hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_08990.1
Complex Portal: CPX-25673
Confidence: High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| DYNLL2 | Dynein light chain 2, cytoplasmic (8 kDa dynein light chain b) (DLC8b) (Dynein light chain LC8-type 2) | 5 | UniProt NCBI |
| KANK1 | KN motif and ankyrin repeat domain-containing protein 1 (Ankyrin repeat domain-containing protein 15) (Kidney ankyrin repeat-containing protein) | 5 | UniProt NCBI |
| DYNLL1 | Dynein light chain 1, cytoplasmic (8 kDa dynein light chain) (DLC8) (Dynein light chain LC8-type 1) (Protein inhibitor of neuronal nitric oxide synthase) (PIN) | 5 | UniProt NCBI |
| DYNC1I1 | Cytoplasmic dynein 1 intermediate chain 1 (Cytoplasmic dynein intermediate chain 1) (Dynein intermediate chain 1, cytosolic) (DH IC-1) | 5 | UniProt NCBI |
| FAM117B | Protein FAM117B (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 13 protein) | 5 | UniProt NCBI |
| ZNF710 | Zinc finger protein 710 | 3 | UniProt NCBI |
| MORC3 | MORC family CW-type zinc finger protein 3 (Nuclear matrix protein 2) (Zinc finger CW-type coiled-coil domain protein 3) | 5 | UniProt NCBI |
| ZNF608 | Zinc finger protein 608 (Renal carcinoma antigen NY-REN-36) | 3 | UniProt NCBI |
| BLTP3B | Bridge-like lipid transfer protein family member 3B (Syntaxin-6 Habc-interacting protein of 164 kDa) (UHRF1-binding protein 1-like) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP4532 | 4.27786265801e-05 | 0.333333333333 | DYNLL1 DYNLL2 DYNC1I1 | Intraflagellar transport proteins binding to dynein |
| KEGG:04962 | 7.97446218061e-05 | 0.333333333333 | DYNLL1 DYNLL2 DYNC1I1 | Vasopressin-regulated water reabsorption |
| WP:WP5085 | 0.000143918669646 | 0.333333333333 | DYNLL1 DYNLL2 DYNC1I1 | Vasopressin regulated water reabsorption |
| CORUM:6038 | 0.000164069436391 | 0.222222222222 | DYNLL1 DYNC1I1 | Dynein complex |
| CORUM:6039 | 0.000273361732609 | 0.222222222222 | DYNLL1 DYNC1I1 | Dynein-dynactin complex |
| REAC:R-HSA-9646399 | 0.000403163829071 | 0.333333333333 | DYNLL1 DYNLL2 DYNC1I1 | Aggrephagy |
| REAC:R-HSA-6811436 | 0.000739221826765 | 0.333333333333 | DYNLL1 DYNLL2 DYNC1I1 | COPI-independent Golgi-to-ER retrograde traffic |
| REAC:R-HSA-3371497 | 0.000832996184822 | 0.333333333333 | DYNLL1 DYNLL2 DYNC1I1 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand |
| CORUM:6236 | 0.00180015784734 | 0.222222222222 | DYNLL1 DYNLL2 | Dynein-2 complex, cytoplasmic |
| REAC:R-HSA-9663891 | 0.00252715769562 | 0.333333333333 | DYNLL1 DYNLL2 DYNC1I1 | Selective autophagy |
| REAC:R-HSA-141444 | 0.00467528343252 | 0.333333333333 | DYNLL1 DYNLL2 DYNC1I1 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal |
| REAC:R-HSA-141424 | 0.00467528343252 | 0.333333333333 | DYNLL1 DYNLL2 DYNC1I1 | Amplification of signal from the kinetochores |
| REAC:R-HSA-6807878 | 0.00531278422874 | 0.333333333333 | DYNLL1 DYNLL2 DYNC1I1 | COPI-mediated anterograde transport |
| KEGG:04814 | 0.00540604860567 | 0.333333333333 | DYNLL1 DYNLL2 DYNC1I1 | Motor proteins |
| REAC:R-HSA-69618 | 0.00756314206499 | 0.333333333333 | DYNLL1 DYNLL2 DYNC1I1 | Mitotic Spindle Checkpoint |
| REAC:R-HSA-9648025 | 0.00866038135537 | 0.333333333333 | DYNLL1 DYNLL2 DYNC1I1 | EML4 and NUDC in mitotic spindle formation |
| REAC:R-HSA-2132295 | 0.00960997261146 | 0.333333333333 | DYNLL1 DYNLL2 DYNC1I1 | MHC class II antigen presentation |
| REAC:R-HSA-9609690 | 0.0103654411628 | 0.333333333333 | DYNLL1 DYNLL2 DYNC1I1 | HCMV Early Events |
| REAC:R-HSA-2500257 | 0.0106256828826 | 0.333333333333 | DYNLL1 DYNLL2 DYNC1I1 | Resolution of Sister Chromatid Cohesion |
| GO:0005868 | 0.0106791414882 | 0.333333333333 | DYNLL1 DYNLL2 DYNC1I1 | cytoplasmic dynein complex |
| REAC:R-HSA-1632852 | 0.0119915115759 | 0.333333333333 | DYNLL1 DYNLL2 DYNC1I1 | Macroautophagy |
| REAC:R-HSA-8856688 | 0.0119915115759 | 0.333333333333 | DYNLL1 DYNLL2 DYNC1I1 | Golgi-to-ER retrograde transport |
| REAC:R-HSA-5663220 | 0.0137769859127 | 0.333333333333 | DYNLL1 DYNLL2 DYNC1I1 | RHO GTPases Activate Formins |
| KEGG:05132 | 0.0140921621497 | 0.333333333333 | DYNLL1 DYNLL2 DYNC1I1 | Salmonella infection |
| REAC:R-HSA-9612973 | 0.0167694259816 | 0.333333333333 | DYNLL1 DYNLL2 DYNC1I1 | Autophagy |
| REAC:R-HSA-9609646 | 0.0171260552969 | 0.333333333333 | DYNLL1 DYNLL2 DYNC1I1 | HCMV Infection |
| REAC:R-HSA-199977 | 0.0174876293585 | 0.333333333333 | DYNLL1 DYNLL2 DYNC1I1 | ER to Golgi Anterograde Transport |
| REAC:R-HSA-948021 | 0.030266432518 | 0.333333333333 | DYNLL1 DYNLL2 DYNC1I1 | Transport to the Golgi and subsequent modification |
| REAC:R-HSA-114452 | 0.0344394959621 | 0.222222222222 | DYNLL1 DYNLL2 | Activation of BH3-only proteins |
| REAC:R-HSA-2467813 | 0.036958409223 | 0.333333333333 | DYNLL1 DYNLL2 DYNC1I1 | Separation of Sister Chromatids |
| REAC:R-HSA-6811442 | 0.042565070201 | 0.333333333333 | DYNLL1 DYNLL2 DYNC1I1 | Intra-Golgi and retrograde Golgi-to-ER traffic |
| GO:0030286 | 0.0436468140298 | 0.333333333333 | DYNLL1 DYNLL2 DYNC1I1 | dynein complex |
| REAC:R-HSA-68877 | 0.043881940329 | 0.333333333333 | DYNLL1 DYNLL2 DYNC1I1 | Mitotic Prometaphase |
| WP:WP4906 | 0.0482342246392 | 0.222222222222 | DYNLL1 DYNLL2 | 3q29 copy number variation syndrome |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| DYNC1I1 | DYNLL1 | 0.997 | 0.214 |
mutually_exclusive (Q96FJ2)
structurally_consistent (dimer) |
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM |
| DYNLL1 | MORC3 | 0.995 | 0.222 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt youn_WMM hein () boldt_WMM | |
| DYNC1I1 | DYNLL2 | 0.995 | 0.136 |
mutually_exclusive (P63167)
structurally_consistent (dimer) |
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM |
| DYNLL1 | FAM117B | 0.993 | 0.19 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM hein () boldt_WMM | |
| DYNLL2 | DYNLL1 | 0.99 | 0.214 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt youn_WMM gupta_WMM boldt_WMM WMM_only |
| DYNLL1 | KANK1 | 0.983 | 0.176 | hein_WMM bioplex3_HEK293 bioplex3_WMM hein () | |
| DYNLL2 | FAM117B | 0.981 | 0.1 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM boldt_WMM | |
| DYNLL1 | BLTP3B | 0.98 | 0.156 | hein_WMM bioplex3_HEK293 bioplex3_WMM boldt youn_WMM hein () boldt_WMM | |
| DYNLL2 | MORC3 | 0.979 | 0.088 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt boldt_WMM WMM_only | |
| FAM117B | BLTP3B | 0.965 | 0.078 | hein_WMM bioplex3_WMM boldt youn_WMM boldt_WMM bioplex_WMM WMM_only | |
| DYNLL1 | ZNF710 | 0.959 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| DYNLL1 | ZNF608 | 0.954 | 0.342 | bioplex3_HEK293 bioplex3_WMM youn_WMM WMM_only | |
| FAM117B | KANK1 | 0.952 | 0.046 | hein_WMM bioplex3_WMM WMM_only | |
| DYNLL2 | KANK1 | 0.949 | 0.133162162162 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| DYNLL2 | BLTP3B | 0.923 | 0.08 | bioplex3_HEK293 bioplex3_WMM boldt youn_WMM gupta_WMM boldt_WMM WMM_only | |
| KANK1 | BLTP3B | 0.918 | 0.088 | hein_WMM bioplex3_WMM WMM_only | |
| DYNLL2 | ZNF608 | 0.897 | 0.142 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| DYNLL2 | ZNF710 | 0.89 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| ZNF710 | ZNF608 | 0.391 | bioplex3_WMM WMM_only | ||
| DYNC1I1 | ZNF710 | 0.287 | bioplex3_WMM WMM_only | ||
| MORC3 | FAM117B | 0.269 | 0.048 | bioplex3_WMM boldt boldt_WMM WMM_only | |
| MORC3 | BLTP3B | 0.169 | 0.092 | bioplex3_WMM boldt boldt_WMM WMM_only | |
| ZNF710 | MORC3 | 0.135 | bioplex3_WMM WMM_only | ||
| DYNC1I1 | ZNF608 | 0.123 | 0.106 | bioplex3_WMM WMM_only | |
| MORC3 | ZNF608 | 0.114 | 0.152 | bioplex3_WMM youn_WMM WMM_only | |
| DYNC1I1 | BLTP3B | 0.079 | 0.062 | bioplex3_WMM WMM_only | |
| DYNC1I1 | KANK1 | 0.079 | 0.08 | bioplex3_WMM WMM_only | |
| DYNC1I1 | MORC3 | 0.079 | 0.116 | bioplex3_WMM WMM_only | |
| ZNF608 | BLTP3B | 0.079 | 0.12 | bioplex3_WMM WMM_only | |
| ZNF710 | BLTP3B | 0.079 | bioplex3_WMM WMM_only | ||
| MORC3 | KANK1 | 0.079 | 0.05 | bioplex3_WMM WMM_only | |
| ZNF710 | FAM117B | 0.079 | bioplex3_WMM WMM_only | ||
| ZNF710 | KANK1 | 0.079 | bioplex3_WMM WMM_only | ||
| DYNC1I1 | FAM117B | 0.079 | 0.078 | bioplex3_WMM WMM_only | |
| ZNF608 | KANK1 | 0.079 | 0.092 | bioplex3_WMM WMM_only | |
| ZNF608 | FAM117B | 0.079 | 0.106 | bioplex3_WMM WMM_only |
Related Complexes