hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_08860.1
Confidence: High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| FBXW4 | F-box/WD repeat-containing protein 4 (Dactylin) (F-box and WD-40 domain-containing protein 4) | 4 | UniProt NCBI |
| PFDN5 | Prefoldin subunit 5 (Myc modulator 1) (c-Myc-binding protein Mm-1) | 5 | UniProt NCBI |
| VBP1 | Prefoldin subunit 3 (HIBBJ46) (von Hippel-Lindau-binding protein 1) (VBP-1) (VHL-binding protein 1) | 5 | UniProt NCBI |
| WSB2 | WD repeat and SOCS box-containing protein 2 (WSB-2) (CS box-containing WD protein) | 3 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP4918 | 3.82933516227e-05 | 0.5 | PFDN5 VBP1 | Cellular proteostasis |
| CORUM:33 | 7.68662167609e-05 | 0.5 | PFDN5 VBP1 | Prefoldin complex |
| CORUM:112 | 7.68662167609e-05 | 0.5 | PFDN5 VBP1 | Prefoldin complex |
| REAC:R-HSA-390466 | 0.000138011947324 | 0.75 | FBXW4 VBP1 PFDN5 | Chaperonin-mediated protein folding |
| REAC:R-HSA-391251 | 0.000175410417245 | 0.75 | FBXW4 VBP1 PFDN5 | Protein folding |
| REAC:R-HSA-389957 | 0.00359044851421 | 0.5 | PFDN5 VBP1 | Prefoldin mediated transfer of substrate to CCT/TriC |
| REAC:R-HSA-389958 | 0.00507136546841 | 0.5 | PFDN5 VBP1 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding |
| REAC:R-HSA-392499 | 0.0339333915692 | 1.0 | FBXW4 WSB2 VBP1 PFDN5 | Metabolism of proteins |
| GO:0016272 | 0.042122686785 | 0.5 | PFDN5 VBP1 | prefoldin complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| PFDN5 | VBP1 | 1.0 | 0.866 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM boldt youn_WMM hein () bioplex3_HCT116 gupta_WMM fraction boldt_WMM |
| WSB2 | PFDN5 | 0.989 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| FBXW4 | VBP1 | 0.984 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 | |
| WSB2 | VBP1 | 0.973 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| FBXW4 | PFDN5 | 0.957 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| WSB2 | FBXW4 | 0.046 | bioplex3_WMM WMM_only |
Related Complexes