hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_09040.1
Complex Portal: CPX-19143
Confidence: Moderate High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| TEAD4 | Transcriptional enhancer factor TEF-3 (TEA domain family member 4) (TEAD-4) (Transcription factor 13-like 1) (Transcription factor RTEF-1) | 5 | UniProt NCBI |
| TEAD2 | Transcriptional enhancer factor TEF-4 (TEA domain family member 2) (TEAD-2) | 5 | UniProt NCBI |
| VGLL4 | Transcription cofactor vestigial-like protein 4 (Vgl-4) | 5 | UniProt NCBI |
| TEAD1 | Transcriptional enhancer factor TEF-1 (NTEF-1) (Protein GT-IIC) (TEA domain family member 1) (TEAD-1) (Transcription factor 13) (TCF-13) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-8951671 | 7.85597209803e-08 | 0.75 | TEAD1 TEAD4 TEAD2 | RUNX3 regulates YAP1-mediated transcription |
| WP:WP4541 | 7.94631888247e-08 | 1.0 | TEAD1 VGLL4 TEAD4 TEAD2 | Hippo Merlin signaling dysregulation |
| WP:WP3967 | 1.95604750042e-07 | 0.75 | TEAD1 TEAD4 TEAD2 | miR 509 3p alteration of YAP1 ECM axis |
| WP:WP4533 | 2.84994785564e-07 | 0.75 | TEAD1 TEAD4 TEAD2 | Transcription co factors SKI and SKIL protein partners |
| REAC:R-HSA-2032785 | 3.0856409449e-07 | 0.75 | TEAD1 TEAD4 TEAD2 | YAP1- and WWTR1 (TAZ)-stimulated gene expression |
| WP:WP4537 | 3.38413923581e-07 | 0.75 | TEAD1 TEAD4 TEAD2 | Hippo YAP signaling |
| KEGG:04392 | 8.91489558656e-07 | 0.75 | TEAD1 TEAD4 TEAD2 | Hippo signaling pathway - multiple species |
| WP:WP4542 | 1.27546878771e-06 | 0.75 | TEAD1 TEAD4 TEAD2 | Leukocyte intrinsic Hippo pathway functions |
| GO:0035329 | 2.94517278885e-06 | 1.0 | TEAD1 VGLL4 TEAD4 TEAD2 | hippo signaling |
| WP:WP4534 | 3.44677262663e-06 | 0.75 | TEAD1 TEAD4 TEAD2 | Mechanoregulation and pathology of YAP TAZ via Hippo and non Hippo mechanisms |
| WP:WP5087 | 1.87804194763e-05 | 1.0 | TEAD1 VGLL4 TEAD4 TEAD2 | Pleural mesothelioma |
| WP:WP4540 | 3.08286329452e-05 | 0.75 | TEAD1 TEAD4 TEAD2 | Hippo signaling regulation pathways |
| REAC:R-HSA-8878159 | 0.000153311097908 | 0.75 | TEAD1 TEAD4 TEAD2 | Transcriptional regulation by RUNX3 |
| KEGG:04390 | 0.000173136486645 | 0.75 | TEAD1 TEAD4 TEAD2 | Hippo signaling pathway |
| REAC:R-HSA-9796292 | 0.000368856835097 | 0.5 | TEAD4 TEAD2 | Formation of axial mesoderm |
| REAC:R-HSA-9758941 | 0.0068064250699 | 0.5 | TEAD4 TEAD2 | Gastrulation |
| GO:0140552 | 0.00842684400117 | 0.5 | TEAD2 TEAD1 | TEAD-YAP complex |
| WP:WP2857 | 0.0202008249203 | 0.5 | TEAD2 TEAD1 | Mesodermal commitment pathway |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| TEAD2 | TEAD1 | 1.0 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| TEAD4 | TEAD1 | 0.999 | 0.38 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| TEAD2 | TEAD4 | 0.998 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| VGLL4 | TEAD1 | 0.991 | 0.136 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| VGLL4 | TEAD4 | 0.99 | 0.11 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| VGLL4 | TEAD2 | 0.378 |
mutually_exclusive (P28347)
|
bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes