hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_08949.1
Confidence: High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| MAPK1 | Mitogen-activated protein kinase 1 (MAP kinase 1) (MAPK 1) (EC 2.7.11.24) (ERT1) (Extracellular signal-regulated kinase 2) (ERK-2) (MAP kinase isoform p42) (p42-MAPK) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2) | 5 | UniProt NCBI |
| PTPRR | Receptor-type tyrosine-protein phosphatase R (R-PTP-R) (EC 3.1.3.48) (Ch-1PTPase) (NC-PTPCOM1) (Protein-tyrosine phosphatase PCPTP1) | 5 | UniProt NCBI |
| MAPK3 | Mitogen-activated protein kinase 3 (MAP kinase 3) (MAPK 3) (EC 2.7.11.24) (ERT2) (Extracellular signal-regulated kinase 1) (ERK-1) (Insulin-stimulated MAP2 kinase) (MAP kinase isoform p44) (p44-MAPK) (Microtubule-associated protein 2 kinase) (p44-ERK1) | 5 | UniProt NCBI |
| RPS6KA2 | Ribosomal protein S6 kinase alpha-2 (S6K-alpha-2) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 2) (p90-RSK 2) (p90RSK2) (MAP kinase-activated protein kinase 1c) (MAPK-activated protein kinase 1c) (MAPKAP kinase 1c) (MAPKAPK-1c) (Ribosomal S6 kinase 3) (RSK-3) (pp90RSK3) | 5 | UniProt NCBI |
| DHPS | Deoxyhypusine synthase (DHS) (EC 2.5.1.46) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-444257 | 0.000215205765992 | 0.5 | MAPK3 RPS6KA2 | RSK activation |
| KEGG:04010 | 0.000800866642312 | 0.75 | PTPRR RPS6KA2 MAPK3 | MAPK signaling pathway |
| WP:WP4877 | 0.00110807642161 | 0.5 | MAPK3 RPS6KA2 | Host pathogen interaction of human coronaviruses MAPK signaling |
| REAC:R-HSA-881907 | 0.00122873738811 | 0.5 | MAPK3 RPS6KA2 | Gastrin-CREB signalling pathway via PKC and MAPK |
| WP:WP4566 | 0.0020866894725 | 0.5 | MAPK3 RPS6KA2 | Translation inhibitors in chronically activated PDGFRA cells |
| REAC:R-HSA-198753 | 0.00214930898727 | 0.5 | MAPK3 RPS6KA2 | ERK/MAPK targets |
| REAC:R-HSA-442742 | 0.00236402400204 | 0.5 | MAPK3 RPS6KA2 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling |
| KEGG:04720 | 0.00357225272753 | 0.5 | MAPK3 RPS6KA2 | Long-term potentiation |
| REAC:R-HSA-450282 | 0.00444848198459 | 0.5 | MAPK3 RPS6KA2 | MAPK targets/ Nuclear events mediated by MAP kinases |
| WP:WP2037 | 0.00561306746582 | 0.5 | MAPK3 RPS6KA2 | Prolactin signaling pathway |
| KEGG:04914 | 0.00826911293642 | 0.5 | MAPK3 RPS6KA2 | Progesterone-mediated oocyte maturation |
| KEGG:04722 | 0.0123049375309 | 0.5 | MAPK3 RPS6KA2 | Neurotrophin signaling pathway |
| KEGG:04114 | 0.0133093129958 | 0.5 | MAPK3 RPS6KA2 | Oocyte meiosis |
| REAC:R-HSA-198725 | 0.0146019089592 | 0.5 | MAPK3 RPS6KA2 | Nuclear Events (kinase and transcription factor activation) |
| REAC:R-HSA-450294 | 0.0157112703152 | 0.5 | MAPK3 RPS6KA2 | MAP kinase activation |
| KEGG:05135 | 0.0162723391924 | 0.5 | MAPK3 RPS6KA2 | Yersinia infection |
| WP:WP3915 | 0.0162815495406 | 0.5 | MAPK3 RPS6KA2 | Angiopoietin like protein 8 regulatory pathway |
| REAC:R-HSA-448424 | 0.019281632575 | 0.5 | MAPK3 RPS6KA2 | Interleukin-17 signaling |
| REAC:R-HSA-438064 | 0.0232149434748 | 0.5 | MAPK3 RPS6KA2 | Post NMDA receptor activation events |
| CORUM:6801 | 0.0249718442456 | 0.25 | MAPK3 | VEGFR2-S1PR3-ERK1/2-PKC-alpha complex |
| WP:WP481 | 0.0255965717397 | 0.5 | MAPK3 RPS6KA2 | Insulin signaling |
| WP:WP437 | 0.0259547050416 | 0.5 | PTPRR RPS6KA2 | EGF EGFR signaling pathway |
| KEGG:04150 | 0.0269222811984 | 0.5 | MAPK3 RPS6KA2 | mTOR signaling pathway |
| REAC:R-HSA-442755 | 0.0321680026233 | 0.5 | MAPK3 RPS6KA2 | Activation of NMDA receptors and postsynaptic events |
| KEGG:05207 | 0.0326315237827 | 0.5 | MAPK3 RPS6KA2 | Chemical carcinogenesis - receptor activation |
| REAC:R-HSA-975871 | 0.0338007536087 | 0.5 | MAPK3 RPS6KA2 | MyD88 cascade initiated on plasma membrane |
| REAC:R-HSA-168142 | 0.0338007536087 | 0.5 | MAPK3 RPS6KA2 | Toll Like Receptor 10 (TLR10) Cascade |
| REAC:R-HSA-168176 | 0.0338007536087 | 0.5 | MAPK3 RPS6KA2 | Toll Like Receptor 5 (TLR5) Cascade |
| REAC:R-HSA-975138 | 0.0354736093287 | 0.5 | MAPK3 RPS6KA2 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation |
| REAC:R-HSA-168181 | 0.0363250695065 | 0.5 | MAPK3 RPS6KA2 | Toll Like Receptor 7/8 (TLR7/8) Cascade |
| REAC:R-HSA-975155 | 0.0363250695065 | 0.5 | MAPK3 RPS6KA2 | MyD88 dependent cascade initiated on endosome |
| REAC:R-HSA-168138 | 0.0398310607487 | 0.5 | MAPK3 RPS6KA2 | Toll Like Receptor 9 (TLR9) Cascade |
| REAC:R-HSA-168164 | 0.041644107744 | 0.5 | MAPK3 RPS6KA2 | Toll Like Receptor 3 (TLR3) Cascade |
| REAC:R-HSA-937061 | 0.0434971593242 | 0.5 | MAPK3 RPS6KA2 | TRIF(TICAM1)-mediated TLR4 signaling |
| REAC:R-HSA-166166 | 0.0434971593242 | 0.5 | MAPK3 RPS6KA2 | MyD88-independent TLR4 cascade |
| REAC:R-HSA-168188 | 0.0453901932463 | 0.5 | MAPK3 RPS6KA2 | Toll Like Receptor TLR6:TLR2 Cascade |
| REAC:R-HSA-166058 | 0.0453901932463 | 0.5 | MAPK3 RPS6KA2 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane |
| REAC:R-HSA-187037 | 0.0473231872721 | 0.5 | MAPK3 RPS6KA2 | Signaling by NTRK1 (TRKA) |
| REAC:R-HSA-181438 | 0.0473231872721 | 0.5 | MAPK3 RPS6KA2 | Toll Like Receptor 2 (TLR2) Cascade |
| REAC:R-HSA-168179 | 0.0473231872721 | 0.5 | MAPK3 RPS6KA2 | Toll Like Receptor TLR1:TLR2 Cascade |
| REAC:R-HSA-2559582 | 0.0473231872721 | 0.5 | MAPK3 RPS6KA2 | Senescence-Associated Secretory Phenotype (SASP) |
| CORUM:7504 | 0.049938562206 | 0.25 | MAPK3 | CD44-ERK1-ERK2-RHAMM complex |
| CORUM:6800 | 0.049938562206 | 0.25 | MAPK3 | VEGFR2-S1PR2-ERK1/2-PKC-alpha complex |
| CORUM:6799 | 0.049938562206 | 0.25 | MAPK3 | VEGFR2-S1PR1-ERK1/2-PKC-alpha complex |
| CORUM:55 | 0.049938562206 | 0.25 | MAPK3 | HDAC4-ERK1 complex |
| CORUM:6802 | 0.049938562206 | 0.25 | MAPK3 | VEGFR2-S1PR5-ERK1/2-PKC-alpha complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| MAPK1 | MAPK3 | 0.999 | 0.446 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 fraction boldt_WMM |
| DHPS | MAPK1 | 0.998 | 0.024 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 WMM_only |
| DHPS | MAPK3 | 0.985 | 0.022 | hein_WMM bioplex_WMM bioplex3_WMM hein () |
| MAPK1 | PTPRR | 0.977 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| MAPK3 | RPS6KA2 | 0.959 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| MAPK1 | RPS6KA2 | 0.948 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| PTPRR | MAPK3 | 0.162 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| DHPS | RPS6KA2 | 0.026 | bioplex3_WMM youn_WMM WMM_only |
Related Complexes