hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_09019.1
Complex Portal: CPX-12424
Confidence: Moderate High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| TMEM87A | Transmembrane protein 87A (Elkin1) | 5 | UniProt NCBI |
| CERS4 | Ceramide synthase 4 (CerS4) (EC 2.3.1.-) (LAG1 longevity assurance homolog 4) (Sphingosine N-acyltransferase CERS4) (EC 2.3.1.24) | 5 | UniProt NCBI |
| STIM1 | Stromal interaction molecule 1 | 5 | UniProt NCBI |
| MSMO1 | Methylsterol monooxygenase 1 (EC 1.14.18.9) (C-4 methylsterol oxidase) (Sterol-C4-methyl oxidase) | 5 | UniProt NCBI |
| CERS5 | Ceramide synthase 5 (CerS5) (LAG1 longevity assurance homolog 5) (Sphingoid base N-palmitoyltransferase CERS5) (EC 2.3.1.291) (Sphingosine N-acyltransferase CERS5) (EC 2.3.1.24) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP5194 | 0.00100346979189 | 0.4 | CERS4 CERS5 | Synthesis of ceramides and 1 deoxyceramides |
| WP:WP4726 | 0.00148385269311 | 0.4 | CERS4 CERS5 | Sphingolipid metabolism integrated pathway |
| WP:WP1422 | 0.00205749802636 | 0.4 | CERS4 CERS5 | Sphingolipid pathway |
| KEGG:00600 | 0.00488363922167 | 0.4 | CERS4 CERS5 | Sphingolipid metabolism |
| REAC:R-HSA-1660661 | 0.00849065158197 | 0.4 | CERS4 CERS5 | Sphingolipid de novo biosynthesis |
| KEGG:04071 | 0.0235498516465 | 0.4 | CERS4 CERS5 | Sphingolipid signaling pathway |
| REAC:R-HSA-428157 | 0.0395622673154 | 0.4 | CERS4 CERS5 | Sphingolipid metabolism |
| CORUM:6108 | 0.0498708842806 | 0.2 | STIM1 | STIM1-TRPV4 complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| TMEM87A | CERS4 | 0.975 | 0.088 | bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | |
| CERS4 | CERS5 | 0.974 | 0.102 | bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | |
| TMEM87A | STIM1 | 0.971 | 0.056 | bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM fraction | |
| TMEM87A | MSMO1 | 0.964 | 0.016 | bioplex_WMM bioplex3_WMM WMM_only | |
| MSMO1 | CERS5 | 0.959 | 0.044 | bioplex_WMM bioplex3_WMM WMM_only | |
| TMEM87A | CERS5 | 0.931 | 0.092 | bioplex_WMM bioplex3_WMM WMM_only | |
| CERS4 | MSMO1 | 0.791 | 0.032 | bioplex_WMM bioplex3_WMM WMM_only | |
| STIM1 | CERS5 | 0.045 | 0.184 | bioplex3_WMM WMM_only | |
| CERS4 | STIM1 | 0.02 | 0.044 | youn_WMM gupta_WMM WMM_only | |
| STIM1 | MSMO1 | 0.019 | 0.014 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes