hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_09037.1
Confidence: Moderate High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| UBE2D4 | Ubiquitin-conjugating enzyme E2 D4 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme D4) (HBUCE1) (Ubiquitin carrier protein D4) (Ubiquitin-protein ligase D4) | 5 | UniProt NCBI |
| UBE2E2 | Ubiquitin-conjugating enzyme E2 E2 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme E2) (UbcH8) (Ubiquitin carrier protein E2) (Ubiquitin-protein ligase E2) | 5 | UniProt NCBI |
| RNF10 | E3 ubiquitin-protein ligase RNF10 (EC 2.3.2.27) (RING finger protein 10) | 5 | UniProt NCBI |
| UBE2D1 | Ubiquitin-conjugating enzyme E2 D1 (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme D1) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme D1) (Stimulator of Fe transport) (SFT) (UBC4/5 homolog) (UbcH5) (Ubiquitin carrier protein D1) (Ubiquitin-conjugating enzyme E2(17)KB 1) (Ubiquitin-conjugating enzyme E2-17 kDa 1) (Ubiquitin-protein ligase D1) | 5 | UniProt NCBI |
| UBE2D2 | Ubiquitin-conjugating enzyme E2 D2 (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme D2) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme D2) (Ubiquitin carrier protein D2) (Ubiquitin-conjugating enzyme E2(17)KB 2) (Ubiquitin-conjugating enzyme E2-17 kDa 2) (Ubiquitin-protein ligase D2) (p53-regulated ubiquitin-conjugating enzyme 1) | 5 | UniProt NCBI |
| RNF25 | E3 ubiquitin-protein ligase RNF25 (EC 2.3.2.27) (RING finger protein 25) (RING finger protein AO7) | 5 | UniProt NCBI |
| OTUB1 | Ubiquitin thioesterase OTUB1 (EC 3.4.19.12) (Deubiquitinating enzyme OTUB1) (OTU domain-containing ubiquitin aldehyde-binding protein 1) (Otubain-1) (hOTU1) (Ubiquitin-specific-processing protease OTUB1) | 5 | UniProt NCBI |
| UBE2E3 | Ubiquitin-conjugating enzyme E2 E3 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme E3) (UbcH9) (Ubiquitin carrier protein E3) (Ubiquitin-conjugating enzyme E2-23 kDa) (Ubiquitin-protein ligase E3) | 5 | UniProt NCBI |
| UBE2D3 | Ubiquitin-conjugating enzyme E2 D3 (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme D3) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme D3) (Ubiquitin carrier protein D3) (Ubiquitin-conjugating enzyme E2(17)KB 3) (Ubiquitin-conjugating enzyme E2-17 kDa 3) (Ubiquitin-protein ligase D3) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0061631 | 1.83662539324e-10 | 0.666666666667 | UBE2E3 UBE2D2 UBE2D3 UBE2D1 UBE2D4 UBE2E2 | ubiquitin conjugating enzyme activity |
| GO:0061650 | 5.01622720499e-10 | 0.666666666667 | UBE2E3 UBE2D2 UBE2D3 UBE2D1 UBE2D4 UBE2E2 | ubiquitin-like protein conjugating enzyme activity |
| KEGG:04120 | 2.30614694402e-09 | 0.666666666667 | UBE2E3 UBE2D2 UBE2D3 UBE2D1 UBE2D4 UBE2E2 | Ubiquitin mediated proteolysis |
| REAC:R-HSA-983168 | 7.63393696818e-09 | 0.777777777778 | UBE2D1 RNF25 UBE2D2 UBE2E2 UBE2E3 UBE2D4 UBE2D3 | Antigen processing: Ubiquitination & Proteasome degradation |
| GO:0070647 | 3.18314712685e-08 | 1.0 | UBE2E3 RNF25 UBE2D2 UBE2D3 UBE2E2 UBE2D1 UBE2D4 RNF10 OTUB1 | protein modification by small protein conjugation or removal |
| REAC:R-HSA-983169 | 3.21523862361e-08 | 0.777777777778 | UBE2D1 RNF25 UBE2D2 UBE2E2 UBE2E3 UBE2D4 UBE2D3 | Class I MHC mediated antigen processing & presentation |
| GO:0004842 | 3.83301413838e-08 | 0.888888888889 | UBE2E3 RNF25 UBE2D2 UBE2E2 UBE2D1 UBE2D4 RNF10 UBE2D3 | ubiquitin-protein transferase activity |
| GO:0070936 | 4.79699121645e-08 | 0.666666666667 | UBE2E3 UBE2D2 UBE2D3 UBE2D1 UBE2D4 UBE2E2 | protein K48-linked ubiquitination |
| GO:0043687 | 5.76495803351e-08 | 1.0 | UBE2E3 RNF25 UBE2D2 UBE2D3 UBE2E2 UBE2D1 UBE2D4 RNF10 OTUB1 | post-translational protein modification |
| GO:0019787 | 7.20043659477e-08 | 0.888888888889 | UBE2E3 RNF25 UBE2D2 UBE2E2 UBE2D1 UBE2D4 RNF10 UBE2D3 | ubiquitin-like protein transferase activity |
| GO:0016755 | 9.49441556905e-08 | 0.888888888889 | UBE2E3 RNF25 UBE2D2 UBE2E2 UBE2D1 UBE2D4 RNF10 UBE2D3 | aminoacyltransferase activity |
| GO:0000209 | 2.53556221256e-07 | 0.777777777778 | UBE2D1 RNF25 UBE2D2 UBE2E2 UBE2E3 UBE2D4 UBE2D3 | protein polyubiquitination |
| GO:0016567 | 1.01456141238e-06 | 0.888888888889 | UBE2E3 RNF25 UBE2D2 UBE2E2 UBE2D1 UBE2D4 RNF10 UBE2D3 | protein ubiquitination |
| GO:0016746 | 1.92533769058e-06 | 0.888888888889 | UBE2E3 RNF25 UBE2D2 UBE2E2 UBE2D1 UBE2D4 RNF10 UBE2D3 | acyltransferase activity |
| GO:0032446 | 2.84641388412e-06 | 0.888888888889 | UBE2E3 RNF25 UBE2D2 UBE2E2 UBE2D1 UBE2D4 RNF10 UBE2D3 | protein modification by small protein conjugation |
| REAC:R-HSA-1280218 | 3.05180298279e-06 | 0.777777777778 | UBE2D1 RNF25 UBE2D2 UBE2E2 UBE2E3 UBE2D4 UBE2D3 | Adaptive Immune System |
| KEGG:03083 | 5.46074507464e-06 | 0.444444444444 | UBE2D3 UBE2D4 UBE2D2 UBE2D1 | Polycomb repressive complex |
| REAC:R-HSA-8852135 | 1.77357526438e-05 | 0.444444444444 | UBE2D3 UBE2D1 UBE2D2 UBE2E3 | Protein ubiquitination |
| REAC:R-HSA-168927 | 3.68972254137e-05 | 0.333333333333 | UBE2D1 UBE2D2 UBE2D3 | TICAM1, RIP1-mediated IKK complex recruitment |
| REAC:R-HSA-937041 | 4.3395124826e-05 | 0.333333333333 | UBE2D1 UBE2D2 UBE2D3 | IKK complex recruitment mediated by RIP1 |
| REAC:R-HSA-9705462 | 6.73524036089e-05 | 0.333333333333 | UBE2D1 UBE2D2 UBE2D3 | Inactivation of CSF3 (G-CSF) signaling |
| GO:0070979 | 6.74377942697e-05 | 0.444444444444 | UBE2D3 UBE2D4 UBE2E2 UBE2E3 | protein K11-linked ubiquitination |
| KEGG:04141 | 7.63235808715e-05 | 0.444444444444 | UBE2D3 UBE2D4 UBE2D2 UBE2D1 | Protein processing in endoplasmic reticulum |
| REAC:R-HSA-9674555 | 0.000124396764524 | 0.333333333333 | UBE2D1 UBE2D2 UBE2D3 | Signaling by CSF3 (G-CSF) |
| REAC:R-HSA-8866652 | 0.000154071905864 | 0.333333333333 | UBE2D1 UBE2D2 UBE2E3 | Synthesis of active ubiquitin: roles of E1 and E2 enzymes |
| GO:0140096 | 0.000193323768734 | 1.0 | UBE2E3 RNF25 UBE2D2 UBE2D3 UBE2E2 UBE2D1 UBE2D4 RNF10 OTUB1 | catalytic activity, acting on a protein |
| REAC:R-HSA-936440 | 0.00020685693853 | 0.333333333333 | UBE2D1 UBE2D2 UBE2D3 | Negative regulators of DDX58/IFIH1 signaling |
| KEGG:05131 | 0.000339656530832 | 0.444444444444 | UBE2D3 UBE2D4 UBE2D2 UBE2D1 | Shigellosis |
| REAC:R-HSA-5357905 | 0.000500428099492 | 0.333333333333 | UBE2D1 UBE2D2 UBE2D3 | Regulation of TNFR1 signaling |
| WP:WP183 | 0.000520868847011 | 0.333333333333 | UBE2D1 UBE2D2 UBE2D3 | Proteasome degradation |
| REAC:R-HSA-9033241 | 0.000652728146316 | 0.333333333333 | UBE2D1 UBE2D2 UBE2D3 | Peroxisomal protein import |
| REAC:R-HSA-75893 | 0.000882703573715 | 0.333333333333 | UBE2D1 UBE2D2 UBE2D3 | TNF signaling |
| REAC:R-HSA-8866654 | 0.000934338987799 | 0.333333333333 | UBE2D1 UBE2D2 UBE2D3 | E3 ubiquitin ligases ubiquitinate target proteins |
| GO:0036211 | 0.00110547635355 | 1.0 | UBE2E3 RNF25 UBE2D2 UBE2D3 UBE2E2 UBE2D1 UBE2D4 RNF10 OTUB1 | protein modification process |
| REAC:R-HSA-1234176 | 0.00149172026983 | 0.333333333333 | UBE2D1 UBE2D2 UBE2D3 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha |
| REAC:R-HSA-168256 | 0.00186369688073 | 0.777777777778 | UBE2D1 RNF25 UBE2D2 UBE2E2 UBE2E3 UBE2D4 UBE2D3 | Immune System |
| REAC:R-HSA-1234174 | 0.00205183750398 | 0.333333333333 | UBE2D1 UBE2D2 UBE2D3 | Cellular response to hypoxia |
| GO:0043412 | 0.00232053828013 | 1.0 | UBE2E3 RNF25 UBE2D2 UBE2D3 UBE2E2 UBE2D1 UBE2D4 RNF10 OTUB1 | macromolecule modification |
| REAC:R-HSA-168928 | 0.00252715769562 | 0.333333333333 | UBE2D1 UBE2D2 UBE2D3 | DDX58/IFIH1-mediated induction of interferon-alpha/beta |
| GO:0085020 | 0.00292902387419 | 0.333333333333 | UBE2D4 UBE2D3 RNF25 | protein K6-linked ubiquitination |
| REAC:R-HSA-168164 | 0.00452422603622 | 0.333333333333 | UBE2D1 UBE2D2 UBE2D3 | Toll Like Receptor 3 (TLR3) Cascade |
| REAC:R-HSA-166166 | 0.00482963386549 | 0.333333333333 | UBE2D1 UBE2D2 UBE2D3 | MyD88-independent TLR4 cascade |
| REAC:R-HSA-937061 | 0.00482963386549 | 0.333333333333 | UBE2D1 UBE2D2 UBE2D3 | TRIF(TICAM1)-mediated TLR4 signaling |
| GO:0006511 | 0.00537628237252 | 0.666666666667 | RNF25 UBE2D2 UBE2D3 UBE2D1 UBE2D4 RNF10 | ubiquitin-dependent protein catabolic process |
| GO:0019941 | 0.00591809375688 | 0.666666666667 | RNF25 UBE2D2 UBE2D3 UBE2D1 UBE2D4 RNF10 | modification-dependent protein catabolic process |
| GO:0043632 | 0.00673624890584 | 0.666666666667 | RNF25 UBE2D2 UBE2D3 UBE2D1 UBE2D4 RNF10 | modification-dependent macromolecule catabolic process |
| GO:0031625 | 0.00821785904547 | 0.555555555556 | UBE2D3 UBE2D4 OTUB1 UBE2D2 UBE2D1 | ubiquitin protein ligase binding |
| GO:0061630 | 0.00943499601168 | 0.555555555556 | RNF25 UBE2D1 UBE2D3 RNF10 UBE2D2 | ubiquitin protein ligase activity |
| GO:0044389 | 0.0109971005091 | 0.555555555556 | UBE2D3 UBE2D4 OTUB1 UBE2D2 UBE2D1 | ubiquitin-like protein ligase binding |
| REAC:R-HSA-166016 | 0.0111589919648 | 0.333333333333 | UBE2D1 UBE2D2 UBE2D3 | Toll Like Receptor 4 (TLR4) Cascade |
| REAC:R-HSA-73887 | 0.0122778305747 | 0.333333333333 | UBE2D1 UBE2D2 UBE2D3 | Death Receptor Signaling |
| GO:0061659 | 0.0127581775757 | 0.555555555556 | RNF25 UBE2D1 UBE2D3 RNF10 UBE2D2 | ubiquitin-like protein ligase activity |
| REAC:R-HSA-9609507 | 0.0150593300182 | 0.333333333333 | UBE2D1 UBE2D2 UBE2D3 | Protein localization |
| GO:0016740 | 0.0165367263596 | 0.888888888889 | UBE2E3 RNF25 UBE2D2 UBE2E2 UBE2D1 UBE2D4 RNF10 UBE2D3 | transferase activity |
| REAC:R-HSA-168898 | 0.0171260552969 | 0.333333333333 | UBE2D1 UBE2D2 UBE2D3 | Toll-like Receptor Cascades |
| GO:0051603 | 0.0183571145865 | 0.666666666667 | RNF25 UBE2D2 UBE2D3 UBE2D1 UBE2D4 RNF10 | proteolysis involved in protein catabolic process |
| REAC:R-HSA-201451 | 0.0237893486791 | 0.222222222222 | UBE2D1 UBE2D3 | Signaling by BMP |
| REAC:R-HSA-2173795 | 0.032153801025 | 0.222222222222 | UBE2D1 UBE2D3 | Downregulation of SMAD2/3:SMAD4 transcriptional activity |
| HPA:0340451 | 0.0423337699608 | 0.777777777778 | UBE2D1 UBE2D2 OTUB1 UBE2E3 UBE2D4 RNF10 UBE2E2 | ovary; follicle cells[>=Low] |
| REAC:R-HSA-5689896 | 0.0470317013402 | 0.222222222222 | UBE2D1 OTUB1 | Ovarian tumor domain proteases |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| RNF25 | UBE2E3 | 0.999 | 0.06 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| RNF25 | UBE2D2 | 0.999 | 0.088 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| RNF25 | UBE2D3 | 0.998 | 0.064 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| RNF25 | UBE2D1 | 0.997 | 0.144 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only |
| RNF25 | UBE2D4 | 0.99 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| UBE2E2 | OTUB1 | 0.988 | 0.082 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| RNF25 | UBE2E2 | 0.984 | 0.046 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| UBE2D2 | OTUB1 | 0.982 | 0.246 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 |
| RNF10 | UBE2E3 | 0.981 | 0.064 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| UBE2D3 | UBE2D1 | 0.975 | 0.369636363636 | bioplex3_HEK293 bioplex3_WMM WMM_only |
| UBE2D3 | UBE2D2 | 0.975 | 0.22 | bioplex_WMM bioplex3_WMM WMM_only |
| UBE2D4 | OTUB1 | 0.963 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| UBE2D3 | RNF10 | 0.954 | 0.204 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only |
| RNF10 | UBE2D4 | 0.946 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| UBE2D2 | UBE2E3 | 0.945 | 0.164 | bioplex_WMM bioplex3_WMM WMM_only |
| UBE2D3 | UBE2D4 | 0.909 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only | |
| UBE2D1 | UBE2E3 | 0.869 | 0.295222222222 | bioplex3_WMM WMM_only |
| RNF10 | UBE2D1 | 0.869 | 0.3551 | bioplex3_HEK293 bioplex3_WMM WMM_only |
| UBE2D3 | UBE2E3 | 0.823 | 0.09 | bioplex_WMM bioplex3_WMM WMM_only |
| OTUB1 | UBE2E3 | 0.669 | 0.13 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| RNF10 | OTUB1 | 0.581 | 0.074 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only boldt_WMM |
| RNF25 | OTUB1 | 0.562 | 0.084 | bioplex_WMM bioplex3_WMM WMM_only |
| UBE2E2 | UBE2E3 | 0.548 | 0.144 | bioplex_WMM bioplex3_WMM WMM_only |
| RNF25 | RNF10 | 0.531 | 0.136 | bioplex_WMM bioplex3_WMM WMM_only |
| UBE2D4 | UBE2E2 | 0.502 | bioplex_WMM bioplex3_WMM WMM_only | |
| UBE2D2 | UBE2D1 | 0.388 | 0.308 | bioplex3_WMM youn_WMM WMM_only |
| UBE2D4 | UBE2E3 | 0.303 | bioplex_WMM bioplex3_WMM WMM_only | |
| UBE2D1 | OTUB1 | 0.259 | 0.272 | bioplex3_HEK293 bioplex3_WMM WMM_only |
| UBE2D1 | UBE2D4 | 0.214 | bioplex3_WMM WMM_only | |
| UBE2D1 | UBE2E2 | 0.214 | 0.214 | bioplex3_WMM WMM_only |
| UBE2D2 | RNF10 | 0.178 | 0.148 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| UBE2D3 | UBE2E2 | 0.153 | 0.062 | bioplex_WMM bioplex3_WMM WMM_only |
| UBE2D2 | UBE2D4 | 0.15 | bioplex_WMM bioplex3_WMM WMM_only | |
| UBE2D2 | UBE2E2 | 0.143 | 0.15 | bioplex_WMM bioplex3_WMM WMM_only |
| UBE2D3 | OTUB1 | 0.034 | 0.396 | bioplex_WMM bioplex3_WMM gupta_WMM WMM_only treiber_WMM |
Related Complexes