hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_08904.1
Complex Portal: CPX-23745
Confidence: High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| POLDIP3 | Polymerase delta-interacting protein 3 (46 kDa DNA polymerase delta interaction protein) (p46) (S6K1 Aly/REF-like target) (SKAR) | 5 | UniProt NCBI |
| NCBP3 | Nuclear cap-binding protein subunit 3 (Protein ELG) | 5 | UniProt NCBI |
| THOC6 | THO complex subunit 6 homolog (Functional spliceosome-associated protein 35) (fSAP35) (WD repeat-containing protein 58) | 5 | UniProt NCBI |
| RSPO1 | R-spondin-1 (Roof plate-specific spondin-1) (hRspo1) | 5 | UniProt NCBI |
| DDX39A | ATP-dependent RNA helicase DDX39A (EC 3.6.4.13) (DEAD box protein 39) (Nuclear RNA helicase URH49) | 5 | UniProt NCBI |
| ALYREF | THO complex subunit 4 (Tho4) (Ally of AML-1 and LEF-1) (Aly/REF export factor) (Transcriptional coactivator Aly/REF) (bZIP-enhancing factor BEF) | 5 | UniProt NCBI |
| THOC3 | THO complex subunit 3 (Tho3) (TEX1 homolog) (hTREX45) | 5 | UniProt NCBI |
| THOC2 | THO complex subunit 2 (Tho2) (hTREX120) | 5 | UniProt NCBI |
| CHTOP | Chromatin target of PRMT1 protein (Friend of PRMT1 protein) (Small arginine- and glycine-rich protein) (SRAG) | 5 | UniProt NCBI |
| DDX39B | Spliceosome RNA helicase DDX39B (EC 3.6.4.13) (56 kDa U2AF65-associated protein) (ATP-dependent RNA helicase p47) (DEAD box protein UAP56) (HLA-B-associated transcript 1 protein) | 5 | UniProt NCBI |
| FYTTD1 | UAP56-interacting factor (Forty-two-three domain-containing protein 1) (Protein 40-2-3) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0006406 | 2.20522626394e-16 | 0.9 | DDX39A FYTTD1 THOC6 THOC3 CHTOP DDX39B POLDIP3 NCBP3 THOC2 | mRNA export from nucleus |
| REAC:R-HSA-72187 | 2.55375421284e-16 | 0.8 | DDX39A FYTTD1 THOC6 THOC3 DDX39B POLDIP3 CHTOP THOC2 | mRNA 3'-end processing |
| GO:0051028 | 5.06897744375e-16 | 0.9 | DDX39A FYTTD1 THOC6 THOC3 CHTOP DDX39B POLDIP3 NCBP3 THOC2 | mRNA transport |
| REAC:R-HSA-73856 | 8.11517670097e-16 | 0.8 | DDX39A FYTTD1 THOC6 THOC3 DDX39B POLDIP3 CHTOP THOC2 | RNA Polymerase II Transcription Termination |
| REAC:R-HSA-159236 | 1.97641943565e-15 | 0.8 | DDX39A FYTTD1 THOC6 THOC3 DDX39B POLDIP3 CHTOP THOC2 | Transport of Mature mRNA derived from an Intron-Containing Transcript |
| GO:0006405 | 2.45013265731e-15 | 0.9 | DDX39A FYTTD1 THOC6 THOC3 CHTOP DDX39B POLDIP3 NCBP3 THOC2 | RNA export from nucleus |
| REAC:R-HSA-72202 | 5.45590966423e-15 | 0.8 | DDX39A FYTTD1 THOC6 THOC3 DDX39B POLDIP3 CHTOP THOC2 | Transport of Mature Transcript to Cytoplasm |
| GO:0050658 | 2.13071987843e-14 | 0.9 | DDX39A FYTTD1 THOC6 THOC3 CHTOP DDX39B POLDIP3 NCBP3 THOC2 | RNA transport |
| GO:0050657 | 2.13071987843e-14 | 0.9 | DDX39A FYTTD1 THOC6 THOC3 CHTOP DDX39B POLDIP3 NCBP3 THOC2 | nucleic acid transport |
| GO:0051236 | 2.75887453671e-14 | 0.9 | DDX39A FYTTD1 THOC6 THOC3 CHTOP DDX39B POLDIP3 NCBP3 THOC2 | establishment of RNA localization |
| GO:0006403 | 2.59702585952e-13 | 0.9 | DDX39A FYTTD1 THOC6 THOC3 CHTOP DDX39B POLDIP3 NCBP3 THOC2 | RNA localization |
| GO:0051168 | 2.96144859743e-13 | 0.9 | DDX39A FYTTD1 THOC6 THOC3 CHTOP DDX39B POLDIP3 NCBP3 THOC2 | nuclear export |
| GO:0015931 | 4.62146882012e-13 | 0.9 | DDX39A FYTTD1 THOC6 THOC3 CHTOP DDX39B POLDIP3 NCBP3 THOC2 | nucleobase-containing compound transport |
| GO:0006913 | 3.9767910013e-11 | 0.9 | DDX39A FYTTD1 THOC6 THOC3 CHTOP DDX39B POLDIP3 NCBP3 THOC2 | nucleocytoplasmic transport |
| GO:0051169 | 3.9767910013e-11 | 0.9 | DDX39A FYTTD1 THOC6 THOC3 CHTOP DDX39B POLDIP3 NCBP3 THOC2 | nuclear transport |
| REAC:R-HSA-72203 | 1.45108678872e-10 | 0.8 | DDX39A FYTTD1 THOC6 THOC3 DDX39B POLDIP3 CHTOP THOC2 | Processing of Capped Intron-Containing Pre-mRNA |
| CORUM:770 | 2.82054434053e-10 | 0.4 | DDX39B THOC6 THOC3 THOC2 | TREX complex |
| GO:0000346 | 1.04653440308e-09 | 0.5 | DDX39B THOC6 CHTOP THOC3 THOC2 | transcription export complex |
| GO:0046784 | 1.93207287326e-07 | 0.4 | DDX39B THOC6 THOC3 THOC2 | viral mRNA export from host cell nucleus |
| GO:0044417 | 1.93207287326e-07 | 0.4 | DDX39B THOC6 THOC3 THOC2 | translocation of molecules into host |
| REAC:R-HSA-8953854 | 2.21197932626e-07 | 0.8 | DDX39A FYTTD1 THOC6 THOC3 DDX39B POLDIP3 CHTOP THOC2 | Metabolism of RNA |
| CORUM:6160 | 3.36408067008e-07 | 0.3 | THOC6 THOC3 THOC2 | hTREX84 complex |
| GO:0016607 | 7.24645069198e-06 | 0.7 | DDX39A FYTTD1 THOC6 NCBP3 DDX39B POLDIP3 CHTOP | nuclear speck |
| REAC:R-HSA-73857 | 1.29782281188e-05 | 0.8 | DDX39A FYTTD1 THOC6 THOC3 DDX39B POLDIP3 CHTOP THOC2 | RNA Polymerase II Transcription |
| KEGG:03013 | 2.20057011919e-05 | 0.4 | DDX39B THOC6 THOC3 THOC2 | Nucleocytoplasmic transport |
| GO:0071705 | 2.87777511018e-05 | 0.9 | DDX39A FYTTD1 THOC6 THOC3 CHTOP DDX39B POLDIP3 NCBP3 THOC2 | nitrogen compound transport |
| GO:0046907 | 2.99986682905e-05 | 0.9 | DDX39A FYTTD1 THOC6 THOC3 CHTOP DDX39B POLDIP3 NCBP3 THOC2 | intracellular transport |
| REAC:R-HSA-74160 | 3.48228100394e-05 | 0.8 | DDX39A FYTTD1 THOC6 THOC3 DDX39B POLDIP3 CHTOP THOC2 | Gene expression (Transcription) |
| CORUM:351 | 0.000108429290393 | 0.4 | DDX39B THOC6 THOC3 THOC2 | Spliceosome |
| GO:0071702 | 0.000175683706472 | 0.9 | DDX39A FYTTD1 THOC6 THOC3 CHTOP DDX39B POLDIP3 NCBP3 THOC2 | organic substance transport |
| GO:0000445 | 0.0002304395259 | 0.3 | THOC6 THOC3 THOC2 | THO complex part of transcription export complex |
| GO:0000347 | 0.0002304395259 | 0.3 | THOC6 THOC3 THOC2 | THO complex |
| GO:0051649 | 0.000279066091397 | 0.9 | DDX39A FYTTD1 THOC6 THOC3 CHTOP DDX39B POLDIP3 NCBP3 THOC2 | establishment of localization in cell |
| CORUM:774 | 0.000307240465423 | 0.2 | THOC6 THOC2 | THO complex |
| HPA:0460643 | 0.00137479109622 | 0.5 | DDX39B CHTOP FYTTD1 NCBP3 THOC2 | skin 1; Langerhans[High] |
| HPA:0470683 | 0.00149413052618 | 0.6 | FYTTD1 NCBP3 DDX39B POLDIP3 CHTOP THOC2 | skin 2; epidermal cells[High] |
| GO:0016604 | 0.00187652761406 | 0.7 | DDX39A FYTTD1 THOC6 NCBP3 DDX39B POLDIP3 CHTOP | nuclear body |
| HPA:0490693 | 0.00220214226468 | 0.5 | DDX39B CHTOP FYTTD1 NCBP3 THOC2 | smooth muscle; smooth muscle cells[High] |
| HPA:0620223 | 0.00253814295094 | 0.6 | FYTTD1 THOC3 NCBP3 DDX39B THOC2 CHTOP | vagina; squamous epithelial cells[High] |
| HPA:0060103 | 0.00273661010257 | 0.7 | FYTTD1 THOC3 NCBP3 DDX39B POLDIP3 CHTOP THOC2 | bronchus; respiratory epithelial cells[High] |
| HPA:0460663 | 0.00278635984855 | 0.5 | DDX39B CHTOP FYTTD1 NCBP3 THOC2 | skin 1; keratinocytes[High] |
| GO:0006810 | 0.00294091790142 | 1.0 | CHTOP DDX39A FYTTD1 THOC6 THOC3 NCBP3 DDX39B POLDIP3 RSPO1 THOC2 | transport |
| HPA:0330223 | 0.00294262071087 | 0.6 | THOC3 NCBP3 FYTTD1 POLDIP3 CHTOP THOC2 | oral mucosa; squamous epithelial cells[High] |
| KEGG:03040 | 0.00353228654663 | 0.3 | DDX39B THOC3 THOC2 | Spliceosome |
| HPA:0380513 | 0.0039301289462 | 0.6 | FYTTD1 THOC3 NCBP3 DDX39B THOC2 CHTOP | placenta; decidual cells[High] |
| HPA:0610833 | 0.005272601598 | 0.7 | FYTTD1 THOC3 NCBP3 DDX39B POLDIP3 CHTOP THOC2 | urinary bladder; urothelial cells[High] |
| GO:0033036 | 0.00570021213464 | 0.9 | DDX39A FYTTD1 THOC6 THOC3 CHTOP DDX39B POLDIP3 NCBP3 THOC2 | macromolecule localization |
| GO:0051234 | 0.00732138304297 | 1.0 | CHTOP DDX39A FYTTD1 THOC6 THOC3 NCBP3 DDX39B POLDIP3 RSPO1 THOC2 | establishment of localization |
| HPA:0340463 | 0.00779741013231 | 0.4 | CHTOP POLDIP3 THOC2 NCBP3 | ovary; ovarian stroma cells[High] |
| HPA:0440343 | 0.0105955198196 | 0.5 | DDX39B CHTOP FYTTD1 NCBP3 THOC2 | skeletal muscle; myocytes[High] |
| HPA:0190223 | 0.0218133120002 | 0.6 | FYTTD1 THOC3 NCBP3 DDX39B THOC2 CHTOP | esophagus; squamous epithelial cells[High] |
| GO:0003729 | 0.0265327626105 | 0.5 | FYTTD1 CHTOP POLDIP3 THOC2 NCBP3 | mRNA binding |
| HPA:0630223 | 0.0282884693364 | 0.5 | DDX39B CHTOP FYTTD1 NCBP3 THOC2 | cervix; squamous epithelial cells[High] |
| GO:0051179 | 0.0339375137834 | 1.0 | CHTOP DDX39A FYTTD1 THOC6 THOC3 NCBP3 DDX39B POLDIP3 RSPO1 THOC2 | localization |
| HPA:0320103 | 0.034154447049 | 0.6 | THOC3 NCBP3 DDX39B POLDIP3 CHTOP THOC2 | nasopharynx; respiratory epithelial cells[High] |
| GO:0051641 | 0.0345887146099 | 0.9 | DDX39A FYTTD1 THOC6 THOC3 CHTOP DDX39B POLDIP3 NCBP3 THOC2 | cellular localization |
| GO:0051701 | 0.035560081123 | 0.4 | DDX39B THOC6 THOC3 THOC2 | biological process involved in interaction with host |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap |
|---|---|---|---|---|
| THOC6 | THOC3 | 1.0 | 0.342 |
structurally_consistent (dimer)
|
| THOC6 | THOC2 | 1.0 | 0.874 | |
| THOC3 | THOC2 | 1.0 | 0.46 |
structurally_consistent (dimer)
|
| CHTOP | FYTTD1 | 1.0 | 0.086 | |
| THOC6 | NCBP3 | 0.999 | 0.448 | |
| ALYREF | CHTOP | 0.999 | 0.572 | |
| THOC2 | DDX39B | 0.999 | 0.458 |
structurally_consistent (dimer)
|
| THOC6 | DDX39B | 0.999 | 0.408 | |
| DDX39B | NCBP3 | 0.998 | 0.208 | |
| DDX39A | DDX39B | 0.998 | 0.446 | |
| CHTOP | DDX39B | 0.998 | 0.684 | |
| THOC6 | DDX39A | 0.997 | 0.164 | |
| CHTOP | NCBP3 | 0.997 | 0.208 | |
| ALYREF | NCBP3 | 0.997 | 0.298 | |
| THOC2 | FYTTD1 | 0.997 | 0.208 | |
| FYTTD1 | NCBP3 | 0.996 | 0.114 | |
| RSPO1 | CHTOP | 0.995 | ||
| THOC2 | NCBP3 | 0.992 | 0.386 | |
| POLDIP3 | THOC6 | 0.992 | 0.304 |
structurally_consistent (dimer)
|
| CHTOP | THOC2 | 0.991 | 0.288 | |
| POLDIP3 | FYTTD1 | 0.99 | 0.194 | |
| DDX39A | NCBP3 | 0.99 | 0.086 |
mutually_exclusive (Q96J01)
|
| DDX39A | THOC2 | 0.989 | 0.174 |
mutually_exclusive (Q96J01)
structurally_consistent (dimer) |
| CHTOP | DDX39A | 0.988 | 0.13 |
mutually_exclusive (Q96J01)
|
| ALYREF | THOC2 | 0.988 | 0.674 |
mutually_exclusive (O00148)
|
| THOC3 | DDX39B | 0.986 | 0.238 | |
| THOC6 | FYTTD1 | 0.985 | 0.248 | |
| THOC3 | ALYREF | 0.984 | 0.246 |
structurally_consistent (dimer)
|
| THOC3 | FYTTD1 | 0.984 | 0.048 | |
| ALYREF | DDX39B | 0.983 | 0.816 | |
| THOC3 | NCBP3 | 0.98 | 0.108 |
structurally_consistent (dimer)
|
| DDX39A | FYTTD1 | 0.977 | 0.098 | |
| POLDIP3 | THOC2 | 0.975 | 0.562 | |
| POLDIP3 | ALYREF | 0.974 | 0.484 | |
| THOC3 | DDX39A | 0.974 | 0.128 |
structurally_consistent (dimer)
|
| POLDIP3 | NCBP3 | 0.973 | 0.184 | |
| THOC6 | CHTOP | 0.972 | 0.146 |
mutually_exclusive (Q96J01)
|
| ALYREF | DDX39A | 0.972 | 0.406 |
structurally_consistent (dimer)
|
| THOC3 | CHTOP | 0.97 | 0.134 |
mutually_exclusive (Q96A72)
structurally_consistent (dimer) |
| ALYREF | FYTTD1 | 0.962 | 0.13685 | |
| POLDIP3 | CHTOP | 0.96 | 0.322 | |
| THOC6 | ALYREF | 0.949 | 0.284 |
structurally_consistent (dimer)
|
| DDX39B | FYTTD1 | 0.937 | 0.09 | |
| POLDIP3 | DDX39B | 0.917 | 0.266 | |
| POLDIP3 | THOC3 | 0.914 | 0.234 |
mutually_exclusive (Q96A72)
|
| POLDIP3 | DDX39A | 0.866 | 0.3 |
structurally_consistent (dimer)
|
| THOC6 | RSPO1 | 0.038 | ||
| THOC3 | RSPO1 | 0.009 | ||
| RSPO1 | DDX39B | 0.008 | ||
| RSPO1 | ALYREF | 0.004 |
Related Complexes