hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_09035.1
Confidence: Moderate High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| NEK1 | Serine/threonine-protein kinase Nek1 (EC 2.7.11.1) (Never in mitosis A-related kinase 1) (NimA-related protein kinase 1) (Renal carcinoma antigen NY-REN-55) | 5 | UniProt NCBI |
| TEKT4 | Tektin-4 | 5 | UniProt NCBI |
| ODAD4 | Outer dynein arm-docking complex subunit 4 (Tetratricopeptide repeat protein 25) (TPR repeat protein 25) | 5 | UniProt NCBI |
| CFAP410 | Cilia- and flagella-associated protein 410 (C21orf-HUMF09G8.5) (Leucine-rich repeat-containing protein 76) (YF5/A2) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP4803 | 0.00021522017766 | 0.75 | NEK1 ODAD4 CFAP410 | Ciliopathies |
| HPA:0060861 | 0.00166430896677 | 0.75 | CFAP410 TEKT4 ODAD4 | bronchus; ciliated cells (cilia axoneme)[>=Low] |
| WP:WP5234 | 0.00722934152515 | 0.5 | NEK1 CFAP410 | Bardet Biedl syndrome |
| HPA:0060881 | 0.00799590140567 | 0.75 | CFAP410 TEKT4 ODAD4 | bronchus; ciliated cells (tip of cilia)[>=Low] |
| HP:0002878 | 0.00803184965878 | 0.75 | NEK1 ODAD4 CFAP410 | Respiratory failure |
| HPA:0210882 | 0.0117448030838 | 0.75 | CFAP410 TEKT4 ODAD4 | fallopian tube; ciliated cells (tip of cilia)[>=Medium] |
| HP:0009067 | 0.0176079483787 | 0.5 | NEK1 CFAP410 | Progressive spinal muscular atrophy |
| HP:0000556 | 0.019095104138 | 0.75 | NEK1 ODAD4 CFAP410 | Retinal dystrophy |
| HP:0008955 | 0.0198386649826 | 0.5 | NEK1 CFAP410 | Progressive distal muscular atrophy |
| HPA:0210881 | 0.0219529719185 | 0.75 | CFAP410 TEKT4 ODAD4 | fallopian tube; ciliated cells (tip of cilia)[>=Low] |
| HP:0025425 | 0.0234332085093 | 0.5 | NEK1 CFAP410 | Laryngospasm |
| HP:0033683 | 0.0234332085093 | 0.5 | NEK1 CFAP410 | Jaw hyperreflexia |
| HP:0030195 | 0.0259951101914 | 0.5 | NEK1 CFAP410 | Fatigable weakness of swallowing muscles |
| HP:0012473 | 0.0315158796726 | 0.5 | NEK1 CFAP410 | Tongue atrophy |
| HP:0025424 | 0.0315158796726 | 0.5 | NEK1 CFAP410 | Abnormal larynx physiology |
| HP:0007354 | 0.034474601612 | 0.5 | NEK1 CFAP410 | Amyotrophic lateral sclerosis |
| HP:0002145 | 0.0375654511359 | 0.5 | NEK1 CFAP410 | Frontotemporal dementia |
| HP:0007269 | 0.040788355352 | 0.5 | NEK1 CFAP410 | Spinal muscular atrophy |
| HP:0000217 | 0.040788355352 | 0.5 | NEK1 CFAP410 | Xerostomia |
| HP:0030196 | 0.0458701548093 | 0.5 | NEK1 CFAP410 | Fatigable weakness of respiratory muscles |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| NEK1 | CFAP410 | 1.0 | 0.166 | hein_WMM bioplex_WMM bioplex3_WMM boldt hein () gupta_WMM boldt_WMM |
| NEK1 | TEKT4 | 0.998 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| TEKT4 | CFAP410 | 0.997 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| CFAP410 | ODAD4 | 0.983 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| NEK1 | ODAD4 | 0.98 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
Related Complexes
| Genename | Complexes |
|---|---|
| NEK1 | huMAP3_02277.1 huMAP3_09035.1 huMAP3_15205.1 |
| TEKT4 | huMAP3_02277.1 huMAP3_09035.1 |
| ODAD4 | huMAP3_09035.1 huMAP3_15030.1 |
| CFAP410 | huMAP3_02277.1 huMAP3_09035.1 |