hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_08949.1

Complex Portal: CPX-20537

Confidence: High

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Genename	Protein Name	Uniprot Annotation Score	Links
DHPS	Deoxyhypusine synthase (DHS) (EC 2.5.1.46)	5	UniProt NCBI
MAPK1	Mitogen-activated protein kinase 1 (MAP kinase 1) (MAPK 1) (EC 2.7.11.24) (ERT1) (Extracellular signal-regulated kinase 2) (ERK-2) (MAP kinase isoform p42) (p42-MAPK) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2)	5	UniProt NCBI
MAPK3	Mitogen-activated protein kinase 3 (MAP kinase 3) (MAPK 3) (EC 2.7.11.24) (ERT2) (Extracellular signal-regulated kinase 1) (ERK-1) (Insulin-stimulated MAP2 kinase) (MAP kinase isoform p44) (p44-MAPK) (Microtubule-associated protein 2 kinase) (p44-ERK1)	5	UniProt NCBI
PTPRR	Receptor-type tyrosine-protein phosphatase R (R-PTP-R) (EC 3.1.3.48) (Ch-1PTPase) (NC-PTPCOM1) (Protein-tyrosine phosphatase PCPTP1)	5	UniProt NCBI
RPS6KA2	Ribosomal protein S6 kinase alpha-2 (S6K-alpha-2) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 2) (p90-RSK 2) (p90RSK2) (MAP kinase-activated protein kinase 1c) (MAPK-activated protein kinase 1c) (MAPKAP kinase 1c) (MAPKAPK-1c) (Ribosomal S6 kinase 3) (RSK-3) (pp90RSK3)	5	UniProt NCBI

Showing 1 to 5 of 5 entries

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Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
REAC:R-HSA-444257	0.000215205765992	0.5	RPS6KA2 MAPK3	RSK activation
KEGG:04010	0.000800866642312	0.75	RPS6KA2 PTPRR MAPK3	MAPK signaling pathway
WP:WP4877	0.00110807642161	0.5	RPS6KA2 MAPK3	Host pathogen interaction of human coronaviruses MAPK signaling
REAC:R-HSA-881907	0.00122873738811	0.5	RPS6KA2 MAPK3	Gastrin-CREB signalling pathway via PKC and MAPK
WP:WP4566	0.0020866894725	0.5	RPS6KA2 MAPK3	Translation inhibitors in chronically activated PDGFRA cells
REAC:R-HSA-198753	0.00214930898727	0.5	RPS6KA2 MAPK3	ERK/MAPK targets
REAC:R-HSA-442742	0.00236402400204	0.5	RPS6KA2 MAPK3	CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling
KEGG:04720	0.00357225272753	0.5	RPS6KA2 MAPK3	Long-term potentiation
REAC:R-HSA-450282	0.00444848198459	0.5	RPS6KA2 MAPK3	MAPK targets/ Nuclear events mediated by MAP kinases
WP:WP2037	0.00561306746582	0.5	RPS6KA2 MAPK3	Prolactin signaling pathway

Showing 1 to 10 of 46 entries

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Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap	Evidence
MAPK1	MAPK3	0.999	0.446	structurally_consistent (dimer)	bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 fraction boldt_WMM
DHPS	MAPK1	0.998	0.024	mutually_exclusive (P27361) structurally_consistent (dimer)	bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 WMM_only
DHPS	MAPK3	0.985	0.022	mutually_exclusive (P28482) structurally_consistent (dimer)	hein_WMM bioplex_WMM bioplex3_WMM hein ()
MAPK1	PTPRR	0.977		structurally_consistent (dimer)	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
MAPK3	RPS6KA2	0.959		mutually_exclusive (P28482) structurally_consistent (dimer)	bioplex3_HEK293 bioplex3_WMM WMM_only
MAPK1	RPS6KA2	0.948		structurally_consistent (dimer)	bioplex3_HEK293 bioplex3_WMM WMM_only
PTPRR	MAPK3	0.162		mutually_exclusive (P28482)	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM
DHPS	RPS6KA2	0.026		mutually_exclusive (P28482)	bioplex3_WMM youn_WMM WMM_only

Showing 1 to 8 of 8 entries

Related Complexes

Genename	Complexes
MAPK1	huMAP3_02651.1 huMAP3_02744.1 huMAP3_04858.1 huMAP3_08949.1 huMAP3_09817.1 huMAP3_10404.1 huMAP3_11291.1 huMAP3_13355.1 huMAP3_13479.1 huMAP3_14916.1
PTPRR	huMAP3_02651.1 huMAP3_02744.1 huMAP3_04858.1 huMAP3_08949.1 huMAP3_09817.1 huMAP3_10404.1 huMAP3_11291.1 huMAP3_12424.1 huMAP3_13355.1 huMAP3_14916.1
MAPK3	huMAP3_04858.1 huMAP3_06471.1 huMAP3_08949.1 huMAP3_09817.1 huMAP3_10404.1 huMAP3_13355.1 huMAP3_13479.1 huMAP3_14916.1
RPS6KA2	huMAP3_08875.1 huMAP3_08949.1 huMAP3_09817.1 huMAP3_11291.1 huMAP3_13282.1 huMAP3_13479.1 huMAP3_14916.1
DHPS	huMAP3_01869.1 huMAP3_02651.1 huMAP3_06471.1 huMAP3_08949.1 huMAP3_09817.1 huMAP3_10404.1 huMAP3_12783.1 huMAP3_13479.1