hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_08909.1
Confidence: High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| HSD3B1 | 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1 (3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type I) (3-beta-HSD I) (3-beta-hydroxy-5-ene steroid dehydrogenase) (3-beta-hydroxy-Delta(5)-steroid dehydrogenase) (EC 1.1.1.145) (3-beta-hydroxysteroid 3-dehydrogenase) (EC 1.1.1.270) (Delta-5-3-ketosteroid isomerase) (Dihydrotestosterone oxidoreductase) (EC 1.1.1.210) (Steroid Delta-isomerase) (EC 5.3.3.1) (Trophoblast antigen FDO161G) | 5 | UniProt NCBI |
| HSD3B2 | 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2 (3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II) (3-beta-HSD II) (3-beta-HSD adrenal and gonadal type) [Includes: 3-beta-hydroxy-Delta(5)-steroid dehydrogenase (EC 1.1.1.145) (3-beta-hydroxy-5-ene steroid dehydrogenase) (Progesterone reductase); Steroid Delta-isomerase (EC 5.3.3.1) (Delta-5-3-ketosteroid isomerase)] | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP5277 | 0.0227167507414 | 1.0 | HSD3B2 | Steroid hormone precursor biosynthesis |
| HPA:0020023 | 0.0228076177443 | 1.0 | HSD3B2 | adrenal gland; cells in zona fasciculata[High] |
| HPA:0020033 | 0.0248810375393 | 1.0 | HSD3B2 | adrenal gland; cells in zona glomerulosa[High] |
| HPA:0020022 | 0.0269544573342 | 1.0 | HSD3B2 | adrenal gland; cells in zona fasciculata[>=Medium] |
| WP:WP4873 | 0.0272601008896 | 1.0 | HSD3B2 | Peroxiredoxin 2 induced ovarian failure |
| HPA:0020021 | 0.0290278771291 | 1.0 | HSD3B2 | adrenal gland; cells in zona fasciculata[>=Low] |
| HPA:0020032 | 0.0290278771291 | 1.0 | HSD3B2 | adrenal gland; cells in zona glomerulosa[>=Medium] |
| WP:WP496 | 0.0318034510379 | 1.0 | HSD3B2 | Steroid biosynthesis |
| HPA:0020031 | 0.033174716719 | 1.0 | HSD3B2 | adrenal gland; cells in zona glomerulosa[>=Low] |
| WP:WP4524 | 0.0363468011862 | 1.0 | HSD3B2 | Alternative pathway of fetal androgen synthesis |
| WP:WP5320 | 0.0363468011862 | 1.0 | HSD3B2 | Male steroid hormones in cardiomyocyte energy metabolism |
| REAC:R-HSA-193993 | 0.0374577663684 | 1.0 | HSD3B2 | Mineralocorticoid biosynthesis |
| WP:WP4523 | 0.0454335014827 | 1.0 | HSD3B2 | Classical pathway of steroidogenesis with glucocorticoid and mineralocorticoid metabolism |
| HP:0031078 | 0.0495817777049 | 1.0 | HSD3B2 | Impaired cortisol response to corticotropin releasing hormone stimulation test |
| HP:0033809 | 0.0495817777049 | 1.0 | HSD3B2 | Increased circulating 17 hydroxypregnenolone concentration |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| HSD3B1 | HSD3B2 | 0.994 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
Related Complexes
| Genename | Complexes |
|---|---|
| HSD3B1 | huMAP3_01457.1 huMAP3_02933.1 huMAP3_06693.1 huMAP3_08909.1 |
| HSD3B2 | huMAP3_01457.1 huMAP3_02933.1 huMAP3_06693.1 huMAP3_08909.1 |