hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_08988.1

Complex Portal: CPX-10706

Confidence: High

Genename	Protein Name	Uniprot Annotation Score	Links
PGLYRP1	Peptidoglycan recognition protein 1 (Peptidoglycan recognition protein short) (PGRP-S)	5	UniProt NCBI
OR6C70	Olfactory receptor 6C70	3	UniProt NCBI
SCGB1A1	Uteroglobin (Club cell phospholipid-binding protein) (CCPBP) (Club cells 10 kDa secretory protein) (CC10) (Secretoglobin family 1A member 1) (Urinary protein 1) (UP-1) (UP1) (Urine protein 1)	5	UniProt NCBI
PADI2	Protein-arginine deiminase type-2 (EC 3.5.3.15) (PAD-H19) (Peptidylarginine deiminase II) (Protein-arginine deiminase type II)	5	UniProt NCBI
APOL1	Apolipoprotein L1 (Apolipoprotein L) (Apo-L) (ApoL) (Apolipoprotein L-I) (ApoL-I)	5	UniProt NCBI
DYSF	Dysferlin (Dystrophy-associated fer-1-like protein) (Fer-1-like protein 1)	5	UniProt NCBI
RAB3D	Ras-related protein Rab-3D	5	UniProt NCBI
ITGB2	Integrin beta-2 (Cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta) (Complement receptor C3 subunit beta) (CD antigen CD18)	5	UniProt NCBI
CFI	Complement factor I (EC 3.4.21.45) (C3B/C4B inactivator) [Cleaved into: Complement factor I heavy chain; Complement factor I light chain]	5	UniProt NCBI
PTPRC	Receptor-type tyrosine-protein phosphatase C (EC 3.1.3.48) (Leukocyte common antigen) (L-CA) (T200) (CD antigen CD45)	5	UniProt NCBI
CAMP	Cathelicidin antimicrobial peptide (18 kDa cationic antimicrobial protein) (CAP-18) (hCAP-18) [Cleaved into: Antibacterial peptide FALL-39 (FALL-39 peptide antibiotic); Antibacterial peptide LL-37; Antibacterial peptide KR-20; Antibacterial peptide LL-23; Antibacterial peptide LL-29; Antibacterial peptide KS-30; Antibacterial peptide RK-31; Antibacterial peptide FF-33]	5	UniProt NCBI
NCF2	Neutrophil cytosol factor 2 (NCF-2) (67 kDa neutrophil oxidase factor) (NADPH oxidase activator 2) (Neutrophil NADPH oxidase factor 2) (p67-phox)	5	UniProt NCBI
APOC1	Apolipoprotein C-I (Apo-CI) (ApoC-I) (Apolipoprotein C1) [Cleaved into: Truncated apolipoprotein C-I]	5	UniProt NCBI
CCDC103	Coiled-coil domain-containing protein 103	5	UniProt NCBI
FERMT3	Fermitin family homolog 3 (Kindlin-3) (MIG2-like protein) (Unc-112-related protein 2)	5	UniProt NCBI
ITGAM	Integrin alpha-M (CD11 antigen-like family member B) (CR-3 alpha chain) (Cell surface glycoprotein MAC-1 subunit alpha) (Leukocyte adhesion receptor MO1) (Neutrophil adherence receptor) (CD antigen CD11b)	5	UniProt NCBI
KLK10	Kallikrein-10 (EC 3.4.21.-) (Normal epithelial cell-specific 1) (Protease serine-like 1)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
REAC:R-HSA-168249	0.000236501400451	0.533333333333	PGLYRP1 PADI2 CAMP RAB3D CFI ITGB2 PTPRC NCF2	Innate Immune System
HP:0002718	0.000423756445283	0.333333333333	FERMT3 ITGB2 CFI CCDC103 NCF2	Recurrent bacterial infections
GO:0099503	0.000430514036287	0.6	KLK10 PGLYRP1 PADI2 CAMP RAB3D PTPRC ITGB2 DYSF FERMT3	secretory vesicle
REAC:R-HSA-6798695	0.000739202047229	0.4	PGLYRP1 PADI2 CAMP RAB3D PTPRC ITGB2	Neutrophil degranulation
KEGG:05150	0.00100823768972	0.2	ITGB2 CFI CAMP	Staphylococcus aureus infection
HP:0005420	0.00349480667591	0.2	ITGB2 CFI NCF2	Recurrent gram-negative bacterial infections
GO:0030141	0.00357686820592	0.533333333333	KLK10 PGLYRP1 PADI2 CAMP RAB3D PTPRC ITGB2 FERMT3	secretory granule
HP:0001581	0.00498386535344	0.266666666667	FERMT3 ITGB2 CFI NCF2	Recurrent skin infections
KEGG:04613	0.0246227279016	0.2	ITGB2 CAMP NCF2	Neutrophil extracellular trap formation
REAC:R-HSA-168256	0.0282326490997	0.533333333333	PGLYRP1 PADI2 CAMP RAB3D CFI ITGB2 PTPRC NCF2	Immune System
GO:0031410	0.030153536677	0.666666666667	KLK10 PGLYRP1 PADI2 CAMP RAB3D NCF2 PTPRC ITGB2 DYSF FERMT3	cytoplasmic vesicle
GO:0097708	0.03067331448	0.666666666667	KLK10 PGLYRP1 PADI2 CAMP RAB3D NCF2 PTPRC ITGB2 DYSF FERMT3	intracellular vesicle
GO:0005576	0.0312849140696	0.8	KLK10 PGLYRP1 APOL1 PADI2 CAMP APOC1 RAB3D CFI PTPRC ITGB2 DYSF FERMT3	extracellular region
HP:0012647	0.0341273835805	0.466666666667	FERMT3 CCDC103 APOL1 NCF2 ITGB2 PTPRC CFI	Abnormal inflammatory response
HP:0012649	0.0341273835805	0.466666666667	FERMT3 CCDC103 APOL1 NCF2 ITGB2 PTPRC CFI	Increased inflammatory response
HP:0011123	0.0379662958601	0.333333333333	FERMT3 ITGB2 NCF2 CFI PTPRC	Inflammatory abnormality of the skin
HPA:0640411	0.0386282849298	0.133333333333	DYSF NCF2	endometrium; macrophages[>=Low]
HPA:0640412	0.0386282849298	0.133333333333	DYSF NCF2	endometrium; macrophages[>=Medium]
HP:0005224	0.0391658859752	0.133333333333	ITGB2 NCF2	Rectal abscess
HPA:0640203	0.042114966983	0.133333333333	DYSF NCF2	endometrium; endothelial cells[High]

Edges

Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap
CFI	KLK10	0.992
APOC1	KLK10	0.989
APOL1	KLK10	0.989
KLK10	RAB3D	0.985
DYSF	KLK10	0.984
KLK10	FERMT3	0.983
KLK10	CCDC103	0.978
KLK10	ITGAM	0.977
PADI2	KLK10	0.977
PTPRC	KLK10	0.975
KLK10	ITGB2	0.975
PGLYRP1	KLK10	0.97
CAMP	KLK10	0.97
OR6C70	KLK10	0.968
SCGB1A1	KLK10	0.964
NCF2	KLK10	0.962
PGLYRP1	RAB3D	0.904
CAMP	ITGAM	0.904	0.304
SCGB1A1	ITGB2	0.904
PGLYRP1	ITGAM	0.904
CAMP	RAB3D	0.904	0.054
NCF2	ITGB2	0.904	0.272
APOL1	PTPRC	0.902	0.302
APOL1	FERMT3	0.902	0.134
PGLYRP1	APOL1	0.902
PGLYRP1	DYSF	0.902
DYSF	CAMP	0.902	0.066
PTPRC	APOC1	0.902
PTPRC	FERMT3	0.902	0.42
PGLYRP1	FERMT3	0.902
APOL1	CAMP	0.902
SCGB1A1	APOC1	0.902
CAMP	FERMT3	0.902	0.16
SCGB1A1	FERMT3	0.902
DYSF	PTPRC	0.902	0.325010752688
APOL1	NCF2	0.902
SCGB1A1	NCF2	0.902
APOL1	APOC1	0.902
CAMP	NCF2	0.902
PGLYRP1	CAMP	0.902		mutually_exclusive (P02750) structurally_consistent (dimer)
NCF2	FERMT3	0.902	0.194
APOC1	FERMT3	0.902
PGLYRP1	SCGB1A1	0.902
PGLYRP1	PTPRC	0.902
SCGB1A1	APOL1	0.902
SCGB1A1	PTPRC	0.902
PGLYRP1	APOC1	0.902
APOL1	DYSF	0.902	0.110115942029
NCF2	APOC1	0.902
DYSF	FERMT3	0.902	0.19
PGLYRP1	NCF2	0.902
PTPRC	NCF2	0.902	0.1606
SCGB1A1	DYSF	0.902
SCGB1A1	CAMP	0.902
DYSF	NCF2	0.902	0.07
DYSF	APOC1	0.902
CAMP	APOC1	0.902
CAMP	PTPRC	0.902	0.318
DYSF	RAB3D	0.902	0.056
PGLYRP1	ITGB2	0.902
APOC1	ITGB2	0.902
CFI	NCF2	0.902
PADI2	DYSF	0.902	0.096
PGLYRP1	PADI2	0.902
DYSF	CFI	0.902	0.112
CFI	APOC1	0.902
DYSF	ITGB2	0.902	0.172
PGLYRP1	CFI	0.902
PADI2	CAMP	0.902	0.118
PADI2	APOC1	0.902
PADI2	CFI	0.902
PTPRC	ITGB2	0.902	0.478
PTPRC	RAB3D	0.902	0.078
APOC1	ITGAM	0.902
DYSF	ITGAM	0.902	0.198
SCGB1A1	PADI2	0.902
SCGB1A1	CFI	0.902
PADI2	NCF2	0.902	0.132
CAMP	ITGB2	0.902	0.368
APOL1	ITGB2	0.902	0.212
APOL1	CFI	0.902	0.222
APOL1	ITGAM	0.902
PADI2	APOL1	0.902
CFI	FERMT3	0.902	0.194
PADI2	FERMT3	0.902	0.056
PADI2	PTPRC	0.902	0.28
APOL1	RAB3D	0.902	0.046
PTPRC	ITGAM	0.902	0.312
APOC1	RAB3D	0.902
CAMP	CFI	0.902
CFI	PTPRC	0.902	0.318
RAB3D	FERMT3	0.892	0.034
NCF2	RAB3D	0.892	0.15
ITGAM	FERMT3	0.892	0.318
NCF2	ITGAM	0.892	0.2
SCGB1A1	ITGAM	0.892
ITGB2	FERMT3	0.892	0.454
SCGB1A1	RAB3D	0.892
CFI	ITGB2	0.722	0.304
PADI2	ITGB2	0.717	0.168
PADI2	RAB3D	0.703	0.076
PADI2	ITGAM	0.703	0.204
CFI	RAB3D	0.676	0.042
ITGAM	ITGB2	0.633	0.338
CFI	ITGAM	0.633
RAB3D	ITGB2	0.468	0.058
RAB3D	ITGAM	0.418	0.064
PGLYRP1	OR6C70	0.214
OR6C70	CFI	0.214
OR6C70	DYSF	0.214
OR6C70	RAB3D	0.214
OR6C70	NCF2	0.214
OR6C70	FERMT3	0.214
OR6C70	SCGB1A1	0.214
OR6C70	PTPRC	0.214
OR6C70	APOL1	0.214
OR6C70	PADI2	0.214
OR6C70	CAMP	0.214
OR6C70	ITGB2	0.214
OR6C70	APOC1	0.214
OR6C70	ITGAM	0.214

Related Complexes

Genename	Complexes
PGLYRP1	huMAP3_00689.1 huMAP3_05990.1 huMAP3_08224.1 huMAP3_08988.1 huMAP3_09434.1 huMAP3_14295.1
OR6C70	huMAP3_00689.1 huMAP3_05873.1 huMAP3_08224.1 huMAP3_08988.1 huMAP3_09434.1
SCGB1A1	huMAP3_00689.1 huMAP3_06530.1 huMAP3_08988.1 huMAP3_14295.1
PADI2	huMAP3_00689.1 huMAP3_05578.1 huMAP3_05873.1 huMAP3_05990.1 huMAP3_06488.1 huMAP3_06524.1 huMAP3_06530.1 huMAP3_07054.1 huMAP3_08224.1 huMAP3_08988.1 huMAP3_09434.1 huMAP3_14295.1
APOL1	huMAP3_00689.1 huMAP3_05578.1 huMAP3_05873.1 huMAP3_05990.1 huMAP3_06488.1 huMAP3_06524.1 huMAP3_06530.1 huMAP3_07054.1 huMAP3_08224.1 huMAP3_08988.1 huMAP3_09434.1 huMAP3_14295.1
DYSF	huMAP3_00689.1 huMAP3_05578.1 huMAP3_05873.1 huMAP3_05990.1 huMAP3_06488.1 huMAP3_06524.1 huMAP3_06530.1 huMAP3_07054.1 huMAP3_08224.1 huMAP3_08988.1 huMAP3_09434.1 huMAP3_14295.1
RAB3D	huMAP3_01245.1 huMAP3_07182.1 huMAP3_08115.1 huMAP3_08988.1 huMAP3_11660.1 huMAP3_14295.1
ITGB2	huMAP3_02169.1 huMAP3_06558.1 huMAP3_08257.1 huMAP3_08988.1 huMAP3_14295.1
CFI	huMAP3_00689.1 huMAP3_07054.1 huMAP3_08988.1 huMAP3_14295.1 huMAP3_14445.1 huMAP3_14656.1
PTPRC	huMAP3_00689.1 huMAP3_06488.1 huMAP3_08224.1 huMAP3_08988.1 huMAP3_09434.1 huMAP3_14295.1
CAMP	huMAP3_00689.1 huMAP3_05578.1 huMAP3_08988.1 huMAP3_14295.1
NCF2	huMAP3_00689.1 huMAP3_06524.1 huMAP3_08224.1 huMAP3_08988.1 huMAP3_09434.1 huMAP3_14295.1
APOC1	huMAP3_00689.1 huMAP3_05578.1 huMAP3_05873.1 huMAP3_05990.1 huMAP3_06488.1 huMAP3_06524.1 huMAP3_06530.1 huMAP3_07054.1 huMAP3_08224.1 huMAP3_08988.1 huMAP3_09434.1 huMAP3_14295.1
CCDC103	huMAP3_04183.1 huMAP3_08988.1 huMAP3_13710.1 huMAP3_14752.1
FERMT3	huMAP3_03613.1 huMAP3_08988.1 huMAP3_14295.1
ITGAM	huMAP3_02125.1 huMAP3_02768.1 huMAP3_05837.1 huMAP3_07446.1 huMAP3_08139.1 huMAP3_08988.1 huMAP3_09846.1 huMAP3_10260.1 huMAP3_14295.1
KLK10	huMAP3_00689.1 huMAP3_05578.1 huMAP3_05873.1 huMAP3_05990.1 huMAP3_06488.1 huMAP3_06524.1 huMAP3_06530.1 huMAP3_07054.1 huMAP3_08224.1 huMAP3_08988.1 huMAP3_09434.1 huMAP3_10678.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_08988.1

Complex Portal: CPX-10706