hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_09010.1
Confidence: Moderate High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| LDHC | L-lactate dehydrogenase C chain (LDH-C) (EC 1.1.1.27) (Cancer/testis antigen 32) (CT32) (LDH testis subunit) (LDH-X) | 5 | UniProt NCBI |
| LDHA | L-lactate dehydrogenase A chain (LDH-A) (EC 1.1.1.27) (Cell proliferation-inducing gene 19 protein) (LDH muscle subunit) (LDH-M) (Renal carcinoma antigen NY-REN-59) | 5 | UniProt NCBI |
| ACADM | Medium-chain specific acyl-CoA dehydrogenase, mitochondrial (MCAD) (EC 1.3.8.7) (Medium chain acyl-CoA dehydrogenase) (MCADH) | 5 | UniProt NCBI |
| LDHB | L-lactate dehydrogenase B chain (LDH-B) (EC 1.1.1.27) (LDH heart subunit) (LDH-H) (Renal carcinoma antigen NY-REN-46) | 5 | UniProt NCBI |
| LDHAL6A | L-lactate dehydrogenase A-like 6A (LDHA-like protein 6A) (EC 1.1.1.27) | 4 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0004457 | 1.31563155046e-10 | 1.0 | LDHC LDHAL6A LDHA LDHB | lactate dehydrogenase activity |
| GO:0004459 | 1.31563155046e-10 | 1.0 | LDHC LDHAL6A LDHA LDHB | L-lactate dehydrogenase activity |
| KEGG:00640 | 7.39220477413e-10 | 1.0 | LDHC LDHAL6A LDHA LDHB | Propanoate metabolism |
| REAC:R-HSA-70268 | 2.63174325842e-09 | 1.0 | LDHC LDHAL6A LDHA LDHB | Pyruvate metabolism |
| KEGG:00620 | 2.89932302932e-09 | 1.0 | LDHC LDHAL6A LDHA LDHB | Pyruvate metabolism |
| GO:0006089 | 3.31539150715e-09 | 1.0 | LDHC LDHAL6A LDHA LDHB | lactate metabolic process |
| KEGG:00270 | 3.83377383145e-09 | 1.0 | LDHC LDHAL6A LDHA LDHB | Cysteine and methionine metabolism |
| KEGG:00010 | 1.31056871833e-08 | 1.0 | LDHC LDHAL6A LDHA LDHB | Glycolysis / Gluconeogenesis |
| KEGG:05230 | 1.80072369785e-08 | 1.0 | LDHC LDHAL6A LDHA LDHB | Central carbon metabolism in cancer |
| REAC:R-HSA-71406 | 2.59981278465e-08 | 1.0 | LDHC LDHAL6A LDHA LDHB | Pyruvate metabolism and Citric Acid (TCA) cycle |
| KEGG:04922 | 6.56442584798e-08 | 1.0 | LDHC LDHAL6A LDHA LDHB | Glucagon signaling pathway |
| KEGG:04066 | 8.84380684533e-08 | 1.0 | LDHC LDHAL6A LDHA LDHB | HIF-1 signaling pathway |
| WP:WP4236 | 9.9913533089e-08 | 0.75 | LDHC LDHA LDHB | Krebs cycle disorders |
| REAC:R-HSA-1428517 | 3.14936514356e-06 | 1.0 | LDHC LDHAL6A LDHA LDHB | The citric acid (TCA) cycle and respiratory electron transport |
| WP:WP534 | 4.00454251624e-06 | 0.75 | LDHC LDHA LDHB | Glycolysis and gluconeogenesis |
| WP:WP4018 | 2.35146163933e-05 | 0.75 | LDHC LDHA LDHB | Clear cell renal cell carcinoma pathways |
| WP:WP5355 | 3.5618246416e-05 | 0.75 | LDHC LDHA LDHB | Metabolic Epileptic Disorders |
| GO:0006090 | 6.13581611239e-05 | 1.0 | LDHC LDHAL6A LDHA LDHB | pyruvate metabolic process |
| GO:0016616 | 0.000111817498921 | 1.0 | LDHC LDHAL6A LDHA LDHB | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| WP:WP5314 | 0.000140344895657 | 0.5 | LDHA LDHB | Lactate shuttle in glial cells |
| GO:0016614 | 0.000151907686653 | 1.0 | LDHC LDHAL6A LDHA LDHB | oxidoreductase activity, acting on CH-OH group of donors |
| KEGG:01100 | 0.00275730008049 | 1.0 | LDHC LDHAL6A LDHA LDHB | Metabolic pathways |
| GO:1901615 | 0.0111408206209 | 1.0 | LDHC LDHAL6A LDHA LDHB | organic hydroxy compound metabolic process |
| GO:0032787 | 0.0317425976647 | 1.0 | LDHC LDHAL6A LDHA LDHB | monocarboxylic acid metabolic process |
| REAC:R-HSA-1430728 | 0.0393174957935 | 1.0 | LDHC LDHAL6A LDHA LDHB | Metabolism |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| LDHC | LDHA | 1.0 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 fraction | |
| LDHB | LDHC | 0.997 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| LDHB | LDHA | 0.997 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM gupta_WMM boldt_WMM treiber_WMM | |
| ACADM | LDHA | 0.988 | hein_WMM bioplex_WMM Guru bioplex3_WMM fraction boldt_WMM treiber_WMM | |
| LDHC | LDHAL6A | 0.974 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| LDHAL6A | LDHA | 0.825 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| LDHB | ACADM | 0.757 | 0.112 | hein_WMM bioplex_WMM Guru bioplex3_WMM fraction boldt_WMM treiber_WMM |
| LDHB | LDHAL6A | 0.069 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| LDHC | ACADM | 0.007 | bioplex3_HEK293 bioplex () bioplex3_HCT116 | |
| LDHAL6A | ACADM | 0.002 | bioplex3_HEK293 bioplex3_HCT116 WMM_only |
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