hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_09006.1
Confidence: High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| TRAF6 | TNF receptor-associated factor 6 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRAF6) (Interleukin-1 signal transducer) (RING finger protein 85) (RING-type E3 ubiquitin transferase TRAF6) | 5 | UniProt NCBI |
| IRAK2 | Interleukin-1 receptor-associated kinase-like 2 (IRAK-2) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-937042 | 7.68942788458e-05 | 1.0 | TRAF6 IRAK2 | IRAK2 mediated activation of TAK1 complex |
| REAC:R-HSA-937072 | 0.000133283416666 | 1.0 | TRAF6 IRAK2 | TRAF6-mediated induction of TAK1 complex within TLR4 complex |
| REAC:R-HSA-975163 | 0.000133283416666 | 1.0 | TRAF6 IRAK2 | IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation |
| WP:WP4496 | 0.000185152102942 | 1.0 | TRAF6 IRAK2 | Signal transduction through IL1R |
| WP:WP4136 | 0.00022473634564 | 1.0 | TRAF6 IRAK2 | Fibrin complement receptor 3 signaling pathway |
| REAC:R-HSA-450321 | 0.00023239159829 | 1.0 | TRAF6 IRAK2 | JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 |
| REAC:R-HSA-450302 | 0.000324664732905 | 1.0 | TRAF6 IRAK2 | activated TAK1 mediates p38 MAPK activation |
| WP:WP2637 | 0.000384350227487 | 1.0 | TRAF6 IRAK2 | Interleukin 1 IL 1 structural pathway |
| WP:WP195 | 0.000480118556595 | 1.0 | TRAF6 IRAK2 | IL 1 signaling pathway |
| KEGG:04722 | 0.000804719987643 | 1.0 | TRAF6 IRAK2 | Neurotrophin signaling pathway |
| REAC:R-HSA-168638 | 0.000847545829056 | 1.0 | TRAF6 IRAK2 | NOD1/2 Signaling Pathway |
| REAC:R-HSA-445989 | 0.00107651990384 | 1.0 | TRAF6 IRAK2 | TAK1-dependent IKK and NF-kappa-B activation |
| REAC:R-HSA-9692916 | 0.00120125951175 | 1.0 | TRAF6 IRAK2 | SARS-CoV-1 activates/modulates innate immune responses |
| KEGG:05152 | 0.001720800216 | 1.0 | TRAF6 IRAK2 | Tuberculosis |
| REAC:R-HSA-168643 | 0.00176856841345 | 1.0 | TRAF6 IRAK2 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways |
| REAC:R-HSA-450294 | 0.00263149309828 | 1.0 | TRAF6 IRAK2 | MAP kinase activation |
| REAC:R-HSA-448424 | 0.00323126847328 | 1.0 | TRAF6 IRAK2 | Interleukin-17 signaling |
| REAC:R-HSA-975871 | 0.00567479777882 | 1.0 | TRAF6 IRAK2 | MyD88 cascade initiated on plasma membrane |
| REAC:R-HSA-168176 | 0.00567479777882 | 1.0 | TRAF6 IRAK2 | Toll Like Receptor 5 (TLR5) Cascade |
| REAC:R-HSA-168142 | 0.00567479777882 | 1.0 | TRAF6 IRAK2 | Toll Like Receptor 10 (TLR10) Cascade |
| REAC:R-HSA-975138 | 0.00595674346792 | 1.0 | TRAF6 IRAK2 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation |
| REAC:R-HSA-975155 | 0.0061002794551 | 1.0 | TRAF6 IRAK2 | MyD88 dependent cascade initiated on endosome |
| REAC:R-HSA-168181 | 0.0061002794551 | 1.0 | TRAF6 IRAK2 | Toll Like Receptor 7/8 (TLR7/8) Cascade |
| REAC:R-HSA-168138 | 0.00669151102134 | 1.0 | TRAF6 IRAK2 | Toll Like Receptor 9 (TLR9) Cascade |
| REAC:R-HSA-168164 | 0.00699737937497 | 1.0 | TRAF6 IRAK2 | Toll Like Receptor 3 (TLR3) Cascade |
| REAC:R-HSA-937061 | 0.00731008277561 | 1.0 | TRAF6 IRAK2 | TRIF(TICAM1)-mediated TLR4 signaling |
| REAC:R-HSA-9692914 | 0.00731008277561 | 1.0 | TRAF6 IRAK2 | SARS-CoV-1-host interactions |
| REAC:R-HSA-166166 | 0.00731008277561 | 1.0 | TRAF6 IRAK2 | MyD88-independent TLR4 cascade |
| REAC:R-HSA-168188 | 0.00762962122326 | 1.0 | TRAF6 IRAK2 | Toll Like Receptor TLR6:TLR2 Cascade |
| REAC:R-HSA-166058 | 0.00762962122326 | 1.0 | TRAF6 IRAK2 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane |
| REAC:R-HSA-181438 | 0.00795599471791 | 1.0 | TRAF6 IRAK2 | Toll Like Receptor 2 (TLR2) Cascade |
| REAC:R-HSA-168179 | 0.00795599471791 | 1.0 | TRAF6 IRAK2 | Toll Like Receptor TLR1:TLR2 Cascade |
| REAC:R-HSA-9020702 | 0.00828920325958 | 1.0 | TRAF6 IRAK2 | Interleukin-1 signaling |
| REAC:R-HSA-9705671 | 0.0106216630512 | 1.0 | TRAF6 IRAK2 | SARS-CoV-2 activates/modulates innate and adaptive immune responses |
| REAC:R-HSA-166016 | 0.0128208394262 | 1.0 | TRAF6 IRAK2 | Toll Like Receptor 4 (TLR4) Cascade |
| REAC:R-HSA-446652 | 0.0141075370256 | 1.0 | TRAF6 IRAK2 | Interleukin-1 family signaling |
| REAC:R-HSA-9678108 | 0.0147739541089 | 1.0 | TRAF6 IRAK2 | SARS-CoV-1 Infection |
| REAC:R-HSA-168898 | 0.0171064139006 | 1.0 | TRAF6 IRAK2 | Toll-like Receptor Cascades |
| CORUM:2074 | 0.0249718442457 | 0.5 | TRAF6 | TRAF6 homo-oligomer complex |
| CORUM:2073 | 0.0249718442457 | 0.5 | TRAF6 | TNFRSF11A-TRAF6-SRC complex |
| REAC:R-HSA-9705683 | 0.0300366140789 | 1.0 | TRAF6 IRAK2 | SARS-CoV-2-host interactions |
| GO:0002755 | 0.0365196561665 | 1.0 | TRAF6 IRAK2 | MyD88-dependent toll-like receptor signaling pathway |
| WP:WP3926 | 0.0373151717536 | 0.5 | TRAF6 | ApoE and miR 146 in inflammation and atherosclerosis |
| WP:WP4788 | 0.049750157242 | 0.5 | TRAF6 | Autosomal recessive osteopetrosis pathways |
| WP:WP5116 | 0.049750157242 | 0.5 | TRAF6 | SARS CoV 2 B 1 1 7 variant antagonises innate immune activation |
| CORUM:1944 | 0.0499419797295 | 0.5 | IRAK2 | IRAK1-IRAK2 complex |
| CORUM:748 | 0.0499419797295 | 0.5 | TRAF6 | TRAF6-TAK1 complex |
| CORUM:2743 | 0.0499419797295 | 0.5 | TRAF6 | TRAF6-MALT1 complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| IRAK2 | TRAF6 | 0.983 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
Related Complexes
| Genename | Complexes |
|---|---|
| TRAF6 | huMAP3_09006.1 huMAP3_14463.1 |
| IRAK2 | huMAP3_03555.1 huMAP3_09006.1 huMAP3_13697.1 huMAP3_14870.1 huMAP3_15080.1 |