hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_09052.1
Confidence: Moderate High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| ABHD11 | sn-1-specific diacylglycerol lipase ABHD11 (EC 3.1.1.116) (Alpha/beta hydrolase domain-containing protein 11) (Abhydrolase domain-containing protein 11) (Williams-Beuren syndrome chromosomal region 21 protein) | 5 | UniProt NCBI |
| FAHD1 | Acylpyruvase FAHD1, mitochondrial (EC 3.7.1.5) (Fumarylacetoacetate hydrolase domain-containing protein 1) (FAH domain-containing protein 1) (Oxaloacetate decarboxylase) (OAA decarboxylase) (EC 4.1.1.112) (YisK-like protein) | 5 | UniProt NCBI |
| PCK2 | Phosphoenolpyruvate carboxykinase [GTP], mitochondrial (PEPCK-M) (EC 4.1.1.32) (Phosphoenolpyruvate carboxykinase 2, mitochondrial) (mtPCK2) | 5 | UniProt NCBI |
| IDH3G | Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial (Isocitric dehydrogenase subunit gamma) (NAD(+)-specific ICDH subunit gamma) | 5 | UniProt NCBI |
| GUK1 | Guanylate kinase (EC 2.7.4.8) (GMP kinase) (Guanylate kinase 1) | 5 | UniProt NCBI |
| TRMT5 | tRNA (guanine(37)-N1)-methyltransferase (EC 2.1.1.228) (M1G-methyltransferase) (tRNA [GM37] methyltransferase) (tRNA methyltransferase 5 homolog) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:00020 | 0.0031464101682 | 0.333333333333 | IDH3G PCK2 | Citrate cycle (TCA cycle) |
| GO:0005759 | 0.00456204960132 | 0.833333333333 | ABHD11 TRMT5 PCK2 IDH3G FAHD1 | mitochondrial matrix |
| REAC:R-HSA-71403 | 0.00540340354533 | 0.333333333333 | FAHD1 IDH3G | Citric acid cycle (TCA cycle) |
| REAC:R-HSA-71406 | 0.0339259639772 | 0.333333333333 | FAHD1 IDH3G | Pyruvate metabolism and Citric Acid (TCA) cycle |
| KEGG:01100 | 0.0414134615413 | 0.666666666667 | FAHD1 PCK2 GUK1 IDH3G | Metabolic pathways |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| FAHD1 | GUK1 | 0.977 | 0.042 | bioplex3_WMM bioplex3_HCT116 WMM_only |
| FAHD1 | TRMT5 | 0.975 | 0.034 | bioplex3_WMM bioplex3_HCT116 WMM_only |
| FAHD1 | IDH3G | 0.967 | 0.34 | bioplex3_WMM bioplex3_HCT116 fraction |
| PCK2 | FAHD1 | 0.96 | 0.04 | bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 fraction |
| FAHD1 | ABHD11 | 0.957 | 0.064 | bioplex3_WMM bioplex3_HCT116 fraction |
| GUK1 | TRMT5 | 0.715 | 0.014 | bioplex3_WMM WMM_only |
| GUK1 | ABHD11 | 0.621 | 0.062 | bioplex3_WMM WMM_only |
| ABHD11 | IDH3G | 0.606 | 0.098 | bioplex_WMM bioplex3_WMM fraction |
| GUK1 | IDH3G | 0.586 | 0.04 | bioplex3_WMM WMM_only |
| TRMT5 | IDH3G | 0.479 | 0.008 | bioplex3_WMM WMM_only |
| PCK2 | ABHD11 | 0.316 | 0.126 | bioplex_WMM bioplex3_WMM fraction |
| PCK2 | TRMT5 | 0.158 | 0.028 | bioplex3_WMM youn_WMM WMM_only |
| TRMT5 | ABHD11 | 0.131 | 0.008 | bioplex3_WMM WMM_only |
| PCK2 | IDH3G | 0.123 | 0.188 | bioplex_WMM bioplex3_WMM fraction |
| PCK2 | GUK1 | 0.108 | 0.052 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes