hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_08861.1
Complex Portal: CPX-22230
Confidence: High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| KLK14 | Kallikrein-14 (hK14) (EC 3.4.21.-) (Kallikrein-like protein 6) (KLK-L6) | 5 | UniProt NCBI |
| SAMD9 | Sterile alpha motif domain-containing protein 9 (SAM domain-containing protein 9) | 5 | UniProt NCBI |
| FNDC5 | Fibronectin type III domain-containing protein 5 (Fibronectin type III repeat-containing protein 2) [Cleaved into: Irisin] | 5 | UniProt NCBI |
| CEACAM5 | Carcinoembryonic antigen-related cell adhesion molecule 5 (Carcinoembryonic antigen) (CEA) (Meconium antigen 100) (CD antigen CD66e) | 5 | UniProt NCBI |
| FUT3 | 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase FUT3 (EC 2.4.1.65) (4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase) (EC 2.4.1.152) (Alpha-3-fucosyltransferase FUT3) (EC 2.4.1.-) (Blood group Lewis alpha-4-fucosyltransferase) (Lewis FT) (Fucosyltransferase 3) (Fucosyltransferase III) (FucT-III) | 5 | UniProt NCBI |
| MUC1 | Mucin-1 (MUC-1) (Breast carcinoma-associated antigen DF3) (Cancer antigen 15-3) (CA 15-3) (Carcinoma-associated mucin) (Episialin) (H23AG) (Krebs von den Lungen-6) (KL-6) (PEMT) (Peanut-reactive urinary mucin) (PUM) (Polymorphic epithelial mucin) (PEM) (Tumor-associated epithelial membrane antigen) (EMA) (Tumor-associated mucin) (CD antigen CD227) [Cleaved into: Mucin-1 subunit alpha (MUC1-NT) (MUC1-alpha); Mucin-1 subunit beta (MUC1-beta) (MUC1-CT)] | 5 | UniProt NCBI |
| STATH | Statherin | 5 | UniProt NCBI |
| NUCB2 | Nucleobindin-2 (DNA-binding protein NEFA) (Epididymis secretory protein Li 109) (Gastric cancer antigen Zg4) (Prepronesfatin) [Cleaved into: Nesfatin-1] | 5 | UniProt NCBI |
| CXCL17 | C-X-C motif chemokine 17 (6-Cys CXCL17) (Dendritic cell and monocyte chemokine-like protein) (DMC) (VEGF coregulated chemokine 1) [Cleaved into: 4-Cys CXCL17] | 5 | UniProt NCBI |
| RPTN | Repetin | 4 | UniProt NCBI |
| SARG | Specifically androgen-regulated gene protein | 5 | UniProt NCBI |
| KLK13 | Kallikrein-13 (EC 3.4.21.-) (Kallikrein-like protein 4) (KLK-L4) | 4 | UniProt NCBI |
| DPP4 | Dipeptidyl peptidase 4 (EC 3.4.14.5) (ADABP) (Adenosine deaminase complexing protein 2) (ADCP-2) (Dipeptidyl peptidase IV) (DPP IV) (T-cell activation antigen CD26) (TP103) (CD antigen CD26) [Cleaved into: Dipeptidyl peptidase 4 membrane form (Dipeptidyl peptidase IV membrane form); Dipeptidyl peptidase 4 soluble form (Dipeptidyl peptidase IV soluble form)] | 5 | UniProt NCBI |
| TMPRSS11D | Transmembrane protease serine 11D (EC 3.4.21.-) (Airway trypsin-like protease) [Cleaved into: Transmembrane protease serine 11D non-catalytic chain; Transmembrane protease serine 11D catalytic chain] | 5 | UniProt NCBI |
| MGP | Matrix Gla protein (MGP) (Cell growth-inhibiting gene 36 protein) | 5 | UniProt NCBI |
| VSIG10L | V-set and immunoglobulin domain-containing protein 10-like (VSIG10-like protein) | 4 | UniProt NCBI |
| CES2 | Cocaine esterase (EC 3.1.1.84) (Carboxylesterase 2) (CE-2) (hCE-2) (EC 3.1.1.1) (Methylumbelliferyl-acetate deacetylase 2) (EC 3.1.1.56) | 5 | UniProt NCBI |
| ODAM | Odontogenic ameloblast-associated protein (Apin) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| HPA:0131322 | 0.0042225731656 | 0.235294117647 | CES2 DPP4 CEACAM5 FUT3 | colon; enterocytes - Microvilli[>=Medium] |
| HPA:0131321 | 0.0055258281789 | 0.235294117647 | CES2 DPP4 CEACAM5 FUT3 | colon; enterocytes - Microvilli[>=Low] |
| REAC:R-HSA-6809371 | 0.0192924644181 | 0.176470588235 | KLK13 KLK14 RPTN | Formation of the cornified envelope |
| REAC:R-HSA-6805567 | 0.0210699634633 | 0.176470588235 | KLK13 KLK14 RPTN | Keratinization |
| GO:0005576 | 0.0256704799285 | 0.764705882353 | MGP SARG KLK13 STATH CXCL17 ODAM NUCB2 TMPRSS11D CEACAM5 FNDC5 DPP4 FUT3 KLK14 | extracellular region |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap |
|---|---|---|---|---|
| FNDC5 | KLK13 | 0.999 | ||
| SAMD9 | FNDC5 | 0.999 | ||
| CES2 | FNDC5 | 0.998 | ||
| FNDC5 | VSIG10L | 0.998 | ||
| FNDC5 | MUC1 | 0.998 | ||
| FNDC5 | SARG | 0.998 | ||
| FNDC5 | FUT3 | 0.997 | ||
| FNDC5 | CXCL17 | 0.997 | ||
| MGP | FNDC5 | 0.997 | ||
| KLK14 | FNDC5 | 0.996 | ||
| CEACAM5 | FNDC5 | 0.996 | ||
| FNDC5 | RPTN | 0.996 | ||
| FNDC5 | DPP4 | 0.996 | ||
| FNDC5 | TMPRSS11D | 0.996 | ||
| FNDC5 | STATH | 0.995 | ||
| NUCB2 | FNDC5 | 0.988 | ||
| ODAM | FNDC5 | 0.988 | ||
| KLK14 | TMPRSS11D | 0.904 | ||
| SAMD9 | FUT3 | 0.904 | ||
| CEACAM5 | SAMD9 | 0.904 | 0.048 | |
| KLK14 | CEACAM5 | 0.904 | ||
| KLK14 | FUT3 | 0.904 | ||
| MUC1 | KLK13 | 0.904 | ||
| STATH | CXCL17 | 0.902 | ||
| STATH | RPTN | 0.902 | ||
| TMPRSS11D | DPP4 | 0.902 | ||
| RPTN | DPP4 | 0.902 | ||
| STATH | DPP4 | 0.902 | ||
| STATH | TMPRSS11D | 0.902 | ||
| CXCL17 | DPP4 | 0.902 | ||
| RPTN | VSIG10L | 0.902 | ||
| CEACAM5 | RPTN | 0.902 | ||
| RPTN | TMPRSS11D | 0.902 | ||
| CEACAM5 | MUC1 | 0.902 | 0.222 | |
| CXCL17 | RPTN | 0.902 | ||
| CXCL17 | TMPRSS11D | 0.902 | ||
| CEACAM5 | CXCL17 | 0.902 | ||
| STATH | VSIG10L | 0.902 | ||
| CXCL17 | VSIG10L | 0.902 | ||
| CEACAM5 | TMPRSS11D | 0.902 | ||
| CEACAM5 | DPP4 | 0.902 | 0.084 | |
| MUC1 | TMPRSS11D | 0.902 | ||
| CEACAM5 | STATH | 0.902 | ||
| TMPRSS11D | VSIG10L | 0.902 | ||
| CEACAM5 | VSIG10L | 0.902 | ||
| MUC1 | STATH | 0.902 | ||
| VSIG10L | DPP4 | 0.902 | ||
| MUC1 | CXCL17 | 0.902 | ||
| MUC1 | RPTN | 0.902 | ||
| MUC1 | DPP4 | 0.902 | 0.158 | |
| MUC1 | VSIG10L | 0.902 | ||
| SAMD9 | VSIG10L | 0.902 | ||
| SAMD9 | DPP4 | 0.902 | 0.056 | |
| MGP | SAMD9 | 0.902 | 0.036 | |
| STATH | SARG | 0.902 | ||
| KLK14 | STATH | 0.902 | ||
| MUC1 | FUT3 | 0.902 | ||
| KLK13 | VSIG10L | 0.902 | ||
| STATH | KLK13 | 0.902 | ||
| STATH | FUT3 | 0.902 | ||
| CES2 | MUC1 | 0.902 | 0.114 | |
| CEACAM5 | FUT3 | 0.902 | ||
| SAMD9 | MUC1 | 0.902 | 0.06 | |
| SAMD9 | STATH | 0.902 | ||
| MGP | TMPRSS11D | 0.902 | ||
| CES2 | STATH | 0.902 | ||
| MUC1 | SARG | 0.902 | ||
| KLK14 | VSIG10L | 0.902 | ||
| MGP | STATH | 0.902 | ||
| KLK14 | MGP | 0.902 | ||
| RPTN | KLK13 | 0.902 | ||
| SAMD9 | RPTN | 0.902 | ||
| CEACAM5 | MGP | 0.902 | ||
| SAMD9 | CXCL17 | 0.902 | ||
| CXCL17 | KLK13 | 0.902 | ||
| CXCL17 | FUT3 | 0.902 | ||
| VSIG10L | FUT3 | 0.902 | ||
| SARG | VSIG10L | 0.902 | ||
| MGP | RPTN | 0.902 | ||
| SARG | DPP4 | 0.902 | 0.1 | |
| CES2 | CXCL17 | 0.902 | ||
| CES2 | DPP4 | 0.902 | 0.132 | |
| SARG | TMPRSS11D | 0.902 | ||
| RPTN | SARG | 0.902 | ||
| MGP | DPP4 | 0.902 | 0.078 | |
| CEACAM5 | CES2 | 0.902 | 0.112 | |
| CES2 | TMPRSS11D | 0.902 | ||
| DPP4 | FUT3 | 0.902 | ||
| CEACAM5 | SARG | 0.902 | ||
| TMPRSS11D | FUT3 | 0.902 | ||
| MGP | FUT3 | 0.902 | ||
| CES2 | RPTN | 0.902 | ||
| CES2 | VSIG10L | 0.902 | ||
| MGP | CXCL17 | 0.902 | ||
| MGP | VSIG10L | 0.902 | ||
| KLK14 | MUC1 | 0.902 | ||
| CXCL17 | SARG | 0.902 | ||
| KLK13 | DPP4 | 0.902 | ||
| KLK14 | CXCL17 | 0.902 | ||
| KLK14 | RPTN | 0.902 | ||
| KLK14 | DPP4 | 0.902 | ||
| MGP | MUC1 | 0.902 | ||
| RPTN | FUT3 | 0.902 | ||
| NUCB2 | RPTN | 0.875 | ||
| NUCB2 | VSIG10L | 0.875 | ||
| NUCB2 | DPP4 | 0.875 | 0.3 | |
| NUCB2 | STATH | 0.875 | ||
| NUCB2 | CXCL17 | 0.875 | ||
| KLK14 | SAMD9 | 0.869 | ||
| KLK13 | TMPRSS11D | 0.796 | ||
| SAMD9 | TMPRSS11D | 0.773 | ||
| CEACAM5 | KLK13 | 0.768 | ||
| NUCB2 | MUC1 | 0.737 | 0.112 | |
| CES2 | SAMD9 | 0.722 | 0.062 | |
| KLK14 | CES2 | 0.722 | ||
| KLK14 | SARG | 0.722 | ||
| CES2 | MGP | 0.717 | 0.056 | |
| MGP | SARG | 0.717 | 0.11 | |
| CES2 | FUT3 | 0.717 | ||
| SARG | FUT3 | 0.717 | ||
| MGP | KLK13 | 0.714 | ||
| CES2 | SARG | 0.698 | 0.126 | |
| NUCB2 | CEACAM5 | 0.696 | 0.066 | |
| NUCB2 | TMPRSS11D | 0.696 | ||
| SARG | KLK13 | 0.633 | ||
| SAMD9 | SARG | 0.602 | 0.084 | |
| SAMD9 | KLK13 | 0.49 | ||
| CES2 | KLK13 | 0.468 | ||
| KLK13 | FUT3 | 0.468 | ||
| KLK14 | KLK13 | 0.418 | ||
| NUCB2 | MGP | 0.406 | 0.046 | |
| NUCB2 | FUT3 | 0.388 | ||
| NUCB2 | SAMD9 | 0.376 | 0.018 | |
| KLK14 | NUCB2 | 0.376 | ||
| NUCB2 | CES2 | 0.357 | 0.104 | |
| NUCB2 | SARG | 0.357 | 0.026 | |
| NUCB2 | KLK13 | 0.244 |
Related Complexes