hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_08913.1
Confidence: High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| RFFL | E3 ubiquitin-protein ligase rififylin (EC 2.3.2.27) (Caspase regulator CARP2) (Caspases-8 and -10-associated RING finger protein 2) (CARP-2) (FYVE-RING finger protein Sakura) (Fring) (RING finger and FYVE-like domain-containing protein 1) (RING finger protein 189) (RING finger protein 34-like) (RING-type E3 ubiquitin transferase rififylin) | 5 | UniProt NCBI |
| RNF34 | E3 ubiquitin-protein ligase RNF34 (EC 2.3.2.27) (Caspase regulator CARP1) (Caspases-8 and -10-associated RING finger protein 1) (CARP-1) (FYVE-RING finger protein Momo) (Human RING finger homologous to inhibitor of apoptosis protein) (hRFI) (RING finger protein 34) (RING finger protein RIFF) (RING-type E3 ubiquitin transferase RNF34) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-6804757 | 0.00101671324252 | 1.0 | RFFL RNF34 | Regulation of TP53 Degradation |
| REAC:R-HSA-6806003 | 0.00107651990384 | 1.0 | RFFL RNF34 | Regulation of TP53 Expression and Degradation |
| GO:2001271 | 0.00140460216025 | 1.0 | RFFL RNF34 | negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis |
| GO:2001270 | 0.00468200720083 | 1.0 | RFFL RNF34 | regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis |
| GO:1900118 | 0.00983221512175 | 1.0 | RFFL RNF34 | negative regulation of execution phase of apoptosis |
| REAC:R-HSA-5633007 | 0.0196097498674 | 1.0 | RFFL RNF34 | Regulation of TP53 Activity |
| GO:1900117 | 0.0257510396046 | 1.0 | RFFL RNF34 | regulation of execution phase of apoptosis |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| RNF34 | RFFL | 0.999 | 0.158 | bioplex3_HEK293 bioplex () bioplex3_WMM bioplex3_HCT116 |
Related Complexes