hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_08914.1
Confidence: High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| PIP4K2A | Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha (EC 2.7.1.149) (1-phosphatidylinositol 5-phosphate 4-kinase 2-alpha) (Diphosphoinositide kinase 2-alpha) (PIP5KIII) (Phosphatidylinositol 5-Phosphate 4-Kinase) (PI5P4Kalpha) (Phosphatidylinositol 5-phosphate 4-kinase type II alpha) (PI(5)P 4-kinase type II alpha) (PIP4KII-alpha) (PtdIns(4)P-5-kinase B isoform) (PtdIns(4)P-5-kinase C isoform) (PtdIns(5)P-4-kinase isoform 2-alpha) | 5 | UniProt NCBI |
| PIP4K2B | Phosphatidylinositol 5-phosphate 4-kinase type-2 beta (EC 2.7.1.149) (1-phosphatidylinositol 5-phosphate 4-kinase 2-beta) (Diphosphoinositide kinase 2-beta) (Phosphatidylinositol 5-phosphate 4-kinase type II beta) (PI(5)P 4-kinase type II beta) (PIP4KII-beta) (PtdIns(5)P-4-kinase isoform 2-beta) | 5 | UniProt NCBI |
| PPRC1 | Peroxisome proliferator-activated receptor gamma coactivator-related protein 1 (PGC-1-related coactivator) (PRC) | 5 | UniProt NCBI |
| PNISR | Arginine/serine-rich protein PNISR (PNN-interacting serine/arginine-rich protein) (SR-related protein) (SR-rich protein) (Serine/arginine-rich-splicing regulatory protein 130) (SRrp130) (Splicing factor, arginine/serine-rich 130) (Splicing factor, arginine/serine-rich 18) | 5 | UniProt NCBI |
| PIP4K2C | Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma (EC 2.7.1.149) (Phosphatidylinositol 5-phosphate 4-kinase type II gamma) (PI(5)P 4-kinase type II gamma) (PIP4KII-gamma) | 5 | UniProt NCBI |
| NOLC1 | Nucleolar and coiled-body phosphoprotein 1 (140 kDa nucleolar phosphoprotein) (Nopp140) (Hepatitis C virus NS5A-transactivated protein 13) (HCV NS5A-transactivated protein 13) (Nucleolar 130 kDa protein) (Nucleolar phosphoprotein p130) | 5 | UniProt NCBI |
| NOS1AP | Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein (C-terminal PDZ ligand of neuronal nitric oxide synthase protein) (Nitric oxide synthase 1 adaptor protein) | 5 | UniProt NCBI |
| CHD9 | Chromodomain-helicase-DNA-binding protein 9 (CHD-9) (EC 3.6.4.12) (ATP-dependent helicase CHD9) (Chromatin-related mesenchymal modulator) (CReMM) (Chromatin-remodeling factor CHROM1) (Kismet homolog 2) (PPAR-alpha-interacting complex protein 320 kDa) (Peroxisomal proliferator-activated receptor A-interacting complex 320 kDa protein) | 5 | UniProt NCBI |
| C1orf226 | Uncharacterized protein C1orf226 | 2 | UniProt NCBI |
| GRM3 | Metabotropic glutamate receptor 3 (mGluR3) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-8847453 | 2.22806969851e-07 | 0.3 | PIP4K2B PIP4K2A PIP4K2C | Synthesis of PIPs in the nucleus |
| REAC:R-HSA-6811555 | 4.67054604924e-06 | 0.3 | PIP4K2B PIP4K2A PIP4K2C | PI5P Regulates TP53 Acetylation |
| GO:0016309 | 1.15344049292e-05 | 0.3 | PIP4K2B PIP4K2A PIP4K2C | 1-phosphatidylinositol-5-phosphate 4-kinase activity |
| GO:1902633 | 1.15344049292e-05 | 0.3 | PIP4K2B PIP4K2A PIP4K2C | 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate metabolic process |
| GO:1902635 | 1.15344049292e-05 | 0.3 | PIP4K2B PIP4K2A PIP4K2C | 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process |
| REAC:R-HSA-6804758 | 0.000224045063065 | 0.3 | PIP4K2B PIP4K2A PIP4K2C | Regulation of TP53 Activity through Acetylation |
| WP:WP5411 | 0.000257029627199 | 0.3 | PIP4K2B PIP4K2A PIP4K2C | Phosphatidyl inositol phosphate pathway |
| WP:WP4971 | 0.000257029627199 | 0.3 | PIP4K2B PIP4K2A PIP4K2C | Phosphoinositides metabolism |
| KEGG:00562 | 0.000496184652725 | 0.3 | PIP4K2B PIP4K2A PIP4K2C | Inositol phosphate metabolism |
| GO:0016308 | 0.000644767051209 | 0.3 | PIP4K2B PIP4K2A PIP4K2C | 1-phosphatidylinositol-4-phosphate 5-kinase activity |
| REAC:R-HSA-1660499 | 0.000889345061537 | 0.3 | PIP4K2B PIP4K2A PIP4K2C | Synthesis of PIPs at the plasma membrane |
| KEGG:04070 | 0.00111392910382 | 0.3 | PIP4K2B PIP4K2A PIP4K2C | Phosphatidylinositol signaling system |
| REAC:R-HSA-1483255 | 0.00324177286499 | 0.3 | PIP4K2B PIP4K2A PIP4K2C | PI Metabolism |
| REAC:R-HSA-6811558 | 0.00352101579197 | 0.3 | PIP4K2B PIP4K2A PIP4K2C | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling |
| REAC:R-HSA-199418 | 0.00462261836145 | 0.3 | PIP4K2B PIP4K2A PIP4K2C | Negative regulation of the PI3K/AKT network |
| WP:WP51 | 0.00741001219045 | 0.3 | PIP4K2B PIP4K2A PIP4K2C | Regulation of actin cytoskeleton |
| GO:2000786 | 0.00780402634424 | 0.3 | PIP4K2B PIP4K2A PIP4K2C | positive regulation of autophagosome assembly |
| KEGG:04810 | 0.0131897245274 | 0.3 | PIP4K2B PIP4K2A PIP4K2C | Regulation of actin cytoskeleton |
| GO:0044090 | 0.0176420810956 | 0.3 | PIP4K2B PIP4K2A PIP4K2C | positive regulation of vacuole organization |
| GO:0052742 | 0.0202810995064 | 0.3 | PIP4K2B PIP4K2A PIP4K2C | phosphatidylinositol kinase activity |
| GO:0046627 | 0.0263201547963 | 0.3 | PIP4K2B PIP4K2A PIP4K2C | negative regulation of insulin receptor signaling pathway |
| GO:1900077 | 0.0297425210859 | 0.3 | PIP4K2B PIP4K2A PIP4K2C | negative regulation of cellular response to insulin stimulus |
| REAC:R-HSA-5633007 | 0.0303025076515 | 0.3 | PIP4K2B PIP4K2A PIP4K2C | Regulation of TP53 Activity |
| REAC:R-HSA-1483257 | 0.0467630388005 | 0.3 | PIP4K2B PIP4K2A PIP4K2C | Phospholipid metabolism |
| CORUM:6371 | 0.0499436884912 | 0.1 | GRM3 | mGluR3-mGluR8 complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| PIP4K2B | PIP4K2C | 1.0 | 0.014 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt youn_WMM hein () bioplex3_HCT116 gupta_WMM boldt_WMM |
| PIP4K2A | PIP4K2C | 1.0 | 0.0883043478261 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM hein () bioplex3_HCT116 gupta_WMM boldt_WMM |
| PIP4K2A | PIP4K2B | 1.0 | 0.318 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM bioplex3_HCT116 gupta_WMM boldt_WMM |
| PIP4K2A | NOLC1 | 0.998 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM | |
| PIP4K2A | NOS1AP | 0.997 | 0.074 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 |
| PIP4K2C | NOLC1 | 0.996 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM WMM_only | |
| PIP4K2A | PNISR | 0.99 | 0.024 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM |
| PIP4K2A | GRM3 | 0.983 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| PIP4K2C | NOS1AP | 0.982 | 0.098 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 WMM_only |
| NOS1AP | C1orf226 | 0.973 | 0.166 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
| CHD9 | PIP4K2A | 0.972 | 0.088 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| PIP4K2B | NOS1AP | 0.971 | 0.042 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| PIP4K2A | PPRC1 | 0.969 | 0.038 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| PIP4K2A | C1orf226 | 0.952 | 0.104 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| CHD9 | PNISR | 0.786 | 0.174 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| CHD9 | NOS1AP | 0.541 | 0.136 | bioplex_WMM bioplex3_WMM WMM_only |
| PPRC1 | GRM3 | 0.53 | bioplex_WMM bioplex3_WMM WMM_only | |
| PNISR | GRM3 | 0.502 | bioplex_WMM bioplex3_WMM WMM_only | |
| CHD9 | PPRC1 | 0.433 | 0.114 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
| GRM3 | C1orf226 | 0.333 | bioplex_WMM bioplex3_WMM WMM_only | |
| PIP4K2B | GRM3 | 0.333 | bioplex_WMM bioplex3_WMM WMM_only | |
| NOLC1 | NOS1AP | 0.32 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| CHD9 | GRM3 | 0.303 | bioplex_WMM bioplex3_WMM WMM_only | |
| PNISR | NOLC1 | 0.243 | bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only boldt_WMM | |
| PIP4K2B | PPRC1 | 0.213 | 0.048 | bioplex_WMM bioplex3_WMM WMM_only |
| CHD9 | NOLC1 | 0.205 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| CHD9 | C1orf226 | 0.198 | 0.106 | bioplex_WMM bioplex3_WMM WMM_only |
| NOLC1 | GRM3 | 0.193 | bioplex_WMM bioplex3_WMM WMM_only | |
| PNISR | C1orf226 | 0.189 | 0.108 | bioplex_WMM bioplex3_WMM WMM_only |
| PIP4K2C | C1orf226 | 0.188 | 0.072 | bioplex_WMM bioplex3_WMM WMM_only |
| PPRC1 | PIP4K2C | 0.187 | 0.076 | bioplex_WMM bioplex3_WMM WMM_only |
| PIP4K2B | NOLC1 | 0.178 | bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only | |
| PPRC1 | PNISR | 0.172 | 0.094 | bioplex_WMM bioplex3_WMM WMM_only |
| PNISR | NOS1AP | 0.167 | 0.114 | bioplex_WMM bioplex3_WMM WMM_only |
| PPRC1 | C1orf226 | 0.164 | 0.082 | bioplex_WMM bioplex3_WMM WMM_only |
| CHD9 | PIP4K2C | 0.162 | 0.04 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| PPRC1 | NOS1AP | 0.145 | 0.164 | bioplex_WMM bioplex3_WMM WMM_only |
| PIP4K2C | GRM3 | 0.143 | bioplex_WMM bioplex3_WMM WMM_only | |
| PIP4K2B | C1orf226 | 0.131 | 0.078 | bioplex_WMM bioplex3_WMM WMM_only |
| CHD9 | PIP4K2B | 0.127 | 0.096 | bioplex_WMM bioplex3_WMM WMM_only |
| GRM3 | NOS1AP | 0.123 | bioplex_WMM bioplex3_WMM WMM_only | |
| NOLC1 | C1orf226 | 0.106 | bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | |
| PPRC1 | NOLC1 | 0.101 | bioplex_WMM bioplex3_WMM gupta_WMM WMM_only | |
| PIP4K2B | PNISR | 0.082 | 0.022 | bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only |
| PIP4K2C | PNISR | 0.075 | 0.054 | bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only |
Related Complexes