hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_08875.1
Confidence: High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| RPS6KA2 | Ribosomal protein S6 kinase alpha-2 (S6K-alpha-2) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 2) (p90-RSK 2) (p90RSK2) (MAP kinase-activated protein kinase 1c) (MAPK-activated protein kinase 1c) (MAPKAP kinase 1c) (MAPKAPK-1c) (Ribosomal S6 kinase 3) (RSK-3) (pp90RSK3) | 5 | UniProt NCBI |
| RPS6KA3 | Ribosomal protein S6 kinase alpha-3 (S6K-alpha-3) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 3) (p90-RSK 3) (p90RSK3) (Insulin-stimulated protein kinase 1) (ISPK-1) (MAP kinase-activated protein kinase 1b) (MAPK-activated protein kinase 1b) (MAPKAP kinase 1b) (MAPKAPK-1b) (Ribosomal S6 kinase 2) (RSK-2) (pp90RSK2) | 5 | UniProt NCBI |
| RPS6KA1 | Ribosomal protein S6 kinase alpha-1 (S6K-alpha-1) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 1) (p90-RSK 1) (p90RSK1) (p90S6K) (MAP kinase-activated protein kinase 1a) (MAPK-activated protein kinase 1a) (MAPKAP kinase 1a) (MAPKAPK-1a) (Ribosomal S6 kinase 1) (RSK-1) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-444257 | 1.63310749402e-08 | 1.0 | RPS6KA1 RPS6KA2 RPS6KA3 | RSK activation |
| REAC:R-HSA-199920 | 1.63310749402e-08 | 1.0 | RPS6KA1 RPS6KA2 RPS6KA3 | CREB phosphorylation |
| REAC:R-HSA-881907 | 2.61297199043e-07 | 1.0 | RPS6KA1 RPS6KA2 RPS6KA3 | Gastrin-CREB signalling pathway via PKC and MAPK |
| WP:WP4877 | 3.14715618363e-07 | 1.0 | RPS6KA1 RPS6KA2 RPS6KA3 | Host pathogen interaction of human coronaviruses MAPK signaling |
| REAC:R-HSA-198753 | 6.20580847727e-07 | 1.0 | RPS6KA1 RPS6KA2 RPS6KA3 | ERK/MAPK targets |
| REAC:R-HSA-442742 | 7.18567297368e-07 | 1.0 | RPS6KA1 RPS6KA2 RPS6KA3 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling |
| GO:0004711 | 9.61200410764e-07 | 1.0 | RPS6KA1 RPS6KA2 RPS6KA3 | ribosomal protein S6 kinase activity |
| KEGG:04720 | 1.29573994503e-06 | 1.0 | RPS6KA1 RPS6KA2 RPS6KA3 | Long-term potentiation |
| REAC:R-HSA-450282 | 1.89440469306e-06 | 1.0 | RPS6KA1 RPS6KA2 RPS6KA3 | MAPK targets/ Nuclear events mediated by MAP kinases |
| KEGG:04914 | 4.62629936833e-06 | 1.0 | RPS6KA1 RPS6KA2 RPS6KA3 | Progesterone-mediated oocyte maturation |
| REAC:R-HSA-437239 | 7.08302050262e-06 | 1.0 | RPS6KA1 RPS6KA2 RPS6KA3 | Recycling pathway of L1 |
| KEGG:04931 | 7.94536617802e-06 | 1.0 | RPS6KA1 RPS6KA2 RPS6KA3 | Insulin resistance |
| WP:WP477 | 8.21632560798e-06 | 1.0 | RPS6KA1 RPS6KA2 RPS6KA3 | Cytoplasmic ribosomal proteins |
| KEGG:04722 | 8.44707100112e-06 | 1.0 | RPS6KA1 RPS6KA2 RPS6KA3 | Neurotrophin signaling pathway |
| WP:WP4321 | 9.41705095982e-06 | 1.0 | RPS6KA1 RPS6KA2 RPS6KA3 | Thermogenesis |
| KEGG:04114 | 9.51295867401e-06 | 1.0 | RPS6KA1 RPS6KA2 RPS6KA3 | Oocyte meiosis |
| REAC:R-HSA-198725 | 1.1573599509e-05 | 1.0 | RPS6KA1 RPS6KA2 RPS6KA3 | Nuclear Events (kinase and transcription factor activation) |
| KEGG:05135 | 1.28981080119e-05 | 1.0 | RPS6KA1 RPS6KA2 RPS6KA3 | Yersinia infection |
| REAC:R-HSA-450294 | 1.29342113526e-05 | 1.0 | RPS6KA1 RPS6KA2 RPS6KA3 | MAP kinase activation |
| REAC:R-HSA-448424 | 1.76468929782e-05 | 1.0 | RPS6KA1 RPS6KA2 RPS6KA3 | Interleukin-17 signaling |
| WP:WP3915 | 1.86398464173e-05 | 1.0 | RPS6KA1 RPS6KA2 RPS6KA3 | Angiopoietin like protein 8 regulatory pathway |
| REAC:R-HSA-438064 | 2.33842329058e-05 | 1.0 | RPS6KA1 RPS6KA2 RPS6KA3 | Post NMDA receptor activation events |
| KEGG:04150 | 2.7655198514e-05 | 1.0 | RPS6KA1 RPS6KA2 RPS6KA3 | mTOR signaling pathway |
| WP:WP481 | 3.69900149365e-05 | 1.0 | RPS6KA1 RPS6KA2 RPS6KA3 | Insulin signaling |
| KEGG:05207 | 3.7014626318e-05 | 1.0 | RPS6KA1 RPS6KA2 RPS6KA3 | Chemical carcinogenesis - receptor activation |
| WP:WP437 | 3.77770365309e-05 | 1.0 | RPS6KA1 RPS6KA2 RPS6KA3 | EGF EGFR signaling pathway |
| REAC:R-HSA-442755 | 3.83360319167e-05 | 1.0 | RPS6KA1 RPS6KA2 RPS6KA3 | Activation of NMDA receptors and postsynaptic events |
| REAC:R-HSA-168142 | 4.132228562e-05 | 1.0 | RPS6KA1 RPS6KA2 RPS6KA3 | Toll Like Receptor 10 (TLR10) Cascade |
| REAC:R-HSA-168176 | 4.132228562e-05 | 1.0 | RPS6KA1 RPS6KA2 RPS6KA3 | Toll Like Receptor 5 (TLR5) Cascade |
| REAC:R-HSA-975871 | 4.132228562e-05 | 1.0 | RPS6KA1 RPS6KA2 RPS6KA3 | MyD88 cascade initiated on plasma membrane |
| REAC:R-HSA-975138 | 4.44597184171e-05 | 1.0 | RPS6KA1 RPS6KA2 RPS6KA3 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation |
| REAC:R-HSA-975155 | 4.60862934812e-05 | 1.0 | RPS6KA1 RPS6KA2 RPS6KA3 | MyD88 dependent cascade initiated on endosome |
| REAC:R-HSA-168181 | 4.60862934812e-05 | 1.0 | RPS6KA1 RPS6KA2 RPS6KA3 | Toll Like Receptor 7/8 (TLR7/8) Cascade |
| REAC:R-HSA-168138 | 5.29892055573e-05 | 1.0 | RPS6KA1 RPS6KA2 RPS6KA3 | Toll Like Receptor 9 (TLR9) Cascade |
| REAC:R-HSA-168164 | 5.66851611173e-05 | 1.0 | RPS6KA1 RPS6KA2 RPS6KA3 | Toll Like Receptor 3 (TLR3) Cascade |
| REAC:R-HSA-166166 | 6.05490934482e-05 | 1.0 | RPS6KA1 RPS6KA2 RPS6KA3 | MyD88-independent TLR4 cascade |
| REAC:R-HSA-937061 | 6.05490934482e-05 | 1.0 | RPS6KA1 RPS6KA2 RPS6KA3 | TRIF(TICAM1)-mediated TLR4 signaling |
| REAC:R-HSA-168188 | 6.4584735367e-05 | 1.0 | RPS6KA1 RPS6KA2 RPS6KA3 | Toll Like Receptor TLR6:TLR2 Cascade |
| REAC:R-HSA-166058 | 6.4584735367e-05 | 1.0 | RPS6KA1 RPS6KA2 RPS6KA3 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane |
| REAC:R-HSA-2559582 | 6.87958196908e-05 | 1.0 | RPS6KA1 RPS6KA2 RPS6KA3 | Senescence-Associated Secretory Phenotype (SASP) |
| REAC:R-HSA-187037 | 6.87958196908e-05 | 1.0 | RPS6KA1 RPS6KA2 RPS6KA3 | Signaling by NTRK1 (TRKA) |
| REAC:R-HSA-181438 | 6.87958196908e-05 | 1.0 | RPS6KA1 RPS6KA2 RPS6KA3 | Toll Like Receptor 2 (TLR2) Cascade |
| REAC:R-HSA-168179 | 6.87958196908e-05 | 1.0 | RPS6KA1 RPS6KA2 RPS6KA3 | Toll Like Receptor TLR1:TLR2 Cascade |
| KEGG:04714 | 7.39136996301e-05 | 1.0 | RPS6KA1 RPS6KA2 RPS6KA3 | Thermogenesis |
| REAC:R-HSA-373760 | 8.01155876351e-05 | 1.0 | RPS6KA1 RPS6KA2 RPS6KA3 | L1CAM interactions |
| REAC:R-HSA-166520 | 0.000112201017269 | 1.0 | RPS6KA1 RPS6KA2 RPS6KA3 | Signaling by NTRKs |
| KEGG:04010 | 0.000123391020622 | 1.0 | RPS6KA1 RPS6KA2 RPS6KA3 | MAPK signaling pathway |
| REAC:R-HSA-166016 | 0.000141203606556 | 1.0 | RPS6KA1 RPS6KA2 RPS6KA3 | Toll Like Receptor 4 (TLR4) Cascade |
| REAC:R-HSA-416476 | 0.000170844040971 | 1.0 | RPS6KA1 RPS6KA2 RPS6KA3 | G alpha (q) signalling events |
| REAC:R-HSA-168898 | 0.000217987188301 | 1.0 | RPS6KA1 RPS6KA2 RPS6KA3 | Toll-like Receptor Cascades |
| REAC:R-HSA-112314 | 0.000300937850546 | 1.0 | RPS6KA1 RPS6KA2 RPS6KA3 | Neurotransmitter receptors and postsynaptic signal transmission |
| REAC:R-HSA-2559583 | 0.000409665014874 | 1.0 | RPS6KA1 RPS6KA2 RPS6KA3 | Cellular Senescence |
| REAC:R-HSA-112315 | 0.000640971827897 | 1.0 | RPS6KA1 RPS6KA2 RPS6KA3 | Transmission across Chemical Synapses |
| WP:WP4566 | 0.000927197171072 | 0.666666666667 | RPS6KA2 RPS6KA1 | Translation inhibitors in chronically activated PDGFRA cells |
| WP:WP304 | 0.00144101964081 | 0.666666666667 | RPS6KA3 RPS6KA1 | Kit receptor signaling pathway |
| REAC:R-HSA-112316 | 0.00203732306248 | 1.0 | RPS6KA1 RPS6KA2 RPS6KA3 | Neuronal System |
| WP:WP5353 | 0.00304949085786 | 0.666666666667 | RPS6KA3 RPS6KA1 | A network map of Macrophage stimulating protein MSP signaling |
| REAC:R-HSA-388396 | 0.00381272507886 | 1.0 | RPS6KA1 RPS6KA2 RPS6KA3 | GPCR downstream signalling |
| REAC:R-HSA-449147 | 0.00479274122097 | 1.0 | RPS6KA1 RPS6KA2 RPS6KA3 | Signaling by Interleukins |
| REAC:R-HSA-372790 | 0.00563898766183 | 1.0 | RPS6KA1 RPS6KA2 RPS6KA3 | Signaling by GPCR |
| REAC:R-HSA-9006934 | 0.00622622698696 | 1.0 | RPS6KA1 RPS6KA2 RPS6KA3 | Signaling by Receptor Tyrosine Kinases |
| WP:WP2380 | 0.00845205977617 | 0.666666666667 | RPS6KA3 RPS6KA1 | Brain derived neurotrophic factor BDNF signaling pathway |
| REAC:R-HSA-422475 | 0.00865423788864 | 1.0 | RPS6KA1 RPS6KA2 RPS6KA3 | Axon guidance |
| REAC:R-HSA-9675108 | 0.00966263043996 | 1.0 | RPS6KA1 RPS6KA2 RPS6KA3 | Nervous system development |
| REAC:R-HSA-1280215 | 0.01747853546 | 1.0 | RPS6KA1 RPS6KA2 RPS6KA3 | Cytokine Signaling in Immune system |
| REAC:R-HSA-2262752 | 0.0292688889279 | 1.0 | RPS6KA1 RPS6KA2 RPS6KA3 | Cellular responses to stress |
| REAC:R-HSA-8953897 | 0.0301284815898 | 1.0 | RPS6KA1 RPS6KA2 RPS6KA3 | Cellular responses to stimuli |
| REAC:R-HSA-1266738 | 0.0482660739102 | 1.0 | RPS6KA1 RPS6KA2 RPS6KA3 | Developmental Biology |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| RPS6KA3 | RPS6KA2 | 0.999 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only | |
| RPS6KA3 | RPS6KA1 | 0.998 | 0.154 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only |
| RPS6KA1 | RPS6KA2 | 0.992 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes