hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_08883.1
Confidence: High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| UBE2D4 | Ubiquitin-conjugating enzyme E2 D4 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme D4) (HBUCE1) (Ubiquitin carrier protein D4) (Ubiquitin-protein ligase D4) | 5 | UniProt NCBI |
| UBE2E2 | Ubiquitin-conjugating enzyme E2 E2 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme E2) (UbcH8) (Ubiquitin carrier protein E2) (Ubiquitin-protein ligase E2) | 5 | UniProt NCBI |
| UBE2D1 | Ubiquitin-conjugating enzyme E2 D1 (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme D1) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme D1) (Stimulator of Fe transport) (SFT) (UBC4/5 homolog) (UbcH5) (Ubiquitin carrier protein D1) (Ubiquitin-conjugating enzyme E2(17)KB 1) (Ubiquitin-conjugating enzyme E2-17 kDa 1) (Ubiquitin-protein ligase D1) | 5 | UniProt NCBI |
| UBE2D2 | Ubiquitin-conjugating enzyme E2 D2 (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme D2) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme D2) (Ubiquitin carrier protein D2) (Ubiquitin-conjugating enzyme E2(17)KB 2) (Ubiquitin-conjugating enzyme E2-17 kDa 2) (Ubiquitin-protein ligase D2) (p53-regulated ubiquitin-conjugating enzyme 1) | 5 | UniProt NCBI |
| RNF25 | E3 ubiquitin-protein ligase RNF25 (EC 2.3.2.27) (RING finger protein 25) (RING finger protein AO7) | 5 | UniProt NCBI |
| OTUB1 | Ubiquitin thioesterase OTUB1 (EC 3.4.19.12) (Deubiquitinating enzyme OTUB1) (OTU domain-containing ubiquitin aldehyde-binding protein 1) (Otubain-1) (hOTU1) (Ubiquitin-specific-processing protease OTUB1) | 5 | UniProt NCBI |
| UBE2D3 | Ubiquitin-conjugating enzyme E2 D3 (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme D3) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme D3) (Ubiquitin carrier protein D3) (Ubiquitin-conjugating enzyme E2(17)KB 3) (Ubiquitin-conjugating enzyme E2-17 kDa 3) (Ubiquitin-protein ligase D3) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0061631 | 2.68699780911e-08 | 0.714285714286 | UBE2D4 UBE2D3 UBE2D2 UBE2D1 UBE2E2 | ubiquitin conjugating enzyme activity |
| GO:0061650 | 6.1175480481e-08 | 0.714285714286 | UBE2D4 UBE2D3 UBE2D2 UBE2D1 UBE2E2 | ubiquitin-like protein conjugating enzyme activity |
| REAC:R-HSA-983168 | 6.53511311138e-08 | 0.857142857143 | RNF25 UBE2E2 UBE2D2 UBE2D1 UBE2D3 UBE2D4 | Antigen processing: Ubiquitination & Proteasome degradation |
| KEGG:04120 | 6.74214704969e-08 | 0.714285714286 | UBE2D4 UBE2D3 UBE2D2 UBE2D1 UBE2E2 | Ubiquitin mediated proteolysis |
| REAC:R-HSA-983169 | 2.24325333482e-07 | 0.857142857143 | RNF25 UBE2E2 UBE2D2 UBE2D1 UBE2D3 UBE2D4 | Class I MHC mediated antigen processing & presentation |
| KEGG:03083 | 1.57924080729e-06 | 0.571428571429 | UBE2D4 UBE2D3 UBE2D2 UBE2D1 | Polycomb repressive complex |
| GO:0070936 | 2.62550964059e-06 | 0.714285714286 | UBE2D4 UBE2D3 UBE2D2 UBE2D1 UBE2E2 | protein K48-linked ubiquitination |
| GO:0000209 | 3.45773769452e-06 | 0.857142857143 | RNF25 UBE2E2 UBE2D2 UBE2D1 UBE2D3 UBE2D4 | protein polyubiquitination |
| REAC:R-HSA-1280218 | 1.12246516662e-05 | 0.857142857143 | RNF25 UBE2E2 UBE2D2 UBE2D1 UBE2D3 UBE2D4 | Adaptive Immune System |
| REAC:R-HSA-168927 | 1.25938591632e-05 | 0.428571428571 | UBE2D1 UBE2D2 UBE2D3 | TICAM1, RIP1-mediated IKK complex recruitment |
| REAC:R-HSA-937041 | 1.48132609528e-05 | 0.428571428571 | UBE2D1 UBE2D2 UBE2D3 | IKK complex recruitment mediated by RIP1 |
| GO:0070647 | 1.65049967933e-05 | 1.0 | OTUB1 UBE2E2 UBE2D2 UBE2D1 UBE2D4 UBE2D3 RNF25 | protein modification by small protein conjugation or removal |
| KEGG:04141 | 2.22555639889e-05 | 0.571428571429 | UBE2D4 UBE2D3 UBE2D2 UBE2D1 | Protein processing in endoplasmic reticulum |
| REAC:R-HSA-9705462 | 2.29983491089e-05 | 0.428571428571 | UBE2D1 UBE2D2 UBE2D3 | Inactivation of CSF3 (G-CSF) signaling |
| GO:0043687 | 2.61778064538e-05 | 1.0 | OTUB1 UBE2E2 UBE2D2 UBE2D1 UBE2D4 UBE2D3 RNF25 | post-translational protein modification |
| REAC:R-HSA-9674555 | 4.24987071653e-05 | 0.428571428571 | UBE2D1 UBE2D2 UBE2D3 | Signaling by CSF3 (G-CSF) |
| GO:0004842 | 5.58899145539e-05 | 0.857142857143 | RNF25 UBE2E2 UBE2D2 UBE2D1 UBE2D3 UBE2D4 | ubiquitin-protein transferase activity |
| REAC:R-HSA-936440 | 7.07065782066e-05 | 0.428571428571 | UBE2D1 UBE2D2 UBE2D3 | Negative regulators of DDX58/IFIH1 signaling |
| GO:0019787 | 8.95265998312e-05 | 0.857142857143 | RNF25 UBE2E2 UBE2D2 UBE2D1 UBE2D3 UBE2D4 | ubiquitin-like protein transferase activity |
| KEGG:05131 | 9.98209485344e-05 | 0.571428571429 | UBE2D4 UBE2D3 UBE2D2 UBE2D1 | Shigellosis |
| GO:0016755 | 0.00011008224453 | 0.857142857143 | RNF25 UBE2E2 UBE2D2 UBE2D1 UBE2D3 UBE2D4 | aminoacyltransferase activity |
| REAC:R-HSA-5357905 | 0.000171246735353 | 0.428571428571 | UBE2D1 UBE2D2 UBE2D3 | Regulation of TNFR1 signaling |
| WP:WP183 | 0.00021674375056 | 0.428571428571 | UBE2D1 UBE2D2 UBE2D3 | Proteasome degradation |
| REAC:R-HSA-9033241 | 0.000223455724258 | 0.428571428571 | UBE2D1 UBE2D2 UBE2D3 | Peroxisomal protein import |
| REAC:R-HSA-75893 | 0.00030234111687 | 0.428571428571 | UBE2D1 UBE2D2 UBE2D3 | TNF signaling |
| REAC:R-HSA-8866654 | 0.000320060028097 | 0.428571428571 | UBE2D1 UBE2D2 UBE2D3 | E3 ubiquitin ligases ubiquitinate target proteins |
| REAC:R-HSA-1234176 | 0.000511465276813 | 0.428571428571 | UBE2D1 UBE2D2 UBE2D3 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha |
| GO:0016567 | 0.000646842943794 | 0.857142857143 | RNF25 UBE2E2 UBE2D2 UBE2D1 UBE2D3 UBE2D4 | protein ubiquitination |
| REAC:R-HSA-1234174 | 0.000704018847769 | 0.428571428571 | UBE2D1 UBE2D2 UBE2D3 | Cellular response to hypoxia |
| REAC:R-HSA-8852135 | 0.000833024196193 | 0.428571428571 | UBE2D1 UBE2D2 UBE2D3 | Protein ubiquitination |
| REAC:R-HSA-168928 | 0.000867554862533 | 0.428571428571 | UBE2D1 UBE2D2 UBE2D3 | DDX58/IFIH1-mediated induction of interferon-alpha/beta |
| GO:0016746 | 0.00104430392014 | 0.857142857143 | RNF25 UBE2E2 UBE2D2 UBE2D1 UBE2D3 UBE2D4 | acyltransferase activity |
| GO:0085020 | 0.00122180600483 | 0.428571428571 | UBE2D4 RNF25 UBE2D3 | protein K6-linked ubiquitination |
| GO:0032446 | 0.00139888544054 | 0.857142857143 | RNF25 UBE2E2 UBE2D2 UBE2D1 UBE2D3 UBE2D4 | protein modification by small protein conjugation |
| GO:0031625 | 0.00140854347899 | 0.714285714286 | OTUB1 UBE2D4 UBE2D3 UBE2D2 UBE2D1 | ubiquitin protein ligase binding |
| REAC:R-HSA-168164 | 0.00155569177621 | 0.428571428571 | UBE2D1 UBE2D2 UBE2D3 | Toll Like Receptor 3 (TLR3) Cascade |
| REAC:R-HSA-937061 | 0.0016610504278 | 0.428571428571 | UBE2D1 UBE2D2 UBE2D3 | TRIF(TICAM1)-mediated TLR4 signaling |
| REAC:R-HSA-166166 | 0.0016610504278 | 0.428571428571 | UBE2D1 UBE2D2 UBE2D3 | MyD88-independent TLR4 cascade |
| GO:0044389 | 0.00188817498962 | 0.714285714286 | OTUB1 UBE2D4 UBE2D3 UBE2D2 UBE2D1 | ubiquitin-like protein ligase binding |
| REAC:R-HSA-168256 | 0.00286965709282 | 0.857142857143 | RNF25 UBE2E2 UBE2D2 UBE2D1 UBE2D3 UBE2D4 | Immune System |
| REAC:R-HSA-166016 | 0.00384976500914 | 0.428571428571 | UBE2D1 UBE2D2 UBE2D3 | Toll Like Receptor 4 (TLR4) Cascade |
| REAC:R-HSA-73887 | 0.00423749994086 | 0.428571428571 | UBE2D1 UBE2D2 UBE2D3 | Death Receptor Signaling |
| REAC:R-HSA-9609507 | 0.00520230847661 | 0.428571428571 | UBE2D1 UBE2D2 UBE2D3 | Protein localization |
| REAC:R-HSA-168898 | 0.00591992337161 | 0.428571428571 | UBE2D1 UBE2D2 UBE2D3 | Toll-like Receptor Cascades |
| GO:0070979 | 0.0109646664486 | 0.428571428571 | UBE2D4 UBE2D3 UBE2E2 | protein K11-linked ubiquitination |
| REAC:R-HSA-201451 | 0.0113729617035 | 0.285714285714 | UBE2D1 UBE2D3 | Signaling by BMP |
| GO:0140096 | 0.0143665978048 | 1.0 | OTUB1 UBE2E2 UBE2D2 UBE2D1 UBE2D4 UBE2D3 RNF25 | catalytic activity, acting on a protein |
| REAC:R-HSA-2173795 | 0.0153773615715 | 0.285714285714 | UBE2D1 UBE2D3 | Downregulation of SMAD2/3:SMAD4 transcriptional activity |
| REAC:R-HSA-8866652 | 0.0164719839916 | 0.285714285714 | UBE2D1 UBE2D2 | Synthesis of active ubiquitin: roles of E1 and E2 enzymes |
| REAC:R-HSA-5689896 | 0.0225049419259 | 0.285714285714 | UBE2D1 OTUB1 | Ovarian tumor domain proteases |
| REAC:R-HSA-8951664 | 0.0233324089042 | 0.428571428571 | UBE2D1 UBE2D2 UBE2D3 | Neddylation |
| GO:0006511 | 0.0416503840831 | 0.714285714286 | UBE2D4 UBE2D3 UBE2D2 RNF25 UBE2D1 | ubiquitin-dependent protein catabolic process |
| GO:0019941 | 0.0451283589106 | 0.714285714286 | UBE2D4 UBE2D3 UBE2D2 RNF25 UBE2D1 | modification-dependent protein catabolic process |
| REAC:R-HSA-2173793 | 0.0461752771557 | 0.285714285714 | UBE2D1 UBE2D3 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| RNF25 | UBE2D2 | 0.999 | 0.088 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| RNF25 | UBE2D3 | 0.998 | 0.064 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| RNF25 | UBE2D1 | 0.997 | 0.144 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only |
| RNF25 | UBE2D4 | 0.99 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| UBE2E2 | OTUB1 | 0.988 | 0.082 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| RNF25 | UBE2E2 | 0.984 | 0.046 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| UBE2D2 | OTUB1 | 0.982 | 0.246 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 |
| UBE2D3 | UBE2D1 | 0.975 | 0.369636363636 | bioplex3_HEK293 bioplex3_WMM WMM_only |
| UBE2D3 | UBE2D2 | 0.975 | 0.22 | bioplex_WMM bioplex3_WMM WMM_only |
| UBE2D4 | OTUB1 | 0.963 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| UBE2D3 | UBE2D4 | 0.909 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only | |
| RNF25 | OTUB1 | 0.562 | 0.084 | bioplex_WMM bioplex3_WMM WMM_only |
| UBE2D4 | UBE2E2 | 0.502 | bioplex_WMM bioplex3_WMM WMM_only | |
| UBE2D2 | UBE2D1 | 0.388 | 0.308 | bioplex3_WMM youn_WMM WMM_only |
| UBE2D1 | OTUB1 | 0.259 | 0.272 | bioplex3_HEK293 bioplex3_WMM WMM_only |
| UBE2D1 | UBE2E2 | 0.214 | 0.214 | bioplex3_WMM WMM_only |
| UBE2D1 | UBE2D4 | 0.214 | bioplex3_WMM WMM_only | |
| UBE2D3 | UBE2E2 | 0.153 | 0.062 | bioplex_WMM bioplex3_WMM WMM_only |
| UBE2D2 | UBE2D4 | 0.15 | bioplex_WMM bioplex3_WMM WMM_only | |
| UBE2D2 | UBE2E2 | 0.143 | 0.15 | bioplex_WMM bioplex3_WMM WMM_only |
| UBE2D3 | OTUB1 | 0.034 | 0.396 | bioplex_WMM bioplex3_WMM gupta_WMM WMM_only treiber_WMM |
Related Complexes