	3.24295323063e-07	0.571428571429	HDAC3 NCOR2 TBL1X NCOR1	NOTCH1 Intracellular Domain Regulates Transcription
GO:0003714	5.23281759123e-07	0.857142857143	GPS2 NCOR2 TBL1X HDAC3 TBL1Y NCOR1	transcription corepressor activity
REAC:R-HSA-2644602	6.32195304736e-07	0.571428571429	HDAC3 NCOR2 TBL1X NCOR1	Signaling by NOTCH1 PEST Domain Mutants in Cancer
REAC:R-HSA-2894862	6.32195304736e-07	0.571428571429	HDAC3 NCOR2 TBL1X NCOR1	Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
REAC:R-HSA-2894858	6.32195304736e-07	0.571428571429	HDAC3 NCOR2 TBL1X NCOR1	Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
REAC:R-HSA-2644606	6.32195304736e-07	0.571428571429	HDAC3 NCOR2 TBL1X NCOR1	Constitutive Signaling by NOTCH1 PEST Domain Mutants
REAC:R-HSA-2644603	6.32195304736e-07	0.571428571429	HDAC3 NCOR2 TBL1X NCOR1	Signaling by NOTCH1 in Cancer
GO:0017053	8.61211838165e-07	0.714285714286	HDAC3 TBL1X NCOR2 GPS2 NCOR1	transcription repressor complex
REAC:R-HSA-1980143	1.6099599394e-06	0.571428571429	HDAC3 NCOR2 TBL1X NCOR1	Signaling by NOTCH1
REAC:R-HSA-9707564	1.6099599394e-06	0.571428571429	HDAC3 NCOR2 TBL1X NCOR1	Cytoprotection by HMOX1
REAC:R-HSA-381340	4.28820405091e-06	0.571428571429	HDAC3 NCOR2 TBL1X NCOR1	Transcriptional regulation of white adipocyte differentiation
REAC:R-HSA-9006931	5.24319565641e-06	0.714285714286	HDAC3 TBL1X NCOR2 GPS2 NCOR1	Signaling by Nuclear Receptors
REAC:R-HSA-3247509	5.57024440449e-06	0.714285714286	HDAC3 TBL1X NCOR2 GPS2 NCOR1	Chromatin modifying enzymes
REAC:R-HSA-4839726	5.57024440449e-06	0.714285714286	HDAC3 TBL1X NCOR2 GPS2 NCOR1	Chromatin organization
CORUM:5426	2.05265451394e-05	0.285714285714	HDAC3 ANKRD11	ANCO1-HDAC3 complex
REAC:R-HSA-1368071	0.00011430200373	0.285714285714	HDAC3 NCOR1	NR1D1 (REV-ERBA) represses gene expression
REAC:R-HSA-9707616	0.00014849904315	0.428571428571	HDAC3 TBL1X NCOR1	Heme signaling
REAC:R-HSA-9711123	0.000156692130662	0.571428571429	HDAC3 NCOR2 TBL1X NCOR1	Cellular response to chemical stress
GO:0003712	0.000177928273763	0.857142857143	GPS2 NCOR2 TBL1X HDAC3 TBL1Y NCOR1	transcription coregulator activity
REAC:R-HSA-2151201	0.000223455724258	0.428571428571	HDAC3 TBL1X NCOR1	Transcriptional activation of mitochondrial biogenesis
REAC:R-HSA-157118	0.000241955069178	0.571428571429	HDAC3 NCOR2 TBL1X NCOR1	Signaling by NOTCH
REAC:R-HSA-400253	0.000463730815151	0.428571428571	HDAC3 TBL1X NCOR1	Circadian Clock
REAC:R-HSA-556833	0.00048075687601	0.714285714286	HDAC3 TBL1X NCOR2 GPS2 NCOR1	Metabolism of lipids
GO:0000118	0.000579396940492	0.571428571429	HDAC3 TBL1X TBL1Y NCOR1	histone deacetylase complex
CORUM:1413	0.000922010129722	0.285714285714	HDAC3 NCOR1	NCOR1 complex
REAC:R-HSA-9824446	0.000953213883488	0.714285714286	HDAC3 TBL1X NCOR2 GPS2 NCOR1	Viral Infection Pathways
REAC:R-HSA-1592230	0.00131187888511	0.428571428571	HDAC3 TBL1X NCOR1	Mitochondrial biogenesis
REAC:R-HSA-9623433	0.00136974769985	0.285714285714	NCOR1 NCOR2	NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis
REAC:R-HSA-5663202	0.00260870632592	0.571428571429	HDAC3 NCOR2 TBL1X NCOR1	Diseases of signal transduction by growth factor receptors and second messengers
REAC:R-HSA-5663205	0.00262907091591	0.714285714286	HDAC3 TBL1X NCOR2 GPS2 NCOR1	Infectious disease
CORUM:5614	0.00349645023665	0.285714285714	HDAC3 TBL1Y	Emerin complex 32
REAC:R-HSA-212436	0.00607059142443	0.714285714286	HDAC3 TBL1X NCOR2 GPS2 NCOR1	Generic Transcription Pathway
GO:0030674	0.00649171551793	0.857142857143	GPS2 NCOR2 TBL1X HDAC3 TBL1Y NCOR1	protein-macromolecule adaptor activity
GO:0005667	0.00877209748987	0.714285714286	HDAC3 TBL1X NCOR2 GPS2 NCOR1	transcription regulator complex
REAC:R-HSA-73857	0.0103732213005	0.714285714286	HDAC3 TBL1X NCOR2 GPS2 NCOR1	RNA Polymerase II Transcription
GO:0046329	0.0150353457168	0.428571428571	HDAC3 GPS2 NCOR1	negative regulation of JNK cascade
REAC:R-HSA-2173795	0.0153773615715	0.285714285714	NCOR1 NCOR2	Downregulation of SMAD2/3:SMAD4 transcriptional activity
GO:0060090	0.0165456942242	0.857142857143	GPS2 NCOR2 TBL1X HDAC3 TBL1Y NCOR1	molecular adaptor activity
WP:WP61	0.0166893818359	0.285714285714	NCOR1 NCOR2	Notch signaling pathway
REAC:R-HSA-383280	0.0187732752758	0.285714285714	NCOR1 NCOR2	Nuclear Receptor transcription pathway
REAC:R-HSA-74160	0.0190899982826	0.714285714286	HDAC3 TBL1X NCOR2 GPS2 NCOR1	Gene expression (Transcription)
HPA:0490692	0.029093044107	0.857142857143	ANKRD11 GPS2 NCOR2 TBL1X HDAC3 NCOR1	smooth muscle; smooth muscle cells[>=Medium]
HPA:0170252	0.0319022744941	0.714285714286	HDAC3 ANKRD11 NCOR2 TBL1X NCOR1	endometrium 2; cells in endometrial stroma[>=Medium]
HPA:0090193	0.0319517165126	0.571428571429	HDAC3 ANKRD11 TBL1X NCOR2	cerebellum; cells in molecular layer[High]
REAC:R-HSA-2262752	0.0357359015554	0.571428571429	HDAC3 NCOR2 TBL1X NCOR1	Cellular responses to stress
REAC:R-HSA-1643685	0.0367346572641	0.714285714286	HDAC3 TBL1X NCOR2 GPS2 NCOR1	Disease
REAC:R-HSA-8953897	0.037098775361	0.571428571429	HDAC3 NCOR2 TBL1X NCOR1	Cellular responses to stimuli
REAC:R-HSA-1852241	0.0422635503964	0.428571428571	HDAC3 TBL1X NCOR1	Organelle biogenesis and maintenance
REAC:R-HSA-2173793	0.0461752771557	0.285714285714	NCOR1 NCOR2	Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer

Edges

Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap	Evidence
NCOR1	GPS2	1.0	0.152		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM
NCOR2	GPS2	1.0	0.274		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM
GPS2	HDAC3	1.0	0.2296		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM
GPS2	TBL1X	1.0	0.082		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116
NCOR2	TBL1Y	0.999			bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
ANKRD11	GPS2	0.999	0.136		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116
GPS2	TBL1Y	0.999		mutually_exclusive (Q9BZK7)	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
TBL1X	TBL1Y	0.999		mutually_exclusive (Q9BZK7) structurally_consistent (dimer)	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
NCOR1	TBL1Y	0.998			bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
HDAC3	TBL1Y	0.998			bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
NCOR1	HDAC3	0.959	0.28		bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only
NCOR2	TBL1X	0.955	0.216		bioplex_WMM bioplex3_WMM youn_WMM WMM_only
ANKRD11	TBL1X	0.954	0.066		bioplex_WMM bioplex3_WMM youn_WMM WMM_only
ANKRD11	HDAC3	0.952	0.366		bioplex_WMM bioplex3_WMM youn_WMM WMM_only
NCOR1	TBL1X	0.95	0.154		bioplex_WMM bioplex3_WMM youn_WMM WMM_only
NCOR2	ANKRD11	0.92	0.288		hein_WMM bioplex_WMM bioplex3_WMM youn_WMM WMM_only
NCOR2	HDAC3	0.919	0.4		hein_WMM bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only
TBL1X	HDAC3	0.892	0.4		bioplex_WMM bioplex3_WMM youn_WMM WMM_only
NCOR1	ANKRD11	0.885	0.242		hein_WMM bioplex_WMM bioplex3_WMM youn_WMM WMM_only
NCOR1	NCOR2	0.676	0.19		hein_WMM bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only

Related Complexes

Genename	Complexes
HDAC3	huMAP3_04325.1 huMAP3_05713.1 huMAP3_06120.1 huMAP3_06185.1 huMAP3_07614.1 huMAP3_08843.1 huMAP3_10798.1
NCOR1	huMAP3_03197.1 huMAP3_04325.1 huMAP3_05713.1 huMAP3_06120.1 huMAP3_06185.1 huMAP3_06884.1 huMAP3_07695.1 huMAP3_08843.1 huMAP3_13269.1
TBL1Y	huMAP3_04325.1 huMAP3_05713.1 huMAP3_06120.1 huMAP3_06185.1 huMAP3_06884.1 huMAP3_07695.1 huMAP3_08843.1 huMAP3_13269.1 huMAP3_14743.1
NCOR2	huMAP3_03197.1 huMAP3_05713.1 huMAP3_06185.1 huMAP3_07695.1 huMAP3_08843.1 huMAP3_13269.1
ANKRD11	huMAP3_03197.1 huMAP3_04325.1 huMAP3_05713.1 huMAP3_06120.1 huMAP3_06185.1 huMAP3_07614.1 huMAP3_07695.1 huMAP3_08843.1 huMAP3_13269.1
GPS2	huMAP3_03197.1 huMAP3_04325.1 huMAP3_05713.1 huMAP3_06120.1 huMAP3_06185.1 huMAP3_06884.1 huMAP3_07695.1 huMAP3_08843.1 huMAP3_13269.1
TBL1X	huMAP3_03197.1 huMAP3_04325.1 huMAP3_05713.1 huMAP3_06120.1 huMAP3_06185.1 huMAP3_07695.1 huMAP3_08843.1 huMAP3_13269.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_08843.1

Complex Portal: CPX-22988