hu.MAP 3.0: Complex View

Human Protein Complex Map

Genename	Protein Name	Uniprot Annotation Score	Links
NEK1	Serine/threonine-protein kinase Nek1 (EC 2.7.11.1) (Never in mitosis A-related kinase 1) (NimA-related protein kinase 1) (Renal carcinoma antigen NY-REN-55)	5	UniProt NCBI
TEKT4	Tektin-4	5	UniProt NCBI
ODAD4	Outer dynein arm-docking complex subunit 4 (Tetratricopeptide repeat protein 25) (TPR repeat protein 25)	5	UniProt NCBI
CFAP410	Cilia- and flagella-associated protein 410 (C21orf-HUMF09G8.5) (Leucine-rich repeat-containing protein 76) (YF5/A2)	5	UniProt NCBI

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
WP:WP4803	0.00021522017766	0.75	CFAP410 NEK1 ODAD4	Ciliopathies
HPA:0060861	0.00166430896677	0.75	TEKT4 ODAD4 CFAP410	bronchus; ciliated cells (cilia axoneme)[>=Low]
WP:WP5234	0.00722934152515	0.5	CFAP410 NEK1	Bardet Biedl syndrome
HPA:0060881	0.00799590140567	0.75	TEKT4 ODAD4 CFAP410	bronchus; ciliated cells (tip of cilia)[>=Low]
HP:0002878	0.00803184965878	0.75	CFAP410 NEK1 ODAD4	Respiratory failure
HPA:0210882	0.0117448030838	0.75	TEKT4 ODAD4 CFAP410	fallopian tube; ciliated cells (tip of cilia)[>=Medium]
HP:0009067	0.0176079483787	0.5	CFAP410 NEK1	Progressive spinal muscular atrophy
HP:0000556	0.019095104138	0.75	CFAP410 NEK1 ODAD4	Retinal dystrophy
HP:0008955	0.0198386649826	0.5	CFAP410 NEK1	Progressive distal muscular atrophy
HPA:0210881	0.0219529719185	0.75	TEKT4 ODAD4 CFAP410	fallopian tube; ciliated cells (tip of cilia)[>=Low]
HP:0025425	0.0234332085093	0.5	CFAP410 NEK1	Laryngospasm
HP:0033683	0.0234332085093	0.5	CFAP410 NEK1	Jaw hyperreflexia
HP:0030195	0.0259951101914	0.5	CFAP410 NEK1	Fatigable weakness of swallowing muscles
HP:0012473	0.0315158796726	0.5	CFAP410 NEK1	Tongue atrophy
HP:0025424	0.0315158796726	0.5	CFAP410 NEK1	Abnormal larynx physiology
HP:0007354	0.034474601612	0.5	CFAP410 NEK1	Amyotrophic lateral sclerosis
HP:0002145	0.0375654511359	0.5	CFAP410 NEK1	Frontotemporal dementia
HP:0007269	0.040788355352	0.5	CFAP410 NEK1	Spinal muscular atrophy
HP:0000217	0.040788355352	0.5	CFAP410 NEK1	Xerostomia
HP:0030196	0.0458701548093	0.5	CFAP410 NEK1	Fatigable weakness of respiratory muscles

Protein 1	Protein 2	Score	ProteomeHD	Evidence
NEK1	CFAP410	1.0	0.166	hein_WMM bioplex_WMM bioplex3_WMM boldt hein () gupta_WMM boldt_WMM
NEK1	TEKT4	0.998		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
TEKT4	CFAP410	0.997		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
CFAP410	ODAD4	0.983		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM
NEK1	ODAD4	0.98		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM