hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_08889.1
Complex Portal: CPX-12974
Confidence: High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| PLAT | Tissue-type plasminogen activator (t-PA) (t-plasminogen activator) (tPA) (EC 3.4.21.68) (Alteplase) (Reteplase) [Cleaved into: Tissue-type plasminogen activator chain A; Tissue-type plasminogen activator chain B] | 5 | UniProt NCBI |
| SERPING1 | Plasma protease C1 inhibitor (C1 Inh) (C1Inh) (C1 esterase inhibitor) (C1-inhibiting factor) (Serpin G1) | 5 | UniProt NCBI |
| SERPINF2 | Alpha-2-antiplasmin (Alpha-2-AP) (Alpha-2-plasmin inhibitor) (Alpha-2-PI) (Serpin F2) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP558 | 1.2569245694e-06 | 1.0 | SERPINF2 PLAT SERPING1 | Complement and coagulation cascades |
| KEGG:04610 | 2.98572877594e-06 | 1.0 | SERPINF2 PLAT SERPING1 | Complement and coagulation cascades |
| WP:WP272 | 0.000173183276299 | 0.666666666667 | PLAT SERPINF2 | Blood clotting cascade |
| REAC:R-HSA-75205 | 0.000531572756485 | 0.666666666667 | PLAT SERPINF2 | Dissolution of Fibrin Clot |
| HPA:0471431 | 0.00297211905194 | 0.666666666667 | PLAT SERPING1 | skin 2; extracellular matrix[>=Low] |
| REAC:R-HSA-109582 | 0.0111889093738 | 1.0 | SERPINF2 PLAT SERPING1 | Hemostasis |
| GO:0010757 | 0.0210651876021 | 0.666666666667 | PLAT SERPINF2 | negative regulation of plasminogen activation |
| REAC:R-HSA-114608 | 0.037053837229 | 0.666666666667 | SERPING1 SERPINF2 | Platelet degranulation |
| REAC:R-HSA-76005 | 0.0406752460979 | 0.666666666667 | SERPING1 SERPINF2 | Response to elevated platelet cytosolic Ca2+ |
| WP:WP5089 | 0.0413734636003 | 0.333333333333 | SERPING1 | Kinin Kallikrein pathway |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| PLAT | SERPING1 | 0.993 | 0.1976 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| SERPINF2 | PLAT | 0.962 | 0.31 |
mutually_exclusive (P05155)
|
bioplex3_HEK293 bioplex3_WMM WMM_only |
| SERPINF2 | SERPING1 | 0.384 | 0.388 |
structurally_consistent (dimer)
|
bioplex3_WMM WMM_only |
Related Complexes
| Genename | Complexes |
|---|---|
| PLAT | huMAP3_03904.1 huMAP3_08889.1 |
| SERPING1 | huMAP3_08889.1 huMAP3_09273.1 huMAP3_09531.1 huMAP3_10101.1 huMAP3_10678.1 huMAP3_15040.1 |
| SERPINF2 | huMAP3_00178.1 huMAP3_03904.1 huMAP3_05943.1 huMAP3_07119.1 huMAP3_08889.1 huMAP3_11660.1 huMAP3_14445.1 huMAP3_14656.1 |