hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_08899.1
Confidence: High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| CCDC61 | Centrosomal protein CCDC61 (Coiled-coil domain-containing protein 61) (VFL3 homolog) | 5 | UniProt NCBI |
| IQCB1 | IQ calmodulin-binding motif-containing protein 1 (Nephrocystin-5) (p53 and DNA damage-regulated IQ motif protein) (PIQ) | 5 | UniProt NCBI |
| CEP290 | Centrosomal protein of 290 kDa (Cep290) (Bardet-Biedl syndrome 14 protein) (Cancer/testis antigen 87) (CT87) (Nephrocystin-6) (Tumor antigen se2-2) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:6597 | 3.41752350426e-06 | 0.666666666667 | IQCB1 CEP290 | CEP290-IQCB1 complex |
| WP:WP5234 | 0.00321742070882 | 0.666666666667 | IQCB1 CEP290 | Bardet Biedl syndrome |
| HP:0000090 | 0.00708857159683 | 0.666666666667 | IQCB1 CEP290 | Nephronophthisis |
| HP:0001141 | 0.00888120343534 | 0.666666666667 | IQCB1 CEP290 | Severely reduced visual acuity |
| HP:0002612 | 0.00936084070842 | 0.666666666667 | IQCB1 CEP290 | Congenital hepatic fibrosis |
| WP:WP4803 | 0.0135986549013 | 0.666666666667 | IQCB1 CEP290 | Ciliopathies |
| HP:0100957 | 0.0180650213362 | 0.666666666667 | IQCB1 CEP290 | Abnormal renal medulla morphology |
| HP:0008209 | 0.0208637442425 | 0.666666666667 | IQCB1 CEP290 | Premature ovarian insufficiency |
| WP:WP4352 | 0.0243888015773 | 0.666666666667 | IQCB1 CEP290 | Ciliary landscape |
| REAC:R-HSA-5620912 | 0.0290482612381 | 0.666666666667 | IQCB1 CEP290 | Anchoring of the basal body to the plasma membrane |
| HP:0010579 | 0.0304647837379 | 0.666666666667 | IQCB1 CEP290 | Cone-shaped epiphysis |
| HP:0031066 | 0.037868427304 | 0.666666666667 | IQCB1 CEP290 | Abnormal ovarian physiology |
| HP:0000563 | 0.0482497424485 | 0.666666666667 | IQCB1 CEP290 | Keratoconus |
| CORUM:6594 | 0.0499402709677 | 0.333333333333 | CEP290 | CCP110-CEP290 complex |
| CORUM:6598 | 0.0499402709677 | 0.333333333333 | CEP290 | CC2D2A-CEP290 complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| IQCB1 | CEP290 | 0.987 | 0.228 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM gupta () boldt hein () gupta_WMM boldt_WMM |
| CEP290 | CCDC61 | 0.959 | 0.312816326531 | hein_WMM gupta_WMM gupta () WMM_only |
| IQCB1 | CCDC61 | 0.01 | 0.166 | gupta_WMM WMM_only |
Related Complexes