hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_08957.1
Complex Portal: CPX-13343
Confidence: High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| ITGA3 | Integrin alpha-3 (CD49 antigen-like family member C) (FRP-2) (Galactoprotein B3) (GAPB3) (VLA-3 subunit alpha) (CD antigen CD49c) [Cleaved into: Integrin alpha-3 heavy chain; Integrin alpha-3 light chain] | 5 | UniProt NCBI |
| CACNA2D1 | Voltage-dependent calcium channel subunit alpha-2/delta-1 (Voltage-gated calcium channel subunit alpha-2/delta-1) [Cleaved into: Voltage-dependent calcium channel subunit alpha-2-1; Voltage-dependent calcium channel subunit delta-1] | 5 | UniProt NCBI |
| LRP6 | Low-density lipoprotein receptor-related protein 6 (LRP-6) | 5 | UniProt NCBI |
| ITGA2 | Integrin alpha-2 (CD49 antigen-like family member B) (Collagen receptor) (Platelet membrane glycoprotein Ia) (GPIa) (VLA-2 subunit alpha) (CD antigen CD49b) | 5 | UniProt NCBI |
| ITGA6 | Integrin alpha-6 (CD49 antigen-like family member F) (VLA-6) (CD antigen CD49f) [Cleaved into: Integrin alpha-6 heavy chain; Integrin alpha-6 light chain; Processed integrin alpha-6 (Alpha6p)] | 5 | UniProt NCBI |
| CANT1 | Soluble calcium-activated nucleotidase 1 (SCAN-1) (EC 3.6.1.6) (Apyrase homolog) (Putative MAPK-activating protein PM09) (Putative NF-kappa-B-activating protein 107) | 5 | UniProt NCBI |
| CNNM2 | Metal transporter CNNM2 (Ancient conserved domain-containing protein 2) (Cyclin-M2) | 5 | UniProt NCBI |
| TMEM131L | Transmembrane protein 131-like | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:05412 | 0.0163630378499 | 0.333333333333 | ITGA3 CACNA2D1 | Arrhythmogenic right ventricular cardiomyopathy |
| WP:WP2118 | 0.0170615762461 | 0.333333333333 | ITGA3 CACNA2D1 | Arrhythmogenic right ventricular cardiomyopathy |
| WP:WP2572 | 0.0188461436964 | 0.333333333333 | ITGA3 LRP6 | Primary focal segmental glomerulosclerosis FSGS |
| KEGG:05410 | 0.0204418285401 | 0.333333333333 | ITGA3 CACNA2D1 | Hypertrophic cardiomyopathy |
| KEGG:05414 | 0.0204418285401 | 0.333333333333 | ITGA3 CACNA2D1 | Dilated cardiomyopathy |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| ITGA3 | ITGA6 | 0.994 | 0.318 |
mutually_exclusive (P48509)
|
hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
| TMEM131L | CANT1 | 0.993 | 0.11 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| ITGA2 | ITGA6 | 0.991 | 0.196 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only | |
| CACNA2D1 | ITGA6 | 0.988 | 0.096 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | |
| TMEM131L | ITGA6 | 0.987 | 0.102 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| ITGA6 | CNNM2 | 0.986 | 0.034 | bioplex_WMM bioplex3_WMM gupta_WMM WMM_only | |
| LRP6 | ITGA6 | 0.968 | 0.122 | bioplex_WMM bioplex3_WMM gupta_WMM WMM_only | |
| ITGA3 | ITGA2 | 0.967 | 0.55 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | |
| CANT1 | CNNM2 | 0.963 | 0.082 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM | |
| ITGA6 | CANT1 | 0.96 | 0.112 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM | |
| TMEM131L | CNNM2 | 0.948 | 0.11 | bioplex_WMM bioplex3_WMM WMM_only | |
| ITGA3 | CACNA2D1 | 0.936 | 0.118 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | |
| ITGA2 | LRP6 | 0.873 | 0.186 | bioplex_WMM bioplex3_WMM gupta_WMM WMM_only | |
| ITGA3 | LRP6 | 0.79 | 0.11 | bioplex_WMM bioplex3_WMM WMM_only | |
| ITGA2 | CACNA2D1 | 0.649 | 0.184 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | |
| ITGA2 | CNNM2 | 0.572 | 0.07 | bioplex_WMM bioplex3_WMM gupta_WMM WMM_only | |
| CACNA2D1 | CNNM2 | 0.502 | 0.104 | bioplex_WMM bioplex3_WMM WMM_only | |
| CACNA2D1 | LRP6 | 0.485 | 0.17 | bioplex_WMM bioplex3_WMM WMM_only | |
| ITGA2 | TMEM131L | 0.323 | 0.082 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| CACNA2D1 | TMEM131L | 0.253 | 0.102 | bioplex_WMM bioplex3_WMM WMM_only | |
| ITGA3 | TMEM131L | 0.164 | 0.074 | bioplex3_WMM WMM_only | |
| ITGA2 | CANT1 | 0.161 | 0.076 | bioplex3_WMM bioplex3_HCT116 gupta_WMM WMM_only | |
| ITGA3 | CNNM2 | 0.153 | 0.048 | bioplex_WMM bioplex3_WMM WMM_only | |
| LRP6 | CANT1 | 0.15 | 0.106 | bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM WMM_only | |
| LRP6 | CNNM2 | 0.114 | 0.106 | bioplex_WMM bioplex3_WMM gupta_WMM WMM_only | |
| TMEM131L | LRP6 | 0.045 | 0.092 | bioplex_WMM bioplex3_WMM WMM_only | |
| ITGA3 | CANT1 | 0.026 | 0.108 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| CACNA2D1 | CANT1 | 0.016 | 0.088 | bioplex_WMM bioplex3_WMM fraction |
Related Complexes