hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_09036.1
Confidence: Moderate High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| FBXW4 | F-box/WD repeat-containing protein 4 (Dactylin) (F-box and WD-40 domain-containing protein 4) | 4 | UniProt NCBI |
| PFDN5 | Prefoldin subunit 5 (Myc modulator 1) (c-Myc-binding protein Mm-1) | 5 | UniProt NCBI |
| WSB2 | WD repeat and SOCS box-containing protein 2 (WSB-2) (CS box-containing WD protein) | 3 | UniProt NCBI |
| VBP1 | Prefoldin subunit 3 (HIBBJ46) (von Hippel-Lindau-binding protein 1) (VBP-1) (VHL-binding protein 1) | 5 | UniProt NCBI |
| PFDN2 | Prefoldin subunit 2 | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP4918 | 2.41433268812e-08 | 0.6 | PFDN5 VBP1 PFDN2 | Cellular proteostasis |
| CORUM:33 | 5.60294116544e-08 | 0.6 | PFDN5 VBP1 PFDN2 | Prefoldin complex |
| CORUM:112 | 5.60294116544e-08 | 0.6 | PFDN5 VBP1 PFDN2 | Prefoldin complex |
| REAC:R-HSA-390466 | 8.61057377169e-07 | 0.8 | FBXW4 PFDN2 VBP1 PFDN5 | Chaperonin-mediated protein folding |
| REAC:R-HSA-391251 | 1.18778119207e-06 | 0.8 | FBXW4 PFDN2 VBP1 PFDN5 | Protein folding |
| REAC:R-HSA-389957 | 9.10580767182e-06 | 0.6 | PFDN5 VBP1 PFDN2 | Prefoldin mediated transfer of substrate to CCT/TriC |
| REAC:R-HSA-389958 | 1.54330255969e-05 | 0.6 | PFDN5 VBP1 PFDN2 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding |
| GO:0016272 | 1.92180881975e-05 | 0.6 | PFDN5 VBP1 PFDN2 | prefoldin complex |
| GO:1905907 | 0.000158467845213 | 0.6 | PFDN5 VBP1 PFDN2 | negative regulation of amyloid fibril formation |
| GO:1905906 | 0.000436807598019 | 0.6 | PFDN5 VBP1 PFDN2 | regulation of amyloid fibril formation |
| REAC:R-HSA-392499 | 0.00352060064826 | 1.0 | VBP1 FBXW4 PFDN2 WSB2 PFDN5 | Metabolism of proteins |
| GO:1990000 | 0.00807957978043 | 0.6 | PFDN5 VBP1 PFDN2 | amyloid fibril formation |
| GO:0061077 | 0.0343879535233 | 0.6 | PFDN5 VBP1 PFDN2 | chaperone-mediated protein folding |
| GO:0001540 | 0.0457443058639 | 0.6 | PFDN5 VBP1 PFDN2 | amyloid-beta binding |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| PFDN2 | VBP1 | 1.0 | 0.924 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM boldt youn_WMM hein () bioplex3_HCT116 gupta_WMM fraction boldt_WMM |
| PFDN5 | PFDN2 | 1.0 | 0.93 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM boldt youn_WMM hein () bioplex3_HCT116 gupta_WMM fraction boldt_WMM |
| PFDN5 | VBP1 | 1.0 | 0.866 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM boldt youn_WMM hein () bioplex3_HCT116 gupta_WMM fraction boldt_WMM |
| FBXW4 | PFDN2 | 0.99 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 | |
| WSB2 | PFDN5 | 0.989 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| FBXW4 | VBP1 | 0.984 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 | |
| WSB2 | PFDN2 | 0.984 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| WSB2 | VBP1 | 0.973 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| FBXW4 | PFDN5 | 0.957 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| WSB2 | FBXW4 | 0.046 | bioplex3_WMM WMM_only |
Related Complexes