hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_08906.1

Complex Portal: CPX-22069

Confidence: High

Genename	Protein Name	Uniprot Annotation Score	Links
GATAD2B	Transcriptional repressor p66-beta (GATA zinc finger domain-containing protein 2B) (p66/p68)	5	UniProt NCBI
RBBP4	Histone-binding protein RBBP4 (Chromatin assembly factor 1 subunit C) (CAF-1 subunit C) (Chromatin assembly factor I p48 subunit) (CAF-I 48 kDa subunit) (CAF-I p48) (Nucleosome-remodeling factor subunit RBAP48) (Retinoblastoma-binding protein 4) (RBBP-4) (Retinoblastoma-binding protein p48)	5	UniProt NCBI
SMARCA1	Probable global transcription activator SNF2L1 (EC 3.6.4.-) (ATP-dependent helicase SMARCA1) (Nucleosome-remodeling factor subunit SNF2L) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 1)	5	UniProt NCBI
BPTF	Nucleosome-remodeling factor subunit BPTF (Bromodomain and PHD finger-containing transcription factor) (Fetal Alz-50 clone 1 protein) (Fetal Alzheimer antigen)	5	UniProt NCBI
CHD5	Chromodomain-helicase-DNA-binding protein 5 (CHD-5) (EC 3.6.4.12) (ATP-dependent helicase CHD5)	5	UniProt NCBI
ZBTB2	Zinc finger and BTB domain-containing protein 2	5	UniProt NCBI
RBBP7	Histone-binding protein RBBP7 (Histone acetyltransferase type B subunit 2) (Nucleosome-remodeling factor subunit RBAP46) (Retinoblastoma-binding protein 7) (RBBP-7) (Retinoblastoma-binding protein p46)	5	UniProt NCBI
PWWP2B	PWWP domain-containing protein 2B	5	UniProt NCBI
ZNF512B	Zinc finger protein 512B	5	UniProt NCBI
SHPRH	E3 ubiquitin-protein ligase SHPRH (EC 2.3.2.27) (EC 3.6.4.-) (RING-type E3 ubiquitin transferase SHPRH) (SNF2, histone-linker, PHD and RING finger domain-containing helicase)	5	UniProt NCBI
SALL4	Sal-like protein 4 (Zinc finger protein 797) (Zinc finger protein SALL4)	5	UniProt NCBI
MBD2	Methyl-CpG-binding domain protein 2 (Demethylase) (DMTase) (Methyl-CpG-binding protein MBD2)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
CORUM:685	1.45017792512e-09	0.363636363636	RBBP7 MBD2 GATAD2B RBBP4	MeCP1 complex
CORUM:659	1.45017792512e-09	0.363636363636	RBBP7 MBD2 GATAD2B RBBP4	MeCP1 complex
GO:0016581	1.24498687632e-08	0.454545454545	CHD5 MBD2 GATAD2B RBBP7 RBBP4	NuRD complex
GO:0090545	1.24498687632e-08	0.454545454545	CHD5 MBD2 GATAD2B RBBP7 RBBP4	CHD-type complex
CORUM:919	2.10621603952e-08	0.272727272727	RBBP7 RBBP4 BPTF	hNURF complex
CORUM:100	2.10621603952e-08	0.272727272727	RBBP7 RBBP4 BPTF	hNURF complex
KEGG:03082	3.76951977061e-07	0.454545454545	RBBP7 BPTF MBD2 GATAD2B RBBP4	ATP-dependent chromatin remodeling
CORUM:62	1.17706123706e-06	0.272727272727	MBD2 RBBP4 RBBP7	MeCP1 complex
GO:0070603	1.1878044395e-06	0.545454545455	RBBP7 RBBP4 BPTF CHD5 GATAD2B MBD2	SWI/SNF superfamily-type complex
CORUM:646	1.76486676663e-06	0.272727272727	MBD2 RBBP4 RBBP7	HDAC1-associated protein complex
CORUM:649	1.76486676663e-06	0.272727272727	MBD2 RBBP4 RBBP7	HDAC1-associated core complex cII
CORUM:282	1.17319928104e-05	0.272727272727	MBD2 RBBP4 RBBP7	SNF2h-cohesin-NuRD complex
GO:1904949	1.47519352579e-05	0.545454545455	RBBP7 RBBP4 BPTF CHD5 GATAD2B MBD2	ATPase complex
REAC:R-HSA-8943724	1.74138924259e-05	0.363636363636	RBBP7 SALL4 GATAD2B RBBP4	Regulation of PTEN gene transcription
CORUM:778	2.02755307584e-05	0.272727272727	MBD2 GATAD2B RBBP4	LARC complex (LCR-associated remodeling complex)
GO:0000118	3.10831691296e-05	0.454545454545	CHD5 MBD2 GATAD2B RBBP7 RBBP4	histone deacetylase complex
GO:0006338	0.000155563544425	0.636363636364	PWWP2B RBBP4 BPTF CHD5 GATAD2B MBD2 RBBP7	chromatin remodeling
REAC:R-HSA-73854	0.00015675550649	0.363636363636	RBBP7 MBD2 GATAD2B RBBP4	RNA Polymerase I Promoter Clearance
REAC:R-HSA-73864	0.000163292886702	0.363636363636	RBBP7 MBD2 GATAD2B RBBP4	RNA Polymerase I Transcription
WP:WP4320	0.000253697493864	0.272727272727	MBD2 RBBP4 RBBP7	Effect of progerin on genes involved in Hutchinson Gilford progeria syndrome
REAC:R-HSA-6804758	0.000329950651236	0.272727272727	RBBP7 GATAD2B RBBP4	Regulation of TP53 Activity through Acetylation
CORUM:3048	0.000341558207359	0.181818181818	RBBP4 RBBP7	mSin3A complex
CORUM:889	0.000341558207359	0.181818181818	RBBP4 RBBP7	MTA1-HDAC core complex
CORUM:105	0.000341558207359	0.181818181818	RBBP4 RBBP7	Polycomb repressive complex 2 (PRC 2)
GO:0006325	0.000401078542902	0.636363636364	PWWP2B RBBP4 BPTF CHD5 GATAD2B MBD2 RBBP7	chromatin organization
CORUM:886	0.000512126948792	0.181818181818	RBBP4 RBBP7	MTA1 complex
GO:0016589	0.000554182028596	0.272727272727	RBBP7 RBBP4 BPTF	NURF complex
REAC:R-HSA-6807070	0.000566116726913	0.363636363636	RBBP7 SALL4 GATAD2B RBBP4	PTEN Regulation
CORUM:61	0.000716683342105	0.181818181818	RBBP4 RBBP7	Mi2/NuRD complex
CORUM:54	0.000716683342105	0.181818181818	RBBP4 RBBP7	SIN3 complex
CORUM:596	0.000716683342105	0.181818181818	RBBP4 RBBP7	SIN3-HDAC-SAP30-ARID4 complex
CORUM:650	0.000716683342105	0.181818181818	RBBP4 RBBP7	HDAC2-asscociated core complex
CORUM:695	0.000716683342105	0.181818181818	RBBP4 RBBP7	SIN3-HDAC-SAP30-ARID4 complex
CORUM:698	0.000716683342105	0.181818181818	RBBP4 RBBP7	SIN3-HDAC-SAP30-ARID4 complex
CORUM:732	0.000716683342105	0.181818181818	RBBP4 RBBP7	SIN3 complex
CORUM:283	0.000716683342105	0.181818181818	RBBP4 RBBP7	Sin3 complex
CORUM:587	0.000955185435728	0.181818181818	RBBP4 RBBP7	NuRD.1 complex
CORUM:591	0.000955185435728	0.181818181818	RBBP4 RBBP7	SAP complex (Sin3-associated protein complex)
CORUM:696	0.000955185435728	0.181818181818	RBBP4 RBBP7	BRMS1-SIN3-HDAC complex
CORUM:888	0.000955185435728	0.181818181818	RBBP4 RBBP7	MTA2 complex
GO:0045892	0.00102609437145	0.727272727273	RBBP4 BPTF ZNF512B CHD5 GATAD2B ZBTB2 MBD2 RBBP7	negative regulation of DNA-templated transcription
GO:0071824	0.001108873533	0.636363636364	PWWP2B RBBP4 BPTF CHD5 GATAD2B MBD2 RBBP7	protein-DNA complex organization
GO:1902679	0.00112317878821	0.727272727273	RBBP4 BPTF ZNF512B CHD5 GATAD2B ZBTB2 MBD2 RBBP7	negative regulation of RNA biosynthetic process
CORUM:592	0.00122759131257	0.181818181818	RBBP4 RBBP7	SAP complex (Sin3-associated protein complex)
CORUM:738	0.00122759131257	0.181818181818	RBBP4 RBBP7	SIN3-ING1b complex I
REAC:R-HSA-73762	0.00130859353099	0.272727272727	RBBP7 GATAD2B RBBP4	RNA Polymerase I Transcription Initiation
REAC:R-HSA-212165	0.00145095120366	0.363636363636	RBBP7 MBD2 GATAD2B RBBP4	Epigenetic regulation of gene expression
CORUM:691	0.00153385909002	0.181818181818	RBBP4 RBBP7	SIN3-SAP25 complex
CORUM:743	0.00153385909002	0.181818181818	RBBP4 RBBP7	SIN3-SAP25 complex
CORUM:2851	0.00187394691988	0.181818181818	RBBP4 RBBP7	ING2 complex
GO:0051253	0.0024230510168	0.727272727273	RBBP4 BPTF ZNF512B CHD5 GATAD2B ZBTB2 MBD2 RBBP7	negative regulation of RNA metabolic process
GO:0000122	0.00325254302622	0.636363636364	RBBP4 BPTF CHD5 GATAD2B ZBTB2 MBD2 RBBP7	negative regulation of transcription by RNA polymerase II
REAC:R-HSA-427389	0.00333896784021	0.272727272727	RBBP7 GATAD2B RBBP4	ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
CORUM:739	0.00408022457695	0.181818181818	RBBP4 RBBP7	SIN3-ING1b complex II
CORUM:2721	0.00408022457695	0.181818181818	RBBP4 RBBP7	HCF-1 complex
GO:0006355	0.00451084211889	0.909090909091	PWWP2B RBBP4 BPTF ZNF512B CHD5 GATAD2B SALL4 ZBTB2 MBD2 RBBP7	regulation of DNA-templated transcription
CORUM:632	0.00462235583528	0.181818181818	RBBP4 RBBP7	Anti-HDAC2 complex
REAC:R-HSA-1257604	0.00468418463907	0.363636363636	RBBP7 SALL4 GATAD2B RBBP4	PIP3 activates AKT signaling
GO:2001141	0.00478749411208	0.909090909091	PWWP2B RBBP4 BPTF ZNF512B CHD5 GATAD2B SALL4 ZBTB2 MBD2 RBBP7	regulation of RNA biosynthetic process
GO:0045934	0.00532192710495	0.727272727273	RBBP4 BPTF ZNF512B CHD5 GATAD2B ZBTB2 MBD2 RBBP7	negative regulation of nucleobase-containing compound metabolic process
HPA:0471383	0.00568047694226	0.181818181818	RBBP4 RBBP7	skin 2; arrector pili muscle cells[High]
GO:0031010	0.00574694403184	0.272727272727	RBBP7 RBBP4 BPTF	ISWI-type complex
WP:WP2916	0.00641421525353	0.181818181818	RBBP4 RBBP7	Interactome of polycomb repressive complex 2 PRC2
REAC:R-HSA-3214815	0.00654112583449	0.272727272727	RBBP7 GATAD2B RBBP4	HDACs deacetylate histones
GO:0006351	0.0071899107241	0.909090909091	PWWP2B RBBP4 BPTF ZNF512B CHD5 GATAD2B SALL4 ZBTB2 MBD2 RBBP7	DNA-templated transcription
REAC:R-HSA-9679191	0.00784735633052	0.272727272727	RBBP7 GATAD2B RBBP4	Potential therapeutics for SARS
GO:0032774	0.00798646080955	0.909090909091	PWWP2B RBBP4 BPTF ZNF512B CHD5 GATAD2B SALL4 ZBTB2 MBD2 RBBP7	RNA biosynthetic process
REAC:R-HSA-9006925	0.00817206080952	0.363636363636	RBBP7 SALL4 GATAD2B RBBP4	Intracellular signaling by second messengers
GO:0006357	0.00930963969897	0.818181818182	PWWP2B RBBP4 BPTF SALL4 CHD5 GATAD2B ZBTB2 MBD2 RBBP7	regulation of transcription by RNA polymerase II
REAC:R-HSA-5250913	0.0102761155863	0.272727272727	RBBP7 GATAD2B RBBP4	Positive epigenetic regulation of rRNA expression
GO:0005654	0.0105448660706	1.0	PWWP2B RBBP4 BPTF SHPRH ZNF512B CHD5 GATAD2B SALL4 ZBTB2 MBD2 RBBP7	nucleoplasm
CORUM:1257	0.0127895235697	0.181818181818	RBBP4 RBBP7	ALL-1 supercomplex
GO:0042659	0.012862104388	0.272727272727	RBBP7 GATAD2B RBBP4	regulation of cell fate specification
GO:0051252	0.0135387581616	0.909090909091	PWWP2B RBBP4 BPTF ZNF512B CHD5 GATAD2B SALL4 ZBTB2 MBD2 RBBP7	regulation of RNA metabolic process
GO:0006366	0.0148548770213	0.818181818182	PWWP2B RBBP4 BPTF SALL4 CHD5 GATAD2B ZBTB2 MBD2 RBBP7	transcription by RNA polymerase II
HPA:0471433	0.0183496241297	0.181818181818	RBBP4 RBBP7	skin 2; extracellular matrix[High]
GO:0031981	0.0214587900711	1.0	PWWP2B RBBP4 BPTF SHPRH ZNF512B CHD5 GATAD2B SALL4 ZBTB2 MBD2 RBBP7	nuclear lumen
GO:0034654	0.0273693774831	0.909090909091	PWWP2B RBBP4 BPTF ZNF512B CHD5 GATAD2B SALL4 ZBTB2 MBD2 RBBP7	nucleobase-containing compound biosynthetic process
GO:0010453	0.0318245054916	0.272727272727	RBBP7 GATAD2B RBBP4	regulation of cell fate commitment
GO:0018130	0.0327201680984	0.909090909091	PWWP2B RBBP4 BPTF ZNF512B CHD5 GATAD2B SALL4 ZBTB2 MBD2 RBBP7	heterocycle biosynthetic process
GO:0019438	0.0330622518626	0.909090909091	PWWP2B RBBP4 BPTF ZNF512B CHD5 GATAD2B SALL4 ZBTB2 MBD2 RBBP7	aromatic compound biosynthetic process
GO:0019219	0.0331769891161	0.909090909091	PWWP2B RBBP4 BPTF ZNF512B CHD5 GATAD2B SALL4 ZBTB2 MBD2 RBBP7	regulation of nucleobase-containing compound metabolic process
HPA:0471382	0.0381379224589	0.181818181818	RBBP4 RBBP7	skin 2; arrector pili muscle cells[>=Medium]
GO:1901362	0.0438918850918	0.909090909091	PWWP2B RBBP4 BPTF ZNF512B CHD5 GATAD2B SALL4 ZBTB2 MBD2 RBBP7	organic cyclic compound biosynthetic process
REAC:R-HSA-5633007	0.0443476855597	0.272727272727	RBBP7 GATAD2B RBBP4	Regulation of TP53 Activity

Edges

Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap
CHD5	GATAD2B	1.0	0.326
GATAD2B	MBD2	1.0	0.088
RBBP7	CHD5	1.0	0.134	structurally_consistent (dimer)
RBBP4	RBBP7	1.0	0.664	structurally_consistent (dimer)
RBBP4	GATAD2B	1.0	0.378
RBBP7	GATAD2B	0.999	0.104
RBBP4	CHD5	0.999	0.382
BPTF	RBBP7	0.999	0.094
ZBTB2	GATAD2B	0.999	0.157272727273
RBBP4	MBD2	0.998	0.044	structurally_consistent (dimer)
RBBP7	MBD2	0.998	0.064
RBBP4	PWWP2B	0.996		structurally_consistent (dimer)
RBBP4	BPTF	0.995	0.214
RBBP4	ZBTB2	0.993	0.264
SHPRH	RBBP7	0.993	0.218	structurally_consistent (dimer)
CHD5	MBD2	0.992	0.176
ZBTB2	MBD2	0.992	0.104
PWWP2B	RBBP7	0.99
RBBP7	ZBTB2	0.99	0.227130434783	structurally_consistent (dimer)
SALL4	GATAD2B	0.987
ZNF512B	GATAD2B	0.986	0.082
ZNF512B	RBBP7	0.984	0.132
RBBP4	SALL4	0.983
SALL4	MBD2	0.981
RBBP4	ZNF512B	0.979	0.294
ZNF512B	MBD2	0.977	0.174
RBBP4	SMARCA1	0.972	0.216
RBBP4	SHPRH	0.969	0.119	structurally_consistent (dimer)
SMARCA1	RBBP7	0.965	0.086
ZBTB2	CHD5	0.952	0.134
SMARCA1	BPTF	0.933	0.214
RBBP7	SALL4	0.917
PWWP2B	CHD5	0.854
BPTF	CHD5	0.847	0.548
BPTF	MBD2	0.845	0.072
PWWP2B	MBD2	0.822		mutually_exclusive (Q09028)
BPTF	GATAD2B	0.818	0.304
ZNF512B	SHPRH	0.697	0.146
PWWP2B	GATAD2B	0.659
PWWP2B	ZBTB2	0.654
SMARCA1	PWWP2B	0.595
BPTF	PWWP2B	0.555
BPTF	ZBTB2	0.511	0.254
ZBTB2	SALL4	0.423
BPTF	ZNF512B	0.405	0.292
ZNF512B	CHD5	0.391	0.226
SHPRH	CHD5	0.378	0.138
SMARCA1	GATAD2B	0.366	0.184
SMARCA1	ZNF512B	0.361	0.172
SMARCA1	SHPRH	0.324	0.046
SMARCA1	MBD2	0.317	0.018
SMARCA1	CHD5	0.311	0.1
BPTF	SHPRH	0.283	0.066
SHPRH	ZBTB2	0.257	0.094	structurally_consistent (Q16576)
SMARCA1	ZBTB2	0.245	0.116
PWWP2B	ZNF512B	0.241
SHPRH	MBD2	0.233	0.012	mutually_exclusive (Q09028)
ZNF512B	ZBTB2	0.217	0.074
SHPRH	GATAD2B	0.134	0.06
PWWP2B	SHPRH	0.106		mutually_exclusive (Q09028)

Related Complexes

Genename	Complexes
GATAD2B	huMAP3_06728.1 huMAP3_08906.1 huMAP3_09499.1 huMAP3_10472.1 huMAP3_15128.1
RBBP4	huMAP3_00206.1 huMAP3_06728.1 huMAP3_07299.1 huMAP3_08906.1 huMAP3_09499.1 huMAP3_10472.1 huMAP3_12711.1 huMAP3_13482.1 huMAP3_15128.1
SMARCA1	huMAP3_00206.1 huMAP3_00746.1 huMAP3_06728.1 huMAP3_07299.1 huMAP3_08549.1 huMAP3_08906.1 huMAP3_09198.1 huMAP3_09499.1 huMAP3_10118.1 huMAP3_10472.1 huMAP3_13482.1 huMAP3_13516.1 huMAP3_14567.1 huMAP3_15095.1 huMAP3_15128.1
BPTF	huMAP3_00206.1 huMAP3_00746.1 huMAP3_06728.1 huMAP3_07299.1 huMAP3_08833.1 huMAP3_08906.1 huMAP3_09198.1 huMAP3_09499.1 huMAP3_10472.1 huMAP3_10593.1 huMAP3_13482.1 huMAP3_14567.1 huMAP3_15095.1 huMAP3_15128.1
CHD5	huMAP3_03905.1 huMAP3_06728.1 huMAP3_08906.1 huMAP3_09499.1 huMAP3_10472.1 huMAP3_13482.1 huMAP3_15128.1
ZBTB2	huMAP3_00766.1 huMAP3_04896.1 huMAP3_06728.1 huMAP3_08906.1 huMAP3_09164.1 huMAP3_09499.1 huMAP3_10472.1 huMAP3_11045.1 huMAP3_12513.1 huMAP3_15128.1
RBBP7	huMAP3_00429.1 huMAP3_04616.1 huMAP3_06728.1 huMAP3_07299.1 huMAP3_08800.1 huMAP3_08906.1 huMAP3_09031.1 huMAP3_09499.1 huMAP3_10118.1 huMAP3_10472.1 huMAP3_13482.1 huMAP3_15128.1
PWWP2B	huMAP3_00206.1 huMAP3_00429.1 huMAP3_03441.1 huMAP3_06728.1 huMAP3_06889.1 huMAP3_07158.1 huMAP3_07299.1 huMAP3_08290.1 huMAP3_08800.1 huMAP3_08906.1 huMAP3_09031.1 huMAP3_09499.1 huMAP3_10118.1 huMAP3_10472.1 huMAP3_13482.1 huMAP3_15128.1
ZNF512B	huMAP3_00206.1 huMAP3_06728.1 huMAP3_07299.1 huMAP3_08906.1 huMAP3_09499.1 huMAP3_10472.1 huMAP3_13875.1 huMAP3_15128.1
SHPRH	huMAP3_00429.1 huMAP3_04616.1 huMAP3_06728.1 huMAP3_07299.1 huMAP3_08906.1 huMAP3_09499.1 huMAP3_10118.1 huMAP3_10472.1 huMAP3_12711.1 huMAP3_13482.1 huMAP3_15128.1
SALL4	huMAP3_03905.1 huMAP3_05579.1 huMAP3_08906.1 huMAP3_09499.1 huMAP3_10472.1 huMAP3_11529.1 huMAP3_15128.1
MBD2	huMAP3_07459.1 huMAP3_08906.1 huMAP3_09499.1 huMAP3_10472.1 huMAP3_15128.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_08906.1

Complex Portal: CPX-22069